RGD Reference Report - Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP. - Rat Genome Database

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Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP.

Authors: Pak, DT  Yang, S  Rudolph-Correia, S  Kim, E  Sheng, M 
Citation: Pak DT, etal., Neuron. 2001 Aug 2;31(2):289-303.
RGD ID: 8554032
Pubmed: (View Article at PubMed) PMID:11502259

The PSD-95/SAP90 family of scaffold proteins organizes the postsynaptic density (PSD) and regulates NMDA receptor signaling at excitatory synapses. We report that SPAR, a Rap-specific GTPase-activating protein (RapGAP), interacts with the guanylate kinase-like domain of PSD-95 and forms a complex with PSD-95 and NMDA receptors in brain. In heterologous cells, SPAR reorganizes the actin cytoskeleton and recruits PSD-95 to F-actin. In hippocampal neurons, SPAR localizes to dendritic spines and causes enlargement of spine heads, many of which adopt an irregular appearance with putative multiple synapses. Dominant negative SPAR constructs cause narrowing and elongation of spines. The effects of SPAR on spine morphology depend on the RapGAP and actin-interacting domains, implicating Rap signaling in the regulation of postsynaptic structure.

Annotation

Gene Ontology Annotations    

Cellular Component

Molecular Function

Objects Annotated

Genes (Rattus norvegicus)
Dlg4  (discs large MAGUK scaffold protein 4)
Sipa1l1  (signal-induced proliferation-associated 1 like 1)


Additional Information