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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:transient cerebral ischemia
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Accession:DOID:224 term browser browse the term
Definition:A brain ischemia that is characterized by ischemia of brief duration and without resultant tissue death. (DO)
Synonyms:exact_synonym: Brain Stem Ischemia, Transient;   Brain Stem Transient Ischemic Attack;   Brain TIA;   Brainstem Transient Ischemic Attack;   Carotid Circulation Transient Ischemic Attack;   Posterior Circulation Transient Ischemic Attack;   TIA;   TIA (Transient Ischemic Attack);   TIA - transient ischaemic attack;   Transient Brainstem Ischemia;   Transient Cerebral Ischemias;   Transient cerebral ischaemia;   anterior circulation transient ischemic attack;   crescendo transient ischemic attacks;   transient brainstem ischemias;   transient ischemic attack;   transient ischemic attacks;   vertebrobasilar circulation transient ischemic attack
 related_synonym: Brain Ischemia-Reperfusion Injury;   Brain Reperfusion Injury
 primary_id: MESH:D002546
 xref: EFO:0003764;   ICD10CM:G45.9;   NCI:C50781
For additional species annotation, visit the Alliance of Genome Resources.


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transient cerebral ischemia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvrl1 activin A receptor like type 1 IEP RGD PMID:15781474 RGD:1579751 NCBI chr 7:132,239,200...132,256,592
Ensembl chr 7:132,239,729...132,256,591 		JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 IEP mRNA, protein:increased expression:brain RGD PMID:16630594 RGD:9681747 NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103 		JBrowse link
G Adamts4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 IEP RGD PMID:16630594 RGD:9681747 NCBI chr13:83,670,556...83,680,045
Ensembl chr13:83,670,183...83,680,065 		JBrowse link
G Adarb1 adenosine deaminase, RNA-specific, B1 IMP RGD PMID:16504947 RGD:10755337 NCBI chr20:11,222,569...11,350,854
Ensembl chr20:11,222,583...11,350,852 		JBrowse link
G Adora1 adenosine A1 receptor ISO CTD Direct Evidence: therapeutic CTD PMID:23437309 NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801 		JBrowse link
G Ager advanced glycosylation end product-specific receptor IEP
ISO		 protein:altered expression:cerebral cortex, striatum (rat)
protein:increased expression:brain, plasma		 RGD PMID:22528836 PMID:23288172 RGD:7245542, RGD:8696004 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Agt angiotensinogen IEP RGD PMID:21934531 RGD:8549480 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Ahr aryl hydrocarbon receptor treatment IMP RGD PMID:32913241 RGD:401793747 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 IEP
ISO		 mRNA:decreased expression, altered localization:CA1 pyramidal layer, nucleus:
protein:increased expression:nucleus:		 RGD PMID:14526224 PMID:15087715 RGD:10047409, RGD:10053562 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Ang angiogenin treatment IEP RGD PMID:30258350 RGD:155663419 NCBI chr15:24,312,711...24,323,361 JBrowse link
G Ank1 ankyrin 1 IEP RGD PMID:9202331 RGD:1599109 NCBI chr16:68,876,294...69,054,963
Ensembl chr16:68,877,504...69,054,759 		JBrowse link
G Ank2 ankyrin 2 IEP RGD PMID:9202331 RGD:1599109 NCBI chr 2:215,378,028...215,954,015
Ensembl chr 2:215,379,680...215,862,923 		JBrowse link
G Apoe apolipoprotein E IEP RGD PMID:19623195 RGD:6903926 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Aqp4 aquaporin 4 treatment IEP RGD PMID:24773551 RGD:13207320 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856 		JBrowse link
G Atf2 activating transcription factor 2 IDA
IEP		 RGD PMID:10077326 PMID:9813301 RGD:10047405, RGD:10047413 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236 		JBrowse link
G Atp5f1b ATP synthase F1 subunit beta IEP protein:increased expression:cerebrum (rat) RGD PMID:21950801 RGD:13792582 NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273 		JBrowse link
G Axin2 axin 2 treatment IEP RGD PMID:31650542 RGD:151356749 NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231 		JBrowse link
G Bace1 beta-secretase 1 IEP protein:increased activity,increased expression:brain cortex RGD PMID:15120577 RGD:13782170 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876 		JBrowse link
G Bad BCL2-associated agonist of cell death ISO CTD Direct Evidence: marker/mechanism CTD PMID:12629175 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator treatment IEP RGD PMID:21167243 RGD:10054102 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 IEP protein:increased expression:hippocampus CA1, pyramidal cell RGD PMID:12913114 RGD:634629 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl2 BCL2, apoptosis regulator treatment IEP
IDA		 protein:decreased expression:brain RGD PMID:18083315 PMID:16732092 PMID:22509406 RGD:2290557, RGD:11522725, RGD:11561910 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l2 Bcl2-like 2 treatment IEP
ISO		 protein:increased expression:cortex and caudate putamen RGD PMID:10724126 PMID:12571640 RGD:14394498, RGD:14394500 NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624 		JBrowse link
G Becn1 beclin 1 treatment IEP RGD PMID:22509406 RGD:11561910 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Bex3 brain expressed X-linked 3 IEP RGD PMID:11124986 RGD:9743974 NCBI chr  X:99,273,270...99,274,799
Ensembl chr  X:99,273,161...99,274,800 		JBrowse link
