Pak3 (p21 (RAC1) activated kinase 3) - Rat Genome Database

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Pathways
Gene: Pak3 (p21 (RAC1) activated kinase 3) Rattus norvegicus
Analyze
Symbol: Pak3
Name: p21 (RAC1) activated kinase 3
RGD ID: 3251
Description: Enables GTPase binding activity and protein serine/threonine kinase activity. Involved in several processes, including positive regulation of DNA biosynthetic process; positive regulation of dendritic spine morphogenesis; and positive regulation of fibroblast migration. Located in endosome. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 30. Orthologous to human PAK3 (p21 (RAC1) activated kinase 3); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; renal cell carcinoma pathway; T cell receptor signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: beta-PAK; p21 (CDKN1A)-activated kinase 3; p21 protein (Cdc42/Rac)-activated kinase 3; p21-activated kinase 3; p21/Cdc42/Rac1-activated kinase 3 (yeast Ste20-related); p65-PAK; PAK-3; serine/threonine-protein kinase PAK 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X107,116,308 - 107,374,342 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX107,260,898 - 107,368,314 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX109,398,307 - 109,506,166 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X112,897,991 - 113,005,870 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X110,452,018 - 110,559,437 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X114,784,452 - 115,042,683 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX114,929,029 - 115,036,669 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X113,227,320 - 113,495,881 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X34,734,814 - 34,842,093 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X34,788,282 - 34,895,562 (-)NCBI
CeleraX106,660,352 - 106,767,478 (+)NCBICelera
Cytogenetic MapXq33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acids  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
folic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
kainic acid  (EXP)
levonorgestrel  (ISO)
lipopolysaccharide  (ISO)
methoxychlor  (EXP)
nickel atom  (ISO)
ochratoxin A  (EXP)
panobinostat  (ISO)
paracetamol  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
potassium chromate  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
Tesaglitazar  (EXP)
testosterone undecanoate  (ISO)
tetrachloroethene  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Light-Induced photoreceptor degeneration in the mouse involves activation of the small GTPase Rac1. Belmonte MA, etal., Invest Ophthalmol Vis Sci. 2006 Mar;47(3):1193-200.
2. Distinct, but compensatory roles of PAK1 and PAK3 in spine morphogenesis. Boda B, etal., Hippocampus. 2008;18(9):857-61. doi: 10.1002/hipo.20451.
3. The mental retardation protein PAK3 contributes to synapse formation and plasticity in hippocampus. Boda B, etal., J Neurosci. 2004 Dec 1;24(48):10816-25.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. p21-activated kinase 3 (PAK3) is an AP-1 regulated gene contributing to actin organisation and migration of transformed fibroblasts. Holderness Parker N, etal., PLoS One. 2013 Jun 20;8(6):e66892. doi: 10.1371/journal.pone.0066892. Print 2013.
6. Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart. Kim SO, etal., J Cell Biochem 1998 Nov 1;71(2):286-301.
7. The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338. King AJ, etal., Nature. 1998 Nov 12;396(6707):180-3.
8. Molecular cloning of a new member of the p21-Cdc42/Rac-activated kinase (PAK) family. Manser E, etal., J Biol Chem 1995 Oct 20;270(42):25070-8.
9. A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Manser E, etal., Nature 1994 Jan 6;367(6458):40-6.
10. DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3. McPhie DL, etal., J Neurosci. 2003 Jul 30;23(17):6914-27.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Synapsin I is phosphorylated at Ser603 by p21-activated kinases (PAKs) in vitro and in PC12 cells stimulated with bradykinin. Sakurada K, etal., J Biol Chem 2002 Nov 22;277(47):45473-9.
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
20. Rat thy-1 antigens from thymus and brain: their tissue distribution, purification, and chemical composition. Williams AF, etal., Cold Spring Harb Symp Quant Biol 1977;41 Pt 1:51-61.
