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ONTOLOGY REPORT - ANNOTATIONS

Term:positive regulation of dendritic spine development
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Accession:GO:0060999 term browser browse the term
Definition:Any process that increases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure.


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positive regulation of dendritic spine development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:24328732)
GO_REF:0000107		 RGD
Ensembl		 PMID:24328732 GO_REF:0000107 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Arf1 ADP-ribosylation factor 1 IMP RGD PMID:23889934 RGD:8553918 NCBI chr10:43,997,983...44,014,461
Ensembl chr10:43,997,986...44,014,434 		JBrowse link
G C11h21orf91 similar to human chromosome 21 open reading frame 91 involved_in ISO (MGI:5908509|PMID:27404227) RGD PMID:27404227 MGI:5908509 NCBI chr11:17,229,129...17,262,307
Ensembl chr11:17,229,138...17,262,483 		JBrowse link
G Camk1 calcium/calmodulin-dependent protein kinase I involved_in ISO
IEA
ISS		 (PMID:18184567)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:18184567 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:146,481,196...146,492,039
Ensembl chr 4:146,481,196...146,492,081 		JBrowse link
G Cdkl5 cyclin-dependent kinase-like 5 IMP RGD PMID:23671101 RGD:12791021 NCBI chr  X:33,757,605...33,988,075
Ensembl chr  X:33,821,257...33,986,582 		JBrowse link
G Cfl1 cofilin 1 IMP RGD PMID:25723479 RGD:11570400 NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587 		JBrowse link
G Cpeb3 cytoplasmic polyadenylation element binding protein 3 involved_in ISO (MGI:5300629|PMID:22153079) RGD PMID:22153079 MGI:5300629 NCBI chr 1:234,749,138...234,931,219
Ensembl chr 1:234,751,733...234,931,560 		JBrowse link
G Crebbp CREB binding protein IMP RGD PMID:32206715 RGD:126848802 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888 		JBrowse link
G Dlg5 discs large MAGUK scaffold protein 5 involved_in ISO (MGI:5608921|PMID:25232112) RGD PMID:25232112 MGI:5608921 NCBI chr15:75,786...209,735
Ensembl chr15:75,786...187,837 		JBrowse link
G Eif4g2 eukaryotic translation initiation factor 4, gamma 2 IMP RGD PMID:22514323 RGD:10755512 NCBI chr 1:165,181,433...165,193,583
Ensembl chr 1:165,181,434...165,193,588 		JBrowse link
G Fmr1 fragile X messenger ribonucleoprotein 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:3798322|PMID:18539120)		 UniProt
RGD		 PMID:18539120 GO_REF:0000024 MGI:3798322 NCBI chr  X:147,240,239...147,278,057
Ensembl chr  X:147,240,301...147,278,050 		JBrowse link
G Foxo6 forkhead box O6 involved_in ISO (MGI:5461238|PMID:23222102) RGD PMID:23222102 MGI:5461238 NCBI chr 5:133,856,087...133,876,387
Ensembl chr 5:133,856,072...133,876,573 		JBrowse link
G Grn granulin precursor IMP RGD PMID:21813674 RGD:5509044 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775 		JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K IMP RGD PMID:24990929 RGD:10002784 NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997 		JBrowse link
G Il2 interleukin 2 IDA RGD PMID:20225203 RGD:5147914 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Itsn1 intersectin 1 IMP RGD PMID:19258322 RGD:13461864 NCBI chr11:30,978,590...31,160,645
Ensembl chr11:30,978,590...31,160,645 		JBrowse link
G Kalrn kalirin, RhoGEF kinase acts_upstream_of_or_within ISO MGI:3831288|MGI:3831292|MGI:97845 (MGI:3821420|PMID:19020030), (MGI:5645427|PMID:25865668) RGD PMID:19020030 PMID:25865668 MGI:3821420 MGI:5645427 NCBI chr11:66,198,155...66,803,166
