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ONTOLOGY REPORT - ANNOTATIONS

Term:positive regulation of dendritic spine development
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Accession:GO:0060999 term browser browse the term
Definition:Any process that increases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure.

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positive regulation of dendritic spine development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:24328732)
GO_REF:0000107		 RGD
Ensembl		 PMID:24328732 GO_REF:0000107 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057 		JBrowse link
G Arf1 ADP-ribosylation factor 1 IMP RGD PMID:23889934 RGD:8553918 NCBI chr10:45,562,700...45,579,214
Ensembl chr10:45,563,547...45,579,029 		JBrowse link
G Camk1 calcium/calmodulin-dependent protein kinase I involved_in ISO
ISS		 (PMID:18184567)
GO_REF:0000024		 RGD
UniProt		 PMID:18184567 GO_REF:0000024 NCBI chr 4:145,289,300...145,300,146
Ensembl chr 4:145,288,996...145,300,177 		JBrowse link
G Cdkl5 cyclin-dependent kinase-like 5 IMP RGD PMID:23671101 RGD:12791021 NCBI chr  X:35,536,396...35,773,204
Ensembl chr  X:35,599,258...35,771,711 		JBrowse link
G Cfl1 cofilin 1 IMP RGD PMID:25723479 RGD:11570400 NCBI chr 1:220,869,805...220,873,337
Ensembl chr 1:220,869,805...220,873,337 		JBrowse link
G Cpeb3 cytoplasmic polyadenylation element binding protein 3 involved_in ISO (MGI:5300629|PMID:22153079) RGD PMID:22153079 MGI:5300629 NCBI chr 1:255,660,165...255,842,671
Ensembl chr 1:255,665,238...255,815,733 		JBrowse link
G Dlg5 discs large MAGUK scaffold protein 5 involved_in ISO (MGI:5608921|PMID:25232112) RGD PMID:25232112 MGI:5608921 NCBI chr15:120,213...230,312
Ensembl chr15:120,372...228,977 		JBrowse link
G Eif4g2 eukaryotic translation initiation factor 4, gamma 2 IMP RGD PMID:22514323 RGD:10755512 NCBI chr 1:175,883,362...175,895,510
Ensembl chr 1:175,883,363...175,895,510 		JBrowse link
G Fmr1 FMRP translational regulator 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:3798322|PMID:18539120)		 UniProt
RGD		 PMID:18539120 GO_REF:0000024 MGI:3798322 NCBI chr  X:154,684,924...154,722,369
Ensembl chr  X:154,684,935...154,722,314 		JBrowse link
G Foxo6 forkhead box O6 involved_in ISO (MGI:5461238|PMID:23222102) RGD PMID:23222102 MGI:5461238 NCBI chr 5:139,208,153...139,227,288
Ensembl chr 5:139,208,046...139,227,196 		JBrowse link
G Grn granulin precursor IMP RGD PMID:21813674 RGD:5509044 NCBI chr10:90,377,103...90,383,207
Ensembl chr10:90,376,933...90,383,205 		JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K IMP RGD PMID:24990929 RGD:10002784 NCBI chr17:6,664,730...6,676,753
Ensembl chr17:6,665,659...6,676,654 		JBrowse link
G Il2 interleukin 2 IDA RGD PMID:20225203 RGD:5147914 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854 		JBrowse link
G Itsn1 intersectin 1 IMP RGD PMID:19258322 RGD:13461864 NCBI chr11:31,943,119...32,069,249
Ensembl chr11:31,893,489...32,069,249 		JBrowse link
G Kalrn kalirin, RhoGEF kinase acts_upstream_of_or_within ISO MGI:3831288|MGI:3831292|MGI:97845 (MGI:3821420|PMID:19020030), (MGI:5645427|PMID:25865668) RGD PMID:19020030 PMID:25865668 MGI:3821420 MGI:5645427 NCBI chr11:69,484,293...70,025,682
Ensembl chr11:69,484,293...70,025,633 		JBrowse link
G Llph LLP homolog, long-term synaptic facilitation factor involved_in ISO (MGI:5796065|PMID:26961175) RGD PMID:26961175 MGI:5796065 NCBI chr 7:65,004,544...65,009,509
Ensembl chr 7:65,005,791...65,008,823 		JBrowse link
G LOC103690160 SH3 and multiple ankyrin repeat domains protein 2-like involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr 1:215,208,591...215,246,638
