RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Hashimoto Disease
Accession: DOID:9007355
browse the term
Definition: Chronic autoimmune thyroiditis, characterized by the presence of high serum thyroid AUTOANTIBODIES; GOITER; and HYPOTHYROIDISM.
Synonyms: exact_synonym: Chronic Lymphocytic Thyroiditis; HT; Hashimoto Struma; Hashimoto Syndrome; Hashimoto Thyroiditides; Hashimoto thyroiditis; Hashimoto's Struma; Hashimoto's Syndromes; Hashimoto's disease; Hashimoto's syndrome; Hashimotos Disease; Hashimotos Syndrome; chronic lymphocytic thyroiditides
narrow_synonym: HYPOTHYROIDISM, AUTOIMMUNE THYROID AUTOANTIBODIES
primary_id: MESH:D050031
alt_id: OMIM:140300
xref: EFO:0003779 ; NCI:C27191
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Bank1
B-cell scaffold protein with ankyrin repeats 1
susceptibility
ISO
DNA:SNP: :rs3733197(human)
RGD
PMID:24127308
RGD:9684981
NCBI chr 2:224,530,475...224,800,420
Ensembl chr 2:224,530,475...224,800,405
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C1s
complement C1s
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11390518
NCBI chr 4:157,430,249...157,442,438
Ensembl chr 4:157,430,117...157,442,303
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Cat
catalase
ISO
protein:increased activity:plasma:
RGD
PMID:20204550
RGD:9068926
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cd40
CD40 molecule
ISO
protein:increased expression:serum
RGD
PMID:17558708
RGD:8547767
NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
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Cd40lg
CD40 ligand
ISO
protein:increased expression:serum
RGD
PMID:17558708
RGD:8547767
NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306
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Ctla4
cytotoxic T-lymphocyte-associated protein 4
susceptibility
ISO
DNA:SNP:cds:+49A/G (rs231775)(human) ClinVar Annotator: match by term: Hashimoto Disease CTD Direct Evidence: marker/mechanism
ClinVar CTD OMIM RGD
PMID:25741868 PMID:26884280 PMID:27102614 PMID:27577878 PMID:28492532 PMID:30377434 PMID:30940614 PMID:18752454 More...
RGD:7421513
NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963
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Esr2
estrogen receptor 2
no_association
ISO
DNA:repeat
RGD
PMID:11180758
RGD:10045850
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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Fas
Fas cell surface death receptor
severity
ISO
protein:increased expression:peripheral blood, CD8-Positive T-Lymphocytes (human)
RGD
PMID:15242568
RGD:8662824
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Hspd1
heat shock protein family D (Hsp60) member 1
ISO
protein:increased expression:throcyte:
RGD
PMID:9161695
RGD:12910543
NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
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Icam1
intercellular adhesion molecule 1
ISO
protein:increased expression:serum
RGD
PMID:7626551
RGD:8547592
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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Ifng
interferon gamma
severity
ISO
DNA:polymorphism:cds:+874A>T(human)
RGD
PMID:16820703
RGD:8142375
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Il6
interleukin 6
ISO
DNA:polymorphism:promoter:-572C>G(human) CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:16372246 PMID:21235536
RGD:7829719
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Il6r
interleukin 6 receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16372246
NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
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Mbl2
mannose binding lectin 2
susceptibility
ISO
DNA:polymorphism:exon:
RGD
PMID:22360648
RGD:8693703
NCBI chr 1:228,016,439...228,024,736
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Psmb9
proteasome 20S subunit beta 9
ISO
RGD
PMID:19924240
RGD:6483332
NCBI chr20:4,667,044...4,672,512
Ensembl chr20:4,666,046...4,672,512
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Ptpn22
protein tyrosine phosphatase, non-receptor type 22
ISO
DNA: snp: cds: rs2476601
RGD
PMID:15719322
RGD:6484548
NCBI chr 2:191,366,761...191,414,782
Ensembl chr 2:191,366,808...191,414,779
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RT1-Ba
RT1 class II, locus Ba
susceptibility
ISO
DNA:polymorphism (human)
RGD
PMID:19254248
RGD:5147613
NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744
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RT1-Bb
RT1 class II, locus Bb
susceptibility
ISO
DNA:polymorphisms (human) associated with Diabetes Mellitus, Type 1;DNA:polymorphism:cds:HLA-DQB1*0302 (human)
RGD
PMID:19254248 PMID:8157715
RGD:5147613 , RGD:7483569
NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597
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RT1-Db1
RT1 class II, locus Db1
susceptibility
ISO
DNA:polymorphisms (human)
RGD
PMID:19254248
RGD:5147613
NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
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Tg
thyroglobulin
no_association
ISO IDA
DNA:SNPs:exon:multiple CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:30373627 PMID:14636875 PMID:21559421 PMID:18656705 PMID:3052944
RGD:8548606 , RGD:8548607 , RGD:8548630 , RGD:8548647
NCBI chr 7:98,418,293...98,603,210
Ensembl chr 7:98,418,293...98,603,210
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Tnfrsf8
TNF receptor superfamily member 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16372246
NCBI chr 5:157,123,183...157,168,421
Ensembl chr 5:157,123,185...157,168,421
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Tnfsf8
TNF superfamily member 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16372246
NCBI chr 5:77,250,942...77,277,364
Ensembl chr 5:77,251,373...77,277,421
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Tshr
thyroid stimulating hormone receptor
ISO
DNA:SNP:intron:rs3783938 (human)
RGD
PMID:22673349
RGD:8548662
NCBI chr 6:110,341,585...110,475,297
Ensembl chr 6:110,341,581...110,474,538
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Ctla4
cytotoxic T-lymphocyte-associated protein 4
ISO
ClinVar Annotator: match by term: HYPOTHYROIDISM, AUTOIMMUNE
ClinVar
PMID:25741868 PMID:26884280 PMID:27102614 PMID:27577878 PMID:28492532 PMID:30377434 PMID:30940614 More...
NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963
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