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Gene: Fmr1 (FMRP translational regulator 1) Rattus norvegicus
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Symbol: Fmr1
Name: FMRP translational regulator 1
RGD ID: 2623
Description: Exhibits RNA binding activity; enzyme binding activity; and protein domain specific binding activity. Involved in several processes, including modulation of chemical synaptic transmission; negative regulation of transport; and regulation of cellular protein metabolic process. Localizes to several cellular components, including cytoplasmic ribonucleoprotein granule; dendrite; and distal axon. Colocalizes with microtubule. Used to study autism spectrum disorder and fragile X syndrome. Biomarker of childhood onset epileptic encephalopathy; transient cerebral ischemia; and withdrawal disorder. Human ortholog(s) of this gene implicated in fragile X syndrome; fragile X-associated tremor/ataxia syndrome; and premature ovarian failure. Orthologous to human FMR1 (FMRP translational regulator 1); INTERACTS WITH (S)-3,5-dihydroxyphenylglycine; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: FMRP; fragile X mental retardation 1; fragile X mental retardation protein 1 homolog; fragile X mental retardation syndrome 1 homolog; fragile X mental retardation-1 protein; protein FMR-1; ragile X mental retardation protein; synaptic functional regulator FMR1
Orthologs:
Homo sapiens (human) : FMR1 (FMRP translational regulator 1)  HGNC  Alliance
Mus musculus (house mouse) : Fmr1 (FMRP translational regulator 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fmr1 (FMRP translational regulator 1)
Pan paniscus (bonobo/pygmy chimpanzee) : FMR1 (FMRP translational regulator 1)
Canis lupus familiaris (dog) : FMR1 (FMRP translational regulator 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fmr1 (FMRP translational regulator 1)
Sus scrofa (pig) : FMR1 (FMRP translational regulator 1)
Chlorocebus sabaeus (African green monkey) : FMR1 (FMRP translational regulator 1)
Heterocephalus glaber (naked mole-rat) : Fmr1 (FMRP translational regulator 1)
more info ...
Allele / Splice: Fmr1em2Mcwi   Fmr1em4Mcwi   Fmr1em1Sage  
Genetic Models: LE-Fmr1em2Mcwi SD-Fmr1em1Sage LE-Fmr1em4Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0X154,684,924 - 154,722,369 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX154,684,935 - 154,722,314 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01150,408,220 - 150,445,658 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X154,756,031 - 154,793,782 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X154,829,463 - 154,867,215 (+)NCBI
Celera1134,092,390 - 134,130,141 (-)NCBICelera
Cytogenetic MapXq37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Fmr1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2623
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-10-06
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.