TITANIUM DIOXIDE NANOPARTICLE RESPONSE PATHWAY (PW:0001437)
Description
Nanoparticles (NP) are increasingly being in used in a wide range of applications, including biomedical and environmental. The potential hazard they may present is the focus of current nanotoxicology research. Among the nanoparticles with a broad spectrum of applications and known cellular responses are the carbon nanotubes, nano-titanium dioxide (TiO2 ) and nano-cerium oxide. TiO2 is a widely used pigment found in many consumer products that include cosmetics and sunscreens, toothpaste, food products (FDA approved) and prosthetic implants. TiO
2 exists in three mineral forms: anatase, rutile and brookite; anatase and rutile have a tetragonal crystalline structure, brookite is orthorhombic. Anatase has high photocatalytic activity under UV light (an application of photocatalysis is the oxidation of organic pollutants in waste waters). The major routes of TiO
2 . NP exposure are inhalation and the skin. Studies conducted in parallel in mice and rats show similar patterns of lung neutrophilia in the two rodents and dependent on the form of TiO
2 used. Intravenous and/or intraperitoneal administration leads to accumulation of TiO
2 in the liver, spleen, kidney and lung but at different levels. Under various types of toxicity conditions, pulmonary toxicity in response to TiO
2 is observed. It is believed that the observed pulmonary inflammation caused by TiO
2 relates to oxidative stress and the expression of inflammatory cytokines. The
in vivo studies show DNA strand breaks, chromosomal damage, endocrine and reproductive systems-related issues. TiO
2 , in its anatase form can interact with DNA in rat and mouse liver cells, either by inserting itself in-between DNA base pairs or binding to DNA nucleotide with three DNA oxygen or nitrogen atoms and two phosphorus.
In vitro studies in human cell lines point to the genotoxic and cytotoxic effects of TiO
2 . Results show impairment of DNA repair pathways, induction of oxidative stress and intrinsic apoptosis via activation of p53 signaling. P53 tumor suppressor transcription factor is a master regulator at the hub of many signaling and regulatory networks. TiO
2 activates both the intrinsic and extrinsic apoptotic pathways via increased expression of Bax and Casp3 and of Fas and Casp8, respectively. TiO
2 has also been shown to induce inflammatory responses via Toll-like receptor signaling involving Tlr4. Toll-like receptors represent a large family of pattern recognition receptors (PRR) that respond to a diverse array of exogenous and endogenous molecules. There are 10 known Toll-like receptors in mammals of which receptors 1 to 9 are conserved. All rely on adaptor proteins to initiate downstream events of which Myd88 represent the main adaptor protein. Thus, downstream events take place in an Myd88-dependent or independent manner. Tlr4 is the only receptor that employs both routes, albeit with different kinetics. Of note, TiO
2 activation of Tlr4 is independent of Lbp and Cd14 - the proteins needed to facilitate LPS (lipopolysaccharide) binding by the Tlr4-Ly96 complex. In human keratinocytes, TiO
2 diminishes mitochondrial function and affects carbohydrate, amino acids and polyamine metabolism. It has to be mentioned that the literature points to contradictory and conflicting results and data regarding both the toxicity and the particle size effects of TiO
2 emphasizing the need for further experimental assessment. In addition, there may be variation in the responses of different species.
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Pathway Diagram:
Genes in Pathway:
G
Bax
BCL2 associated X, apoptosis regulator
ISO
RGD
PMID:22614867 PMID:22419868 RGD:7248687 , RGD:7248688
NCBI chr 1:105,076,472...105,081,906
G
Casp3
caspase 3
ISO
RGD
PMID:22614867 PMID:22419868 RGD:7248687 , RGD:7248688
NCBI chr16:52,395,539...52,413,794
G
Casp8
caspase 8
ISO
RGD
PMID:22419868 RGD:7248688
NCBI chr 9:67,747,109...67,806,699
G
Fas
Fas cell surface death receptor
ISO
RGD
PMID:22419868 RGD:7248688
NCBI chr 1:241,212,155...241,245,774
G
Tlr4
toll-like receptor 4
ISO
RGD
PMID:23803652 RGD:7248686
NCBI chr 5:85,161,247...85,174,882
G
Tp53
tumor protein p53
ISO
RGD
PMID:22614867 RGD:7248687
NCBI chr10:54,798,871...54,810,300
Pathway Gene Annotations
Disease Annotations Associated with Genes in the titanium dioxide nanoparticle response pathway
Bax abdominal obesity-metabolic syndrome 1 , acute kidney failure , Acute Lung Injury , acute lymphoblastic leukemia , acute myocardial infarction , Adrenal Insufficiency , Alzheimer's disease , amyotrophic lateral sclerosis , anti-basement membrane glomerulonephritis , ataxia telangiectasia , brain glioma , Brain Hypoxia-Ischemia , Brain Injuries , breast cancer , Breast Neoplasms , bronchopulmonary dysplasia , Burns , Cerebral Hemorrhage , cervical squamous cell carcinoma , Chemical and Drug Induced Liver Injury , Chronic Intermittent Hypoxia , clear cell renal cell carcinoma , colon adenocarcinoma , colon carcinoma , Colonic Neoplasms , colorectal cancer , Colorectal Neoplasms , congestive heart failure , dementia , depressive disorder , Diabetic Cardiomyopathies , dilated cardiomyopathy , endometriosis , Endotoxemia , Esophageal Neoplasms , Experimental Arthritis , Experimental Diabetes Mellitus , Experimental Mammary Neoplasms , Fetal Growth Retardation , Gastrointestinal Hemorrhage , genetic disease , glaucoma , heart disease , hepatocellular carcinoma , human immunodeficiency