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Gene: Afdn (afadin, adherens junction formation factor) Rattus norvegicus
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Symbol: Afdn
Name: afadin, adherens junction formation factor
Description: Exhibits LIM domain binding activity. Involved in generation of neurons and positive regulation of mini excitatory postsynaptic potential. Localizes to the axon; cell-cell adherens junction; and somatodendritic compartment. Colocalizes with the excitatory synapse. Orthologous to human AFDN (afadin, adherens junction formation factor); PARTICIPATES IN platelet-derived growth factor signaling pathway; INTERACTS WITH 6-propyl-2-thiouracil; benzo[a]pyrene; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Af6; afadin; Mllt4; myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog; myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog (Drosophila); myeloid/lymphoid or mixed-lineage leukemia; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4; protein Af-6; translocated to, 4
Orthologs:
Homo sapiens (human) : AFDN (afadin, adherens junction formation factor)  HGNC  Alliance
Mus musculus (house mouse) : Afdn (afadin, adherens junction formation factor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Afdn (afadin, adherens junction formation factor)
Pan paniscus (bonobo/pygmy chimpanzee) : AFDN (afadin, adherens junction formation factor)
Canis lupus familiaris (dog) : AFDN (afadin, adherens junction formation factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Afdn (afadin, adherens junction formation factor)
Sus scrofa (pig) : AFDN (afadin, adherens junction formation factor)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0153,713,873 - 53,861,918 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0154,955,635 - 55,043,460 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4148,827,687 - 48,913,175 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1148,790,891 - 48,914,438 (+)NCBI
Celera150,355,039 - 50,445,230 (-)NCBICelera
Cytogenetic Map1q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Afdn
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 708561
Created: 2003-09-23
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.