Baiap2 (BAR/IMD domain containing adaptor protein 2) - Rat Genome Database

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Gene: Baiap2 (BAR/IMD domain containing adaptor protein 2) Rattus norvegicus
Analyze
Symbol: Baiap2
Name: BAR/IMD domain containing adaptor protein 2
RGD ID: 619814
Description: Enables PDZ domain binding activity; scaffold protein binding activity; and transcription coregulator binding activity. Involved in several processes, including cellular response to L-glutamate; cellular response to epidermal growth factor stimulus; and regulation of synapse organization. Located in several cellular components, including dendrite; lamellipodium; and neuron projection branch point. Is active in several cellular components, including postsynaptic cytosol; postsynaptic density, intracellular component; and presynaptic cytosol. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome; attention deficit hyperactivity disorder; and autism spectrum disorder. Orthologous to human BAIAP2 (BAR/IMD domain containing adaptor protein 2); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; platelet-derived growth factor signaling pathway; Rho/Rac/Cdc42 mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: BAI-associated protein 2; BAI1-associated protein 2; BAR/IMD domain-containing adapter protein 2; brain-specific angiogenesis inhibitor 1-associated protein 2; brain-specific angiogenesis inhibitor 1-associated protein 2-like; insulin receptor substrate 53; insulin receptor substrate p53; insulin receptor substrate protein of 53 kDa; insulin receptor tyrosine kinase substrate protein p53; Irsp53; LOC102555951
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810105,721,371 - 105,788,549 (+)NCBIGRCr8
mRatBN7.210105,223,065 - 105,290,130 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10105,223,090 - 105,290,134 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10110,326,783 - 110,388,811 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010109,789,816 - 109,851,841 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010105,143,682 - 105,205,178 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010109,107,326 - 109,187,458 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10109,107,389 - 109,187,115 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010108,707,257 - 108,785,617 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410109,351,201 - 109,413,703 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110109,365,704 - 109,428,207 (+)NCBI
Celera10103,768,545 - 103,829,873 (+)NCBICelera
Cytogenetic Map10q32.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,6-dinitrotoluene  (EXP)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
chloroprene  (ISO)
choline  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
flavonoids  (EXP)
fluoxetine  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glycidol  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
graphite  (EXP)
ivermectin  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
Licochalcone B  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
quercitrin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
tetrachloromethane  (ISO)
thiram  (ISO)
triadimefon  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ProSAP/Shank postsynaptic density proteins interact with insulin receptor tyrosine kinase substrate IRSp53. Bockmann J, etal., J Neurochem. 2002 Nov;83(4):1013-7.
2. Postsynaptic distribution of IRSp53 in spiny excitatory and inhibitory neurons. Burette AC, etal., J Comp Neurol. 2014 Jun 15;522(9):2164-78. doi: 10.1002/cne.23526.
3. Nanoscale segregation of actin nucleation and elongation factors determines dendritic spine protrusion. Chazeau A, etal., EMBO J. 2014 Dec 1;33(23):2745-64. doi: 10.15252/embj.201488837. Epub 2014 Oct 7.
4. SH2B1 and IRSp53 proteins promote the formation of dendrites and dendritic branches. Chen CJ, etal., J Biol Chem. 2015 Mar 6;290(10):6010-21. doi: 10.1074/jbc.M114.603795. Epub 2015 Jan 13.
5. Regulation of dendritic spine morphogenesis by insulin receptor substrate 53, a downstream effector of Rac1 and Cdc42 small GTPases. Choi J, etal., J Neurosci. 2005 Jan 26;25(4):869-79.
6. T-Brain-1--A Potential Master Regulator in Autism Spectrum Disorders. Chuang HC, etal., Autism Res. 2015 Aug;8(4):412-26. doi: 10.1002/aur.1456. Epub 2015 Jan 20.
7. Tiam1-IRSp53 complex formation directs specificity of rac-mediated actin cytoskeleton regulation. Connolly BA, etal., Mol Cell Biol. 2005 Jun;25(11):4602-14.
8. Cdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cells. El-Sibai M, etal., J Cell Sci. 2007 Oct 1;120(Pt 19):3465-74. Epub 2007 Sep 12.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. MALS is a binding partner of IRSp53 at cell-cell contacts. Hori K, etal., FEBS Lett. 2003 Nov 6;554(1-2):30-4.
12. NMDA receptor-dependent synaptic translocation of insulin receptor substrate p53 via protein kinase C signaling. Hori K, etal., J Neurosci. 2005 Mar 9;25(10):2670-81.
13. BAIAP2 exhibits association to childhood ADHD especially predominantly inattentive subtype in Chinese Han subjects. Liu L, etal., Behav Brain Funct. 2013 Dec 30;9:48. doi: 10.1186/1744-9081-9-48.
14. Insulin receptor substrate protein 53 (IRSp53) as a binding partner of antimetastasis molecule NESH, a member of Abelson interactor protein family. Matsuda S, etal., Ann Oncol. 2008 Jul;19(7):1356-1357. doi: 10.1093/annonc/mdn293. Epub 2008 May 13.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. IRSp53 is colocalised with WAVE2 at the tips of protruding lamellipodia and filopodia independently of Mena. Nakagawa H, etal., J Cell Sci 2003 Jun 15;116(Pt 12):2577-83. Epub 2003 May 6.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Dentatorubral-pallidoluysian atrophy protein interacts through a proline-rich region near polyglutamine with the SH3 domain of an insulin receptor tyrosine kinase substrate. Okamura-Oho Y, etal., Hum Mol Genet. 1999 Jun;8(6):947-57.
19. Indications of linkage and association of Gilles de la Tourette syndrome in two independent family samples: 17q25 is a putative susceptibility region. Paschou P, etal., Am J Hum Genet. 2004 Oct;75(4):545-60. Epub 2004 Aug 9.
20. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
21. Secretory granules of hypophyseal and pancreatic endocrine cells contain proteins of the neuronal postsynaptic density. Redecker P, etal., Cell Tissue Res. 2007 Apr;328(1):49-55. Epub 2006 Nov 22.
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Rho GTPases in insulin-stimulated glucose uptake. Satoh T Small GTPases. 2014;5:e28102. doi: 10.4161/sgtp.28102. Epub 2014 Mar 10.
24. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
25. Insulin receptor substrate protein p53 localization in rats suggests mechanism for specific polyglutamine neurodegeneration. Thomas EA, etal., Neurosci Lett 2001 Aug 31;309(3):145-8.
26. Association study of six candidate genes asymmetrically expressed in the two cerebral hemispheres suggests the involvement of BAIAP2 in autism. Toma C, etal., J Psychiatr Res. 2011 Feb;45(2):280-2. doi: 10.1016/j.jpsychires.2010.09.001.
27. Synaptopodin protects against proteinuria by disrupting Cdc42:IRSp53:Mena signaling complexes in kidney podocytes. Yanagida-Asanuma E, etal., Am J Pathol. 2007 Aug;171(2):415-27. Epub 2007 Jun 14.
28. Proteomic analysis of postsynaptic density in Alzheimer's disease. Zhou J, etal., Clin Chim Acta. 2013 May;420:62-8. doi: 10.1016/j.cca.2013.03.016. Epub 2013 Mar 26.