virus infectious disease , Huntington's disease , Hyperplasia , hypertension , impotence , intermittent claudication , intestinal disease , Intestinal Neoplasms , ischemia , Kashin-Beck Disease , Kidney Reperfusion Injury , Knee Osteoarthritis , leiomyoma , Liver Reperfusion Injury , Lung Injury , lung non-small cell carcinoma , Lung Reperfusion Injury , macular degeneration , male infertility , Microsatellite Instability , middle cerebral artery infarction , morphine dependence , Multi-Infarct Dementia , myocardial infarction , Myocardial Ischemia , Myocardial Reperfusion Injury , Neoplasm Metastasis , Nerve Degeneration , Optic Nerve Injuries , osteoarthritis , osteoporosis , polycystic ovary syndrome , post-traumatic stress disorder , Postoperative Cognitive Dysfunction , pre-malignant neoplasm , Premature Aging , primary cutaneous T-cell non-Hodgkin lymphoma , prion disease , prostate cancer , prostate carcinoma , Prostatic Neoplasms , Reperfusion Injury , Retina Reperfusion Injury , retinal degeneration , rheumatic heart disease , Right Ventricular Hypertrophy , Sarcopenia , scrapie , Spinal Cord Injuries , status epilepticus , stomach cancer , T-cell acute lymphoblastic leukemia , teratoma , Testis Reperfusion Injury , thyroiditis , toxoplasmosis , transient cerebral ischemia , Transplant Rejection , type 2 diabetes mellitus , urinary bladder cancer , Ventricular Remodeling Casp3 abdominal aortic aneurysm , Acute Liver Failure , Acute Lung Injury , acute myocardial infarction , acute necrotizing pancreatitis , alcohol use disorder , Alzheimer's disease , amyotrophic lateral sclerosis , atherosclerosis , bacterial infectious disease , Binge Drinking , Brain Contusion , brain glioma , Brain Hypoxia-Ischemia , Brain Injuries , brain ischemia , breast cancer , breast carcinoma , bronchopulmonary dysplasia , Burns , calcinosis , cataract , Cerebral Hemorrhage , cervical cancer , Chemical and Drug Induced Liver Injury , chemical colitis , Chronic Hepatitis , chronic obstructive pulmonary disease , colon cancer , Colonic Neoplasms , congestive heart failure , Contrast-Induced Nephropathy , Copper-Overload Cirrhosis , cryptorchidism , diabetes mellitus , diabetic angiopathy , Diabetic Cardiomyopathies , Diabetic Nephropathies , diabetic neuropathy , diabetic retinopathy , dilated cardiomyopathy , Edema , endometritis , Endotoxemia , Experimental Autoimmune Encephalomyelitis , Experimental Autoimmune Myocarditis , Experimental Diabetes Mellitus , Experimental Mammary Neoplasms , Experimental Radiation Injuries , Fetal Growth Retardation , gastric ulcer , heart disease , heart valve disease , Hemorrhagic Shock , hepatocellular carcinoma , Huntington's disease , Hypercholesterolemia , hypertension , hyperthyroidism , hypertrophic cardiomyopathy , Hypoxia , impotence , Insulin Resistance , intermittent claudication , intestinal disease , Intestinal Reperfusion Injury , kidney disease , Kidney Reperfusion Injury , liver cirrhosis , Liver Reperfusion Injury , lung non-small cell carcinoma , Lung Reperfusion Injury , middle cerebral artery infarction , Mycoplasma Infections , myocardial infarction , Myocardial Reperfusion Injury , Neoplasm Metastasis , Nerve Degeneration , nervous system disease , osteoarthritis , Osteoarthritis, Experimental , Oxygen-Induced Retinopathy , pancreatitis , Parkinson's disease , Parkinsonism , Postoperative Cognitive Dysfunction , pre-malignant neoplasm , prostate cancer , Prostatic Neoplasms , renal cell carcinoma , Reperfusion Injury , retinal detachment , retinal disease , salivary gland disease , sciatic neuropathy , scrapie , Sepsis , severe acute respiratory syndrome , spermatic cord torsion , Spinal Cord Injuries , status epilepticus , stomach cancer , stroke , Subarachnoid Hemorrhage , Testis Reperfusion Injury , toxic encephalopathy , transient cerebral ischemia , transitional cell carcinoma , Transplant Rejection , traumatic brain injury , type 1 diabetes mellitus , type 2 diabetes mellitus , ulcerative colitis , ureteral obstruction , urinary bladder cancer , Ventricular Remodeling , Viral Myocarditis Casp8 Acute Liver Failure , Acute Lung Injury , acute lymphoblastic leukemia , adenocarcinoma , alcohol use disorder , Alcohol-Related Disorders , allergic contact dermatitis , Alzheimer's disease , atopic dermatitis , autoimmune disease , autoimmune lymphoproliferative syndrome , autoimmune lymphoproliferative syndrome type 2B , bacterial infectious disease , Brain Contusion , Brain Hypoxia-Ischemia , Brain Injuries , breast cancer , Breast Cancer, Familial , Breast Neoplasms , bronchopulmonary dysplasia , Cerebral Hemorrhage , Chemical and Drug Induced Liver Injury , chronic obstructive pulmonary disease , Colorectal Neoplasms , contact dermatitis , Diabetic Cardiomyopathies , Diabetic Nephropathies , dilated cardiomyopathy , Edema , epilepsy , Esophageal Neoplasms , esophagus adenocarcinoma , esophagus squamous cell carcinoma , Experimental Autoimmune Encephalomyelitis , Experimental Autoimmune Myocarditis , Experimental Diabetes Mellitus , Experimental Mammary Neoplasms , Experimental Radiation Injuries , Familial Prostate Cancer , genetic disease , head and neck squamous cell carcinoma , heart disease , Hemorrhagic Shock , hepatocellular carcinoma , Huntington's disease , hyperglycemia , hypertension , Insulin Resistance , kidney disease , liver cirrhosis , Liver Reperfusion Injury , lung cancer , Lung Neoplasms , lung non-small cell carcinoma , melanoma , mitochondrial metabolism