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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:gastric ulcer
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Accession:DOID:10808 term browser browse the term
Definition:Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
Synonyms:exact_synonym: Gastric Ulcers;   Stomach Ulcer;   Stomach Ulcers;   acute gastric ulcer with haemorrhage and perforation;   acute gastric ulcer with hemorrhage AND with perforation but without obstruction;   acute gastric ulcer with hemorrhage and obstruction;   acute gastric ulcer with hemorrhage and perforation;   acute gastric ulcer with hemorrhage and perforation, with obstruction;   acute gastric ulcer with hemorrhage and perforation, without mention of obstruction;   acute gastric ulcer with hemorrhage, with obstruction;   acute gastric ulcer with hemorrhage, with perforation AND with obstruction;   acute gastric ulcer with perforation;   acute gastric ulcer with perforation AND obstruction;   acute gastric ulcer with perforation, with obstruction;   acute gastric ulcer without hemorrhage and without perforation;   acute gastric ulcer without hemorrhage, without perforation AND without obstruction;   acute gastric ulcer without mention of hemorrhage or perforation, without mention of obstruction;   bleeding acute gastric ulcer;   chronic gastric ulcer without hemorrhage AND without perforation;   chronic gastric ulcer without hemorrhage AND without perforation but with obstruction;   chronic gastric ulcer without mention of hemorrhage or perforation, with obstruction
 primary_id: MESH:D013276
 alt_id: RDO:0006623
 xref: ICD10CM:K25;   ICD9CM:531;   NCI:C3388
For additional species annotation, visit the Alliance of Genome Resources.

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gastric ulcer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin ISO CTD Direct Evidence: therapeutic CTD PMID:9845272 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259 		JBrowse link
G Agt angiotensinogen treatment IDA RGD PMID:24231511 RGD:11039418 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433 		JBrowse link
G Angpt1 angiopoietin 1 IEP protein:increased expression:stomach RGD PMID:12768384 RGD:1601496 NCBI chr 7:81,338,327...81,592,459
Ensembl chr 7:81,342,280...81,592,206 		JBrowse link
G Angpt2 angiopoietin 2 IEP protein:increased expression:stomach (rat) RGD PMID:12768384 RGD:1601496 NCBI chr16:75,966,480...76,016,147
Ensembl chr16:75,966,352...76,016,195 		JBrowse link
G Bad BCL2-associated agonist of cell death treatment IDA RGD PMID:24378970 RGD:10053695 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453 		JBrowse link
G Bcl2 BCL2, apoptosis regulator treatment IDA RGD PMID:24378970 RGD:10053695 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bcl2l1 Bcl2-like 1 treatment IDA RGD PMID:24378970 RGD:10053695 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810 		JBrowse link
G Casp3 caspase 3 treatment IEP RGD PMID:29339218 RGD:13792597 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cat catalase IEP
ISO		 protein:increased expression:stomach
CTD Direct Evidence: therapeutic		 CTD PMID:1887894, PMID:17895592 RGD:5130860 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cblif cobalamin binding intrinsic factor ISO associated with Polycythemia; mRNA:decreased expression:gastric mucosa: RGD PMID:26485402 RGD:11049581 NCBI chr 1:228,118,048...228,132,296
Ensembl chr 1:228,118,048...228,132,404 		JBrowse link
G Cck cholecystokinin ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:9872509 PMID:10422768 PMID:10458643 PMID:11025360 PMID:11787760 PMID:15024038 NCBI chr 8:130,120,525...130,127,515
Ensembl chr 8:130,120,523...130,127,392 		JBrowse link
G Cftr CF transmembrane conductance regulator treatment IDA RGD PMID:23596793 RGD:11567229 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676 		JBrowse link
G Col18a1 collagen type XVIII alpha 1 chain IEP Protein:decreased expression:serum RGD PMID:11353854 RGD:1600910 NCBI chr20:12,225,202...12,332,858
Ensembl chr20:12,225,202...12,332,858 		JBrowse link
G Egf epidermal growth factor ISO CTD Direct Evidence: therapeutic CTD PMID:9324159 PMID:9479624 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Epo erythropoietin ISO CTD Direct Evidence: therapeutic CTD PMID:20723003 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266 		JBrowse link
G F13a1 coagulation factor XIII A1 chain IEP RGD PMID:11435721 RGD:708325 NCBI chr17:28,504,650...28,680,015
Ensembl chr17:28,504,623...28,680,362 		JBrowse link
G Fas Fas cell surface death receptor treatment IEP RGD PMID:29339218 RGD:13792597 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Faslg Fas ligand treatment IEP RGD PMID:29339218 RGD:13792597 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705 		JBrowse link
G Fgf2 fibroblast growth factor 2 treatment ISO RGD PMID:9127818 RGD:8655642 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681 		JBrowse link
G Foxo4 forkhead box O4 IEP mRNA,protein:increased expression:gastric mucosa: RGD PMID:22735908 RGD:10402364 NCBI chr  X:71,155,284...71,162,158
Ensembl chr  X:71,155,601...71,162,158 		JBrowse link
G Ghrl ghrelin and obestatin prepropeptide ISO CTD Direct Evidence: therapeutic CTD PMID:15177919 PMID:16259727 NCBI chr 4:145,674,157...145,678,066
Ensembl chr 4:145,674,157...145,678,066 		JBrowse link