Additional References at PubMed
PMID:11696321   PMID:11741283   PMID:12598619   PMID:14752106   PMID:15489334   PMID:17115031   PMID:19056867   PMID:19193906   PMID:19208628   PMID:19366662   PMID:21795692   PMID:23376485  
PMID:23533145   PMID:23750457   PMID:24076653   PMID:24584464   PMID:25416956   PMID:25468996   PMID:29284046   PMID:29476059   PMID:32357304   PMID:33506012  


Genomics

Comparative Map Data
Baiap2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810105,721,371 - 105,788,549 (+)NCBIGRCr8
mRatBN7.210105,223,065 - 105,290,130 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10105,223,090 - 105,290,134 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10110,326,783 - 110,388,811 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010109,789,816 - 109,851,841 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010105,143,682 - 105,205,178 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010109,107,326 - 109,187,458 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10109,107,389 - 109,187,115 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010108,707,257 - 108,785,617 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410109,351,201 - 109,413,703 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110109,365,704 - 109,428,207 (+)NCBI
Celera10103,768,545 - 103,829,873 (+)NCBICelera
Cytogenetic Map10q32.3NCBI
BAIAP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381781,035,151 - 81,117,434 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1781,035,122 - 81,117,434 (+)EnsemblGRCh38hg38GRCh38
GRCh371779,008,951 - 79,091,234 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361776,623,557 - 76,705,827 (+)NCBINCBI36Build 36hg18NCBI36
Build 341776,623,556 - 76,705,827NCBI
Celera1775,655,595 - 75,719,320 (+)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1774,448,559 - 74,530,873 (+)NCBIHuRef
CHM1_11779,095,216 - 79,177,491 (+)NCBICHM1_1
T2T-CHM13v2.01781,943,527 - 82,025,893 (+)NCBIT2T-CHM13v2.0
Baiap2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911119,833,762 - 119,897,608 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11119,833,589 - 119,897,608 (+)EnsemblGRCm39 Ensembl
GRCm3811119,939,916 - 120,006,782 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11119,942,763 - 120,006,782 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711119,804,406 - 119,868,096 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611119,759,182 - 119,822,869 (+)NCBIMGSCv36mm8
Celera11131,676,861 - 131,740,710 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1183.96NCBI
Baiap2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555061,868,624 - 1,936,786 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555061,868,624 - 1,936,786 (-)NCBIChiLan1.0ChiLan1.0
BAIAP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21997,614,331 - 97,695,648 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117102,513,870 - 102,594,945 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01775,460,491 - 75,542,700 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11781,190,932 - 81,269,634 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1781,187,021 - 81,269,714 (+)Ensemblpanpan1.1panPan2
BAIAP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.19923,519 - 992,254 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl9923,493 - 981,923 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha91,541,460 - 1,600,576 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.091,533,041 - 1,592,186 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl91,503,753 - 1,593,044 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.191,557,068 - 1,616,200 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.091,682,618 - 1,741,733 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.091,763,210 - 1,822,360 (-)NCBIUU_Cfam_GSD_1.0
Baiap2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056021,548,547 - 1,614,912 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365944,797,018 - 4,865,327 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365944,797,068 - 4,863,409 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BAIAP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl121,603,540 - 1,670,075 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1121,609,420 - 1,666,965 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2121,515,849 - 1,572,651 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BAIAP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11672,986,476 - 73,065,358 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1672,986,490 - 73,067,001 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607744,357,902 - 44,435,870 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Baiap2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480110,106,750 - 10,173,188 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480110,106,815 - 10,173,191 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Baiap2
