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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Pleural Effusion
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Accession:DOID:9005883 term browser browse the term
Definition:Presence of fluid in the pleural cavity resulting from excessive transudation or exudation from the pleural surfaces. It is a sign of disease and not a diagnosis in itself.
Synonyms:exact_synonym: Pleural Effusions
 primary_id: MESH:D010996;   RDO:0006358
For additional species annotation, visit the Alliance of Genome Resources.



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Pleural Effusion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme ISO associated with tuberculosis;protein:increased activity:pleural fluid (human) RGD PMID:23091417 RGD:40818411 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Ace2 angiotensin I converting enzyme 2 ISO associated with tuberculosis;protein:decreased activity:pleural fluid (human) RGD PMID:23091417 RGD:40818411 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Ada adenosine deaminase treatment ISO RGD PMID:25547995 RGD:152995274 NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088
JBrowse link
G Chrna1 cholinergic receptor nicotinic alpha 1 subunit ISO ClinVar Annotator: match by term: Pleural effusion ClinVar PMID:25741868 PMID:28492532 PMID:30177536 PMID:31680349 NCBI chr 3:58,454,763...58,469,832
Ensembl chr 3:58,454,744...58,469,840
JBrowse link
G Il15 interleukin 15 ISO RGD PMID:15072171 RGD:4990458 NCBI chr19:25,640,013...25,706,818
Ensembl chr19:25,640,251...25,706,820
JBrowse link
G Lox lysyl oxidase ISO ClinVar Annotator: match by term: Pleural effusion ClinVar PMID:25741868 NCBI chr18:45,964,311...46,041,477
Ensembl chr18:45,967,343...46,041,477
JBrowse link
G Srfbp1 serum response factor binding protein 1 ISO ClinVar Annotator: match by term: Pleural effusion ClinVar PMID:25741868 NCBI chr18:45,920,389...45,945,385
Ensembl chr18:45,920,446...45,942,515
JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: therapeutic CTD PMID:2518282 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
Malignant Pleural Effusions term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase disease_progression ISO protein:increased activity:serum:
protein:decreased expression:serum:
RGD PMID:27300446 PMID:1818842 PMID:1689629 RGD:152995272, RGD:152998934, RGD:152995292 NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088
JBrowse link
G Il10 interleukin 10 ISO RGD PMID:30695099 RGD:14975123 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO associated with pleurisy; protein:decreased activity:pleura RGD PMID:17611666 RGD:5130711 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO associated with pleurisy; protein:decreased activity:pleura RGD PMID:17611666 RGD:5130711 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18156
    disease of anatomical entity 17531
      respiratory system disease 3395
        lower respiratory tract disease 2238
          pleural disease 114
            Pleural Effusion 11
              Malignant Pleural Effusions 4
paths to the root