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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:membranoproliferative glomerulonephritis
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Accession:DOID:2920 term browser browse the term
Definition:Chronic glomerulonephritis characterized histologically by proliferation of MESANGIAL CELLS, increase in the MESANGIAL EXTRACELLULAR MATRIX, and a thickening of the glomerular capillary walls. This may appear as a primary disorder or secondary to other diseases including infections and autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Various subtypes are classified by their abnormal ultrastructures and immune deposits. Hypocomplementemia is a characteristic feature of all types of MPGN.
Synonyms:exact_synonym: Dense Deposit Disease;   Hypocomplementemic Glomerulonephritides;   Hypocomplementemic Glomerulonephritis;   Lobular glomerulonephritis;   MPGN;   Membranoproliferative Glomerulonephritides;   Membranoproliferative Glomerulonephritis, Type I;   Mesangiocapillary Glomerulonephritides;   Mesangiocapillary Glomerulonephritis;   Mesangiocapillary Glomerulonephritis, Type I;   Subendothelial Membranoproliferative Glomerulonephritis;   chronic glomerulonephritis, lobular
 narrow_synonym: MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS WITH COMPLEMENT FACTOR H DEFICIENCY;   MESANGIOCAPILLARY GLOMERULONEPHRITIS, TYPE II;   Membranoproliferative Glomerulonephritis Type II;   Membranoproliferative Glomerulonephritis, Type III;   NON-IMMUNOGLOBULIN-MEDIATED MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS
 primary_id: MESH:D015432
 xref: GARD:11982;   MIM:PS137950;   NCI:C34644
For additional species annotation, visit the Alliance of Genome Resources.


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membranoproliferative glomerulonephritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin ISO CTD Direct Evidence: marker/mechanism CTD PMID:1556257 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Angpt2 angiopoietin 2 IEP
IDA		 protein:increased expression:glomerulus (rat) RGD PMID:18272601 PMID:16014048 RGD:2314193, RGD:2314222 NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804 		JBrowse link
G C1qa complement C1q A chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:8840296 NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534 		JBrowse link
G C3 complement C3 ISO ClinVar Annotator: match by term: Mesangiocapillary glomerulonephritis ClinVar PMID:32581362 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 treatment IMP RGD PMID:10411686 RGD:8549648 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccn2 cellular communication network factor 2 IEP protein:increased expression:kidney, glomerulus (rat) RGD PMID:15172885 RGD:1601118 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Ccr6 C-C motif chemokine receptor 6 treatment IEP RGD PMID:23192593 RGD:7483632 NCBI chr 1:52,474,477...52,508,301
Ensembl chr 1:52,474,168...52,498,603 		JBrowse link
G Cdk2 cyclin dependent kinase 2 IMP RGD PMID:17893107 RGD:2293563 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B IEP protein:decreased expression:kidney RGD PMID:16787597 RGD:2293620 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cfb complement factor B ISO RGD PMID:12091909 PMID:2329415 RGD:734771, RGD:7242760 NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505 		JBrowse link
G Cfh complement factor H ISO
ISS		 CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Mesangiocapillary glomerulonephritis | ClinVar Annotator: match by term: Mesangiocapillary glomerulonephritis, type II | ClinVar Annotator: match by term: Non-immunoglobulin-mediated membranoproliferative glomerulonephritis
OMIM:305800		 CTD
ClinVar
MouseDO		 PMID:14978182 PMID:21415311 PMID:22223606 PMID:22403278 PMID:25741868 More... NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838 		JBrowse link
G Cfi complement factor I ISO RGD PMID:18202746 RGD:6906892 NCBI chr 2:218,389,079...218,430,565
Ensembl chr 2:218,387,990...218,430,561 		JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 IEP RGD PMID:23336303 RGD:7207859 NCBI chr 9:75,766,894...75,771,079
Ensembl chr 9:75,766,770...75,771,084 		JBrowse link
G Edn1 endothelin 1 treatment IEP