403 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:113
Count of miRNA genes:86
Interacting mature miRNAs:98
Transcripts:ENSRNOT00000005687, ENSRNOT00000068437
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1096703043107057807Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1096703043107057807Rat

Markers in Region
D11Mit298.5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210105,232,427 - 105,232,554 (+)MAPPERmRatBN7.2
Rnor_6.010109,116,689 - 109,116,815NCBIRnor6.0
Rnor_5.010108,716,618 - 108,716,744UniSTSRnor5.0
RGSC_v3.410109,361,138 - 109,361,264UniSTSRGSC3.4
Celera10103,777,802 - 103,777,928UniSTS
Cytogenetic Map10q32.3UniSTS
RH127793  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210105,289,830 - 105,290,017 (+)MAPPERmRatBN7.2
Rnor_6.010109,187,159 - 109,187,345NCBIRnor6.0
Rnor_5.010108,785,318 - 108,785,504UniSTSRnor5.0
RGSC_v3.410109,418,900 - 109,419,086UniSTSRGSC3.4
Celera10103,835,070 - 103,835,256UniSTS
Cytogenetic Map10q32.3UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 20 53 37 19 37 58 35 37 11
Low 23 4 4 4 8 11 16 4 8
Below cutoff

Sequence


Ensembl Acc Id: ENSRNOT00000005687   ⟹   ENSRNOP00000005687
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10105,223,090 - 105,290,130 (+)Ensembl
Rnor_6.0 Ensembl10109,107,450 - 109,187,115 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000068437   ⟹   ENSRNOP00000060172
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10105,223,090 - 105,284,857 (+)Ensembl
Rnor_6.0 Ensembl10109,107,389 - 109,181,962 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094446   ⟹   ENSRNOP00000084785
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10105,223,090 - 105,290,134 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104586   ⟹   ENSRNOP00000091928
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10105,223,090 - 105,284,718 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117964   ⟹   ENSRNOP00000090748
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10105,223,090 - 105,290,129 (+)Ensembl
RefSeq Acc Id: NM_057196   ⟹   NP_476544
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810105,721,556 - 105,783,053 (+)NCBI
mRatBN7.210105,223,132 - 105,284,634 (+)NCBI
Rnor_6.010109,107,389 - 109,181,962 (+)NCBI
Rnor_5.010108,707,257 - 108,785,617 (+)NCBI
RGSC_v3.410109,351,201 - 109,413,703 (+)RGD
Celera10103,768,545 - 103,829,873 (+)RGD
Sequence:
RefSeq Acc Id: XM_006247869   ⟹   XP_006247931
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810105,721,394 - 105,788,549 (+)NCBI
mRatBN7.210105,223,066 - 105,290,129 (+)NCBI
Rnor_6.010109,107,326 - 109,187,457 (+)NCBI
Rnor_5.010108,707,257 - 108,785,617 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006247870   ⟹   XP_006247932
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810105,721,436 - 105,788,225 (+)NCBI
mRatBN7.210105,223,090 - 105,290,130 (+)NCBI
Rnor_6.010109,107,326 - 109,187,458 (+)NCBI
Rnor_5.010108,707,257 - 108,785,617 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006247871   ⟹   XP_006247933
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810105,721,400 - 105,788,549 (+)NCBI
mRatBN7.210105,223,065 - 105,290,130 (+)NCBI
Rnor_6.010109,107,326 - 109,187,458 (+)NCBI
Rnor_5.010108,707,257 - 108,785,617 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006247872   ⟹   XP_006247934
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810105,721,371 - 105,784,402 (+)NCBI
mRatBN7.210105,223,066 - 105,285,983 (+)NCBI
Rnor_6.010109,107,326 - 109,183,315 (+)NCBI
Rnor_5.010108,707,257 - 108,785,617 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039085085   ⟹   XP_038941013
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810105,721,517 - 105,788,549 (+)NCBI
mRatBN7.210105,223,104 - 105,290,130 (+)NCBI
RefSeq Acc Id: XM_063268340   ⟹   XP_063124410
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810105,721,519 - 105,784,402 (+)NCBI
RefSeq Acc Id: NP_476544   ⟸   NM_057196
- UniProtKB: A6HLA2 (UniProtKB/TrEMBL),   A0A8I6GJY9 (UniProtKB/TrEMBL),   A6HLA3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247932   ⟸   XM_006247870
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A2M9 (UniProtKB/TrEMBL),   A6HLA1 (UniProtKB/TrEMBL),   A0A8I6GJY9 (UniProtKB/TrEMBL),   A6HLA3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247931   ⟸   XM_006247869
- Peptide Label: isoform X1