Ensembl chr 1:215,214,853...215,241,723 		JBrowse link
G Lpar1 lysophosphatidic acid receptor 1 IDA RGD PMID:16638019 RGD:2317707 NCBI chr 5:75,557,038...75,678,067
Ensembl chr 5:75,557,042...75,676,584 		JBrowse link
G Mapk6 mitogen-activated protein kinase 6 acts_upstream_of_or_within ISO MGI:1333110 (MGI:5430253|PMID:22508986) RGD PMID:22508986 MGI:5430253 NCBI chr 8:82,328,013...82,351,108
Ensembl chr 8:82,328,020...82,351,108 		JBrowse link
G Mapkapk5 MAPK activated protein kinase 5 acts_upstream_of_or_within ISO MGI:1354946|MGI:2680287 (MGI:5430253|PMID:22508986) RGD PMID:22508986 MGI:5430253 NCBI chr12:40,510,378...40,529,332
Ensembl chr12:40,510,378...40,529,338 		JBrowse link
G Mecp2 methyl CpG binding protein 2 IMP RGD PMID:24188180 RGD:12789443 NCBI chr  X:156,650,389...156,713,813
Ensembl chr  X:156,655,960...156,705,233 		JBrowse link
G Mtor mechanistic target of rapamycin kinase IMP RGD PMID:21683721 RGD:10040994 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967 		JBrowse link
G Neurl1 neuralized E3 ubiquitin protein ligase 1 involved_in ISO (MGI:5300629|PMID:22153079) RGD PMID:22153079 MGI:5300629 NCBI chr 1:266,953,006...267,038,879
Ensembl chr 1:266,952,561...267,038,883 		JBrowse link
G Nlgn1 neuroligin 1 involved_in IDA
ISO
IMP		 PMID:17582332
(MGI:5493186|PMID:23143522)
UniProtKB:Q99K10 (PMID:23143522)		 RGD PMID:23143522, PMID:17582332, PMID:17582332, PMID:15681343 MGI:5493186, RGD:8553502, RGD:8553502, RGD:8553420 NCBI chr 2:111,057,291...111,973,681
Ensembl chr 2:111,057,291...111,793,326 		JBrowse link
G Nlgn2 neuroligin 2 IMP RGD PMID:15681343 RGD:8553420 NCBI chr10:56,431,586...56,444,847
Ensembl chr10:56,431,573...56,444,847 		JBrowse link
G Nlgn3 neuroligin 3 IMP RGD PMID:15681343 RGD:8553420 NCBI chr  X:71,199,390...71,227,460
Ensembl chr  X:71,199,491...71,222,732 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 IMP RGD PMID:22509272 RGD:7174739 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647 		JBrowse link
G Nrg1 neuregulin 1 acts_upstream_of_or_within ISO MGI:1928831 (MGI:3803029|PMID:18596162), (MGI:4461331|PMID:20610754) RGD PMID:18596162 PMID:20610754 MGI:3803029 MGI:4461331 NCBI chr16:62,969,573...64,065,063
Ensembl chr16:63,837,216...64,057,434 		JBrowse link
G Palm paralemmin involved_in ISO (MGI:5009384|PMID:18287537) RGD PMID:18287537 MGI:5009384 NCBI chr 7:12,708,024...12,721,055
Ensembl chr 7:12,708,015...12,793,711 		JBrowse link
G Ppp1r9a protein phosphatase 1, regulatory subunit 9A IMP RGD PMID:12052877 RGD:1299363 NCBI chr 4:29,976,485...30,247,371
Ensembl chr 4:29,978,739...30,241,911 		JBrowse link
G Psen1 presenilin 1 involved_in ISO (PMID:21951279) RGD PMID:21951279 NCBI chr 6:107,169,514...107,221,000
Ensembl chr 6:107,169,528...107,216,798 		JBrowse link
G Rac1 Rac family small GTPase 1 acts_upstream_of_or_within ISO MGI:2685385 (MGI:5645427|PMID:25865668) RGD PMID:25865668 MGI:5645427 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873 		JBrowse link
G RGD1563888 similar to DNA segment, Chr 16, ERATO Doi 472, expressed involved_in ISO (MGI:5908509|PMID:27404227) RGD PMID:27404227 MGI:5908509 NCBI chr11:17,073,296...17,120,235
Ensembl chr11:17,076,980...17,130,120 		JBrowse link
G Shank1 SH3 and multiple ankyrin repeat domains 1 involved_in IDA
IBA		 PMID:18287537
PMID:21873635		 UniProt
GO_Central		 PMID:18287537, PMID:21873635, PMID:18287537, PMID:21873635 RGD:8553517, RGD:13792537, RGD:8553517, RGD:13792537 NCBI chr 1:100,297,137...100,344,377
Ensembl chr 1:100,297,152...100,344,377 		JBrowse link
G Shank2 SH3 and multiple ankyrin repeat domains 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr 1:217,149,156...217,593,950