G Bnip3 BCL2 interacting protein 3 IEP RGD PMID:14972662 RGD:2314028 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G C3 complement C3 treatment IEP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:23199288 PMID:22004711 RGD:7411628 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G Cab39 calcium binding protein 39 IEP protein:increased expression:brain RGD PMID:27798271 RGD:14398833 NCBI chr 9:86,463,095...86,524,545
Ensembl chr 9:86,463,095...86,524,544 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha IEP
ISO		 protein:increased expression:hippocampus RGD PMID:12951199 PMID:12199152 RGD:7241547, RGD:13681927 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994 		JBrowse link
G Casp3 caspase 3 IDA RGD PMID:21712070 RGD:10053706 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 treatment IEP RGD PMID:25872160 RGD:13782285 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 treatment IEP protein:increased expression:cerebral cortex: RGD PMID:30148677 PMID:18096138 RGD:13782286, RGD:4142863 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 IEP
ISO		 associated with Diabetes Mellitus, Experimental;protein:increased expression:neocortex
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:11333366 PMID:15246841 PMID:21712070 RGD:2311321, RGD:10053706 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cav1 caveolin 1 treatment IEP
ISO		 RGD PMID:22007835 PMID:22007835 RGD:8661794, RGD:8661794 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Cbl Cbl proto-oncogene treatment IDA RGD PMID:18773943 RGD:4108486 NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176 		JBrowse link
G Cbs cystathionine beta synthase treatment ISO XCO:0000348
XCO:0000807		 RGD PMID:22212488 PMID:22212488 RGD:41410880, RGD:41410880 NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 treatment IDA
IEP		 mRNA:increased expression:brain (rat) RGD PMID:21487414 PMID:7860708 RGD:8549519, RGD:8549729 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 treatment IMP RGD PMID:19428685 RGD:7488896 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629 		JBrowse link
G Ccnh cyclin H IEP mRNA, protein:increased expression:hippocampus RGD PMID:10501206 RGD:69371 NCBI chr 2:15,835,064...15,855,648
Ensembl chr 2:15,834,833...15,855,819 		JBrowse link
G Ccr6 C-C motif chemokine receptor 6 IEP mRNA:increased expression:brain RGD PMID:19428685 RGD:7488896 NCBI chr 1:52,474,477...52,508,301
Ensembl chr 1:52,474,168...52,498,603 		JBrowse link
G Cd40 CD40 molecule severity ISO RGD PMID:15795333 RGD:11352234 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Cd40lg CD40 ligand severity ISO RGD PMID:15795333 RGD:11352234 NCBI chr  X:135,127,052...135,138,768
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Cdk5 cyclin-dependent kinase 5 treatment IEP RGD PMID:28254431 RGD:13506925 NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A ISO protein:decreased expression:striatum, neuron RGD PMID:11438580 RGD:8552691 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha IEP mRNA, protein:increased expression:hippocampal pyramidal cell layer (rat) RGD PMID:9795105 RGD:10401192 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Chka choline kinase alpha IEP mRNA:increased expression:cerebral cortex (rat) RGD PMID:16300643 RGD:10401831 NCBI chr 1:201,076,804...201,125,517
Ensembl chr 1:201,076,860...201,125,516 		JBrowse link
G Coq7 coenzyme Q7, hydroxylase severity ISO RGD PMID:20170652 RGD:10402096 NCBI chr 1:172,836,359...172,851,173
Ensembl chr 1:172,835,188...172,851,158 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 IDA RGD PMID:10077326 RGD:10047405 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Crem cAMP responsive element modulator IEP mRNA:increased expression:cerebral cortex (rat) RGD PMID:12437578 RGD:632385 NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989 		JBrowse link
G Csf3 colony stimulating factor 3 treatment ISO RGD PMID:12624302 RGD:10450512 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 IEP protein:decreased expression:hippocampus RGD PMID:24447880 RGD:9491776 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 IEP mRNA,protein:decreased expression:hippocampus RGD PMID:24447880 RGD:9491776 NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 IEP protein:increased expression:hippocampus: RGD PMID:24924806 RGD:11352662 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Cycs cytochrome c, somatic ISO CTD Direct Evidence: marker/mechanism CTD PMID:11333366 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Daxx death-domain associated protein treatment IDA
IEP		 mRNA,protein:increased expression:cerebral cortex: RGD PMID:17967739 PMID:18096138 RGD:9587802, RGD:4142863 NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843 		JBrowse link
G Dbn1 drebrin 1 IEP RGD PMID:8583659 RGD:10398814 NCBI chr17:9,150,608...9,164,982
Ensembl chr17:9,150,659...9,164,984 		JBrowse link
G Dffb DNA fragmentation factor subunit beta IEP mRNA, protein:increased expression:hippocampus CA1 RGD PMID:11425895 RGD:628524 NCBI chr 5:164,522,446...164,534,733
Ensembl chr 5:164,522,463...164,534,628 		JBrowse link
G Dll4 delta like canonical Notch ligand 4 ameliorates
disease_progression
treatment		 ISO
IEP		 RGD PMID:31927543 PMID:30653356 PMID:30258350 RGD:155663354, RGD:155663383, RGD:155663419 NCBI chr 3:106,317,114...106,327,004
Ensembl chr 3:106,316,986...106,326,931 		JBrowse link
G Dusp1 dual specificity phosphatase 1 IEP protein:increased expression:brain RGD PMID:22197701 RGD:7771582 NCBI chr10:16,680,478...16,683,275 JBrowse link
G Dusp16 dual specificity phosphatase 16 IEP protein:increased expression, altered localization:hippocampus, cytosol, nucleus RGD PMID:23280045 RGD:7775014 NCBI chr 4:167,546,780...167,630,173