disease , Myocardial Reperfusion Injury , nephritis , Osteoarthritis, Experimental , pancreatic cancer , papillomavirus infectious disease , pre-malignant neoplasm , primary immunodeficiency disease , Reperfusion Injury , retinal detachment , sciatic neuropathy , Sepsis , Skin Neoplasms , status epilepticus , Stomach Neoplasms , transient cerebral ischemia , traumatic brain injury , type 1 diabetes mellitus , type 2 diabetes mellitus , Uterine Cervical Neoplasms , Viral Myocarditis Fas abdominal obesity-metabolic syndrome 1 , Acute Experimental Pancreatitis , acute kidney failure , Acute Liver Failure , Acute Lung Injury , acute lymphoblastic leukemia , acute myeloid leukemia , adult T-cell leukemia/lymphoma , alcohol-associated liver disease , alcoholic hepatitis , Alzheimer's disease , Animal Disease Models , Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis , aplastic anemia , asthma , atherosclerosis , autoimmune disease , autoimmune hepatitis , autoimmune lymphoproliferative syndrome , Autoimmune Lymphoproliferative Syndrome, Type IA , autoimmune thrombocytopenic purpura , B-Cell Chronic Lymphocytic Leukemia , Barrett's esophagus , Behcet's disease , brain glioma , Brain Hypoxia-Ischemia , Brain Injuries , brain ischemia , breast cancer , breast carcinoma , cardiomyopathy , Cardiotoxicity , Cardiovascular Pregnancy Complications , cataract , Chemical and Drug Induced Liver Injury , Chest Trauma , chorioamnionitis , chronic conjunctivitis , chronic myeloid leukemia , chronic obstructive pulmonary disease , Chronic Uveitis , clonorchiasis , Colonic Neoplasms , congestive heart failure , corneal neovascularization , cryptorchidism , cystic fibrosis , dermatomyositis , diabetic angiopathy , Diabetic Nephropathies , diffuse large B-cell lymphoma , dilated cardiomyopathy , Disease Progression , endophthalmitis , Endotoxemia , Esophageal Neoplasms , esophagus adenocarcinoma , Experimental Allergic Asthma , Experimental Autoimmune Uveitis , Experimental Colitis , Experimental Diabetes Mellitus , Experimental Liver Cirrhosis , Experimental Liver Neoplasms , Experimental Mammary Neoplasms , Experimental Radiation Injuries , Experimental Seizures , Fetal Growth Retardation , gastric ulcer , genetic disease , glaucoma , glomerulonephritis , graft-versus-host disease , Graves' disease , Hashimoto Disease , HELLP syndrome , hematopoietic system disease , hepatitis B , hepatoblastoma , hepatocellular carcinoma , heroin dependence , high grade glioma , human immunodeficiency virus infectious disease , Huntington's disease , Hyperoxia , hypersplenism , Hypothermia , idiopathic pulmonary fibrosis , IgA glomerulonephritis , inclusion body myositis , infectious mononucleosis , Insulin Resistance , intrahepatic cholangiocarcinoma , Kashin-Beck Disease , kidney disease , Kidney Reperfusion Injury , left ventricular failure , leukocyte disease , limited scleroderma , liver disease , Liver Injury , Liver Reperfusion Injury , lung adenocarcinoma , Lung Injury , Lung Neoplasms , lupus nephritis , Lymphatic Metastasis , Lymphomatoid Papulosis , lymphoproliferative syndrome , macular degeneration , male infertility , melanoma , Metabolic Brain Diseases , metabolic dysfunction-associated steatotic liver disease , Metabolic Syndrome , mixed connective tissue disease , multiple sclerosis , multiple system atrophy , myasthenia gravis , myelodysplastic syndrome , Myocardial Reperfusion Injury , Nasal Polyps , nasal type extranodal NK/T-cell lymphoma , Necrosis , Neoplasm Metastasis , nephritis , ocular hypertension , ovarian cancer , Oxygen-Induced Retinopathy , Parkinson's disease , peripheral vascular disease , Plasmodium falciparum malaria , pre-eclampsia , pre-malignant neoplasm , primary biliary cholangitis , primary cutaneous T-cell non-Hodgkin lymphoma , primary immunodeficiency disease , prostate cancer , Prostatic Neoplasms , proteinuria , Puromycin Aminonucleoside Nephrosis , relapsing-remitting multiple sclerosis , renal cell carcinoma , Reperfusion Injury , retinal detachment , retinoblastoma , rheumatoid arthritis , sciatic neuropathy , seminoma , Sepsis , short-rib thoracic dysplasia 6 with or without polydactyly , Sjogren's syndrome , Spinal Cord Compression , Spinal Cord Injuries , splenic disease , Splenomegaly , squamous cell carcinoma , systemic lupus erythematosus , Taste Disorders , Temporomandibular Joint Osteoarthritis , Testicular Injury , transient cerebral ischemia , transitional cell carcinoma , type 1 diabetes mellitus , type 2 diabetes mellitus , ulcerative colitis , urinary bladder cancer , varicocele , Viral Bronchiolitis Tlr4 Acanthamoeba Keratitis , acne , Acne Conglobata , Acute Coronary Syndrome , acute kidney failure , Acute Liver Failure , Acute Lung Injury , acute necrotizing pancreatitis , acute pancreatitis , Acute Tubulointerstitial Nephritis , Acute-On-Chronic Liver Failure , alcohol dependence , alcohol use disorder , alcohol-associated liver disease , Alcohol-Related Disorders , alcoholic hepatitis , alcoholic liver cirrhosis , allergic conjunctivitis , allergic contact dermatitis , allergic rhinitis , Alzheimer's disease , ankylosing spondylitis , anogenital venereal wart , anterior uveitis , arteriosclerosis , arthritis , asthma , atherosclerosis , atopic dermatitis , Bacteremia , Bacterial Keratitis , bacterial pneumonia , Behcet's disease , Binge Drinking , Brain Hypoxia-Ischemia , Brain Injuries , brain ischemia , breast cancer , Bronchial Hyperreactivity , carcinoma , carotid artery