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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:allergic conjunctivitis
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Accession:DOID:11204 term browser browse the term
Definition:A chronic conjunctivitis that is an inflammation of the conjunctiva involing red, itchy, and watery eyes a resulting from an exposure to an allergen or an irritant. (DO)
Synonyms:exact_synonym: Allergic Conjunctivitides;   Atopic Conjunctivitides;   Atopic Conjunctivitis
 primary_id: MESH:D003233
 xref: NCI:C34506
For additional species annotation, visit the Alliance of Genome Resources.



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allergic conjunctivitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl11 C-C motif chemokine ligand 11 IEP mRNA:increased expression:conjunctiva RGD PMID:12682842 RGD:2307196 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 ISO RGD PMID:19553621 RGD:8548840 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 IEP mRNA:increased expression:conjunctiva RGD PMID:12682842 RGD:2307196 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 ISO protein:increased expression:conjunctiva RGD PMID:11090473 RGD:6483824 NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
JBrowse link
G Ccr3 C-C motif chemokine receptor 3 ISO RGD PMID:18658092 RGD:6893389 NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990
JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO RGD PMID:8766745 RGD:8547686 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifng interferon gamma IDA
ISO
RGD PMID:12234900 PMID:16123425 RGD:8142386, RGD:8142391 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 treatment ISO protein:increased expression:tear RGD PMID:22092652 PMID:19060266 PMID:15144463 PMID:16914468 RGD:7364837, RGD:7365027, RGD:7365076, RGD:11041889 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il13 interleukin 13 ISO
ISS
associated with Allergic Rhinitis;DNA:SNPs, haplotype:promoter, exon:-1112C>T (rs1800925), p.R130Q (rs20541) (human) MouseDO
RGD
PMID:9191598 PMID:22023794 RGD:8549533, RGD:8549595 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il1b interleukin 1 beta treatment ISO RGD PMID:9326725 RGD:7401198 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1rn interleukin 1 receptor antagonist treatment ISO
ISS
human protein in a mouse model MouseDO
RGD
PMID:10549671 RGD:8549802 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
JBrowse link
G Il4r interleukin 4 receptor susceptibility ISO
ISS
associated with rhinitis; DNA:SNP: : rs2107356 (human) MouseDO
RGD
PMID:20002627 RGD:4890389 NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980
JBrowse link
G Irf1 interferon regulatory factor 1 IEP RGD PMID:14605445 RGD:5128787 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase IDA protein:increased phosphorylation:T cell RGD PMID:14507881 RGD:1600225 NCBI chr 5:141,888,319...141,916,992
Ensembl chr 5:141,888,326...141,903,794
JBrowse link
G Muc1 mucin 1, cell surface associated severity ISO RGD PMID:17177679 RGD:7349351 NCBI chr 2:174,635,559...174,640,738
Ensembl chr 2:174,635,995...174,640,733
JBrowse link
G Muc2 mucin 2, oligomeric mucus/gel-forming severity ISO RGD PMID:17177679 RGD:7349351 NCBI chr 1:196,796,257...196,831,740
Ensembl chr 1:196,799,517...196,831,756
JBrowse link
G Muc4 mucin 4, cell surface associated severity ISO RGD PMID:17177679 PMID:11581187 RGD:7349351, RGD:7349400 NCBI chr11:68,008,245...68,053,229 JBrowse link
G Pla2g2a phospholipase A2 group IIA ISO protein:increased expression:body fluid or substance RGD PMID:21042565 RGD:6482725 NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014
JBrowse link
G Tgfb1 transforming growth factor, beta 1 treatment ISO RGD PMID:16914468 RGD:11041889 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tlr2 toll-like receptor 2 ISO associated with Staphylococcal Infections; RGD PMID:19358332 RGD:8552826 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tlr4 toll-like receptor 4 ISO mRNA,protein:increased expression:conjunctiva: RGD PMID:21820713 PMID:16023216 PMID:21391988 RGD:7777131, RGD:7794849, RGD:7794770 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tlr9 toll-like receptor 9 ISO mRNA,protein:decreased expression:conjunctiva: RGD PMID:16023216 RGD:7794849 NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796
JBrowse link
G Tnc tenascin C ISO
ISS
DNA:SNPs: :multiple (human) MouseDO
RGD
PMID:18305139 RGD:4889589 NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624
JBrowse link
Allergic Rhinoconjunctivitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 treatment ISO associated with Eosinophilic Esophagitis; DNA:polymorphisms:: RGD PMID:26416193 RGD:11352743 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Il3 interleukin 3 susceptibility ISO DNA:SNP: :rs40401(human) RGD PMID:23953855 RGD:13506915 NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18145
    disease of anatomical entity 17519
      immune system disease 4489
        allergic disease 600
          Immediate Hypersensitivity 454
            allergic conjunctivitis 25
              Allergic Rhinoconjunctivitis 2
              Angelucci's syndrome 0
              vernal conjunctivitis 0
Path 2
Term Annotations click to browse term
  disease 18145
    disease of anatomical entity 17519
      nervous system disease 13182
        sensory system disease 6393
          eye disease 2932
            conjunctival disease 60
              conjunctivitis 46
                chronic conjunctivitis 29
                  allergic conjunctivitis 25
                    Allergic Rhinoconjunctivitis 2
                    Angelucci's syndrome 0
                    vernal conjunctivitis 0
paths to the root