Ensembl chr 4:167,548,155...167,629,980 		JBrowse link
G Eed embryonic ectoderm development IDA RGD PMID:24007266 RGD:9588303 NCBI chr 1:143,867,875...143,895,008
Ensembl chr 1:143,867,875...143,894,974 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha ISO
IEP		 associated with Heart Arrest RGD PMID:11520898 PMID:10541873 RGD:10395353, RGD:11041881 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Elane elastase, neutrophil expressed treatment IMP RGD PMID:19168036 RGD:10450558 NCBI chr 7:9,817,251...9,819,174
Ensembl chr 7:9,817,252...9,819,100 		JBrowse link
G Elk1 ETS transcription factor ELK1 treatment IEP RGD PMID:17091294 RGD:7488902 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713 		JBrowse link
G Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 IEP mRNA:increased expression:brain: RGD PMID:9634555 RGD:9685492 NCBI chr 1:239,425,515...239,552,323
Ensembl chr 1:239,425,430...239,552,317 		JBrowse link
G Ep300 E1A binding protein p300 IEP mRNA:increased expression:cerebrum, ipsilateral side (rat) RGD PMID:22196858 RGD:7349341 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Epo erythropoietin treatment IEP
ISO		 RGD PMID:22282883 PMID:24702327 RGD:10401060, RGD:11041699 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit treatment ISO human gene in a rat model RGD PMID:19440222 RGD:2313668 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963 		JBrowse link
G Ercc6 ERCC excision repair 6, chromatin remodeling factor IEP mRNA, protein:increased expression:cerebral cortex RGD PMID:10437118 RGD:10401104 NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587 		JBrowse link
G Esr1 estrogen receptor 1 treatment IDA RGD PMID:24548484 PMID:25098259 RGD:10045843, RGD:10045845 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 IMP RGD PMID:23593292 RGD:7364962 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G F11r F11 receptor treatment IEP RGD PMID:22868201 RGD:7488943 NCBI chr13:83,873,797...83,897,388
Ensembl chr13:83,873,797...83,897,402 		JBrowse link
G F12 coagulation factor XII treatment ISO RGD PMID:16533887 PMID:16533887 RGD:11041786, RGD:11041786 NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530 		JBrowse link
G Fadd Fas associated via death domain IEP mRNA,protein:increased expression:cerebral cortex: RGD PMID:18096138 RGD:4142863 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Fas Fas cell surface death receptor treatment IEP
ISO
IDA		 protein:increased expression:brain
protein:increased expression:brain (rat)		 RGD PMID:18410517 PMID:10972965 PMID:18981705 PMID:30301943 RGD:2311437, RGD:8662928, RGD:8686422, RGD:153297779 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 IEP mRNA:increased expression:cerebral cortex: RGD PMID:8858623 RGD:10402044 NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 treatment IEP associated with Experimental Diabetes Mellitus RGD PMID:22432030 RGD:155882598 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 treatment ISO RGD PMID:17077813 RGD:10402150 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626 		JBrowse link
G Fmr1 fragile X messenger ribonucleoprotein 1 IEP mRNA, protein:increased expression:striatum (rat) RGD PMID:22817682 RGD:11566024 NCBI chr  X:147,240,239...147,278,057
Ensembl chr  X:147,240,301...147,278,050 		JBrowse link
G Fto FTO, alpha-ketoglutarate dependent dioxygenase IEP
ISO		 protein:decreased expression:cerebral cortex
mRNA:decreased expression:heart
mRNA:decreased expression:cerebral cortex		 RGD PMID:32426101 PMID:34413770 PMID:36479246 RGD:329901764, RGD:329901768, RGD:329951019 NCBI chr19:15,284,898...15,692,142
Ensembl chr19:15,349,696...15,692,083 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase IMP RGD PMID:22580330 RGD:10449127 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gad1 glutamate decarboxylase 1 disease_progression IEP RGD PMID:20659561 RGD:401900597 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333 		JBrowse link
G Gad2 glutamate decarboxylase 2 disease_progression IEP RGD PMID:20659561 RGD:401900597 NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155 		JBrowse link
G Gamt guanidinoacetate N-methyltransferase ameliorates ISO DNA:deletion RGD PMID:24004504 RGD:329955375 NCBI chr 7:9,448,590...9,451,413
Ensembl chr 7:9,448,628...9,451,778 		JBrowse link
G Gatm glycine amidinotransferase exacerbates ISO DNA:deletion RGD PMID:24004504 RGD:329955375 NCBI chr 3:109,658,919...109,675,508
Ensembl chr 3:109,658,951...109,684,129 		JBrowse link
G Gch1 GTP cyclohydrolase 1 treatment IMP RGD PMID:9920651 RGD:329961573 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698 		JBrowse link
G Ghsr growth hormone secretagogue receptor IEP mRNA,protein:decreased expression:brain: RGD PMID:17560544 RGD:12907500 NCBI chr 2:110,268,489...110,271,865
Ensembl chr 2:110,268,489...110,271,865 		JBrowse link
G Gja1 gap junction protein, alpha 1 treatment ISO
IEP		 protein:increased expression:brain RGD PMID:22812228 PMID:23328809 RGD:7207263, RGD:8662426 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Gjb6 gap junction protein, beta 6 IEP protein:increased expression:hippocampus: RGD PMID:21718970 RGD:6480433 NCBI chr15:31,284,561...31,294,552
Ensembl chr15:31,284,419...31,294,582 		JBrowse link
G Glrx glutaredoxin IEP mRNA,protein:decreased expression:brain: RGD PMID:10329397 RGD:9686043 NCBI chr 2:5,341,873...5,351,686
Ensembl chr 2:5,341,885...5,351,680 		JBrowse link
G Glul glutamate-ammonia ligase treatment IEP protein:increased expression:hippocampus
