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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:membranoproliferative glomerulonephritis
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Accession:DOID:2920 term browser browse the term
Definition:Chronic glomerulonephritis characterized histologically by proliferation of MESANGIAL CELLS, increase in the MESANGIAL EXTRACELLULAR MATRIX, and a thickening of the glomerular capillary walls. This may appear as a primary disorder or secondary to other diseases including infections and autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Various subtypes are classified by their abnormal ultrastructures and immune deposits. Hypocomplementemia is a characteristic feature of all types of MPGN.
Synonyms:exact_synonym: Dense Deposit Disease;   Hypocomplementemic Glomerulonephritides;   Hypocomplementemic Glomerulonephritis;   Lobular glomerulonephritis;   MPGN;   Membranoproliferative Glomerulonephritides;   Membranoproliferative Glomerulonephritis, Type I;   Mesangiocapillary Glomerulonephritides;   Mesangiocapillary Glomerulonephritis;   Mesangiocapillary Glomerulonephritis, Type I;   Subendothelial Membranoproliferative Glomerulonephritis;   chronic glomerulonephritis, lobular
 narrow_synonym: MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS WITH COMPLEMENT FACTOR H DEFICIENCY;   MESANGIOCAPILLARY GLOMERULONEPHRITIS, TYPE II;   Membranoproliferative Glomerulonephritis Type II;   Membranoproliferative Glomerulonephritis, Type III
 primary_id: MESH:D015432
 alt_id: RDO:0002519
 xref: GARD:11982;   NCI:C34644;   OMIM:PS137950
For additional species annotation, visit the Alliance of Genome Resources.



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membranoproliferative glomerulonephritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin ISO CTD Direct Evidence: marker/mechanism CTD PMID:1556257 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Angpt2 angiopoietin 2 IEP
IDA
protein:increased expression:glomerulus (rat) RGD PMID:18272601 PMID:16014048 RGD:2314193, RGD:2314222 NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804
JBrowse link
G C1qa complement C1q A chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:8840296 NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534
JBrowse link
G C3 complement C3 ISO ClinVar Annotator: match by term: Mesangiocapillary glomerulonephritis ClinVar PMID:32581362 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 treatment IMP RGD PMID:10411686 RGD:8549648 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccn2 cellular communication network factor 2 IEP protein:increased expression:kidney, glomerulus (rat) RGD PMID:15172885 RGD:1601118 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Ccr6 C-C motif chemokine receptor 6 treatment IEP RGD PMID:23192593 RGD:7483632 NCBI chr 1:52,474,477...52,508,301
Ensembl chr 1:52,474,168...52,498,603
JBrowse link
G Cdk2 cyclin dependent kinase 2 IMP RGD PMID:17893107 RGD:2293563 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B IEP protein:decreased expression:kidney RGD PMID:16787597 RGD:2293620 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cfb complement factor B ISO RGD PMID:12091909 PMID:2329415 RGD:734771, RGD:7242760 NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505
JBrowse link
G Cfh complement factor H ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Mesangiocapillary glomerulonephritis | ClinVar Annotator: match by term: Mesangiocapillary glomerulonephritis, type II
CTD
ClinVar
PMID:14978182 PMID:32581362 NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838
JBrowse link
G Cfi complement factor I ISO RGD PMID:18202746 RGD:6906892 NCBI chr 2:218,389,079...218,430,565
Ensembl chr 2:218,387,990...218,430,561
JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 IEP RGD PMID:23336303 RGD:7207859 NCBI chr 9:75,768,124...75,771,122
Ensembl chr 9:75,766,770...75,771,084
JBrowse link
G Edn1 endothelin 1 treatment IEP
IMP
mRNA, protein:increased expression:glomerulus (rat) RGD PMID:8569091 PMID:11601021 RGD:4144848, RGD:8662296 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Ep300 E1A binding protein p300 treatment IMP RGD PMID:24344329 RGD:9588308 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088
JBrowse link
G F5 coagulation factor V IMP RGD PMID:15172885 RGD:1601118 NCBI chr13:76,513,463...76,583,106
Ensembl chr13:76,513,255...76,582,317
JBrowse link
G Fn1 fibronectin 1 IEP RGD PMID:10082755 RGD:7206847 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Il1b interleukin 1 beta IDA RGD PMID:21871881 RGD:7175308 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Kcnt2 potassium sodium-activated channel subfamily T member 2 ISO ClinVar Annotator: match by term: Mesangiocapillary glomerulonephritis ClinVar PMID:32581362 NCBI chr13:51,664,129...52,059,209
Ensembl chr13:51,664,686...52,056,987
JBrowse link
G Myoc myocilin IEP protein:increased expression:renal glomerulus (rat) RGD PMID:15610237 RGD:7401266 NCBI chr13:74,976,730...74,987,128
Ensembl chr13:74,976,730...74,987,127
JBrowse link
G Pfn1 profilin 1 IDA RGD PMID:8651905 RGD:729497 NCBI chr10:55,365,263...55,367,968
Ensembl chr10:55,365,262...55,527,631
JBrowse link
G Pon1 paraoxonase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16175651 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Prf1 perforin 1 IEP mRNA:increased expression:glomerulus RGD PMID:10886554 RGD:1599935 NCBI chr20:29,246,202...29,251,712
Ensembl chr20:29,246,202...29,251,701
JBrowse link
G Sparc secreted protein acidic and cysteine rich IEP mRNA:increased expression:glomerulus RGD PMID:8644857 RGD:2300070 NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 IDA RGD PMID:11703592 RGD:1601601 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228
