RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Chronic Pain
Accession: DOID:9008520
browse the term
Definition: Aching sensation that persists for more than a few months. It may or may not be associated with trauma or disease, and may persist after the initial injury has healed. Its localization, character, and timing are more vague than with acute pain.
Synonyms: exact_synonym: Chronic Pains
narrow_synonym: Widespread Chronic Pain; Widespread Chronic Pains; multisite chronic pain
primary_id: MESH:D059350
xref: EFO:0010099 ; EFO:0010100
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Bdnf
brain-derived neurotrophic factor
IEP
protein:increased expression:frontal cortex, neuron mRNA:decreased expression:anterior cingulate cortex
RGD
PMID:11360665 PMID:24518228
RGD:5684922 , RGD:10059366
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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Cpt2
carnitine palmitoyltransferase 2
ISO
ClinVar Annotator: match by term: Chronic pain
ClinVar
PMID:7711730 PMID:9600456 PMID:10090476 PMID:12410208 PMID:12707442 PMID:15622536 PMID:16996287 PMID:17936304 PMID:20301431 PMID:22975760 PMID:25741868 PMID:28492532 More...
NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095
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Hfe
homeostatic iron regulator
ISO
DNA:missense mutation: :p.C282Y (rs1800562) (human)
RGD
PMID:30657865
RGD:14746966
NCBI chr17:41,413,451...41,421,502
Ensembl chr17:41,413,451...41,421,502
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Ntrk2
neurotrophic receptor tyrosine kinase 2
IEP
protein:increased expression:frontal cortex, neuron
RGD
PMID:11360665
RGD:5684922
NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
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Scn9a
sodium voltage-gated channel alpha subunit 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21634377
NCBI chr 3:51,145,148...51,293,342
Ensembl chr 3:51,145,146...51,293,516
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Tlr2
toll-like receptor 2
ISO
RGD
PMID:24204973
RGD:8553185
NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
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Tlr4
toll-like receptor 4
ISO
RGD
PMID:24204973
RGD:8553185
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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Ush2a
usherin
ISO
ClinVar Annotator: match by term: Chronic pain
ClinVar
PMID:9624053 PMID:10090909 PMID:10729113 PMID:10909849 PMID:11402400 PMID:12112664 PMID:12525556 PMID:14970843 PMID:15025721 PMID:15325563 PMID:15326663 PMID:17405132 PMID:18641288 PMID:19881469 PMID:20145675 PMID:20301515 PMID:20507924 PMID:22135276 PMID:22581970 PMID:23924366 PMID:24033266 PMID:24088041 PMID:24160897 PMID:24607488 PMID:24944099 PMID:25097241 PMID:25404053 PMID:25649381 PMID:25741868 PMID:26629787 PMID:26633545 PMID:26872967 PMID:28041643 PMID:28492532 PMID:29953849 PMID:30718709 PMID:31836858 PMID:34906470 PMID:36011334 PMID:36909829 More...
NCBI chr13:99,837,445...100,503,935
Ensembl chr13:99,837,445...100,503,922
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