associated with carotid artery occlusion		 RGD PMID:27664163 PMID:21371894 PMID:21272618 PMID:25365917 RGD:401794415, RGD:401794419, RGD:401794590, RGD:401794591 NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 treatment ISO
IDA		 human protein in a rat model RGD PMID:24407245 PMID:20145654 PMID:21361730 RGD:13504852, RGD:13504854, RGD:13504855 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Gp6 glycoprotein VI ameliorates ISO RGD PMID:34237320 RGD:401794450 NCBI chr 1:69,429,232...69,492,709
Ensembl chr 1:69,465,789...69,491,326 		JBrowse link
G Gpx3 glutathione peroxidase 3 treatment ISO RGD PMID:30098076 RGD:401827833 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A ameliorates
treatment		 IMP
ISO
IDA		 associated with hyperhomocysteinemia RGD PMID:30885791 PMID:30885791 PMID:12932824 RGD:401940141, RGD:401940141, RGD:401950480 NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B ameliorates IMP RGD PMID:30885791 RGD:401940141 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Gsr glutathione-disulfide reductase treatment IDA RGD PMID:15525350 RGD:10401855 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G H2ax H2A.X variant histone treatment IDA RGD PMID:20830300 RGD:8693742 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 treatment IEP RGD PMID:24771108 RGD:9686115 NCBI chr10:30,882,484...30,914,018
Ensembl chr10:30,882,606...30,909,137 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha treatment IEP protein:increased expression:cerebral cortex, caudoputamen (rat) RGD PMID:20417628 PMID:30258350 RGD:9068877, RGD:155663419 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmgb1 high mobility group box 1 ISO protein:increased expression:brain, plasma RGD PMID:23288172 RGD:8696004 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 IEP protein:altered expression:cerebral cortex, hippocampus (rat) RGD PMID:20421594 RGD:10041006 NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249 		JBrowse link
G Hnrnpab heterogeneous nuclear ribonucleoprotein A/B treatment IDA RGD PMID:22366221 RGD:9999181 NCBI chr10:35,857,040...35,862,935
Ensembl chr10:35,857,041...35,863,344 		JBrowse link
G Hrh2 histamine receptor H 2 IEP protein:decreased expression:caudate putamen (rat) RGD PMID:16181737 RGD:9685533 NCBI chr17:10,366,004...10,407,791
Ensembl chr17:10,368,298...10,407,631 		JBrowse link
G Hsf1 heat shock transcription factor 1 treatment IEP
IDA		 protein:increased expression:brain, nucleus (rat)
associated with Heart Arrest		 RGD PMID:26070787 PMID:23528677 RGD:10402389, RGD:10402772 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 treatment IEP RGD PMID:25632565 RGD:11354959 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 IEP protein:increased expression:brain, postsynaptic density (rat) RGD PMID:9425004 RGD:10059344 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 IEP protein:increased expression:brain,astrocyte: RGD PMID:10559386 RGD:10402577 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Htra2 HtrA serine peptidase 2 treatment IMP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:15306124 PMID:19462455 RGD:10402932 NCBI chr 4:115,556,914...115,560,202
Ensembl chr 4:115,556,916...115,560,095 		JBrowse link
G Htt huntingtin IEP protein:increased degradation:brain RGD PMID:12957494 RGD:1304431 NCBI chr14:75,845,836...75,996,094
Ensembl chr14:75,845,836...75,995,070 		JBrowse link
G Icam1 intercellular adhesion molecule 1 treatment IEP RGD PMID:22379785 RGD:8547729 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifnb1 interferon beta 1 ameliorates IDA RGD PMID:12973019 RGD:401851924 NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523 		JBrowse link
G Igf1 insulin-like growth factor 1 severity IEP protein:decreased expression:serum (rat) RGD PMID:25098324 RGD:12904924 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta treatment IEP RGD PMID:24261295 RGD:7495766 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il10 interleukin 10 treatment IDA RGD PMID:24053818 RGD:7364868 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta IDA
ISO		 RGD PMID:23147509 PMID:22284622 RGD:7175551, RGD:7175554 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1rn interleukin 1 receptor antagonist IDA
ISO		 human protein in a rat model RGD PMID:15837124 PMID:20412072 RGD:1626674, RGD:8551852 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Ilk integrin-linked kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:15472100 NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140 		JBrowse link
G Itgam integrin subunit alpha M treatment ISO
IMP
IEP		 mRNA:increased expression:cerebral cortex (mouse)
mRNA:increased expression:brain (rat)		 RGD PMID:30123113 PMID:8160235 PMID:8581506 PMID:8964796 PMID:19563786 More... RGD:329853754, RGD:329901916, RGD:329901917, RGD:329901921, RGD:329901933, RGD:329901940, RGD:329902058, RGD:329902067 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Itgb3 integrin subunit beta 3 IEP RGD PMID:18638458 RGD:6907424 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 IEP mRNA:decreased expression:cerebral cortex (rat) RGD PMID:7500836 RGD:6482813 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
G Jak1 Janus kinase 1 IEP RGD PMID:10756075 RGD:19165138 NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926 		JBrowse link
G Jak2 Janus kinase 2 IDA RGD PMID:23764464 RGD:8694326 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Kcnj10 potassium inwardly-rectifying channel, subfamily J, member 10 IEP protein:decreased expression:CA1 field of hippocampus, astrocyte, astrocyte projection RGD PMID:20833221 RGD:8662899 NCBI chr13:84,802,026...84,835,383
