Ndp (norrin cystine knot growth factor NDP) - Rat Genome Database

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Gene: Ndp (norrin cystine knot growth factor NDP) Rattus norvegicus
Analyze
Symbol: Ndp
Name: norrin cystine knot growth factor NDP
RGD ID: 1563968
Description: Predicted to enable cytokine activity; frizzled binding activity; and protein homodimerization activity. Involved in decidualization. Predicted to be located in cell surface; collagen-containing extracellular matrix; and extracellular space. Predicted to be active in extracellular matrix. Human ortholog(s) of this gene implicated in Norrie disease; X-linked exudative vitreoretinopathy 2; and retinopathy of prematurity. Orthologous to human NDP (norrin cystine knot growth factor NDP); PARTICIPATES IN Wnt signaling, canonical pathway; INTERACTS WITH acrylamide; bisphenol A; vinclozolin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC100909913; LOC363443; NDP, norrin cystine knot growth factor; Ndph; Norrie disease (pseudoglioma); Norrie disease (pseudoglioma) (human); Norrie disease homolog; Norrie disease homolog (human); norrin; norrin-like; RGD1563968; similar to NDP
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Note: Ndp was annotated incorrectly on Rnor_6.0 (Annotation Release 105) but correctly on Rn_Celera. Annotation of Ndp on Rn_Celera is supported by synteny with human and mouse and this locus is instead annotated as LOC100909913 on Rnor_6.0. Additionally, the locus annotated as Ndp on Rnor_6.0 represents a duplicate placement of this locus and this annotation lacks support by the syntenic region in mouse and human. BLASTing Ndp NM_001108814.1 against the rat genome (Annotation Release 105) shows best hits to the locations where both Ndp and LOC100909913 are annotated on Rnor_6.0 (NC_005120.4, 100% identity at each location) and where Ndp is annotated on Rn_Celera (AC_000089.1, 100% identity). BLASTing LOC100909913 XM_003751998.3 against the rat genome (Annotation Release 105) shows best hits to the locations where both Ndp and LOC100909913 are annotated on Rnor_6.0 (NC_005120.4, 100% identity at each location) and where Ndp is annotated on Rn_Celera (AC_000089.1, 100% identity). 2-sequence BLAST of Ndp NM_001108814.1 against LOC100909913 XM_003751998.3 shows high sequence identity (100% coverage, 100% identity). 2-sequence BLAST of Ndp underlying component AC097257.7 against the LOC100909913 underlying component AABR07073515.1 (both on Rnor_6.0) shows high sequence identity (99%) across ~67 kb. [26 Mar 2015]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X5,796,487 - 5,820,934 (+)NCBImRatBN7.2
mRatBN7.2 EnsemblX5,796,487 - 5,820,934 (+)Ensembl
Rnor_6.0X6,791,090 - 6,815,586 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX6,273,733 - 6,281,789 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 EnsemblX6,791,136 - 6,815,583 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X7,591,522 - 7,615,969 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X17,416,946 - 17,441,393 (+)NCBIRGSC3.4rn4RGSC3.4
CeleraX6,291,036 - 6,315,505 (+)NCBICelera
Cytogenetic MapXq11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Isolation of a candidate gene for Norrie disease by positional cloning. Berger W, etal., Nat Genet. 1992 Jun;1(3):199-203.
2. A mutation in the Norrie disease gene (NDP) associated with X-linked familial exudative vitreoretinopathy. Chen ZY, etal., Nat Genet. 1993 Oct;5(2):180-3.
3. Secreted and transmembrane wnt inhibitors and activators. Cruciat CM and Niehrs C, Cold Spring Harb Perspect Biol. 2013 Mar 1;5(3):a015081. doi: 10.1101/cshperspect.a015081.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Norrin immunolocalization and its possible functions in rat endometrium during the estrus cycle and early pregnancy. Kaloglu C, etal., Dev Growth Differ. 2011 Sep;53(7):887-96. doi: 10.1111/j.1440-169X.2011.01295.x. Epub 2011 Sep 7.
