RGD Reference Report - Induction of spine growth and synapse formation by regulation of the spine actin cytoskeleton. - Rat Genome Database

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Induction of spine growth and synapse formation by regulation of the spine actin cytoskeleton.

Authors: Zito, K  Knott, G  Shepherd, GM  Shenolikar, S  Svoboda, K 
Citation: Zito K, etal., Neuron. 2004 Oct 14;44(2):321-34.
RGD ID: 10043779
Pubmed: (View Article at PubMed) PMID:15473970
DOI: Full-text: DOI:10.1016/j.neuron.2004.09.022

We explored the relationship between regulation of the spine actin cytoskeleton, spine morphogenesis, and synapse formation by manipulating expression of the actin binding protein NrbI and its deletion mutants. In pyramidal neurons of cultured rat hippocampal slices, NrbI is concentrated in dendritic spines by binding to the actin cytoskeleton. Expression of one NrbI deletion mutant, containing the actin binding domain, dramatically increased the density and length of dendritic spines with synapses. This hyperspinogenesis was accompanied by enhanced actin polymerization and spine motility. Synaptic strengths were reduced to compensate for extra synapses, keeping total synaptic input per neuron constant. Our data support a model in which synapse formation is promoted by actin-powered motility.



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Genes (Rattus norvegicus)
Ppp1r9a  (protein phosphatase 1, regulatory subunit 9A)


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