Ensembl chr13:84,802,009...84,835,461 		JBrowse link
G Kcnk2 potassium two pore domain channel subfamily K member 2 severity
treatment		 ISO
IEP
IDA		 protein:increased expression:cerebral cortex (rat) RGD PMID:15175651 PMID:25062759 PMID:24154701 RGD:9831121, RGD:9831122, RGD:9831178 NCBI chr13:100,766,101...100,963,435
Ensembl chr13:100,766,113...100,963,435 		JBrowse link
G Kdm1a lysine demethylase 1A IEP protein:increased expression:cerebral cortex, hippocampus, dentate gyrus (rat) RGD PMID:20542065 RGD:9588301 NCBI chr 5:148,782,976...148,838,319
Ensembl chr 5:148,782,976...148,838,319 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 ISO protein:decreased expression:brain (mouse) RGD PMID:21075092 RGD:6893270 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Klf5 KLF transcription factor 5 ameliorates IMP RGD PMID:32272873 RGD:45073134 NCBI chr15:76,060,320...76,079,445
Ensembl chr15:76,064,258...76,079,445 		JBrowse link
G Kmt2a lysine methyltransferase 2A treatment IMP RGD PMID:34694864 RGD:155888565 NCBI chr 8:45,116,763...45,193,320
Ensembl chr 8:45,118,814...45,193,181 		JBrowse link
G Lcn2 lipocalin 2 IEP protein:increased expression:brain RGD PMID:29122651 PMID:24916903 RGD:126781757, RGD:126790489 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
G Lmna lamin A/C IDA RGD PMID:17683050 RGD:2293745 NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423 		JBrowse link
G Lpar1 lysophosphatidic acid receptor 1 treatment IDA RGD PMID:17173873 RGD:9850154 NCBI chr 5:73,229,047...73,347,874
Ensembl chr 5:73,229,625...73,369,895 		JBrowse link
G Ltbp1 latent transforming growth factor beta binding protein 1 treatment IEP RGD PMID:11720783 RGD:10412057 NCBI chr 6:20,029,629...20,425,339
Ensembl chr 6:20,029,629...20,425,349 		JBrowse link
G Madd MAP-kinase activating death domain IEP RGD PMID:12625816 RGD:9588641 NCBI chr 3:77,114,330...77,157,865
Ensembl chr 3:77,114,314...77,157,701 		JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha treatment IEP RGD PMID:22509406 RGD:11561910 NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 IDA protein:increased threonine phosphorylation:heart, nucleus RGD PMID:9195981 RGD:7495830 NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 IEP protein:increased nitrosylation, activity:hippocampus: RGD PMID:23137546 RGD:10412334 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 ameliorates ISO RGD PMID:32078472 PMID:32382778 PMID:34628598 PMID:32349637 RGD:155791642, RGD:155804272, RGD:155804283, RGD:155804284 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Map4k1 mitogen activated protein kinase kinase kinase kinase 1 treatment IDA RGD PMID:18498770 PMID:18382279 RGD:7495845, RGD:7495847 NCBI chr 1:84,270,951...84,292,496
Ensembl chr 1:84,271,069...84,292,493 		JBrowse link
G Mbd1 methyl-CpG binding domain protein 1 IEP mRNA:increased expression:hippocampus RGD PMID:12421618 RGD:9587846 NCBI chr18:67,869,870...67,884,501
Ensembl chr18:67,869,992...67,886,554 		JBrowse link
G Mbd2 methyl-CpG binding domain protein 2 IEP mRNA:increased expression:hippocampus RGD PMID:12421618 RGD:9587846 NCBI chr18:64,174,002...64,240,795
Ensembl chr18:64,174,002...64,240,794 		JBrowse link
G Mbd3 methyl-CpG binding domain protein 3 IEP mRNA:decreased expression:hippocampus RGD PMID:12421618 RGD:9587846 NCBI chr 7:9,312,961...9,320,166
Ensembl chr 7:9,313,098...9,320,165 		JBrowse link
G Mbp myelin basic protein IEP mRNA:increased expression:oligodendrocyte: RGD PMID:11460777 RGD:7349336 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404 		JBrowse link
G Mcfd2 multiple coagulation factor deficiency 2, ER cargo receptor complex subunit IEP mRNA:increased expression:hippocampus RGD PMID:17610559 RGD:11062141 NCBI chr 6:7,274,469...7,285,841
Ensembl chr 6:7,274,469...7,285,841 		JBrowse link
G Mdm2 MDM2 proto-oncogene treatment IDA RGD PMID:24334056 RGD:10412310 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Mecp2 methyl CpG binding protein 2 IEP mRNA:increased expression:hippocampus RGD PMID:12421618 RGD:9587846 NCBI chr  X:151,781,177...151,844,687
Ensembl chr  X:151,789,930...151,844,689 		JBrowse link
G Mff mitochondrial fission factor treatment IDA RGD PMID:26116440 RGD:12879457 NCBI chr 9:84,007,798...84,036,039
Ensembl chr 9:84,007,798...84,036,039 		JBrowse link
G Mfn2 mitofusin 2 IEP protein:decreased expression:brain (rat) RGD PMID:25147362 RGD:13204807 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342 		JBrowse link
G Mir126a microRNA 126a exacerbates ISO RGD PMID:28101763 RGD:401850574 NCBI chr 3:9,415,063...9,415,180
Ensembl chr 3:9,415,063...9,415,180 		JBrowse link
G Mir155 microRNA 155 treatment IEP RGD PMID:33081480 RGD:151347423 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718 		JBrowse link
G Mir195 microRNA 195 severity IMP RGD PMID:32272873 RGD:45073134 NCBI chr10:54,951,838...54,951,924
Ensembl chr10:54,951,838...54,951,924 		JBrowse link
G Mir223 microRNA 223 IMP RGD PMID:31237865 RGD:25824937 NCBI chr  X:61,141,887...61,141,996
Ensembl chr  X:61,141,887...61,141,996 		JBrowse link
G Mmp2 matrix metallopeptidase 2 treatment IDA
IEP		 protein:increased activity, increased expression:brain RGD PMID:11592852 PMID:24828425 RGD:8547930, RGD:8657086 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 treatment ISO
IDA