Ensembl chr 1:217,151,166...217,592,763 		JBrowse link
G Shank3 SH3 and multiple ankyrin repeat domains 3 involved_in ISS
ISO
IEA
IBA		 PMID:21795692
(MGI:5320264|PMID:21795692)
GO_REF:0000107
PMID:21873635		 RGD
Ensembl		 PMID:21795692, PMID:21795692, PMID:21795692, PMID:21873635, PMID:21873635 GO_REF:0000107 MGI:5320264, RGD:7349315, RGD:7349315, RGD:13792537, RGD:13792537 NCBI chr 7:130,474,278...130,534,679
Ensembl chr 7:130,474,279...130,534,679 		JBrowse link
G Tsc2 TSC complex subunit 2 IMP RGD PMID:16595860 RGD:11568665 NCBI chr10:13,962,006...13,996,684
Ensembl chr10:13,961,947...13,996,584 		JBrowse link
G Zmynd8 zinc finger, MYND-type containing 8 IMP RGD PMID:24117785 RGD:8554267 NCBI chr 3:162,480,766...162,594,145
Ensembl chr 3:162,480,804...162,581,610 		JBrowse link
positive regulation of dendritic spine morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actr2 actin related protein 2 IMP RGD PMID:23441206 RGD:11530033 NCBI chr14:104,338,486...104,375,840
Ensembl chr14:104,340,434...104,375,649 		JBrowse link
G Actr3 actin related protein 3 IMP RGD PMID:23441206 RGD:11530033 NCBI chr13:41,695,520...41,738,622
Ensembl chr13:41,695,183...41,738,658 		JBrowse link
G Afdn afadin, adherens junction formation factor IMP RGD PMID:22948147 RGD:13838731 NCBI chr 1:53,713,873...53,861,918
Ensembl chr 1:53,715,693...53,802,658 		JBrowse link
G Baiap2 BAR/IMD domain containing adaptor protein 2 IMP RGD PMID:15673667 RGD:9684988 NCBI chr10:109,107,326...109,187,458
Ensembl chr10:109,107,389...109,187,115 		JBrowse link
G Bhlhb9 basic helix-loop-helix family member B9 involved_in ISO (MGI:5545985|PMID:21199326) RGD PMID:21199326 MGI:5545985 NCBI chr  X:106,359,981...106,393,457
Ensembl chr  X:106,390,759...106,393,459 		JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta involved_in IMP PMID:12873385 UniProt PMID:12873385, PMID:12873385 RGD:8553829, RGD:8553829 NCBI chr14:86,208,876...86,297,727
Ensembl chr14:86,208,901...86,297,652 		JBrowse link
G Caprin1 cell cycle associated protein 1 involved_in IEA
ISO
ISS		 GO_REF:0000107
(MGI:4888105|PMID:20516077)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:20516077 GO_REF:0000024 GO_REF:0000107 MGI:4888105 NCBI chr 3:93,701,830...93,789,580
Ensembl chr 3:93,702,487...93,789,617 		JBrowse link
G Caprin2 caprin family member 2 involved_in ISO (MGI:4888105|PMID:20516077) RGD PMID:20516077 MGI:4888105 NCBI chr 4:183,304,993...183,374,195
Ensembl chr 4:183,305,813...183,374,195 		JBrowse link
G Cask calcium/calmodulin dependent serine protein kinase IMP RGD PMID:18606847 RGD:11576294 NCBI chr  X:9,815,652...10,156,155
Ensembl chr  X:9,815,652...10,156,155 		JBrowse link
G Cux2 cut-like homeobox 2 involved_in ISO (MGI:4836115|PMID:20510857) RGD PMID:20510857 MGI:4836115 NCBI chr12:40,016,774...40,221,067
Ensembl chr12:40,018,937...40,219,291 		JBrowse link
G Dbn1 drebrin 1 involved_in IMP
ISO
ISS
IBA
IEA		 (MGI:5688247|PMID:25865831)
GO_REF:0000024
PMID:21873635
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:25865831, PMID:19174472, PMID:21873635, PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:5688247, RGD:10398809, RGD:13792537, RGD:13792537 NCBI chr17:9,679,511...9,693,878
Ensembl chr17:9,679,628...9,693,820 		JBrowse link
G Dbnl drebrin-like involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr14:86,029,335...86,044,364
Ensembl chr14:86,029,335...86,044,364 		JBrowse link
G Dhx36 DEAH-box helicase 36 involved_in IMP PMID:23651854 UniProt PMID:23651854, PMID:23651854 RGD:13792545, RGD:13792545 NCBI chr 2:152,785,844...152,824,549
Ensembl chr 2:152,785,844...152,824,547 		JBrowse link
