RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Bacterial Keratitis
Accession: DOID:9003321
browse the term
Definition: Bacterial infection of the cornea which can follow from an injury or from wearing contact lenses.
Synonyms: primary_id: RDO:9000039
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Il1r1
interleukin 1 receptor type 1
ISO
associated with Serratia Infections;
RGD
PMID:23033384
RGD:8662876
NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937
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Ly96
lymphocyte antigen 96
ISO
associated with Serratia Infections;
RGD
PMID:23033384
RGD:8662876
NCBI chr 5:2,582,233...2,612,357
Ensembl chr 5:2,582,254...2,612,386
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Myd88
MYD88, innate immune signal transduction adaptor
ISO
associated with Staphylococcal Infections; associated with Serratia Infections;
RGD
PMID:16926427 PMID:23033384
RGD:8552819 , RGD:8662876
NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
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Tlr2
toll-like receptor 2
ISO
associated with Staphylococcal Infections; associated with Pneumococcal Infections;
RGD
PMID:16926427 PMID:23841825
RGD:8552819 , RGD:8552886
NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
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Tlr4
toll-like receptor 4
ISO
associated with Pneumococcal Infections; associated with Serratia Infections;
RGD
PMID:23841825 PMID:23033384
RGD:8552886 , RGD:8662876
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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Tlr5
toll-like receptor 5
ISO
associated with Serratia Infections;
RGD
PMID:23033384
RGD:8662876
NCBI chr13:94,634,778...94,658,992
Ensembl chr13:94,634,801...94,657,738
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Cebpb
CCAAT/enhancer binding protein beta
treatment
ISO
mRNA, protein:increased expression:cornea (mouse)
RGD
PMID:23626014
RGD:40903020
NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
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Icam1
intercellular adhesion molecule 1
ISO
RGD
PMID:9916118
RGD:8547701
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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Il10
interleukin 10
treatment
ISO
RGD
PMID:23878501
RGD:7364804
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il18
interleukin 18
ISO
RGD
PMID:12023376
RGD:8655931
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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Il1b
interleukin 1 beta
ISO
RGD
PMID:11895986
RGD:7401195
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il1rn
interleukin 1 receptor antagonist
treatment
ISO
mRNA:increased expression:cornea (mouse)
RGD
PMID:11895986 PMID:9423885
RGD:7401195 , RGD:8549805
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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Il6
interleukin 6
ISO
RGD
PMID:11349084
RGD:7829813
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Mmp9
matrix metallopeptidase 9
treatment
ISO
RGD
PMID:16384971
RGD:8547891
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Tlr2
toll-like receptor 2
ISO
mRNA,protein:increased expression:cornea:
RGD
PMID:20012880
RGD:8552969
NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
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Tlr4
toll-like receptor 4
ISO
mRNA,protein:increased expression:cornea:
RGD
PMID:17065506 PMID:20012880
RGD:7794775 , RGD:8552969
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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Tslp
thymic stromal lymphopoietin
severity
ISO
RGD
PMID:30128494
RGD:38596331
NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548
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