disease , carotid stenosis , Chemical and Drug Induced Liver Injury , cholesteatoma , cholesteatoma of middle ear , Chronic Hepatitis B , Chronic Hepatitis C , Chronic Intermittent Hypoxia , chronic obstructive pulmonary disease , Chronic Pain , Chronic Periodontitis , colitis , Colorectal Neoplasms , contact dermatitis , coronary artery disease , COVID-19 , Crohn's disease , cutaneous leishmaniasis , cystic echinococcosis , cystic fibrosis , dermatomyositis , diabetes mellitus , Diabetic Foot , Diabetic Nephropathies , diabetic neuropathy , diabetic retinopathy , dry eye syndrome , Dysbiosis , end stage renal disease , Endotoxemia , Entamoebiasis , Eosinophilia , Escherichia Coli Meningitis , esophagus adenocarcinoma , essential hypertension , eumycotic mycetoma , exfoliation syndrome , Experimental Arthritis , Experimental Autoimmune Encephalomyelitis , Experimental Autoimmune Neuritis , Experimental Autoimmune Uveitis , Experimental Diabetes Mellitus , Experimental Liver Cirrhosis , extrahepatic cholestasis , eye disease , familial combined hyperlipidemia , familial Mediterranean fever , fetal alcohol spectrum disorder , Fever , Fibrosis , Fungal Eye Infections , Fungal Keratitis , glomerulonephritis , glucose intolerance , Hearing Loss , Hemorrhagic Shock , hepatocellular carcinoma , hepatorenal syndrome , Herpes Simplex Encephalitis , herpes simplex virus keratitis , hymenolepiasis , Hyperalgesia , Hypercholesterolemia , hypertension , Hypertriglyceridemia , ileitis , Inflammation , Insulin Resistance , invasive aspergillosis , Kawasaki disease , keratitis , kidney failure , Kidney Reperfusion Injury , learning disability , left ventricular failure , leptospirosis , liver cirrhosis , Liver Injury , Liver Reperfusion Injury , low tension glaucoma , lung adenocarcinoma , lung disease , Lung Injury , Lung Neoplasms , Lung Reperfusion Injury , Lymphatic Metastasis , macular degeneration , mastitis , mastoiditis , melanoma , membranoproliferative glomerulonephritis , meningococcal meningitis , metabolic dysfunction and alcohol associated liver disease , metabolic dysfunction-associated steatotic liver disease , middle cerebral artery infarction , multiple sclerosis , myocardial infarction , Myocardial Reperfusion Injury , Nasal Polyps , Neoplasm Invasiveness , Neoplasm Metastasis , Neuralgia , obesity , Ocular Onchocerciasis , Optic Nerve Injuries , Oral Lichen Planus , otitis media , Otitis Media with Effusion , Ovarian Neoplasms , Pain , Painful Neuropathy , pancreatitis , perinatal necrotizing enterocolitis , periodontitis , Plaque, Atherosclerotic , pleural tuberculosis , Pneumococcal Meningitis , pneumonia , Postoperative Cognitive Dysfunction , pre-eclampsia , primary open angle glaucoma , Prostatic Neoplasms , Pseudomonas Aeruginosa Keratitis , psoriasis , pulmonary edema , pulmonary emphysema , pulmonary fibrosis , pulmonary hypertension , pulmonary tuberculosis , pulpitis , renal fibrosis , Reperfusion Injury , respiratory allergy , Respiratory Sounds , respiratory syncytial virus infectious disease , Retina Reperfusion Injury , Rhinosinusitis , sciatic neuropathy , Seasonal Allergic Rhinitis , Sepsis , severe COVID-19 , sinusitis , Spinal Cord Injuries , Spinal Cord Reperfusion Injury , sporotrichosis , squamous cell carcinoma , Stable Angina , steatotic liver disease , stomach cancer , stroke , Subarachnoid Hemorrhage , suppurative otitis media , systemic lupus erythematosus , temporal arteritis , transient cerebral ischemia , Transplant Rejection , tuberculosis , tympanosclerosis , type 1 diabetes mellitus , type 2 diabetes mellitus , uric acid nephrolithiasis , urinary bladder cancer , urinary tract infection , uveitis , Vibrio Vulnificus Infection , Viral Bronchiolitis , viral meningitis , vitiligo , Wallerian Degeneration , Weight Loss Tp53 Acute Erythroleukemia , acute kidney failure , acute lymphoblastic leukemia , acute megakaryocytic leukemia , acute myeloid leukemia , adenocarcinoma , adenoid cystic carcinoma , adenoma , Adrenal Cortex Neoplasms , Adrenal Gland Neoplasms , adrenocortical carcinoma , adult T-cell leukemia/lymphoma , Alzheimer's disease , amyotrophic lateral sclerosis , anaplastic astrocytoma , anaplastic thyroid carcinoma , angiosarcoma , Animal Disease Models , Arsenic Poisoning , atherosclerosis , atypical teratoid rhabdoid tumor , autosomal recessive dyskeratosis congenita 3 , B-Cell Chronic Lymphocytic Leukemia , B-lymphoblastic leukemia/lymphoma , Balkan nephropathy , basal cell carcinoma , bone development disease , Bone Marrow Failure Syndrome 5 , Bone Marrow Neoplasms , bone osteosarcoma , brain ischemia , Brain Neoplasms , breast adenocarcinoma , breast cancer , Breast Cancer, Familial , breast carcinoma , Breast Neoplasms , bronchiolo-alveolar adenocarcinoma , bronchopulmonary dysplasia , Calcification of Aortic Valve , calcinosis , carcinoma , cardiomyopathy , Cardiotoxicity , carotid artery disease , cataract , Cecal Neoplasms , Central Nervous System Neoplasms , cervical adenocarcinoma , cervical cancer , cervical squamous cell carcinoma , CHARGE syndrome , Chemotherapy-Induced Febrile Neutropenia , cholangiocarcinoma , cholesteatoma of middle ear , choroid plexus carcinoma , choroid plexus papilloma , Chromosome 17 Deletion , chronic lymphocytic leukemia , chronic obstructive pulmonary disease , clear cell adenocarcinoma , clear cell renal cell carcinoma , colon carcinoma , Colon Diverticulum , Colonic Neoplasms , colorectal adenocarcinoma , colorectal cancer , colorectal