Ensembl chr11:66,198,173...66,797,610 		JBrowse link
G Llph LLP homolog, long-term synaptic facilitation factor involved_in ISO (MGI:5796065|PMID:26961175) RGD PMID:26961175 MGI:5796065 NCBI chr 7:55,735,317...55,740,341
Ensembl chr 7:55,735,400...55,740,339 		JBrowse link
G Lpar1 lysophosphatidic acid receptor 1 IDA RGD PMID:16638019 RGD:2317707 NCBI chr 5:73,229,047...73,347,874
Ensembl chr 5:73,229,625...73,369,895 		JBrowse link
G Mapk6 mitogen-activated protein kinase 6 acts_upstream_of_or_within ISO MGI:1333110 (MGI:5430253|PMID:22508986) RGD PMID:22508986 MGI:5430253 NCBI chr 8:76,146,650...76,169,767
Ensembl chr 8:76,146,690...76,169,720 		JBrowse link
G Mapkapk5 MAPK activated protein kinase 5 acts_upstream_of_or_within ISO MGI:1354946|MGI:2680287 (MGI:5430253|PMID:22508986) RGD PMID:22508986 MGI:5430253 NCBI chr12:34,993,520...35,013,059
Ensembl chr12:34,994,092...35,013,052 		JBrowse link
G Mecp2 methyl CpG binding protein 2 IMP RGD PMID:24188180 RGD:12789443 NCBI chr  X:151,781,177...151,844,687
Ensembl chr  X:151,789,930...151,844,689 		JBrowse link
G Mtor mechanistic target of rapamycin kinase IMP RGD PMID:21683721 RGD:10040994 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Neurl1 neuralized E3 ubiquitin protein ligase 1 involved_in ISO (MGI:5300629|PMID:22153079) RGD PMID:22153079 MGI:5300629 NCBI chr 1:246,066,830...246,152,890
Ensembl chr 1:246,067,100...246,152,903 		JBrowse link
G Nlgn1 neuroligin 1 involved_in IMP
IEA
ISO
IDA		 GO_REF:0000107
(MGI:5493186|PMID:23143522)
PMID:17582332
UniProtKB:Q99K10 (PMID:23143522)		 Ensembl
RGD		 PMID:23143522 PMID:15681343 PMID:17582332 GO_REF:0000107 MGI:5493186, RGD:8553420, RGD:8553502 NCBI chr 2:108,256,236...109,181,530
Ensembl chr 2:108,257,824...109,002,464 		JBrowse link
G Nlgn2 neuroligin 2 IMP RGD PMID:15681343 RGD:8553420 NCBI chr10:54,544,461...54,557,854
Ensembl chr10:54,544,588...54,558,434 		JBrowse link
G Nlgn3 neuroligin 3 IMP RGD PMID:15681343 RGD:8553420 NCBI chr  X:66,427,926...66,457,378
Ensembl chr  X:66,429,458...66,451,876 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 IMP RGD PMID:22509272 RGD:7174739 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Nrg1 neuregulin 1 acts_upstream_of_or_within ISO MGI:1928831 (MGI:3803029|PMID:18596162) RGD PMID:18596162 MGI:3803029 NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884 		JBrowse link
G Palm paralemmin involved_in ISO (MGI:5009384|PMID:18287537) RGD PMID:18287537 MGI:5009384 NCBI chr 7:9,886,634...9,912,389
Ensembl chr 7:9,886,643...9,912,555 		JBrowse link
G Pbrm1 polybromo 1 IMP RGD PMID:31723243 RGD:150340632 NCBI chr16:6,213,507...6,312,895
Ensembl chr16:6,213,300...6,311,780 		JBrowse link
G Ppp1r9a protein phosphatase 1, regulatory subunit 9A IMP RGD PMID:12052877 RGD:1299363 NCBI chr 4:32,970,501...33,292,360
Ensembl chr 4:33,024,450...33,286,907 		JBrowse link
G Psen1 presenilin 1 involved_in ISO (PMID:21951279) RGD PMID:21951279 NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Rac1 Rac family small GTPase 1 acts_upstream_of_or_within ISO MGI:2685385 (MGI:5645427|PMID:25865668) RGD PMID:25865668 MGI:5645427 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Shank1 SH3 and multiple ankyrin repeat domains 1 involved_in IDA PMID:18287537 UniProt PMID:18287537 RGD:8553517 NCBI chr 1:94,807,879...94,857,356
Ensembl chr 1:94,808,276...94,855,824 		JBrowse link
G Shank3 SH3 and multiple ankyrin repeat domains 3 involved_in ISS
ISO
IEA		 PMID:21795692
