Pak3 (p21 (RAC1) activated kinase 3) - Rat Genome Database

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Gene: Pak3 (p21 (RAC1) activated kinase 3) Heterocephalus glaber
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Symbol: Pak3
Name: p21 (RAC1) activated kinase 3
RGD ID: 18916727
Description: ENCODES a protein that exhibits GTPase binding (ortholog); MAP kinase kinase activity (ortholog); protein kinase activity (ortholog); INVOLVED IN axonogenesis (ortholog); dendrite development (ortholog); dendritic spine development (ortholog); ASSOCIATED WITH Agenesis of Corpus Callosum (ortholog); attention deficit hyperactivity disorder (ortholog); autistic disorder (ortholog); FOUND IN endosome (ortholog); glutamatergic synapse (ortholog); postsynaptic density (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Serine/threonine-protein kinase PAK 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248034,386,035 - 4,700,450 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_0046248034,392,511 - 4,513,101 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Naked mole-rat maternal EnsemblX31,834,653 - 32,138,383 (+)Ensembl
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Pak3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248034,386,035 - 4,700,450 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_0046248034,392,511 - 4,513,101 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Naked mole-rat maternal EnsemblX31,834,653 - 32,138,383 (+)Ensembl
PAK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X110,944,397 - 111,227,361 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX110,944,285 - 111,227,361 (+)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh37X110,187,625 - 110,470,589 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X110,226,256 - 110,350,816 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34X110,145,744 - 110,270,305NCBI
CeleraX110,667,132 - 110,943,790 (+)NCBICelera
Cytogenetic MapXq23NCBI
HuRefX99,807,691 - 100,086,683 (+)NCBIHuRef
CHM1_1X110,098,857 - 110,375,673 (+)NCBICHM1_1
T2T-CHM13v2.0X109,392,559 - 109,675,560 (+)NCBIT2T-CHM13v2.0
Pak3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X142,301,370 - 142,580,792 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX142,301,303 - 142,580,792 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38X143,518,366 - 143,797,796 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX143,518,591 - 143,797,796 (+)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv37X140,127,830 - 140,226,347 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X138,912,113 - 139,038,179 (+)NCBIMGSCv36mm8
CeleraX127,648,772 - 127,747,962 (+)NCBICelera
Cytogenetic MapXF2NCBI
cM MapX64.5NCBI
Pak3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X111,912,967 - 112,171,037 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX111,913,059 - 112,165,035 (+)EnsemblGRCr8
mRatBN7.2X107,116,308 - 107,374,342 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX107,260,898 - 107,368,314 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX109,398,307 - 109,506,166 (+)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X112,897,991 - 113,005,870 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X110,452,018 - 110,559,437 (+)NCBIUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X114,784,452 - 115,042,683 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX114,929,029 - 115,036,669 (+)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.0X113,227,320 - 113,495,881 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X34,734,814 - 34,842,093 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX106,660,352 - 106,767,478 (+)NCBICelera
RGSC_v3.1X34,788,282 - 34,895,562 (-)NCBI
Cytogenetic MapXq33NCBI
Pak3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554904,545,457 - 4,662,862 (-)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_0049554904,538,933 - 4,833,851 (-)NCBIChiLan1.0ChiLan1.0
PAK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X110,434,847 - 110,720,349 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X110,438,452 - 110,723,954 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X100,060,647 - 100,345,491 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X110,672,659 - 110,804,815 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX110,672,664 - 110,797,992 (+)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
PAK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X84,074,146 - 84,335,699 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX84,074,001 - 84,329,951 (+)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX70,164,167 - 70,430,936 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X85,871,706 - 85,997,455 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.1X83,206,488 - 83,474,638 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X84,896,488 - 85,157,976 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X84,724,769 - 84,986,483 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pak3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap1X37,348,287 - 37,607,375 (-)NCBImIctTri1.hap1