carcinoma , Colorectal Neoplasms , congenital fibrosarcoma , congenital merosin-deficient muscular dystrophy 1A , congestive heart failure , coronary artery disease , coronary restenosis , Craniofacial Abnormalities , demyelinating disease , Diabetic Nephropathies , Diamond-Blackfan anemia , diffuse large B-cell lymphoma , diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype , DiGeorge syndrome , dilated cardiomyopathy , disease of cellular proliferation , Disease Progression , Drug-induced Neutropenia , Drug-Related Side Effects and Adverse Reactions , Ductal Carcinoma , ductal carcinoma in situ , dyskeratosis congenita , Emphysema , endometrial adenocarcinoma , endometrial cancer , endometrial carcinoma , Endometrial Intraepithelial Neoplasia , Endometrial Neoplasms , esophageal cancer , esophageal carcinoma , Esophageal Neoplasms , esophagus adenocarcinoma , esophagus squamous cell carcinoma , Experimental Diabetes Mellitus , Experimental Liver Neoplasms , Experimental Mammary Neoplasms , Experimental Neoplasms , Eye Neoplasms , familial melanoma , Familial Pancreatic Carcinoma , Female Infertility , gallbladder cancer , Gallbladder Neoplasms , gastric adenocarcinoma , glioblastoma , graft-versus-host disease , Graves' disease , head and neck squamous cell carcinoma , hematologic cancer , hepatoblastoma , hepatocellular carcinoma , Hereditary Adrenocortical Carcinoma , hereditary breast ovarian cancer syndrome , Hereditary Neoplastic Syndromes , high grade glioma , hypertension , hypertrophic cardiomyopathy , Hypogonadism and Testicular Atrophy , ischemia , Kaposi's sarcoma , keratosis , Leber hereditary optic neuropathy , leukemia , Li-Fraumeni syndrome , Li-Fraumeni syndrome 1 , Li-Fraumeni-Like Syndrome , Lip Neoplasms , Liver Neoplasms , low tension glaucoma , lung adenocarcinoma , Lung Neoplasms , lung non-small cell carcinoma , lung sarcomatoid carcinoma , lung small cell carcinoma , lung squamous cell carcinoma , Lymphatic Metastasis , lymphoma , male infertility , malignant astrocytoma , malignant mesothelioma , marginal zone lymphoma , medulloblastoma , melanoma , meninges sarcoma , Mesothelioma , mismatch repair cancer syndrome , mitochondrial metabolism disease , Mouth Neoplasms , multiple myeloma , myelodysplastic syndrome , myelofibrosis , myeloid leukemia associated with Down Syndrome , myeloid neoplasm , myocardial infarction , Myocardial Reperfusion Injury , nasal cavity cancer , Nasopharyngeal Neoplasms , nasopharynx carcinoma , Neoplasm Metastasis , Neoplastic Cell Transformation , nephroblastoma , Nerve Sheath Neoplasms , nervous system disease , neuroblastoma , non-Hodgkin lymphoma , Odontogenic Myxoma , Oral Lichen Planus , oral mucosa leukoplakia , oral squamous cell carcinoma , oral submucous fibrosis , Oropharyngeal Neoplasms , osteosarcoma , ovarian cancer , ovarian carcinoma , Ovarian Neoplasms , ovarian small cell carcinoma , ovary serous adenocarcinoma , pancreatic cancer , pancreatic carcinoma , pancreatic ductal carcinoma , pancreatic intraductal papillary-mucinous neoplasm , papillary thyroid carcinoma , paranasal sinus benign neoplasm , Parasitic Liver Diseases , Pediatric Adrenocortical Carcinoma , Penile Neoplasms , Phyllodes Tumor , pleomorphic xanthoastrocytoma , Pleural Effusion , Polyploidy , pre-malignant neoplasm , Premature Aging , primary cutaneous T-cell non-Hodgkin lymphoma , primary open angle glaucoma , prostate adenocarcinoma , prostate cancer , Prostate Cancer, Hereditary, 1 , Prostatic Neoplasms , psoriasis , pterygium , pulmonary hypertension , renal cell carcinoma , Reperfusion Injury , rhabdomyosarcoma , SAPHO syndrome , sarcoma , schizophrenia , serous cystadenocarcinoma , Sezary's disease , skin melanoma , Skin Neoplasms , small cell carcinoma , Spinal Cord Injuries , spondyloarthropathy , squamous cell carcinoma , stomach cancer , Stomach Neoplasms , T-cell non-Hodgkin lymphoma , thymoma , Thymus Neoplasms , Thyroid Neoplasms , Tongue Neoplasms , tongue squamous cell carcinoma , transitional cell carcinoma , traumatic brain injury , Trigeminal Nerve Injuries , ulcerative colitis , urinary bladder cancer , Urinary Bladder Neoplasm , Urogenital Neoplasms , Urologic Neoplasms , vascular dementia , Vulvar Lichen Sclerosus , Vulvar Neoplasms , xeroderma pigmentosum
abdominal aortic aneurysm Casp3 abdominal obesity-metabolic syndrome 1 Bax , Fas Acanthamoeba Keratitis Tlr4 acne Tlr4 Acne Conglobata Tlr4 Acute Coronary Syndrome Tlr4 Acute Erythroleukemia Tp53 Acute Experimental Pancreatitis Fas acute kidney failure Bax , Fas , Tlr4 , Tp53 Acute Liver Failure Casp3 , Casp8 , Fas , Tlr4 Acute Lung Injury Bax , Casp3 , Casp8 , Fas , Tlr4 acute lymphoblastic leukemia Bax , Casp8 , Fas , Tp53 acute megakaryocytic leukemia Tp53 acute myeloid leukemia Fas , Tp53 acute myocardial infarction Bax , Casp3 acute necrotizing pancreatitis Casp3 , Tlr4 acute pancreatitis Tlr4 Acute Tubulointerstitial Nephritis Tlr4 Acute-On-Chronic Liver Failure Tlr4 adenocarcinoma Casp8 , Tp53 adenoid cystic carcinoma Tp53 adenoma Tp53 Adrenal Cortex Neoplasms Tp53 Adrenal Gland Neoplasms Tp53 Adrenal Insufficiency Bax adrenocortical carcinoma Tp53 adult T-cell leukemia/lymphoma Fas , Tp53 alcohol dependence Tlr4 alcohol use disorder Casp3 , Casp8 , Tlr4 alcohol-associated liver disease Fas , Tlr4 Alcohol-Related Disorders Casp8 , Tlr4 alcoholic hepatitis Fas , Tlr4 alcoholic liver cirrhosis Tlr4 allergic conjunctivitis Tlr4 allergic contact dermatitis Casp8 , Tlr4 allergic rhinitis Tlr4 