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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Chronic Pain
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Accession:DOID:9008520 term browser browse the term
Definition:Aching sensation that persists for more than a few months. It may or may not be associated with trauma or disease, and may persist after the initial injury has healed. Its localization, character, and timing are more vague than with acute pain.
Synonyms:exact_synonym: Chronic Pains
 narrow_synonym: Widespread Chronic Pain;   Widespread Chronic Pains;   multisite chronic pain
 primary_id: MESH:D059350
 xref: EFO:0010099;   EFO:0010100


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Chronic Pain term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor IEP protein:increased expression:frontal cortex, neuron
mRNA:decreased expression:anterior cingulate cortex 		RGD PMID:11360665 PMID:24518228 RGD:5684922, RGD:10059366 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 ISO ClinVar Annotator: match by term: Chronic pain ClinVar PMID:7711730 PMID:9600456 PMID:10090476 PMID:12410208 PMID:12673791 More... NCBI chr 5:127,893,450...127,911,347
Ensembl chr 5:122,664,677...122,682,095 		JBrowse link
G Hfe homeostatic iron regulator ISO DNA:missense mutation: :p.C282Y (rs1800562) (human) RGD PMID:30657865 RGD:14746966 NCBI chr17:41,841,302...41,849,359
Ensembl chr17:41,413,451...41,421,502 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 IEP protein:increased expression:frontal cortex, neuron RGD PMID:11360665 RGD:5684922 NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Scn9a sodium voltage-gated channel alpha subunit 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21634377 NCBI chr 3:71,553,185...71,701,377
Ensembl chr 3:51,145,146...51,293,516 		JBrowse link
G Tlr2 toll-like receptor 2 ISO RGD PMID:24204973 RGD:8553185 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr4 toll-like receptor 4 ISO RGD PMID:24204973 RGD:8553185 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19140
    Pathological Conditions, Signs and Symptoms 13626
      Signs and Symptoms 11222
        Neurologic Manifestations 10464
          Pain 350
            Chronic Pain 7
paths to the root