HiC_Itri_2X83,329,189 - 83,584,851 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364994,079,103 - 4,188,774 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364994,079,127 - 4,328,580 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX90,942,077 - 91,238,565 (+)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X90,941,976 - 91,244,331 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PAK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap1X42,121,450 - 42,415,716 (-)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_02366606524,135,627 - 24,263,134 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.1X98,743,525 - 99,031,056 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX98,911,447 - 99,027,769 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Pak3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X95,703,579 - 95,815,497 (+)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_004861431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013078346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013078347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013078348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013078349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021241581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021241582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AHKG01071860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01071861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01071862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01071863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01071864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01071865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01071866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01071867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GEBF01002366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JH173744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSHGLT00000004115   ⟹   ENSHGLP00000004057
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248034,392,511 - 4,513,101 (-)Ensembl
Naked mole-rat maternal EnsemblX32,016,710 - 32,138,383 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000004116   ⟹   ENSHGLP00000004058
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248034,392,511 - 4,513,101 (-)Ensembl
Naked mole-rat maternal EnsemblX32,016,701 - 32,134,618 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000004117   ⟹   ENSHGLP00000004059
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248034,418,686 - 4,482,495 (-)Ensembl
Naked mole-rat maternal EnsemblX31,901,761 - 32,138,383 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000047420   ⟹   ENSHGLP00000057159
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
Naked mole-rat maternal EnsemblX31,834,653 - 32,138,383 (+)Ensembl
RefSeq Acc Id: XM_004861431   ⟹   XP_004861488
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248034,386,035 - 4,700,450 (-)NCBI
RefSeq Acc Id: XM_013078346   ⟹   XP_012933800
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248034,386,035 - 4,700,450 (-)NCBI
RefSeq Acc Id: XM_013078347   ⟹   XP_012933801
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248034,386,035 - 4,513,068 (-)NCBI
RefSeq Acc Id: XM_013078348   ⟹   XP_012933802
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248034,386,035 - 4,700,450 (-)NCBI
RefSeq Acc Id: XM_013078349   ⟹   XP_012933803
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248034,386,035 - 4,513,068 (-)NCBI
RefSeq Acc Id: XM_021241581   ⟹   XP_021097240
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248034,386,035 - 4,488,447 (-)NCBI
RefSeq Acc Id: XM_021241582   ⟹   XP_021097241
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248034,386,035 - 4,700,450 (-)NCBI
RefSeq Acc Id: XP_012933802   ⟸   XM_013078348
- Peptide Label: isoform X1
- UniProtKB: A0A0P6JWY8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004861488   ⟸   XM_004861431
- Peptide Label: isoform X1
- UniProtKB: A0A0P6JWY8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021097241   ⟸   XM_021241582
- Peptide Label: isoform X2
- UniProtKB: A0AAX6RIT0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012933800   ⟸   XM_013078346
- Peptide Label: isoform X1
- UniProtKB: A0A0P6JWY8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012933803   ⟸   XM_013078349
- Peptide Label: isoform X1
- UniProtKB: A0A0P6JWY8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012933801   ⟸   XM_013078347
- Peptide Label: isoform X1
- UniProtKB: A0A0P6JWY8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021097240   ⟸   XM_021241581
- Peptide Label: isoform X1
- UniProtKB: A0A0P6JWY8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000004058   ⟸   ENSHGLT00000004116
Ensembl Acc Id: ENSHGLP00000004057   ⟸   ENSHGLT00000004115
Ensembl Acc Id: ENSHGLP00000004059   ⟸   ENSHGLT00000004117
Ensembl Acc Id: ENSHGLP00000057159   ⟸   ENSHGLT00000047420


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000002988 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000004115 ENTREZGENE
  ENSHGLT00000004116 ENTREZGENE
Gene3D-CATH 3.90.810.10 UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro CRIB_dom UniProtKB/TrEMBL
  CRIB_dom_sf UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PAK3-like UniProtKB/TrEMBL
  PAK_BD UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  STK_PAK3 UniProtKB/TrEMBL
KEGG Report hgl:101712811 UniProtKB/TrEMBL
NCBI Gene Pak3 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED UniProtKB/TrEMBL
  SERINE_THREONINE-PROTEIN KINASE PAK 3 UniProtKB/TrEMBL
Pfam PBD UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PROSITE CRIB UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART PBD UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A0P6JWY8 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6RIT0 ENTREZGENE, UniProtKB/TrEMBL