Additional References at PubMed
PMID:10075701   PMID:10445846   PMID:11278486   PMID:11517222   PMID:15182717   PMID:17060906   PMID:17537723   PMID:21115725   PMID:21177870   PMID:22238087   PMID:23509247   PMID:25851601  
PMID:26460013   PMID:30053369  


Genomics

Comparative Map Data
Pak3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X107,116,308 - 107,374,342 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX107,260,898 - 107,368,314 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX109,398,307 - 109,506,166 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X112,897,991 - 113,005,870 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X110,452,018 - 110,559,437 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X114,784,452 - 115,042,683 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX114,929,029 - 115,036,669 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X113,227,320 - 113,495,881 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X34,734,814 - 34,842,093 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X34,788,282 - 34,895,562 (-)NCBI
CeleraX106,660,352 - 106,767,478 (+)NCBICelera
Cytogenetic MapXq33NCBI
PAK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X110,944,397 - 111,227,361 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX110,944,285 - 111,227,361 (+)EnsemblGRCh38hg38GRCh38
GRCh37X110,187,625 - 110,470,589 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X110,226,256 - 110,350,816 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X110,145,744 - 110,270,305NCBI
CeleraX110,667,132 - 110,943,790 (+)NCBICelera
Cytogenetic MapXq23NCBI
HuRefX99,807,691 - 100,086,683 (+)NCBIHuRef
CHM1_1X110,098,857 - 110,375,673 (+)NCBICHM1_1
T2T-CHM13v2.0X109,392,559 - 109,675,560 (+)NCBIT2T-CHM13v2.0
Pak3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X142,301,370 - 142,580,792 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX142,301,587 - 142,580,792 (+)EnsemblGRCm39 Ensembl
GRCm38X143,518,366 - 143,797,796 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX143,518,591 - 143,797,796 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X140,127,830 - 140,226,347 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X138,912,113 - 139,038,179 (+)NCBIMGSCv36mm8
CeleraX127,648,772 - 127,747,962 (+)NCBICelera
Cytogenetic MapXF2NCBI
cM MapX64.5NCBI
Pak3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554904,545,457 - 4,662,862 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554904,538,933 - 4,833,851 (-)NCBIChiLan1.0ChiLan1.0
PAK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1X110,438,452 - 110,723,954 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X100,060,647 - 100,345,491 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X110,672,659 - 110,804,815 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX110,672,664 - 110,797,992 (+)Ensemblpanpan1.1panPan2
PAK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X84,074,146 - 84,335,699 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX84,074,001 - 84,329,951 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX70,164,167 - 70,430,936 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X85,871,706 - 85,997,455 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X83,206,488 - 83,474,638 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X84,896,488 - 85,157,976 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X84,724,769 - 84,986,483 (+)NCBIUU_Cfam_GSD_1.0
Pak3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X83,329,189 - 83,584,851 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364994,079,103 - 4,188,774 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049364994,079,127 - 4,328,580 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX90,942,077 - 91,238,565 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X90,941,976 - 91,244,331 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PAK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X98,743,525 - 99,031,056 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX98,911,447 - 99,027,769 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606524,135,627 - 24,263,134 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pak3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248034,392,511 - 4,513,101 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248034,386,035 - 4,700,450 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pak3
681 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:122
Count of miRNA genes:84
Interacting mature miRNAs:107
Transcripts:ENSRNOT00000006459
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
724551Glom1Glomerulus QTL 12.80.0004kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)X75294106120294106Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat

Markers in Region
DXRat19  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X107,292,714 - 107,292,880 (+)MAPPERmRatBN7.2
Rnor_6.0X114,961,056 - 114,961,221NCBIRnor6.0
Rnor_5.0X113,414,256 - 113,414,421UniSTSRnor5.0
RGSC_v3.4X34,810,260 - 34,810,426RGDRGSC3.4
RGSC_v3.4X34,810,261 - 34,810,426UniSTSRGSC3.4
RGSC_v3.1X34,863,730 - 34,863,895RGD
CeleraX106,691,934 - 106,692,099UniSTS
RH 3.4 Map71130.82UniSTS
RH 3.4 Map71130.82RGD
SHRSP x BN MapX30.9UniSTS
SHRSP x BN MapX30.9RGD
Cytogenetic MapXq14UniSTS
U39738  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X107,367,951 - 107,368,145 (+)MAPPERmRatBN7.2
Rnor_6.0X115,036,293 - 115,036,486NCBIRnor6.0
Rnor_5.0X113,489,491 - 113,489,684UniSTSRnor5.0
RGSC_v3.4X34,734,997 - 34,735,190UniSTSRGSC3.4
CeleraX106,767,102 - 106,767,295UniSTS
Cytogenetic MapXq14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 74 17
Low 2 13 9 2 2 2 5 5 18 24 6 5
Below cutoff 1 25 22 15 16 15 3 5 10 4 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC117954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U33314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000006459   ⟹   ENSRNOP00000006459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX107,260,898 - 107,368,314 (+)Ensembl
Rnor_6.0 EnsemblX114,929,029 - 115,036,669 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000089141   ⟹   ENSRNOP00000075221
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX107,260,898 - 107,368,314 (+)Ensembl
Rnor_6.0 EnsemblX114,930,457 - 115,036,409 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103683   ⟹   ENSRNOP00000077171