(MGI:5320264|PMID:21795692)
GO_REF:0000107		 RGD
Ensembl		 PMID:21795692 PMID:21795692 GO_REF:0000107 MGI:5320264, RGD:7349315 NCBI chr 7:120,568,707...120,630,796
Ensembl chr 7:120,570,402...120,630,374 		JBrowse link
G Tsc2 TSC complex subunit 2 IMP RGD PMID:16595860 RGD:11568665 NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951 		JBrowse link
G Zmynd8 zinc finger, MYND-type containing 8 IMP RGD PMID:24117785 RGD:8554267 NCBI chr 3:154,528,917...154,629,532
Ensembl chr 3:154,529,043...154,628,463 		JBrowse link
positive regulation of dendritic spine morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actr2 actin related protein 2 IMP RGD PMID:23441206 RGD:11530033 NCBI chr14:94,296,443...94,333,735
Ensembl chr14:94,296,443...94,340,524 		JBrowse link
G Actr3 actin related protein 3 IMP RGD PMID:23441206 RGD:11530033 NCBI chr13:36,800,739...36,843,837
Ensembl chr13:36,800,093...36,844,124 		JBrowse link
G Afdn afadin, adherens junction formation factor IMP RGD PMID:22948147 RGD:13838731 NCBI chr 1:53,905,344...54,034,216
Ensembl chr 1:53,905,373...54,034,216 		JBrowse link
G Baiap2 BAR/IMD domain containing adaptor protein 2 IMP RGD PMID:15673667 RGD:9684988 NCBI chr10:105,223,065...105,290,130
Ensembl chr10:105,223,090...105,290,134 		JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta involved_in IMP PMID:12873385 UniProt PMID:12873385 RGD:8553829 NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994 		JBrowse link
G Caprin1 cell cycle associated protein 1 involved_in ISS
ISO
IEA		 GO_REF:0000024
(MGI:4888105|PMID:20516077)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:20516077 GO_REF:0000024 GO_REF:0000107 MGI:4888105 NCBI chr 3:90,152,305...90,230,447
Ensembl chr 3:90,153,620...90,230,502 		JBrowse link
G Caprin2 caprin family member 2 involved_in ISO (MGI:4888105|PMID:20516077) RGD PMID:20516077 MGI:4888105 NCBI chr 4:181,806,105...181,860,754
Ensembl chr 4:181,806,575...181,860,830 		JBrowse link
G Cask calcium/calmodulin dependent serine protein kinase IMP RGD PMID:18606847 RGD:11576294 NCBI chr  X:8,899,500...9,243,014
Ensembl chr  X:8,899,833...9,238,694 		JBrowse link
G Cux2 cut-like homeobox 2 involved_in ISO (MGI:4836115|PMID:20510857) RGD PMID:20510857 MGI:4836115 NCBI chr12:34,507,723...34,707,581
Ensembl chr12:34,520,959...34,705,806 		JBrowse link
G Dbn1 drebrin 1 involved_in IMP
IEA
IBA
ISS
ISO		 GO_REF:0000107
PMID:21873635
GO_REF:0000024
(MGI:5688247|PMID:25865831)		 Ensembl
UniProt
RGD		 PMID:25865831 PMID:19174472 PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:5688247, RGD:10398809, RGD:13792537 NCBI chr17:9,150,608...9,164,982
Ensembl chr17:9,150,659...9,164,984 		JBrowse link
G Dbnl drebrin-like involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:80,666,115...80,681,155
Ensembl chr14:80,666,124...80,681,155 		JBrowse link
G Dhx36 DEAH-box helicase 36 involved_in IMP PMID:23651854 UniProt PMID:23651854 RGD:13792545 NCBI chr 2:146,856,469...146,894,577
Ensembl chr 2:146,856,469...146,894,572 		JBrowse link
G Dnm1l dynamin 1-like IMP RGD PMID:19605646 RGD:7800727 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482 		JBrowse link
G Eef2k eukaryotic elongation factor-2 kinase IMP RGD PMID:20427644 RGD:10401235 NCBI chr 1:175,393,119...175,456,756
Ensembl chr 1:175,393,154...175,455,164 		JBrowse link
G Ephb2 Eph receptor B2 IMP RGD PMID:21364901 RGD:127285794 NCBI chr 5:148,889,574...149,077,027
Ensembl chr 5:148,897,246...149,077,059 		JBrowse link