IEP		 protein:increased activity, increased expression:brain RGD PMID:16197500 PMID:11592852 PMID:23046750 PMID:24773551 RGD:8547921, RGD:8547930, RGD:13207323, RGD:13207320 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mt1 metallothionein 1 IEP mRNA:increased expression:cerebral cortex RGD PMID:10884303 RGD:10412650 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049 		JBrowse link
G Mt2A metallothionein 2A IEP mRNA:increased expression:cerebral cortex RGD PMID:10884303 RGD:10412650 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784 		JBrowse link
G Mt3 metallothionein 3 IEP mRNA, protein:increased expression:brain RGD PMID:10069533 RGD:9685804 NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158 		JBrowse link
G Mtor mechanistic target of rapamycin kinase treatment IEP RGD PMID:30712471 RGD:155791663 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Myb MYB proto-oncogene, transcription factor IEP mRNA:increased expression:brain: RGD PMID:24828495 RGD:11532683 NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase treatment IMP
ISO		 RGD PMID:28528966 PMID:25603815 RGD:13781879, RGD:13781895 NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100 		JBrowse link
G Ndrg2 NDRG family member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23451161 NCBI chr15:24,600,981...24,609,621
Ensembl chr15:24,600,982...24,609,626 		JBrowse link
G Ndrg4 NDRG family member 4 ISO RGD PMID:21636852 RGD:7247728 NCBI chr19:9,351,408...9,387,398
Ensembl chr19:9,351,404...9,386,914 		JBrowse link
G Nefh neurofilament heavy chain IEP protein:decreased expression:hippocampus RGD PMID:8726968 RGD:9743938 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351 		JBrowse link
G Nefl neurofilament light chain IEP protein:decreased expression:hippocampus RGD PMID:8726968 RGD:9743938 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793 		JBrowse link
G Nefm neurofilament medium chain IEP protein:decreased expression:hippocampus RGD PMID:8726968 RGD:9743938 NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755 		JBrowse link
G Nf1 neurofibromin 1 IEP mRNA,protein:increased expression:astrocyte: RGD PMID:8820972 RGD:12789703 NCBI chr10:64,306,027...64,539,112
Ensembl chr10:64,306,301...64,536,658 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 IEP protein:increased expression:hippocampal pyramidal neuron, nucleus (rat) RGD PMID:9158652 RGD:10045943 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Ngb neuroglobin treatment IEP
IMP
ISO		 associated with Hypertension;mRNA, protein:decreased expression:brain RGD PMID:16647691 PMID:12621155 PMID:12621155 PMID:23342777 RGD:9743952, RGD:9743964, RGD:9743964, RGD:9743965 NCBI chr 6:106,744,378...106,749,830
Ensembl chr 6:106,744,378...106,749,830 		JBrowse link
G Ngfr nerve growth factor receptor IEP RGD PMID:11124986 RGD:9743974 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 ISO mRNA, protein:increased expression:brain RGD PMID:20863826 RGD:5508733 NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177 		JBrowse link
G Nono non-POU domain containing, octamer-binding ISO protein:altered localization:cerebral cortex (mouse) RGD PMID:29426953 RGD:155883175 NCBI chr  X:66,554,131...66,571,992
Ensembl chr  X:66,554,098...66,571,952 		JBrowse link
G Nos1 nitric oxide synthase 1 IDA protein:increased serine phosphorylation:dentate gyrus RGD PMID:23806217 RGD:7257600 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nos3 nitric oxide synthase 3 treatment IEP
IDA		 protein:increased expression:serum (rat) RGD PMID:28944915 PMID:29312485 PMID:29298658 RGD:13450951, RGD:13503330, RGD:13503353 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Notch1 notch receptor 1 treatment IEP RGD PMID:30258350 RGD:155663419 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Nox1 NADPH oxidase 1 ameliorates IMP RGD PMID:25617620 RGD:329955357 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 treatment IEP protein:increased expression:brain (rat)
protein:increased expression:cerebral cortex (rat)		 RGD PMID:29017857 PMID:28552673 PMID:28169530 RGD:13439718, RGD:13439727, RGD:13442499 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nrg1 neuregulin 1 treatment ISO RGD PMID:31560696 RGD:405649728 NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884 		JBrowse link
G Nrp1 neuropilin 1 IEP mRNA:increased expression:brain RGD PMID:33675584 RGD:401901171 NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633 		JBrowse link
G Nrxn1 neurexin 1 IEP associated with Hypertension;mRNA:decreased expression:cerebral cortex RGD PMID:12437578 RGD:632385 NCBI chr 6:3,177,788...4,323,848
Ensembl chr 6:3,177,897...4,322,710 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase IEP protein:increased expression:cerebral cortex RGD PMID:14600440 RGD:8657406 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase treatment ISO
IDA		 protein:altered expression:brain RGD PMID:22345048 PMID:24633199 RGD:7800722, RGD:13208946 NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109 		JBrowse link
G Optn optineurin IEP protein:decreased expression:cerebral cortex (rat) RGD PMID:24235151 RGD:13434905 NCBI chr17:73,209,572...73,260,251
Ensembl chr17:73,209,575...73,260,251 		JBrowse link
G Parl presenilin associated, rhomboid-like severity ISO RGD PMID:23921894 RGD:12902620 NCBI chr11:80,594,059...80,620,506
Ensembl chr11:80,593,192...80,620,506 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 treatment IDA
IEP		 RGD PMID:19840223 PMID:19840223 RGD:2325713, RGD:2325713 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pawr pro-apoptotic WT1 regulator IEP
ISO		 mRNA:increased expression:brain:
