Gene: Fmr1 (fragile X mental retardation 1) Rattus norvegicus
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Symbol: Fmr1
Name: fragile X mental retardation 1
Description: Exhibits several functions, including RNA binding activity, enzyme binding activity, and protein domain specific binding activity; involved in several processes, including cellular response to monosodium glutamate, negative regulation of transport, and regulation of gene expression; localizes to several cellular components, including the Schaffer collateral - CA1 synapse, cytoplasm, and neuron projection; colocalizes with the microtubule; used to study autism spectrum disorder and fragile X syndrome; biomarker of childhood onset epileptic encephalopathy, transient cerebral ischemia, and withdrawal disorder; orthologous to human FMR1 (fragile X mental retardation 1); INTERACTS WITH (S)-3,5-dihydroxyphenylglycine; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: FMRP; fragile X mental retardation protein 1 homolog; fragile X mental retardation syndrome 1 homolog; fragile X mental retardation-1 protein; protein FMR-1; ragile X mental retardation protein; synaptic functional regulator FMR1
Orthologs:
Homo sapiens (human) : FMR1 (fragile X mental retardation 1)  HGNC  Alliance
Mus musculus (house mouse) : Fmr1 (fragile X mental retardation 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fmr1 (fragile X mental retardation 1)
Pan paniscus (bonobo/pygmy chimpanzee) : FMR1 (fragile X mental retardation 1)
Canis lupus familiaris (dog) : FMR1 (fragile X mental retardation 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fmr1 (fragile X mental retardation 1)
Sus scrofa (pig) : FMR1 (fragile X mental retardation 1)
more info ...
Allele / Splice: Fmr1em2Mcwi   Fmr1em4Mcwi   Fmr1em1Sage  
Genetic Models: SD-Fmr1em1Sage LE-Fmr1em2Mcwi LE-Fmr1em4Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0X154,684,924 - 154,722,369 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01150,408,220 - 150,445,658 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X154,756,031 - 154,793,782 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X154,829,463 - 154,867,215 (+)NCBI
Celera1134,092,390 - 134,130,141 (-)NCBICelera
Cytogenetic MapXq37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Fmr1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2623
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.