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Gene: Pak3 (p21 (RAC1) activated kinase 3) Rattus norvegicus
Symbol: Pak3
Name: p21 (RAC1) activated kinase 3
RGD ID: 3251
Description: Exhibits GTPase binding activity and protein serine/threonine kinase activity. Involved in several processes, including positive regulation of DNA biosynthetic process; positive regulation of dendritic spine morphogenesis; and positive regulation of fibroblast migration. Localizes to endosome. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability. Orthologous to human PAK3 (p21 (RAC1) activated kinase 3); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; renal cell carcinoma pathway; T cell receptor signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
Also known as: beta-PAK; p21 (CDKN1A)-activated kinase 3; p21 protein (Cdc42/Rac)-activated kinase 3; p21-activated kinase 3; p21/Cdc42/Rac1-activated kinase 3 (yeast Ste20-related); p65-PAK; PAK-3; serine/threonine-protein kinase PAK 3
Homo sapiens (human) : PAK3 (p21 (RAC1) activated kinase 3)  HGNC  Alliance
Mus musculus (house mouse) : Pak3 (p21 (RAC1) activated kinase 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pak3 (p21 (RAC1) activated kinase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : PAK3 (p21 (RAC1) activated kinase 3)
Canis lupus familiaris (dog) : PAK3 (p21 (RAC1) activated kinase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pak3 (p21 (RAC1) activated kinase 3)
Sus scrofa (pig) : PAK3 (p21 (RAC1) activated kinase 3)
Chlorocebus sabaeus (African green monkey) : PAK3 (p21 (RAC1) activated kinase 3)
Heterocephalus glaber (naked mole-rat) : Pak3 (p21 (RAC1) activated kinase 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0X114,784,452 - 115,042,683 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX114,929,029 - 115,036,669 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X113,227,320 - 113,495,881 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X34,734,814 - 34,842,093 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X34,788,282 - 34,895,562 (-)NCBI
CeleraX106,660,352 - 106,767,478 (+)NCBICelera
Cytogenetic MapXq33NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Pak3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3251
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.