Alzheimer's disease Bax , Casp3 , Casp8 , Fas , Tlr4 , Tp53 amyotrophic lateral sclerosis Bax , Casp3 , Tp53 anaplastic astrocytoma Tp53 anaplastic thyroid carcinoma Tp53 angiosarcoma Tp53 Animal Disease Models Fas , Tp53 ankylosing spondylitis Tlr4 anogenital venereal wart Tlr4 anterior uveitis Tlr4 anti-basement membrane glomerulonephritis Bax Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Fas aplastic anemia Fas Arsenic Poisoning Tp53 arteriosclerosis Tlr4 arthritis Tlr4 asthma Fas , Tlr4 ataxia telangiectasia Bax atherosclerosis Casp3 , Fas , Tlr4 , Tp53 atopic dermatitis Casp8 , Tlr4 atypical teratoid rhabdoid tumor Tp53 autoimmune disease Casp8 , Fas autoimmune hepatitis Fas autoimmune lymphoproliferative syndrome Casp8 , Fas autoimmune lymphoproliferative syndrome type 2B Casp8 Autoimmune Lymphoproliferative Syndrome, Type IA Fas autoimmune thrombocytopenic purpura Fas autosomal recessive dyskeratosis congenita 3 Tp53 B-Cell Chronic Lymphocytic Leukemia Fas , Tp53 B-lymphoblastic leukemia/lymphoma Tp53 Bacteremia Tlr4 bacterial infectious disease Casp3 , Casp8 Bacterial Keratitis Tlr4 bacterial pneumonia Tlr4 Balkan nephropathy Tp53 Barrett's esophagus Fas basal cell carcinoma Tp53 Behcet's disease Fas , Tlr4 Binge Drinking Casp3 , Tlr4 bone development disease Tp53 Bone Marrow Failure Syndrome 5 Tp53 Bone Marrow Neoplasms Tp53 bone osteosarcoma Tp53 Brain Contusion Casp3 , Casp8 brain glioma Bax , Casp3 , Fas Brain Hypoxia-Ischemia Bax , Casp3 , Casp8 , Fas , Tlr4 Brain Injuries Bax , Casp3 , Casp8 , Fas , Tlr4 brain ischemia Casp3 , Fas , Tlr4 , Tp53 Brain Neoplasms Tp53 breast adenocarcinoma Tp53 breast cancer Bax , Casp3 , Casp8 , Fas , Tlr4 , Tp53 Breast Cancer, Familial Casp8 , Tp53 breast carcinoma Casp3 , Fas , Tp53 Breast Neoplasms Bax , Casp8 , Tp53 Bronchial Hyperreactivity Tlr4 bronchiolo-alveolar adenocarcinoma Tp53 bronchopulmonary dysplasia Bax , Casp3 , Casp8 , Tp53 Burns Bax , Casp3 Calcification of Aortic Valve Tp53 calcinosis Casp3 , Tp53 carcinoma Tlr4 , Tp53 cardiomyopathy Fas , Tp53 Cardiotoxicity Fas , Tp53 Cardiovascular Pregnancy Complications Fas carotid artery disease Tlr4 , Tp53 carotid stenosis Tlr4 cataract Casp3 , Fas , Tp53 Cecal Neoplasms Tp53 Central Nervous System Neoplasms Tp53 Cerebral Hemorrhage Bax , Casp3 , Casp8 cervical adenocarcinoma Tp53 cervical cancer Casp3 , Tp53 cervical squamous cell carcinoma Bax , Tp53 CHARGE syndrome Tp53 Chemical and Drug Induced Liver Injury Bax , Casp3 , Casp8 , Fas , Tlr4 chemical colitis Casp3 Chemotherapy-Induced Febrile Neutropenia Tp53 Chest Trauma Fas cholangiocarcinoma Tp53 cholesteatoma Tlr4 cholesteatoma of middle ear Tlr4 , Tp53 chorioamnionitis Fas choroid plexus carcinoma Tp53 choroid plexus papilloma Tp53 Chromosome 17 Deletion Tp53 chronic conjunctivitis Fas Chronic Hepatitis Casp3 Chronic Hepatitis B Tlr4 Chronic Hepatitis C Tlr4 Chronic Intermittent Hypoxia Bax , Tlr4 chronic lymphocytic leukemia Tp53 chronic myeloid leukemia Fas chronic obstructive pulmonary disease Casp3 , Casp8 , Fas , Tlr4 , Tp53 Chronic Pain Tlr4 Chronic Periodontitis Tlr4 Chronic Uveitis Fas clear cell adenocarcinoma Tp53 clear cell renal cell carcinoma Bax , Tp53 clonorchiasis Fas colitis Tlr4 colon adenocarcinoma Bax colon cancer Casp3 colon carcinoma Bax , Tp53 Colon Diverticulum Tp53 Colonic Neoplasms Bax , Casp3 , Fas , Tp53 colorectal adenocarcinoma Tp53 colorectal cancer Bax , Tp53 colorectal carcinoma Tp53 Colorectal Neoplasms Bax , Casp8 , Tlr4 , Tp53 congenital fibrosarcoma Tp53 congenital merosin-deficient muscular dystrophy 1A Tp53 congestive heart failure Bax , Casp3 , Fas , Tp53 contact dermatitis Casp8 , Tlr4 Contrast-Induced Nephropathy Casp3 Copper-Overload Cirrhosis Casp3 corneal neovascularization Fas coronary artery disease Tlr4 , Tp53 coronary restenosis Tp53 COVID-19 Tlr4 Craniofacial Abnormalities Tp53 Crohn's disease Tlr4 cryptorchidism Casp3 , Fas cutaneous leishmaniasis Tlr4 cystic echinococcosis Tlr4 cystic fibrosis Fas , Tlr4 dementia Bax demyelinating disease Tp53 depressive disorder Bax dermatomyositis Fas , Tlr4 diabetes mellitus Casp3 , Tlr4 diabetic angiopathy Casp3 , Fas Diabetic Cardiomyopathies Bax , Casp3 , Casp8 Diabetic Foot Tlr4 Diabetic Nephropathies Casp3 , Casp8 , Fas , Tlr4 , Tp53 diabetic neuropathy Casp3 , Tlr4 diabetic retinopathy Casp3 , Tlr4 Diamond-Blackfan anemia Tp53 diffuse large B-cell lymphoma Fas , Tp53 diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype Tp53 DiGeorge syndrome Tp53 dilated cardiomyopathy Bax , Casp3 , Casp8 , Fas , Tp53 disease of cellular proliferation Tp53 Disease Progression Fas , Tp53 Drug-induced Neutropenia Tp53 Drug-Related Side Effects and Adverse Reactions Tp53 dry eye syndrome Tlr4 Ductal Carcinoma Tp53 ductal carcinoma in situ Tp53 Dysbiosis Tlr4 dyskeratosis congenita Tp53 Edema Casp3 , Casp8 Emphysema Tp53 end stage renal disease Tlr4 endometrial adenocarcinoma Tp53 endometrial cancer Tp53 endometrial carcinoma Tp53 Endometrial Intraepithelial Neoplasia Tp53 Endometrial Neoplasms Tp53 endometriosis Bax endometritis Casp3 endophthalmitis Fas Endotoxemia Bax , Casp3 , Fas , Tlr4 Entamoebiasis Tlr4 Eosinophilia Tlr4 epilepsy Casp8 Escherichia Coli Meningitis Tlr4 esophageal cancer Tp53 esophageal carcinoma Tp53 Esophageal Neoplasms Bax , Casp8 , Fas , Tp53 esophagus adenocarcinoma Casp8 , Fas , Tlr4 , Tp53 esophagus squamous cell carcinoma Casp8 , Tp53 essential hypertension Tlr4 eumycotic mycetoma Tlr4 exfoliation syndrome Tlr4 Experimental Allergic Asthma