6. Comparative genomics on Norrie disease gene. Katoh M and Katoh M, Int J Mol Med. 2005 May;15(5):885-9.
7. Norrin promotes vascular regrowth after oxygen-induced retinal vessel loss and suppresses retinopathy in mice. Ohlmann A, etal., J Neurosci. 2010 Jan 6;30(1):183-93. doi: 10.1523/JNEUROSCI.3210-09.2010.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Identification of missense mutations in the Norrie disease gene associated with advanced retinopathy of prematurity. Shastry BS, etal., Arch Ophthalmol. 1997 May;115(5):651-5.
Additional References at PubMed
PMID:15035989   PMID:16035034   PMID:17955262   PMID:19837032   PMID:20427659   PMID:25188337   PMID:25550365   PMID:29933759  


Genomics

Comparative Map Data
Ndp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X5,796,487 - 5,820,934 (+)NCBImRatBN7.2
mRatBN7.2 EnsemblX5,796,487 - 5,820,934 (+)Ensembl
Rnor_6.0X6,791,090 - 6,815,586 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX6,273,733 - 6,281,789 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 EnsemblX6,791,136 - 6,815,583 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X7,591,522 - 7,615,969 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X17,416,946 - 17,441,393 (+)NCBIRGSC3.4rn4RGSC3.4
CeleraX6,291,036 - 6,315,505 (+)NCBICelera
Cytogenetic MapXq11NCBI
NDP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X43,948,776 - 43,973,390 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX43,948,776 - 43,973,395 (-)EnsemblGRCh38hg38GRCh38
GRCh37X43,808,022 - 43,832,636 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X43,692,966 - 43,717,788 (-)NCBINCBI36hg18NCBI36
Build 34X43,564,279 - 43,589,004NCBI
CeleraX47,947,782 - 47,972,683 (-)NCBI
Cytogenetic MapXp11.3NCBI
HuRefX41,537,322 - 41,562,014 (-)NCBIHuRef
CHM1_1X43,841,148 - 43,866,049 (-)NCBICHM1_1
T2T-CHM13v2.0X43,354,970 - 43,379,584 (-)NCBI
Ndp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X16,751,760 - 16,778,013 (-)NCBIGRCm39mm39
GRCm39 EnsemblX16,751,760 - 16,778,013 (-)Ensembl
GRCm38X16,885,521 - 16,911,774 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX16,885,521 - 16,911,774 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X16,462,647 - 16,488,890 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X16,042,480 - 16,068,723 (-)NCBImm8
CeleraX14,501,428 - 14,528,313 (-)NCBICelera
Cytogenetic MapXA1.2NCBI
cM MapX12.07NCBI
Ndp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555164,218,703 - 4,244,846 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555164,218,703 - 4,244,774 (+)NCBIChiLan1.0ChiLan1.0
NDP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X44,224,161 - 44,249,067 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX44,224,161 - 44,249,067 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X36,399,868 - 36,424,953 (-)NCBIMhudiblu_PPA_v0panPan3
NDP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X37,949,560 - 37,975,573 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX37,950,489 - 37,975,346 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX25,177,615 - 25,203,684 (-)NCBI
ROS_Cfam_1.0X38,037,857 - 38,063,932 (-)NCBI
UMICH_Zoey_3.1X38,078,999 - 38,105,057 (-)NCBI
UNSW_CanFamBas_1.0X38,061,990 - 38,088,102 (-)NCBI
UU_Cfam_GSD_1.0X38,157,025 - 38,183,125 (-)NCBI
LOC101974547
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X30,239,407 - 30,264,429 (-)NCBI
SpeTri2.0NW_00493650210,080,169 - 10,105,155 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NDP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX39,208,119 - 39,235,758 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X39,208,115 - 39,235,879 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X43,540,096 - 43,551,795 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103231843
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X41,122,064 - 41,148,097 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 EnsemblX41,121,874 - 41,147,567 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660766,340,796 - 6,365,938 (-)NCBIVero_WHO_p1.0
Ndp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476211,409,727 - 11,435,811 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462476211,409,837 - 11,435,709 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
