RGD Reference Report - Loss of hnRNP K impairs synaptic plasticity in hippocampal neurons. - Rat Genome Database

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Loss of hnRNP K impairs synaptic plasticity in hippocampal neurons.

Authors: Folci, A  Mapelli, L  Sassone, J  Prestori, F  D'Angelo, E  Bassani, S  Passafaro, M 
Citation: Folci A, etal., J Neurosci. 2014 Jul 2;34(27):9088-95. doi: 10.1523/JNEUROSCI.0303-14.2014.
RGD ID: 10002784
Pubmed: (View Article at PubMed) PMID:24990929
DOI: Full-text: DOI:10.1523/JNEUROSCI.0303-14.2014

Heterogeneous nuclear ribonucleoprotein K (hnRNP K) is an RNA-binding protein implicated in RNA metabolism. Here, we investigated the role of hnRNP K in synapse function. We demonstrated that hnRNP K regulates dendritic spine density and long-term potentiation (LTP) in cultured hippocampal neurons from embryonic rats. LTP requires the extracellular signal-regulated kinase (ERK)1/2-mediated phosphorylation and cytoplasmic accumulation of hnRNP K. Moreover, hnRNP K knockdown prevents ERK cascade activation and GluA1-S845 phosphorylation and surface delivery, which are essential steps for LTP. These findings establish hnRNP K as a new critical regulator of synaptic transmission and plasticity in hippocampal neurons.

Objects Annotated

Genes (Rattus norvegicus)
Hnrnpk  (heterogeneous nuclear ribonucleoprotein K)

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