JBrowse link
G Tlr1 toll-like receptor 1 ISO mRNA:increased expression:renal glomerulus (mouse) RGD PMID:18256364 RGD:7246909 NCBI chr14:43,384,127...43,396,765
Ensembl chr14:43,384,932...43,397,125
JBrowse link
G Tlr11 toll-like receptor 11 ISO mRNA:increased expression:renal glomerulus (mouse) RGD PMID:18256364 RGD:7246909 NCBI chr15:23,545,408...23,549,849
Ensembl chr15:23,545,408...23,549,849
JBrowse link
G Tlr2 toll-like receptor 2 ISO mRNA:increased expression:renal glomerulus (mouse) RGD PMID:18256364 RGD:7246909 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tlr4 toll-like receptor 4 ISO mRNA:increased expression:renal glomerulus (mouse) RGD PMID:18256364 RGD:7246909 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tlr5 toll-like receptor 5 ISO mRNA:increased expression:renal glomerulus (mouse) RGD PMID:18256364 RGD:7246909 NCBI chr13:94,634,778...94,658,992
Ensembl chr13:94,634,801...94,657,738
JBrowse link
G Tlr6 toll-like receptor 6 ISO mRNA:increased expression:renal glomerulus (mouse) RGD PMID:18256364 RGD:7246909 NCBI chr14:43,362,164...43,374,500
Ensembl chr14:43,362,164...43,375,685
JBrowse link
G Tlr7 toll-like receptor 7 ISO mRNA:increased expression:renal glomerulus (mouse) RGD PMID:18256364 RGD:7246909 NCBI chr  X:27,027,380...27,054,309
Ensembl chr  X:27,027,425...27,054,754
JBrowse link
G Tlr8 toll-like receptor 8 ISO mRNA:increased expression:renal glomerulus (mouse) RGD PMID:18256364 RGD:7246909 NCBI chr  X:27,091,780...27,116,092
Ensembl chr  X:27,091,778...27,116,549
JBrowse link
G Tlr9 toll-like receptor 9 ISO mRNA:increased expression:renal glomerulus (mouse) RGD PMID:18256364 RGD:7246909 NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796
JBrowse link
G Tslp thymic stromal lymphopoietin ISO CTD Direct Evidence: marker/mechanism CTD PMID:17686814 NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548
JBrowse link
C3 Glomerulopathy 3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cfh complement factor H ISO ClinVar Annotator: match by term: CFH-Related Dense Deposit Disease / Membranoproliferative Glomerulonephritis Type II ClinVar PMID:8072530 PMID:9536098 PMID:11158219 PMID:11978762 PMID:12424708 More... NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838
JBrowse link
Glomerulonephritis with Isolated C3 Deposits and Factor H Deficiency term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cfh complement factor H ISO DNA:SNPs,Haplotype:: RGD PMID:17517971 PMID:17517971 RGD:7364995, RGD:7364995 NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838
JBrowse link
Glomerulopathy with Giant Fibrillar Deposits term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase ISO ClinVar Annotator: match by term: Glomerulopathy with fibronectin deposits 2 ClinVar PMID:25741868 PMID:28492532 NCBI chr 9:73,164,846...73,184,897
Ensembl chr 9:73,164,846...73,184,889
JBrowse link
G Fn1 fibronectin 1 ISO ClinVar Annotator: match by term: Glomerulopathy with fibronectin deposits 2 OMIM
ClinVar
PMID:1544672 PMID:7747733 PMID:12042895 PMID:18268355 PMID:25741868 More... NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
hypotrichosis-lymphedema-telangiectasia-renal defect syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sox18 SRY-box transcription factor 18 ISO ClinVar Annotator: match by term: Hypotrichosis-lymphedema-telangiectasia-renal defect syndrome OMIM
ClinVar
PMID:2484451 PMID:12740761 PMID:24697860 PMID:25741868 PMID:29307792 NCBI chr 3:168,785,488...168,787,290
Ensembl chr 3:168,785,490...168,787,290
JBrowse link
nephrotic syndrome type 7 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dgke diacylglycerol kinase epsilon ISO ClinVar Annotator: match by term: Immunoglobulin-mediated membranoproliferative glomerulonephritis OMIM
ClinVar
PMID:23274426 PMID:23542698 PMID:24747643 PMID:25349199 PMID:25741868 More... NCBI chr10:73,852,679...73,877,334
Ensembl chr10:73,855,583...73,877,100
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18032
    disease of anatomical entity 17412
      immune system disease 4372
        membranoproliferative glomerulonephritis 39
          C3 Glomerulopathy 3 1
          Glomerulonephritis with Isolated C3 Deposits and Factor H Deficiency 1
          Glomerulonephritis with Isolated C3 Deposits and Factor I Deficiency 0
          Glomerulopathy with Giant Fibrillar Deposits 2
          MPGN II with Complement Factor H Deficiency 0
          Membranoproliferative Glomerulonephritis, X-Linked 0
          hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 1
          nephrotic syndrome type 7 1
Path 2
Term Annotations click to browse term
  disease 18032
    disease of anatomical entity 17412
      Urogenital Diseases 4683
        urinary system disease 2383
          kidney disease 2156
            nephritis 454
              glomerulonephritis 396
                mesangial proliferative glomerulonephritis 49
                  Chronic Mesangial Proliferative Glomerulonephritis 41
                    membranoproliferative glomerulonephritis 39
                      C3 Glomerulopathy 3 1
                      Glomerulonephritis with Isolated C3 Deposits and Factor H Deficiency 1
                      Glomerulonephritis with Isolated C3 Deposits and Factor I Deficiency 0
                      Glomerulopathy with Giant Fibrillar Deposits 2
                      MPGN II with Complement Factor H Deficiency 0
                      Membranoproliferative Glomerulonephritis, X-Linked 0
                      hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 1
                      nephrotic syndrome type 7 1
paths to the root