G Dnm1l dynamin 1-like IMP RGD PMID:19605646 RGD:7800727 NCBI chr11:88,830,968...88,882,271
Ensembl chr11:88,830,957...88,880,198 		JBrowse link
G Eef2k eukaryotic elongation factor-2 kinase IMP RGD PMID:20427644 RGD:10401235 NCBI chr 1:190,780,211...190,839,926
Ensembl chr 1:190,780,236...190,842,324 		JBrowse link
G Itpka inositol-trisphosphate 3-kinase A involved_in IMP PMID:19890013 MGI PMID:19890013, PMID:19890013 RGD:8553536, RGD:8553536 NCBI chr 3:111,545,007...111,553,605
Ensembl chr 3:111,545,007...111,553,604 		JBrowse link
G Kalrn kalirin, RhoGEF kinase acts_upstream_of_or_within
involved_in		 ISO
IEA		 MGI:4358076 (MGI:4355773|PMID:19625617)
GO_REF:0000107		 RGD
Ensembl		 PMID:19625617 GO_REF:0000107 MGI:4355773 NCBI chr11:69,484,293...70,025,682
Ensembl chr11:69,484,293...70,025,633 		JBrowse link
G Lrp8 LDL receptor related protein 8 involved_in ISO (MGI:5426130|PMID:21852430) RGD PMID:21852430 MGI:5426130 NCBI chr 5:127,404,348...127,476,636
Ensembl chr 5:127,404,450...127,476,641 		JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate IMP RGD PMID:16202710 RGD:9685333 NCBI chr20:42,966,140...42,971,838
Ensembl chr20:42,966,140...42,971,838 		JBrowse link
G Mfn1 mitofusin 1 IMP RGD PMID:19605646 RGD:7800727 NCBI chr 2:118,929,738...118,971,689
Ensembl chr 2:118,929,738...118,973,698 		JBrowse link
G Mfn2 mitofusin 2 IMP RGD PMID:19605646 RGD:7800727 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase IMP RGD PMID:19605646 RGD:7800727 NCBI chr11:74,717,600...74,793,902
Ensembl chr11:74,720,254...74,793,803 		JBrowse link
G Pafah1b1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 involved_in ISO (MGI:5619436|PMID:23483716) RGD PMID:23483716 MGI:5619436 NCBI chr10:61,456,144...61,577,412
Ensembl chr10:61,456,145...61,577,412 		JBrowse link
G Pak3 p21 (RAC1) activated kinase 3 IMP RGD PMID:18481281 RGD:7775053 NCBI chr  X:114,784,452...115,042,683
Ensembl chr  X:114,929,029...115,036,669 		JBrowse link
G Reln reelin involved_in IEA
ISO		 GO_REF:0000107
(MGI:5286805|PMID:21664258), (MGI:5426130|PMID:21852430)		 Ensembl
RGD		 PMID:21664258 PMID:21852430 GO_REF:0000107 MGI:5286805 MGI:5426130 NCBI chr 4:9,347,533...9,774,257
Ensembl chr 4:9,347,528...9,773,670 		JBrowse link
G Stau2 staufen double-stranded RNA binding protein 2 IMP RGD PMID:16418534 RGD:10043163 NCBI chr 5:2,257,910...2,497,429 JBrowse link
G Tiam1 TIAM Rac1 associated GEF 1 IMP RGD PMID:16474385 RGD:10043325 NCBI chr11:29,931,083...30,061,173
Ensembl chr11:29,933,163...30,051,103 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20082
    developmental process 6853
      positive regulation of developmental process 1489
        positive regulation of dendritic spine development 64
          positive regulation of dendritic spine morphogenesis 27
Path 2
Term Annotations click to browse term
  biological_process 20082
    developmental process 6853
      anatomical structure development 6313
        multicellular organism development 5789
          system development 5317
            nervous system development 2735
              neurogenesis 1946
                generation of neurons 1789
                  neuron differentiation 1623
                    neuron development 1331
                      neuron projection development 1169
                        dendrite development 319
                          dendritic spine development 131
                            regulation of dendritic spine development 84
                              positive regulation of dendritic spine development 64
                                positive regulation of dendritic spine morphogenesis 27
paths to the root