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Control of excitatory and inhibitory synapse formation by neuroligins.

Authors: Chih, B  Engelman, H  Scheiffele, P 
Citation: Chih B, etal., Science. 2005 Feb 25;307(5713):1324-8. Epub 2005 Jan 27.
Pubmed: (View Article at PubMed) PMID:15681343
DOI: Full-text: DOI:10.1126/science.1107470

The normal function of neural networks depends on a delicate balance between excitatory and inhibitory synaptic inputs. Synapse formation is thought to be regulated by bidirectional signaling between pre- and postsynaptic cells. We demonstrate that members of the Neuroligin family promote postsynaptic differentiation in cultured rat hippocampal neurons. Down-regulation of neuroligin isoform expression by RNA interference results in a loss of excitatory and inhibitory synapses. Electrophysiological analysis revealed a predominant reduction of inhibitory synaptic function. Thus, neuroligins control the formation and functional balance of excitatory and inhibitory synapses in hippocampal neurons.

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RGD ID: 8553420
Created: 2014-05-08
Species: All species
Last Modified: 2014-05-08
Status: ACTIVE



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