protein:increased expression:cortex,striatum:		 RGD PMID:14705148 PMID:11323519 RGD:1302269, RGD:9835381 NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028 		JBrowse link
G Pax6 paired box 6 IEP protein:increased expression:cerebral cortex, striatum, astroglial cell (rat) RGD PMID:24114637 RGD:8552354 NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014 		JBrowse link
G Pcna proliferating cell nuclear antigen IEP RGD PMID:9757027 RGD:10448974 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pde4d phosphodiesterase 4D IEP protein:increased expression:hippocampus CA1 RGD PMID:22860212 RGD:7327148 NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884 		JBrowse link
G Pdyn prodynorphin IEP mRNA:decreased expression:dentate gyrus, granule cell RGD PMID:8914861 RGD:401851049 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 ISO protein:increased expression:brain (mouse) RGD PMID:22382321 RGD:6766379 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116 		JBrowse link
G Plat plasminogen activator, tissue type IEP Protein:increased expression, increased activity:hippocampus (rat) RGD PMID:15882815 RGD:1580875 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Plau plasminogen activator, urokinase IEP
IDA		 protein:increased expression:cerebral cortex (rat) RGD PMID:21375013 PMID:19952306 RGD:7241584, RGD:7241795 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Plxnd1 plexin D1 ameliorates IMP RGD PMID:30653356 RGD:155663383 NCBI chr 4:149,002,786...149,043,097
Ensembl chr 4:149,002,784...149,043,244 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma IMP
IEP		 RGD PMID:18378216 PMID:18973594 PMID:19221220 RGD:2301892, RGD:2301866, RGD:8553032 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A IEP protein:increased expression:cerebral cortex (rat) RGD PMID:15255948 RGD:9999154 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171 		JBrowse link
G Ppp1r9a protein phosphatase 1, regulatory subunit 9A treatment IDA RGD PMID:21278085 RGD:10043805 NCBI chr 4:32,970,501...33,292,360
Ensembl chr 4:33,024,450...33,286,907 		JBrowse link
G Ppp2r5e protein phosphatase 2 regulatory subunit B', epsilon treatment IEP RGD PMID:30712471 RGD:155791663 NCBI chr 6:94,168,846...94,317,872
Ensembl chr 6:94,168,846...94,317,872 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISO protein:decreased expression:cerebral cortex, striatum: RGD PMID:12415119 RGD:10413862 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
G Ptafr platelet-activating factor receptor treatment IEP
IMP		 mRNA:decreased expression:cerebral cortex (rat) RGD PMID:17268849 PMID:8158141 RGD:9999221, RGD:10043297 NCBI chr 5:144,765,770...144,795,057
Ensembl chr 5:144,765,976...144,795,251 		JBrowse link
G Pten phosphatase and tensin homolog IEP RGD PMID:12414116 RGD:1358425 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Ptger4 prostaglandin E receptor 4 IEP protein:increased expression:hippocampus (rat) RGD PMID:16437207 RGD:10043375 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670 		JBrowse link
G Ptgis prostaglandin I2 synthase treatment IMP RGD PMID:27834752 RGD:401960086 NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451 		JBrowse link
G Ptn pleiotrophin IEP mRNA:increased expression:cerebral cortex, vasculature, macrophage (rat) RGD PMID:9570800 RGD:9831440 NCBI chr 4:65,293,731...65,375,572
Ensembl chr 4:65,293,734...65,375,456 		JBrowse link
G Ptpn13 protein tyrosine phosphatase, non-receptor type 13 IEP mRNA,protein:increased expression:cerebral cortex: RGD PMID:18096138 RGD:4142863 NCBI chr14:6,108,202...6,282,619
Ensembl chr14:6,108,211...6,282,563 		JBrowse link
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 treatment
severity		 IEP
IDA
ISO		 protein:decreased phosphorylation, decreased expression:striatum (rat) RGD PMID:24198371 PMID:24198371 PMID:24198371 RGD:9835010, RGD:9835010, RGD:9835010 NCBI chr 1:97,620,638...97,681,186
Ensembl chr 1:97,620,642...97,679,882 		JBrowse link
G Rack1 receptor for activated C kinase 1 IDA RGD PMID:24007266 RGD:9588303 NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975 		JBrowse link
G Robo1 roundabout guidance receptor 1 disease_progression IEP
ISO		 protein:increased expression:hippocampus
protein:increased expression:brain, astrocyte		 RGD PMID:26764532 PMID:27686659 PMID:23473743 RGD:11573340, RGD:243048429, RGD:243048431 NCBI chr11:10,580,863...11,621,675
Ensembl chr11:10,580,908...11,620,203 		JBrowse link
G Robo2 roundabout guidance receptor 2 IEP protein:increased expression:brain, astrocyte RGD PMID:27686659 RGD:243048429 NCBI chr11:12,528,949...14,096,726
Ensembl chr11:12,528,951...13,041,536 		JBrowse link
G Robo4 roundabout guidance receptor 4 IEP protein:increased expression:hippocampus RGD PMID:26764532 RGD:11573340 NCBI chr 8:37,119,953...37,133,887
Ensembl chr 8:37,119,988...37,132,519 		JBrowse link
G Rps6 ribosomal protein S6 IDA RGD PMID:26556340 RGD:11041643 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602 		JBrowse link
G Sema3e semaphorin 3E disease_progression IEP RGD PMID:30653356 RGD:155663383 NCBI chr 4:20,297,534...20,555,287
Ensembl chr 4:20,299,718...20,555,229 		JBrowse link
G Serpine1 serpin family E member 1 treatment IDA RGD PMID:26851971 RGD:11073692 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Serpinf1 serpin family F member 1 treatment ISO human gene in a rat model RGD PMID:18624913 RGD:8613878 NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646 		JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 IEP mRNA:increased expression:hippocampus, pyramidal cell RGD PMID:15046873 RGD:1580967 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283 		JBrowse link
