Pak3 (p21 (RAC1) activated kinase 3) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Pak3 (p21 (RAC1) activated kinase 3) Rattus norvegicus
Analyze
Symbol: Pak3
Name: p21 (RAC1) activated kinase 3
RGD ID: 3251
Description: Enables GTPase binding activity and protein serine/threonine kinase activity. Involved in several processes, including positive regulation of DNA biosynthetic process; positive regulation of dendritic spine morphogenesis; and positive regulation of fibroblast migration. Located in endosome. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 30. Orthologous to human PAK3 (p21 (RAC1) activated kinase 3); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; renal cell carcinoma pathway; T cell receptor signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: beta-PAK; p21 (CDKN1A)-activated kinase 3; p21 protein (Cdc42/Rac)-activated kinase 3; p21-activated kinase 3; p21/Cdc42/Rac1-activated kinase 3 (yeast Ste20-related); p65-PAK; PAK-3; serine/threonine-protein kinase PAK 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X107,116,308 - 107,374,342 (+)NCBI
Rnor_6.0 EnsemblX114,929,029 - 115,036,669 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X114,784,452 - 115,042,683 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X113,227,320 - 113,495,881 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X34,734,814 - 34,842,093 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X34,788,282 - 34,895,562 (-)NCBI
CeleraX106,660,352 - 106,767,478 (+)NCBICelera
Cytogenetic MapXq33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:10075701   PMID:10445846   PMID:11278486   PMID:11517222   PMID:15182717   PMID:17060906   PMID:17537723   PMID:21115725   PMID:21177870   PMID:22238087   PMID:23509247   PMID:25851601  
PMID:26460013   PMID:30053369  


Genomics

Comparative Map Data
Pak3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X107,116,308 - 107,374,342 (+)NCBI
Rnor_6.0 EnsemblX114,929,029 - 115,036,669 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X114,784,452 - 115,042,683 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X113,227,320 - 113,495,881 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X34,734,814 - 34,842,093 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X34,788,282 - 34,895,562 (-)NCBI
CeleraX106,660,352 - 106,767,478 (+)NCBICelera
Cytogenetic MapXq33NCBI
PAK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX110,944,285 - 111,227,361 (+)EnsemblGRCh38hg38GRCh38
GRCh38X110,944,324 - 111,227,361 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X110,187,625 - 110,470,589 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X110,226,256 - 110,350,816 (+)NCBINCBI36hg18NCBI36
Build 34X110,145,744 - 110,270,305NCBI
CeleraX110,667,132 - 110,943,790 (+)NCBI
Cytogenetic MapXq23NCBI
HuRefX99,807,691 - 100,086,683 (+)NCBIHuRef
CHM1_1X110,098,857 - 110,375,673 (+)NCBICHM1_1
Pak3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X142,301,370 - 142,580,792 (+)NCBIGRCm39mm39
GRCm39 EnsemblX142,301,587 - 142,580,792 (+)Ensembl
GRCm38X143,518,366 - 143,797,796 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX143,518,591 - 143,797,796 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X140,127,830 - 140,226,347 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X138,912,113 - 139,038,179 (+)NCBImm8
CeleraX127,648,772 - 127,747,962 (+)NCBICelera
Cytogenetic MapXF2NCBI
Pak3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554904,545,457 - 4,662,862 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554904,538,933 - 4,833,851 (-)NCBIChiLan1.0ChiLan1.0
PAK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X110,672,659 - 110,804,815 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX110,672,664 - 110,797,992 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X100,060,647 - 100,345,491 (+)NCBIMhudiblu_PPA_v0panPan3
PAK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X84,074,146 - 84,335,699 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX84,074,001 - 84,329,951 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX70,164,167 - 70,430,936 (+)NCBI
ROS_Cfam_1.0X85,871,706 - 85,997,455 (+)NCBI
UMICH_Zoey_3.1X83,206,488 - 83,474,638 (+)NCBI
UNSW_CanFamBas_1.0X84,896,488 - 85,157,976 (+)NCBI
UU_Cfam_GSD_1.0X84,724,769 - 84,986,483 (+)NCBI
Pak3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X83,329,189 - 83,584,851 (+)NCBI
SpeTri2.0NW_0049364994,079,127 - 4,328,580 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX90,942,232 - 91,239,440 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X90,941,976 - 91,244,331 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PAK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X98,743,525 - 99,031,056 (+)NCBI
ChlSab1.1 EnsemblX98,911,447 - 99,027,769 (+)Ensembl
Vero_WHO_p1.0NW_02366606524,135,627 - 24,263,134 (+)NCBI
Pak3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248034,386,035 - 4,700,450 (-)NCBI