RH144057  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X5,820,619 - 5,820,771 (+)MAPPERmRatBN7.2
Rnor_6.0X6,815,269 - 6,815,420NCBIRnor6.0
Rnor_6.0X6,282,443 - 6,282,594NCBIRnor6.0
Rnor_5.0X7,105,981 - 7,106,132UniSTSRnor5.0
Rnor_5.0X7,615,655 - 7,615,806UniSTSRnor5.0
RGSC_v3.4X17,441,079 - 17,441,230UniSTSRGSC3.4
CeleraX6,315,191 - 6,315,342UniSTS
Cytogenetic MapXq12UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
70166Bp65Blood pressure QTL 655.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144797211374346Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:234
Count of miRNA genes:156
Interacting mature miRNAs:185
Transcripts:ENSRNOT00000003984, ENSRNOT00000074275
Prediction methods:Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 22 4 7
Low 2 2 3 3 52 18 27 10 3
Below cutoff 1 38 25 12 10 12 5 8 13 7 1 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000003984   ⟹   ENSRNOP00000003984
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX5,796,487 - 5,820,934 (+)Ensembl
Rnor_6.0 EnsemblX6,791,136 - 6,815,583 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000074275   ⟹   ENSRNOP00000064536
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX6,273,733 - 6,281,789 (+)Ensembl
RefSeq Acc Id: NM_001108814   ⟹   NP_001102284
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X5,796,487 - 5,820,934 (+)NCBI
Rnor_6.0X6,791,136 - 6,815,583 (+)NCBI
Rnor_5.0X7,591,522 - 7,615,969 (+)NCBI
RGSC_v3.4X17,416,946 - 17,441,393 (+)RGD
CeleraX6,291,036 - 6,315,505 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102284 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL97666 (Get FASTA)   NCBI Sequence Viewer  
  EDL97667 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001102284   ⟸   NM_001108814
- Peptide Label: precursor
- UniProtKB: D3ZEP2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000064536   ⟸   ENSRNOT00000074275
RefSeq Acc Id: ENSRNOP00000003984   ⟸   ENSRNOT00000003984
Protein Domains
CTCK

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZEP2-F1-model_v2 AlphaFold D3ZEP2 1-131 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563968 AgrOrtholog
BioCyc Gene G2FUF-3115 BioCyc
Ensembl Genes ENSRNOG00000002960 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000046042 Ensembl
Ensembl Protein ENSRNOP00000003984 ENTREZGENE
  ENSRNOP00000003984.4 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003984 ENTREZGENE
  ENSRNOT00000003984.6 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
InterPro Cys_knot_C UniProtKB/TrEMBL
  Cystine-knot_cytokine UniProtKB/TrEMBL
  Glyco_hormone_CN UniProtKB/TrEMBL
  Norrie_dis UniProtKB/TrEMBL
KEGG Report rno:363443 UniProtKB/TrEMBL
NCBI Gene 363443 ENTREZGENE
PANTHER PTHR28611 UniProtKB/TrEMBL
Pfam Cys_knot UniProtKB/TrEMBL
PhenoGen Ndp PhenoGen
PRINTS NORRIEDSEASE UniProtKB/TrEMBL
PROSITE CTCK_1 UniProtKB/TrEMBL
  CTCK_2 UniProtKB/TrEMBL
SMART SM00041 UniProtKB/TrEMBL
UniProt D3ZEP2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ndp  norrin cystine knot growth factor NDP  LOC100909913  norrin-like  Data Merged 737654 PROVISIONAL
2019-04-04 Ndp  norrin cystine knot growth factor NDP  Ndp  NDP, norrin cystine knot growth factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-06-02 Ndp  NDP, norrin cystine knot growth factor  Ndp  Norrie disease (pseudoglioma)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-01-22 Ndp  Norrie disease (pseudoglioma)  Ndp  Norrie disease (pseudoglioma) (human)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100909913  norrin-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-09 Ndp  Norrie disease (pseudoglioma) (human)  Ndph  Norrie disease homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Ndph  Norrie disease homolog  Ndph_predicted  Norrie disease homolog (human) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Ndph_predicted  Norrie disease homolog (human) (predicted)  RGD1563968_predicted  similar to NDP (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1563968_predicted  similar to NDP (predicted)  LOC363443  similar to NDP  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC363443  similar to NDP      Symbol and Name status set to provisional 70820 PROVISIONAL