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX107,260,898 - 107,368,314 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103753   ⟹   ENSRNOP00000081748
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX107,260,898 - 107,368,314 (+)Ensembl
RefSeq Acc Id: NM_019210   ⟹   NP_062083
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X107,260,898 - 107,368,328 (+)NCBI
Rnor_6.0X114,929,029 - 115,036,669 (+)NCBI
Rnor_5.0X113,227,320 - 113,495,881 (+)NCBI
RGSC_v3.4X34,734,814 - 34,842,093 (-)RGD
CeleraX106,660,352 - 106,767,478 (+)RGD
Sequence:
RefSeq Acc Id: XM_006257333   ⟹   XP_006257395
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X107,261,009 - 107,374,342 (+)NCBI
Rnor_6.0X114,927,790 - 115,042,683 (+)NCBI
Rnor_5.0X113,227,320 - 113,495,881 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006257339   ⟹   XP_006257401
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X107,261,009 - 107,374,342 (+)NCBI
Rnor_6.0X114,927,792 - 115,042,683 (+)NCBI
Rnor_5.0X113,227,320 - 113,495,881 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008773404   ⟹   XP_008771626
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X107,261,009 - 107,374,342 (+)NCBI
Rnor_6.0X114,927,788 - 115,042,683 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601937   ⟹   XP_017457426
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X107,261,009 - 107,374,342 (+)NCBI
Rnor_6.0X114,927,788 - 115,042,683 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601938   ⟹   XP_017457427
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X107,261,057 - 107,374,342 (+)NCBI
Rnor_6.0X114,927,788 - 115,042,683 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601939   ⟹   XP_017457428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X107,261,084 - 107,374,342 (+)NCBI
Rnor_6.0X114,927,788 - 115,042,683 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601940   ⟹   XP_017457429
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X107,116,309 - 107,374,342 (+)NCBI
Rnor_6.0X114,784,452 - 115,042,683 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601942   ⟹   XP_017457431
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X107,261,051 - 107,374,342 (+)NCBI
Rnor_6.0X114,927,788 - 115,042,683 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039099537   ⟹   XP_038955465
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X107,116,308 - 107,374,342 (+)NCBI
RefSeq Acc Id: NP_062083   ⟸   NM_019210
- UniProtKB: Q62829 (UniProtKB/Swiss-Prot),   A6KG82 (UniProtKB/TrEMBL),   A0A8I5ZSQ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257395   ⟸   XM_006257333
- Peptide Label: isoform X2
- UniProtKB: A0A8L2RA18 (UniProtKB/TrEMBL),   A0A8I5ZSQ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257401   ⟸   XM_006257339
- Peptide Label: isoform X3
- UniProtKB: Q62829 (UniProtKB/Swiss-Prot),   A6KG82 (UniProtKB/TrEMBL),   A0A8I5ZSQ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771626   ⟸   XM_008773404
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZSQ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457429   ⟸   XM_017601940
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZSQ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457426   ⟸   XM_017601937
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZSQ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457428   ⟸   XM_017601939
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZSQ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457427   ⟸   XM_017601938
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZSQ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457431   ⟸   XM_017601942
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZSQ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000006459   ⟸   ENSRNOT00000006459
RefSeq Acc Id: ENSRNOP00000075221   ⟸   ENSRNOT00000089141
RefSeq Acc Id: XP_038955465   ⟸   XM_039099537
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZSQ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000081748   ⟸   ENSRNOT00000103753
RefSeq Acc Id: ENSRNOP00000077171   ⟸   ENSRNOT00000103683
Protein Domains
CRIB   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62829-F1-model_v2 AlphaFold Q62829 1-544 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3251 AgrOrtholog
BioCyc Gene G2FUF-1501 BioCyc
Ensembl Genes ENSRNOG00000004676 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000006459 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000075221 ENTREZGENE
  ENSRNOP00000075221.2 UniProtKB/TrEMBL
  ENSRNOP00000077171.1 UniProtKB/TrEMBL
  ENSRNOP00000081748.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006459 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000089141 ENTREZGENE
  ENSRNOT00000089141.2 UniProtKB/TrEMBL
  ENSRNOT00000103683.1 UniProtKB/TrEMBL
  ENSRNOT00000103753.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.810.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CRIB_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CRIB_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAK_BD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STK_PAK3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29433 UniProtKB/Swiss-Prot
NCBI Gene 29433 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN KINASE PAK 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE TAO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pak3 PhenoGen
PROSITE CRIB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC220638
UniProt A0A8I5Y791_RAT UniProtKB/TrEMBL
  A0A8I5ZSQ0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2RA18 ENTREZGENE, UniProtKB/TrEMBL
  A6KG82 ENTREZGENE, UniProtKB/TrEMBL
  PAK3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-12 Pak3  p21 (RAC1) activated kinase 3  Pak3  p21 protein (Cdc42/Rac)-activated kinase 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-05-27 Pak3  p21 protein (Cdc42/Rac)-activated kinase 3  Pak3  p21 (CDKN1A)-activated kinase 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Pak3  p21 (CDKN1A)-activated kinase 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function phosphorylates protein serine/threonine residues 61685
gene_function phosphorylates protein serine/threonine residues 70317
gene_product mitogen activated protein kinase kinase kinase family member 61685
gene_product mitogen activated protein kinase kinase kinase family member 70317
gene_protein 65 kDa 61685
gene_protein 65 kDa 70317