Position Markers
DXRat19  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X107,292,714 - 107,292,880 (+)MAPPER
Rnor_6.0X114,961,056 - 114,961,221NCBIRnor6.0
Rnor_5.0X113,414,256 - 113,414,421UniSTSRnor5.0
RGSC_v3.4X34,810,260 - 34,810,426RGDRGSC3.4
RGSC_v3.4X34,810,261 - 34,810,426UniSTSRGSC3.4
RGSC_v3.1X34,863,730 - 34,863,895RGD
CeleraX106,691,934 - 106,692,099UniSTS
RH 3.4 Map71130.82UniSTS
RH 3.4 Map71130.82RGD
SHRSP x BN MapX30.9UniSTS
SHRSP x BN MapX30.9RGD
Cytogenetic MapXq14UniSTS
U39738  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X107,367,951 - 107,368,145 (+)MAPPER
Rnor_6.0X115,036,293 - 115,036,486NCBIRnor6.0
Rnor_5.0X113,489,491 - 113,489,684UniSTSRnor5.0
RGSC_v3.4X34,734,997 - 34,735,190UniSTSRGSC3.4
CeleraX106,767,102 - 106,767,295UniSTS
Cytogenetic MapXq14UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X15688119127888215Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X44320616158345622Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX44557974120045269Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X70352120127888215Rat
724551Glom1Glomerulus QTL 12.80.0004kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)X82930791127930791Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X101333032146333032Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX107886746152409805Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X110957467155957467Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X110957467155957467Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:122
Count of miRNA genes:84
Interacting mature miRNAs:107
Transcripts:ENSRNOT00000006459
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 74 17
Low 2 13 9 2 2 2 5 5 18 24 6 5
Below cutoff 1 25 22 15 16 15 3 5 10 4 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC117954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U33314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000006459   ⟹   ENSRNOP00000006459
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX114,929,029 - 115,036,669 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000089141   ⟹   ENSRNOP00000075221
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX114,930,457 - 115,036,409 (+)Ensembl
RefSeq Acc Id: NM_019210   ⟹   NP_062083
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X107,260,898 - 107,368,328 (+)NCBI
Rnor_6.0X114,929,029 - 115,036,669 (+)NCBI
Rnor_5.0X113,227,320 - 113,495,881 (+)NCBI
RGSC_v3.4X34,734,814 - 34,842,093 (-)RGD
CeleraX106,660,352 - 106,767,478 (+)RGD
Sequence:
RefSeq Acc Id: XM_006257333   ⟹   XP_006257395
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X107,261,009 - 107,374,342 (+)NCBI
Rnor_6.0X114,927,790 - 115,042,683 (+)NCBI
Rnor_5.0X113,227,320 - 113,495,881 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006257339   ⟹   XP_006257401
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X107,261,009 - 107,374,342 (+)NCBI
Rnor_6.0X114,927,792 - 115,042,683 (+)NCBI
Rnor_5.0X113,227,320 - 113,495,881 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008773404   ⟹   XP_008771626
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X107,261,009 - 107,374,342 (+)NCBI
Rnor_6.0X114,927,788 - 115,042,683 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601937   ⟹   XP_017457426
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X107,261,009 - 107,374,342 (+)NCBI
Rnor_6.0X114,927,788 - 115,042,683 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601938   ⟹   XP_017457427
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X107,261,057 - 107,374,342 (+)NCBI
Rnor_6.0X114,927,788 - 115,042,683 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601939   ⟹   XP_017457428
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X107,261,084 - 107,374,342 (+)NCBI
Rnor_6.0X114,927,788 - 115,042,683 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601940   ⟹   XP_017457429
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X107,116,309 - 107,374,342 (+)NCBI
Rnor_6.0X114,784,452 - 115,042,683 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601942   ⟹   XP_017457431
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X107,261,051 - 107,374,342 (+)NCBI
Rnor_6.0X114,927,788 - 115,042,683 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039099537   ⟹   XP_038955465
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X107,116,308 - 107,374,342 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_062083   ⟸   NM_019210
- UniProtKB: Q62829 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006257395   ⟸   XM_006257333
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006257401   ⟸   XM_006257339
- Peptide Label: isoform X3
- UniProtKB: Q62829 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008771626   ⟸   XM_008773404
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017457429   ⟸   XM_017601940
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017457426   ⟸   XM_017601937
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017457428   ⟸   XM_017601939
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017457427   ⟸   XM_017601938
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017457431   ⟸   XM_017601942
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000006459   ⟸   ENSRNOT00000006459
RefSeq Acc Id: ENSRNOP00000075221   ⟸   ENSRNOT00000089141
RefSeq Acc Id: XP_038955465   ⟸   XM_039099537
- Peptide Label: isoform X1
Protein Domains
CRIB   Protein kinase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3251 AgrOrtholog
Ensembl Genes ENSRNOG00000004676 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000006459 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000075221 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006459 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000089141 UniProtKB/Swiss-Prot
Gene3D-CATH 3.90.810.10 UniProtKB/Swiss-Prot
InterPro CRIB_dom UniProtKB/Swiss-Prot
  CRIB_dom_sf UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  PAK_BD UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
  STK_PAK3 UniProtKB/Swiss-Prot
KEGG Report rno:29433 UniProtKB/Swiss-Prot
NCBI Gene 29433 ENTREZGENE
Pfam PBD UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
PhenoGen Pak3 PhenoGen
PROSITE CRIB UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
SMART PBD UniProtKB/Swiss-Prot
  S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
TIGR TC220638
UniProt PAK3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-12 Pak3  p21 (RAC1) activated kinase 3  Pak3  p21 protein (Cdc42/Rac)-activated kinase 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-05-27 Pak3  p21 protein (Cdc42/Rac)-activated kinase 3  Pak3  p21 (CDKN1A)-activated kinase 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Pak3  p21 (CDKN1A)-activated kinase 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function phosphorylates protein serine/threonine residues 61685
gene_function phosphorylates protein serine/threonine residues 70317
gene_product mitogen activated protein kinase kinase kinase family member 61685
gene_product mitogen activated protein kinase kinase kinase family member 70317
gene_protein 65 kDa 61685
gene_protein 65 kDa 70317