G Hrh3 histamine receptor H3 IDA RGD PMID:15680274 RGD:1626428 NCBI chr 3:175,474,310...175,479,395
Ensembl chr 3:175,473,078...175,479,395 		JBrowse link
G Iapp islet amyloid polypeptide ISO CTD Direct Evidence: therapeutic CTD PMID:9286623 NCBI chr 4:176,509,863...176,517,903
Ensembl chr 4:176,510,696...176,516,083 		JBrowse link
G Idua alpha-L-iduronidase IEP RGD PMID:3713687 RGD:12910841 NCBI chr14:2,041,828...2,056,762
Ensembl chr14:2,042,411...2,056,762 		JBrowse link
G Il1b interleukin 1 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:11376495 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il23a interleukin 23 subunit alpha treatment ISO RGD PMID:23874957 RGD:39458037 NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723 		JBrowse link
G Il25 interleukin 25 treatment IEP RGD PMID:26054198 RGD:40902976 NCBI chr15:33,594,852...33,599,692
Ensembl chr15:33,596,301...33,599,685 		JBrowse link
G Lep leptin ISO CTD Direct Evidence: therapeutic CTD PMID:10422768 PMID:11025360 PMID:11787760 PMID:15024038 PMID:16015682 PMID:18181030 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 IDA RGD PMID:25518106 RGD:13800896 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 IDA RGD PMID:25518106 RGD:13800896 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mmp13 matrix metallopeptidase 13 IEP mRNA:increased expression:stomach RGD PMID:15375341 RGD:10043177 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018 		JBrowse link
G Mmp2 matrix metallopeptidase 2 IEP mRNA:increased expression:stomach RGD PMID:15375341 RGD:10043177 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611 		JBrowse link
G Mmp3 matrix metallopeptidase 3 IEP mRNA:increased expression:stomach RGD PMID:15375341 RGD:10043177 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579 		JBrowse link
G Mmp9 matrix metallopeptidase 9 IEP
ISO		 protein:increased expression:stomach secretion
CTD Direct Evidence: marker/mechanism		 CTD PMID:17603938, PMID:17603938 RGD:1642033 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming treatment IEP
IDA		 mRNA, protein:decreased expression:stomach RGD PMID:11956390, PMID:16240224 RGD:2324968, RGD:7364759 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Muc6 mucin 6, oligomeric mucus/gel-forming treatment IDA RGD PMID:16240224 RGD:7364759 NCBI chr 1:214,608,453...214,630,524
Ensembl chr 1:214,608,704...214,629,938 		JBrowse link
G Nos2 nitric oxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12481160 PMID:15138204 PMID:19066340 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nos3 nitric oxide synthase 3 treatment ISO
IEP		 CTD Direct Evidence: marker/mechanism CTD PMID:19066340, PMID:29095895 RGD:13446410 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410 		JBrowse link
G Nrg1 neuregulin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16357062 NCBI chr16:62,969,573...64,065,063
Ensembl chr16:63,837,216...64,057,434 		JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide IDA RGD PMID:11764003 RGD:2304192 NCBI chr 3:123,106,694...123,107,534
Ensembl chr 3:123,106,694...123,107,534 		JBrowse link
G Oxtr oxytocin receptor IMP RGD PMID:11764003 RGD:2304192 NCBI chr 4:144,399,326...144,417,598
Ensembl chr 4:144,403,358...144,416,116 		JBrowse link
G Ptger1 prostaglandin E receptor 1 treatment IMP
ISO		 RGD PMID:10807413, PMID:10807413 RGD:10043357, RGD:10043357 NCBI chr19:24,799,422...24,803,373
Ensembl chr19:24,800,072...24,803,373 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10594344 PMID:19066340 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IMP
ISO		 CTD Direct Evidence: marker/mechanism CTD PMID:9024292 PMID:10594344 PMID:11376495 PMID:12481160 PMID:19066340, PMID:17673547, PMID:17673547 RGD:2300260, RGD:2300260 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Sst somatostatin IEP RGD PMID:17990461 RGD:2303186 NCBI chr11:80,358,172...80,359,449
Ensembl chr11:80,358,211...80,359,444 		JBrowse link
G Tek TEK receptor tyrosine kinase IEP protein:increased expression:stomach RGD PMID:12768384 RGD:1601496 NCBI chr 5:113,725,717...113,852,799
Ensembl chr 5:113,725,717...113,852,799 		JBrowse link
G Tff1 trefoil factor 1 IEP mRNA, protein:increased expression:stomach mucosa RGD PMID:11350545 RGD:2292012 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 IEP mRNA:increased expression:stomach RGD PMID:15375341 RGD:10043177 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384 		JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:15138204 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO CTD Direct Evidence: marker/mechanism CTD PMID:11353854 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
G Vgf VGF nerve growth factor inducible ISO CTD Direct Evidence: therapeutic CTD PMID:20805684 NCBI chr12:22,677,302...22,680,630
Ensembl chr12:22,677,607...22,680,630 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16122
    disease of anatomical entity 15369
      gastrointestinal system disease 4694
        stomach disease 541
          peptic ulcer disease 84
            gastric ulcer 51
Path 2
Term Annotations click to browse term
  disease 16122
    disease of anatomical entity 15369
      gastrointestinal system disease 4694
        Gastrointestinal Diseases 2625
          intestinal disease 1579
            duodenum disease 90
              peptic ulcer disease 84
                gastric ulcer 51
paths to the root