G Sin3a SIN3 transcription regulator family member A IDA RGD PMID:24063527 RGD:9495912 NCBI chr 8:57,481,539...57,536,195
Ensembl chr 8:57,481,573...57,536,192 		JBrowse link
G Sirt6 sirtuin 6 IEP mRNA, protein:decreased expression:brain RGD PMID:23899523 RGD:9586062 NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914 		JBrowse link
G Slc12a2 solute carrier family 12 member 2 IEP RGD PMID:27798271 RGD:14398833 NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440 		JBrowse link
G Slc17a6 solute carrier family 17 member 6 IEP RGD PMID:23458738 RGD:9999193 NCBI chr 1:101,212,489...101,252,543
Ensembl chr 1:101,212,489...101,252,542 		JBrowse link
G Slc17a7 solute carrier family 17 member 7 IEP RGD PMID:23458738 RGD:9999193 NCBI chr 1:95,649,709...95,661,591
Ensembl chr 1:95,649,745...95,661,588 		JBrowse link
G Slc17a8 solute carrier family 17 member 8 IEP RGD PMID:23458738 RGD:9999193 NCBI chr 7:23,994,212...24,049,498
Ensembl chr 7:23,994,217...24,048,079 		JBrowse link
G Slit2 slit guidance ligand 2 IEP protein:increased expression:hippocampus
protein:increased expression:brain, astrocyte		 RGD PMID:26764532 PMID:27686659 RGD:11573340, RGD:243048429 NCBI chr14:62,616,337...62,955,934
Ensembl chr14:62,617,067...62,955,948 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 IDA RGD PMID:24007266 RGD:9588303 NCBI chr19:34,162,337...34,245,786
Ensembl chr19:34,162,341...34,245,749 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 treatment IEP RGD PMID:33081480 RGD:151347423 NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383 		JBrowse link
G Sod1 superoxide dismutase 1 treatment ISO human protein in a rat model
human gene in a rat model
CTD Direct Evidence: therapeutic		 CTD
RGD		 PMID:12629175 PMID:15829915 PMID:16538228 PMID:16868554 PMID:21531066 More... RGD:8655885, RGD:8655986 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 treatment ISO
IEP		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:11333366 PMID:30716316 RGD:27095883 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 exacerbates IDA
IMP		 RGD PMID:23764464 PMID:23884942 RGD:8694326, RGD:8694331 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tert telomerase reverse transcriptase treatment IDA RGD PMID:21914402 RGD:11038669 NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
G Tfpi tissue factor pathway inhibitor treatment ISO RGD PMID:18067952 RGD:11062087 NCBI chr 3:69,533,156...69,582,547
Ensembl chr 3:69,533,156...69,576,880 		JBrowse link
G Tia1 TIA1 cytotoxic granule-associated RNA binding protein IEP RGD PMID:16055272 RGD:10059581 NCBI chr 4:118,852,765...118,883,252
Ensembl chr 4:118,852,837...118,880,586 		JBrowse link
G Tial1 Tia1 cytotoxic granule-associated RNA binding protein-like 1 IEP RGD PMID:10700014 RGD:1357161 NCBI chr 1:183,008,358...183,045,092
Ensembl chr 1:183,009,253...183,031,637 		JBrowse link
G Tnf tumor necrosis factor treatment IDA
IEP		 mRNA:increased expression:striatum,hippocampus: RGD PMID:24053818 PMID:11412877 RGD:7364868, RGD:13825263 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A treatment IEP mRNA:increased expression:striatum,hippocampus: RGD PMID:21868309 PMID:11412877 RGD:8661762, RGD:13825263 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 treatment IDA
ISO		 RGD PMID:23435869 PMID:23043486 PMID:20811149 RGD:7247582, RGD:7247583, RGD:7247585 NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092 		JBrowse link
G Trpm2 transient receptor potential cation channel, subfamily M, member 2 IEP mRNA:increased expression:cerebral cortex RGD PMID:16777714 RGD:10003026 NCBI chr20:10,703,568...10,753,189
Ensembl chr20:10,707,014...10,753,181 		JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 ISO RGD PMID:22284622 RGD:7175554 NCBI chr10:57,883,546...57,915,865
Ensembl chr10:57,883,546...57,913,296 		JBrowse link
G Ucp2 uncoupling protein 2 treatment IDA RGD PMID:19772611 RGD:7204428 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611 		JBrowse link
G Vwf von Willebrand factor treatment IDA RGD PMID:22771326 RGD:7207039 NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539 		JBrowse link
G Wnk1 WNK lysine deficient protein kinase 1 IEP RGD PMID:27798271 RGD:14398833 NCBI chr 4:153,128,334...153,253,905
Ensembl chr 4:153,128,334...153,253,905 		JBrowse link
G Wnk2 WNK lysine deficient protein kinase 2 IEP RGD PMID:27798271 RGD:14398833 NCBI chr17:15,503,672...15,612,479
Ensembl chr17:15,504,261...15,612,479 		JBrowse link
G Wnk4 WNK lysine deficient protein kinase 4 IEP RGD PMID:27798271 RGD:14398833 NCBI chr10:86,202,552...86,219,655
Ensembl chr10:86,188,812...86,231,829 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 treatment IEP RGD PMID:19840223 RGD:2325713 NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 21128
    Nutritional and Metabolic Diseases 8237
      disease of metabolism 8237
        acquired metabolic disease 2535
          Reperfusion Injury 816
            transient cerebral ischemia 241
              basilar artery insufficiency + 0
              vertebral artery insufficiency + 0
Path 2
Term Annotations click to browse term
  disease 21128
    disease of anatomical entity 18211
      nervous system disease 14059
        central nervous system disease 12398
          brain disease 11633
            cerebrovascular disease 1000
              brain ischemia 641
                transient cerebral ischemia 241
                  basilar artery insufficiency + 0
                  vertebral artery insufficiency + 0
paths to the root