- UniProtKB: Q923H3 (UniProtKB/Swiss-Prot),   Q6GMN2 (UniProtKB/Swiss-Prot),   A6HLA0 (UniProtKB/TrEMBL),   A0A8I6GJY9 (UniProtKB/TrEMBL),   A6HLA3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247933   ⟸   XM_006247871
- Peptide Label: isoform X3
- UniProtKB: A0A8I6GJY9 (UniProtKB/TrEMBL),   A6HLA3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247934   ⟸   XM_006247872
- Peptide Label: isoform X4
- UniProtKB: A0A8I6GJY9 (UniProtKB/TrEMBL),   A6HLA3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000060172   ⟸   ENSRNOT00000068437
Ensembl Acc Id: ENSRNOP00000005687   ⟸   ENSRNOT00000005687
RefSeq Acc Id: XP_038941013   ⟸   XM_039085085
- Peptide Label: isoform X5
- UniProtKB: A0A8I6GJY9 (UniProtKB/TrEMBL),   A6HLA3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000084785   ⟸   ENSRNOT00000094446
Ensembl Acc Id: ENSRNOP00000090748   ⟸   ENSRNOT00000117964
Ensembl Acc Id: ENSRNOP00000091928   ⟸   ENSRNOT00000104586
RefSeq Acc Id: XP_063124410   ⟸   XM_063268340
- Peptide Label: isoform X6
- UniProtKB: A0A8I6GJY9 (UniProtKB/TrEMBL),   A6HLA3 (UniProtKB/TrEMBL)
Protein Domains
IMD   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6GMN2-F1-model_v2 AlphaFold Q6GMN2 1-535 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697948
Promoter ID:EPDNEW_R8473
Type:single initiation site
Name:Baiap2_1
Description:BAI1-associated protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.010109,107,347 - 109,107,407EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619814 AgrOrtholog
BioCyc Gene G2FUF-22469 BioCyc
Ensembl Genes ENSRNOG00000004049 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055032377 UniProtKB/Swiss-Prot
  ENSRNOG00060029965 UniProtKB/Swiss-Prot
  ENSRNOG00065004025 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005687.7 UniProtKB/Swiss-Prot
  ENSRNOT00000068437.5 UniProtKB/Swiss-Prot
  ENSRNOT00000094446.1 UniProtKB/TrEMBL
  ENSRNOT00000104586.1 UniProtKB/TrEMBL
  ENSRNOT00000117964.1 UniProtKB/TrEMBL
  ENSRNOT00055055913 UniProtKB/Swiss-Prot
  ENSRNOT00060052126 UniProtKB/Swiss-Prot
  ENSRNOT00065005955 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1270.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 Domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7099884 IMAGE-MGC_LOAD
InterPro AH/BAR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  I-BAR_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IRSp53/IRTKS/Pinkbar UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IRSp53_I-BAR_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Irsp53_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117542 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:91531 IMAGE-MGC_LOAD
NCBI Gene 117542 ENTREZGENE
PANTHER PTHR14206 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR14206:SF3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IMD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Baiap2 PhenoGen
PROSITE IMD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004049 RatGTEx
  ENSRNOG00055032377 RatGTEx
  ENSRNOG00060029965 RatGTEx
  ENSRNOG00065004025 RatGTEx
SMART SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103657 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A2M9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AD66_RAT UniProtKB/TrEMBL
  A0A8I6GJY9 ENTREZGENE, UniProtKB/TrEMBL
  A6HLA0 ENTREZGENE, UniProtKB/TrEMBL
  A6HLA1 ENTREZGENE, UniProtKB/TrEMBL
  A6HLA2 ENTREZGENE, UniProtKB/TrEMBL
  A6HLA3 ENTREZGENE, UniProtKB/TrEMBL
  BAIP2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q923H3 ENTREZGENE
UniProt Secondary Q923H3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Baiap2  BAR/IMD domain containing adaptor protein 2  LOC102555951  brain-specific angiogenesis inhibitor 1-associated protein 2-like  Data merged from RGD:7581982 737654 PROVISIONAL
2019-08-05 Baiap2  BAR/IMD domain containing adaptor protein 2  Baiap2  BAI1-associated protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-12-18 LOC102555951  brain-specific angiogenesis inhibitor 1-associated protein 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-25 Baiap2  BAI1-associated protein 2  Baiap2  brain-specific angiogenesis inhibitor 1-associated protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Baiap2  brain-specific angiogenesis inhibitor 1-associated protein 2      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Baiap2  brain-specific angiogenesis inhibitor 1-associated protein 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed in the cerebellum, subthalamic nucleus, pons, amygdala, hypothalamus, and forebrain structures, including the cerebral cortex, striatum, hippocampus and olfactory bulb 632274