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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:carotid stenosis
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Accession:DOID:13001 term browser browse the term
Definition:Narrowing or stricture of any part of the CAROTID ARTERIES, most often due to atherosclerotic plaque formation. Ulcerations may form in atherosclerotic plaques and induce THROMBUS formation. Platelet or cholesterol emboli may arise from stenotic carotid lesions and induce a TRANSIENT ISCHEMIC ATTACK; CEREBROVASCULAR ACCIDENT; or temporary blindness (AMAUROSIS FUGAX). (From Adams et al., Principles of Neurology, 6th ed, pp 822-3)
Synonyms:exact_synonym: Carotid Artery Narrowing;   Carotid Artery Narrowings;   Carotid Artery Plaque;   Carotid Artery Plaques;   Carotid Artery Stenoses;   Carotid Artery Stenosis;   Carotid Artery Ulcerating Plaque;   Carotid Occlusive Disease;   Carotid Stenoses;   Carotid Ulcer;   Carotid Ulcers;   Common Carotid Artery Stenosis;   External Carotid Artery Stenosis;   Internal Carotid Artery Stenosis
 related_synonym: Carotid Stenosis, Susceptibility To
 primary_id: MESH:D016893
 alt_id: RDO:0007010
 xref: NCI:C95804
For additional species annotation, visit the Alliance of Genome Resources.


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carotid stenosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E ISO CTD Direct Evidence: marker/mechanism CTD PMID:17243563 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Clec11a C-type lectin domain containing 11A ISO CTD Direct Evidence: marker/mechanism CTD PMID:26564003 NCBI chr 1:100,290,374...100,293,515
Ensembl chr 1:100,289,295...100,293,558
JBrowse link
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase IDA RGD PMID:17936728 RGD:6483357 NCBI chr10:88,490,798...88,497,357
Ensembl chr10:88,490,798...88,497,356
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26564003 NCBI chr14:17,228,832...17,233,743
Ensembl chr14:17,228,856...17,234,712
JBrowse link
G F2 coagulation factor II ISO DNA:SNP:3'-UTR:in men only (human) RGD PMID:15748240 RGD:5509914 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G Fabp2 fatty acid binding protein 2 ISO RGD PMID:16013194 RGD:1582392 NCBI chr 2:227,080,912...227,083,654
Ensembl chr 2:227,080,924...227,083,501
JBrowse link
G Faslg Fas ligand ISO RGD PMID:14739407 RGD:1582424 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Gpx1 glutathione peroxidase 1 ISO RGD PMID:23426106 RGD:11352755 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Il10 interleukin 10 no_association ISO RGD PMID:16804000 RGD:1598483 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il4 interleukin 4 treatment IEP RGD PMID:20498142 RGD:7829829 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Itgb3 integrin subunit beta 3 ISO RGD PMID:15007005 RGD:1582450 NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410
JBrowse link
G Mfn2 mitofusin 2 treatment IMP RGD PMID:15322553 RGD:1304351 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
JBrowse link
G Mmp1 matrix metallopeptidase 1 ISO DNA:insertion, haplotype:promoter:g.-1607insG (human) RGD PMID:12364729 RGD:1580553 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mmp14 matrix metallopeptidase 14 ISO RGD PMID:16147977 RGD:1582575 NCBI chr15:33,074,441...33,083,666
Ensembl chr15:33,074,441...33,083,655
JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO RGD PMID:16147977 RGD:1582575 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp3 matrix metallopeptidase 3 ISO RGD PMID:12364729 RGD:1580553 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Mt2A metallothionein 2A ISO DNA:snp:5' utr:g.+838C>G (human) RGD PMID:17622311 RGD:6483844 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO DNA:SNP:CDS:rs1801133, c.677C>T, p.A222V, in men only (human) RGD PMID:15748240 RGD:5509914 NCBI chr 5:164,844,642...164,864,360
Ensembl chr 5:164,845,925...164,860,910
JBrowse link
G Pla2g7 phospholipase A2 group VII severity ISO RGD PMID:22075154 RGD:6482772 NCBI chr 9:19,935,754...19,978,013
Ensembl chr 9:19,935,768...19,978,013
JBrowse link
G Procr protein C receptor IEP associated with Neointima RGD PMID:21903947 RGD:13515129 NCBI chr 3:151,285,321...151,289,581
Ensembl chr 3:151,285,249...151,289,595
JBrowse link
G Spp1 secreted phosphoprotein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26564003 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Tlr2 toll-like receptor 2 treatment IDA RGD PMID:22167462 RGD:7241095 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tlr4 toll-like receptor 4 treatment IDA RGD PMID:22167462 RGD:7241095 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B ISO CTD Direct Evidence: marker/mechanism CTD PMID:26564003 NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 IMP RGD PMID:19958991 RGD:7240515 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
Carotid Atherosclerosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf21 fibroblast growth factor 21 ISO protein:increased expression:serum: RGD PMID:23887638 RGD:10401924 NCBI chr 1:101,595,579...101,596,822
Ensembl chr 1:101,595,579...101,596,822
JBrowse link
G Pcsk5 proprotein convertase subtilisin/kexin type 5 ISO protein:increased expression:myofibroblast: RGD PMID:14970114 RGD:11556214 NCBI chr 1:236,031,988...236,313,858
Ensembl chr 1:236,031,988...236,313,858
JBrowse link
G Sirt1 sirtuin 1 ISO mRNA, protein:decreased expression:carotid artery segment RGD PMID:23224247 RGD:9495924 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16158
    disease of anatomical entity 15408
      cardiovascular system disease 4377
        vascular disease 3313
          Arterial Occlusive Diseases 644
            carotid stenosis 28
              Carotid Atherosclerosis 3
Path 2
Term Annotations click to browse term
  disease 16158
    disease of anatomical entity 15408
      nervous system disease 11007
        central nervous system disease 9126
          brain disease 8438
            cerebrovascular disease 819
              carotid artery disease 126
                carotid stenosis 28
                  Carotid Atherosclerosis 3
paths to the root