Fas Experimental Arthritis Bax , Tlr4 Experimental Autoimmune Encephalomyelitis Casp3 , Casp8 , Tlr4 Experimental Autoimmune Myocarditis Casp3 , Casp8 Experimental Autoimmune Neuritis Tlr4 Experimental Autoimmune Uveitis Fas , Tlr4 Experimental Colitis Fas Experimental Diabetes Mellitus Bax , Casp3 , Casp8 , Fas , Tlr4 , Tp53 Experimental Liver Cirrhosis Fas , Tlr4 Experimental Liver Neoplasms Fas , Tp53 Experimental Mammary Neoplasms Bax , Casp3 , Casp8 , Fas , Tp53 Experimental Neoplasms Tp53 Experimental Radiation Injuries Casp3 , Casp8 , Fas Experimental Seizures Fas extrahepatic cholestasis Tlr4 eye disease Tlr4 Eye Neoplasms Tp53 familial combined hyperlipidemia Tlr4 familial Mediterranean fever Tlr4 familial melanoma Tp53 Familial Pancreatic Carcinoma Tp53 Familial Prostate Cancer Casp8 Female Infertility Tp53 fetal alcohol spectrum disorder Tlr4 Fetal Growth Retardation Bax , Casp3 , Fas Fever Tlr4 Fibrosis Tlr4 Fungal Eye Infections Tlr4 Fungal Keratitis Tlr4 gallbladder cancer Tp53 Gallbladder Neoplasms Tp53 gastric adenocarcinoma Tp53 gastric ulcer Casp3 , Fas Gastrointestinal Hemorrhage Bax genetic disease Bax , Casp8 , Fas glaucoma Bax , Fas glioblastoma Tp53 glomerulonephritis Fas , Tlr4 glucose intolerance Tlr4 graft-versus-host disease Fas , Tp53 Graves' disease Fas , Tp53 Hashimoto Disease Fas head and neck squamous cell carcinoma Casp8 , Tp53 Hearing Loss Tlr4 heart disease Bax , Casp3 , Casp8 heart valve disease Casp3 HELLP syndrome Fas hematologic cancer Tp53 hematopoietic system disease Fas Hemorrhagic Shock Casp3 , Casp8 , Tlr4 hepatitis B Fas hepatoblastoma Fas , Tp53 hepatocellular carcinoma Bax , Casp3 , Casp8 , Fas , Tlr4 , Tp53 hepatorenal syndrome Tlr4 Hereditary Adrenocortical Carcinoma Tp53 hereditary breast ovarian cancer syndrome Tp53 Hereditary Neoplastic Syndromes Tp53 heroin dependence Fas Herpes Simplex Encephalitis Tlr4 herpes simplex virus keratitis Tlr4 high grade glioma Fas , Tp53 human immunodeficiency virus infectious disease Bax , Fas Huntington's disease Bax , Casp3 , Casp8 , Fas hymenolepiasis Tlr4 Hyperalgesia Tlr4 Hypercholesterolemia Casp3 , Tlr4 hyperglycemia Casp8 Hyperoxia Fas Hyperplasia Bax hypersplenism Fas hypertension Bax , Casp3 , Casp8 , Tlr4 , Tp53 hyperthyroidism Casp3 Hypertriglyceridemia Tlr4 hypertrophic cardiomyopathy Casp3 , Tp53 Hypogonadism and Testicular Atrophy Tp53 Hypothermia Fas Hypoxia Casp3 idiopathic pulmonary fibrosis Fas IgA glomerulonephritis Fas ileitis Tlr4 impotence Bax , Casp3 inclusion body myositis Fas infectious mononucleosis Fas Inflammation Tlr4 Insulin Resistance Casp3 , Casp8 , Fas , Tlr4 intermittent claudication Bax , Casp3 intestinal disease Bax , Casp3 Intestinal Neoplasms Bax Intestinal Reperfusion Injury Casp3 intrahepatic cholangiocarcinoma Fas invasive aspergillosis Tlr4 ischemia Bax , Tp53 Kaposi's sarcoma Tp53 Kashin-Beck Disease Bax , Fas Kawasaki disease Tlr4 keratitis Tlr4 keratosis Tp53 kidney disease Casp3 , Casp8 , Fas kidney failure Tlr4 Kidney Reperfusion Injury Bax , Casp3 , Fas , Tlr4 Knee Osteoarthritis Bax learning disability Tlr4 Leber hereditary optic neuropathy Tp53 left ventricular failure Fas , Tlr4 leiomyoma Bax leptospirosis Tlr4 leukemia Tp53 leukocyte disease Fas Li-Fraumeni syndrome Tp53 Li-Fraumeni syndrome 1 Tp53 Li-Fraumeni-Like Syndrome Tp53 limited scleroderma Fas Lip Neoplasms Tp53 liver cirrhosis Casp3 , Casp8 , Tlr4 liver disease Fas Liver Injury Fas , Tlr4 Liver Neoplasms Tp53 Liver Reperfusion Injury Bax , Casp3 , Casp8 , Fas , Tlr4 low tension glaucoma Tlr4 , Tp53 lung adenocarcinoma Fas , Tlr4 , Tp53 lung cancer Casp8 lung disease Tlr4 Lung Injury Bax , Fas , Tlr4 Lung Neoplasms Casp8 , Fas , Tlr4 , Tp53 lung non-small cell carcinoma Bax , Casp3 , Casp8 , Tp53 Lung Reperfusion Injury Bax , Casp3 , Tlr4 lung sarcomatoid carcinoma Tp53 lung small cell carcinoma Tp53 lung squamous cell carcinoma Tp53 lupus nephritis Fas Lymphatic Metastasis Fas , Tlr4 , Tp53 lymphoma Tp53 Lymphomatoid Papulosis Fas lymphoproliferative syndrome Fas macular degeneration Bax , Fas , Tlr4 male infertility Bax , Fas , Tp53 malignant astrocytoma Tp53 malignant mesothelioma Tp53 marginal zone lymphoma Tp53 mastitis Tlr4 mastoiditis Tlr4 medulloblastoma Tp53 melanoma Casp8 , Fas , Tlr4 , Tp53 membranoproliferative glomerulonephritis Tlr4 meninges sarcoma Tp53 meningococcal meningitis Tlr4 Mesothelioma Tp53 Metabolic Brain Diseases Fas metabolic dysfunction and alcohol associated liver disease Tlr4 metabolic dysfunction-associated steatotic liver disease Fas , Tlr4 Metabolic Syndrome Fas Microsatellite Instability Bax middle cerebral artery infarction Bax , Casp3 , Tlr4 mismatch repair cancer syndrome Tp53 mitochondrial metabolism disease Casp8 , Tp53 mixed connective tissue disease Fas morphine dependence Bax Mouth Neoplasms Tp53 Multi-Infarct Dementia Bax multiple myeloma Tp53 multiple sclerosis Fas , Tlr4 multiple system atrophy Fas myasthenia gravis Fas Mycoplasma Infections Casp3 myelodysplastic syndrome Fas , Tp53 myelofibrosis Tp53 myeloid leukemia associated with Down Syndrome Tp53 myeloid neoplasm Tp53 myocardial infarction Bax , Casp3 , Tlr4 , Tp53 Myocardial Ischemia Bax Myocardial Reperfusion Injury Bax , Casp3 , Casp8 , Fas , Tlr4 , Tp53 nasal cavity cancer Tp53 Nasal Polyps Fas , Tlr4 nasal type extranodal NK/T-cell lymphoma Fas Nasopharyngeal Neoplasms Tp53 nasopharynx carcinoma Tp53 Necrosis Fas Neoplasm Invasiveness Tlr4 Neoplasm Metastasis Bax , Casp3 , Fas , Tlr4 , Tp53 Neoplastic Cell Transformation