G Gprasp3 G protein-coupled receptor associated sorting protein family member 3 involved_in ISO (MGI:5545985|PMID:21199326) RGD PMID:21199326 MGI:5545985 NCBI chr  X:98,847,591...98,854,949
Ensembl chr  X:98,817,593...98,854,545 		JBrowse link
G Itpka inositol-trisphosphate 3-kinase A acts_upstream_of_or_within IMP PMID:19890013 MGI PMID:19890013 RGD:8553536 NCBI chr 3:106,726,036...106,734,601
Ensembl chr 3:106,726,036...106,734,600 		JBrowse link
G Kalrn kalirin, RhoGEF kinase acts_upstream_of_or_within
involved_in		 ISO
IEA		 MGI:4358076 (MGI:4355773|PMID:19625617)
GO_REF:0000107		 RGD
Ensembl		 PMID:19625617 GO_REF:0000107 MGI:4355773 NCBI chr11:66,198,155...66,803,166
Ensembl chr11:66,198,173...66,797,610 		JBrowse link
G Lrp8 LDL receptor related protein 8 involved_in ISO (MGI:5426130|PMID:21852430) RGD PMID:21852430 MGI:5426130 NCBI chr 5:122,563,468...122,635,434
Ensembl chr 5:122,563,453...122,631,352 		JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate IMP RGD PMID:16202710 RGD:9685333 NCBI chr20:40,685,315...40,691,012
Ensembl chr20:40,685,315...40,691,012 		JBrowse link
G Mfn1 mitofusin 1 IMP RGD PMID:19605646 RGD:7800727 NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640 		JBrowse link
G Mfn2 mitofusin 2 IMP RGD PMID:19605646 RGD:7800727 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase IMP RGD PMID:19605646 RGD:7800727 NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109 		JBrowse link
G Pafah1b1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 involved_in ISO (MGI:5619436|PMID:23483716) RGD PMID:23483716 MGI:5619436 NCBI chr10:59,533,042...59,591,808
Ensembl chr10:59,534,117...59,591,808 		JBrowse link
G Pak3 p21 (RAC1) activated kinase 3 IMP RGD PMID:18481281 RGD:7775053 NCBI chr  X:107,116,308...107,374,342
Ensembl chr  X:107,260,898...107,368,314 		JBrowse link
G Reln reelin involved_in IEA
ISO		 GO_REF:0000107
(MGI:5286805|PMID:21664258), (MGI:5426130|PMID:21852430)		 Ensembl
RGD		 PMID:21664258 PMID:21852430 GO_REF:0000107 MGI:5286805 MGI:5426130 NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211 		JBrowse link
G Stau2 staufen double-stranded RNA binding protein 2 IMP RGD PMID:16418534 RGD:10043163 NCBI chr 5:2,840,741...3,084,935
Ensembl chr 5:2,840,765...3,084,929 		JBrowse link
G Tiam1 TIAM Rac1 associated GEF 1 IMP RGD PMID:16474385 RGD:10043325 NCBI chr11:29,031,347...29,380,153
Ensembl chr11:29,031,348...29,159,901 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19553
    developmental process 6909
      positive regulation of developmental process 1554
        positive regulation of dendritic spine development 65
          positive regulation of dendritic spine morphogenesis 28
Path 2
Term Annotations click to browse term
  biological_process 19553
    developmental process 6909
      anatomical structure development 6435
        multicellular organism development 5184
          system development 4463
            nervous system development 2734
              neurogenesis 2041
                generation of neurons 1761
                  neuron differentiation 1678
                    neuron development 1381
                      neuron projection development 1208
                        dendrite development 328
                          dendritic spine development 133
                            regulation of dendritic spine development 85
                              positive regulation of dendritic spine development 65
                                positive regulation of dendritic spine morphogenesis 28
paths to the root