Tp53 nephritis Casp8 , Fas nephroblastoma Tp53 Nerve Degeneration Bax , Casp3 Nerve Sheath Neoplasms Tp53 nervous system disease Casp3 , Tp53 Neuralgia Tlr4 neuroblastoma Tp53 non-Hodgkin lymphoma Tp53 obesity Tlr4 ocular hypertension Fas Ocular Onchocerciasis Tlr4 Odontogenic Myxoma Tp53 Optic Nerve Injuries Bax , Tlr4 Oral Lichen Planus Tlr4 , Tp53 oral mucosa leukoplakia Tp53 oral squamous cell carcinoma Tp53 oral submucous fibrosis Tp53 Oropharyngeal Neoplasms Tp53 osteoarthritis Bax , Casp3 Osteoarthritis, Experimental Casp3 , Casp8 osteoporosis Bax osteosarcoma Tp53 otitis media Tlr4 Otitis Media with Effusion Tlr4 ovarian cancer Fas , Tp53 ovarian carcinoma Tp53 Ovarian Neoplasms Tlr4 , Tp53 ovarian small cell carcinoma Tp53 ovary serous adenocarcinoma Tp53 Oxygen-Induced Retinopathy Casp3 , Fas Pain Tlr4 Painful Neuropathy Tlr4 pancreatic cancer Casp8 , Tp53 pancreatic carcinoma Tp53 pancreatic ductal carcinoma Tp53 pancreatic intraductal papillary-mucinous neoplasm Tp53 pancreatitis Casp3 , Tlr4 papillary thyroid carcinoma Tp53 papillomavirus infectious disease Casp8 paranasal sinus benign neoplasm Tp53 Parasitic Liver Diseases Tp53 Parkinson's disease Casp3 , Fas Parkinsonism Casp3 Pediatric Adrenocortical Carcinoma Tp53 Penile Neoplasms Tp53 perinatal necrotizing enterocolitis Tlr4 periodontitis Tlr4 peripheral vascular disease Fas Phyllodes Tumor Tp53 Plaque, Atherosclerotic Tlr4 Plasmodium falciparum malaria Fas pleomorphic xanthoastrocytoma Tp53 Pleural Effusion Tp53 pleural tuberculosis Tlr4 Pneumococcal Meningitis Tlr4 pneumonia Tlr4 polycystic ovary syndrome Bax Polyploidy Tp53 post-traumatic stress disorder Bax Postoperative Cognitive Dysfunction Bax , Casp3 , Tlr4 pre-eclampsia Fas , Tlr4 pre-malignant neoplasm Bax , Casp3 , Casp8 , Fas , Tp53 Premature Aging Bax , Tp53 primary biliary cholangitis Fas primary cutaneous T-cell non-Hodgkin lymphoma Bax , Fas , Tp53 primary immunodeficiency disease Casp8 , Fas primary open angle glaucoma Tlr4 , Tp53 prion disease Bax prostate adenocarcinoma Tp53 prostate cancer Bax , Casp3 , Fas , Tp53 Prostate Cancer, Hereditary, 1 Tp53 prostate carcinoma Bax Prostatic Neoplasms Bax , Casp3 , Fas , Tlr4 , Tp53 proteinuria Fas Pseudomonas Aeruginosa Keratitis Tlr4 psoriasis Tlr4 , Tp53 pterygium Tp53 pulmonary edema Tlr4 pulmonary emphysema Tlr4 pulmonary fibrosis Tlr4 pulmonary hypertension Tlr4 , Tp53 pulmonary tuberculosis Tlr4 pulpitis Tlr4 Puromycin Aminonucleoside Nephrosis Fas relapsing-remitting multiple sclerosis Fas renal cell carcinoma Casp3 , Fas , Tp53 renal fibrosis Tlr4 Reperfusion Injury Bax , Casp3 , Casp8 , Fas , Tlr4 , Tp53 respiratory allergy Tlr4 Respiratory Sounds Tlr4 respiratory syncytial virus infectious disease Tlr4 Retina Reperfusion Injury Bax , Tlr4 retinal degeneration Bax retinal detachment Casp3 , Casp8 , Fas retinal disease Casp3 retinoblastoma Fas rhabdomyosarcoma Tp53 rheumatic heart disease Bax rheumatoid arthritis Fas Rhinosinusitis Tlr4 Right Ventricular Hypertrophy Bax salivary gland disease Casp3 SAPHO syndrome Tp53 sarcoma Tp53 Sarcopenia Bax schizophrenia Tp53 sciatic neuropathy Casp3 , Casp8 , Fas , Tlr4 scrapie Bax , Casp3 Seasonal Allergic Rhinitis Tlr4 seminoma Fas Sepsis Casp3 , Casp8 , Fas , Tlr4 serous cystadenocarcinoma Tp53 severe acute respiratory syndrome Casp3 severe COVID-19 Tlr4 Sezary's disease Tp53 short-rib thoracic dysplasia 6 with or without polydactyly Fas sinusitis Tlr4 Sjogren's syndrome Fas skin melanoma Tp53 Skin Neoplasms Casp8 , Tp53 small cell carcinoma Tp53 spermatic cord torsion Casp3 Spinal Cord Compression Fas Spinal Cord Injuries Bax , Casp3 , Fas , Tlr4 , Tp53 Spinal Cord Reperfusion Injury Tlr4 splenic disease Fas Splenomegaly Fas spondyloarthropathy Tp53 sporotrichosis Tlr4 squamous cell carcinoma Fas , Tlr4 , Tp53 Stable Angina Tlr4 status epilepticus Bax , Casp3 , Casp8 steatotic liver disease Tlr4 stomach cancer Bax , Casp3 , Tlr4 , Tp53 Stomach Neoplasms Casp8 , Tp53 stroke Casp3 , Tlr4 Subarachnoid Hemorrhage Casp3 , Tlr4 suppurative otitis media Tlr4 systemic lupus erythematosus Fas , Tlr4 T-cell acute lymphoblastic leukemia Bax T-cell non-Hodgkin lymphoma Tp53 Taste Disorders Fas temporal arteritis Tlr4 Temporomandibular Joint Osteoarthritis Fas teratoma Bax Testicular Injury Fas Testis Reperfusion Injury Bax , Casp3 thymoma Tp53 Thymus Neoplasms Tp53 Thyroid Neoplasms Tp53 thyroiditis Bax Tongue Neoplasms Tp53 tongue squamous cell carcinoma Tp53 toxic encephalopathy Casp3 toxoplasmosis Bax transient cerebral ischemia Bax , Casp3 , Casp8 , Fas , Tlr4 transitional cell carcinoma Casp3 , Fas , Tp53 Transplant Rejection Bax , Casp3 , Tlr4 traumatic brain injury Casp3 , Casp8 , Tp53 Trigeminal Nerve Injuries Tp53 tuberculosis Tlr4 tympanosclerosis Tlr4 type 1 diabetes mellitus Casp3 , Casp8 , Fas , Tlr4 type 2 diabetes mellitus Bax , Casp3 , Casp8 , Fas , Tlr4 ulcerative colitis Casp3 , Fas , Tp53 ureteral obstruction Casp3 uric acid nephrolithiasis Tlr4 urinary bladder cancer Bax , Casp3 , Fas , Tlr4 , Tp53 Urinary Bladder Neoplasm Tp53 urinary tract infection Tlr4 Urogenital Neoplasms Tp53 Urologic Neoplasms Tp53 Uterine Cervical Neoplasms Casp8 uveitis Tlr4 varicocele Fas vascular dementia Tp53 Ventricular Remodeling Bax , Casp3 Vibrio Vulnificus Infection Tlr4 Viral Bronchiolitis Fas , Tlr4 viral meningitis Tlr4 Viral Myocarditis Casp3 , Casp8 vitiligo Tlr4 Vulvar Lichen Sclerosus Tp53 Vulvar Neoplasms Tp53 Wallerian Degeneration Tlr4 Weight Loss Tlr4 xeroderma pigmentosum Tp53