IMP		 mRNA, protein:increased expression:glomerulus (rat) RGD PMID:8569091 PMID:11601021 RGD:4144848, RGD:8662296 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Ep300 E1A binding protein p300 treatment IMP RGD PMID:24344329 RGD:9588308 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G F5 coagulation factor V IMP RGD PMID:15172885 RGD:1601118 NCBI chr13:76,513,509...76,583,106
Ensembl chr13:76,513,255...76,582,317 		JBrowse link
G Fn1 fibronectin 1 IEP RGD PMID:10082755 RGD:7206847 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Il1b interleukin 1 beta IDA RGD PMID:21871881 RGD:7175308 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Kcnt2 potassium sodium-activated channel subfamily T member 2 ISO ClinVar Annotator: match by term: Mesangiocapillary glomerulonephritis ClinVar PMID:32581362 NCBI chr13:51,664,129...52,059,209
Ensembl chr13:51,664,686...52,056,987 		JBrowse link
G Myoc myocilin IEP protein:increased expression:renal glomerulus (rat) RGD PMID:15610237 RGD:7401266 NCBI chr13:74,976,730...74,987,128
Ensembl chr13:74,976,730...74,987,127 		JBrowse link
G Pfn1 profilin 1 IDA RGD PMID:8651905 RGD:729497 NCBI chr10:55,365,263...55,367,968
Ensembl chr10:55,365,262...55,527,631 		JBrowse link
G Pon1 paraoxonase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16175651 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Prf1 perforin 1 IEP mRNA:increased expression:glomerulus RGD PMID:10886554 RGD:1599935 NCBI chr20:29,246,202...29,251,712
Ensembl chr20:29,246,202...29,251,701 		JBrowse link
G Sparc secreted protein acidic and cysteine rich IEP mRNA:increased expression:glomerulus RGD PMID:8644857 RGD:2300070 NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 IDA RGD PMID:11703592 RGD:1601601 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
G Tlr1 toll-like receptor 1 ISO mRNA:increased expression:renal glomerulus (mouse) RGD PMID:18256364 RGD:7246909 NCBI chr14:43,384,127...43,396,765
Ensembl chr14:43,384,932...43,397,125 		JBrowse link
G Tlr11 toll-like receptor 11 ISO mRNA:increased expression:renal glomerulus (mouse) RGD PMID:18256364 RGD:7246909 NCBI chr15:23,545,408...23,549,849
Ensembl chr15:23,545,408...23,549,849 		JBrowse link
G Tlr2 toll-like receptor 2 ISO mRNA:increased expression:renal glomerulus (mouse) RGD PMID:18256364 RGD:7246909 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr4 toll-like receptor 4 ISO mRNA:increased expression:renal glomerulus (mouse) RGD PMID:18256364 RGD:7246909 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tlr5 toll-like receptor 5 ISO mRNA:increased expression:renal glomerulus (mouse) RGD PMID:18256364 RGD:7246909 NCBI chr13:94,634,778...94,658,992
Ensembl chr13:94,634,801...94,657,738 		JBrowse link
G Tlr6 toll-like receptor 6 ISO mRNA:increased expression:renal glomerulus (mouse) RGD PMID:18256364 RGD:7246909 NCBI chr14:43,362,164...43,374,500
Ensembl chr14:43,362,164...43,375,685 		JBrowse link
G Tlr7 toll-like receptor 7 ISO mRNA:increased expression:renal glomerulus (mouse) RGD PMID:18256364 RGD:7246909 NCBI chr  X:27,027,380...27,054,309
Ensembl chr  X:27,027,425...27,054,754 		JBrowse link
G Tlr8 toll-like receptor 8 ISO mRNA:increased expression:renal glomerulus (mouse) RGD PMID:18256364 RGD:7246909 NCBI chr  X:27,091,780...27,116,092
Ensembl chr  X:27,091,778...27,116,549 		JBrowse link
G Tlr9 toll-like receptor 9 ISO mRNA:increased expression:renal glomerulus (mouse) RGD PMID:18256364 RGD:7246909 NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796 		JBrowse link
G Tslp thymic stromal lymphopoietin ISO
ISS		 CTD Direct Evidence: marker/mechanism
OMIM:305800		 CTD
MouseDO		 PMID:17686814 NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548 		JBrowse link
C3 Glomerulopathy 3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cfh complement factor H ISO ClinVar Annotator: match by term: C3 GLOMERULOPATHY 3 | ClinVar Annotator: match by term: CFH-Related Dense Deposit Disease / Membranoproliferative Glomerulonephritis Type II ClinVar PMID:8072530 PMID:9536098 PMID:11158219 PMID:11978762 PMID:12424708 More... NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838 		JBrowse link
Glomerulonephritis with Isolated C3 Deposits and Factor H Deficiency term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cfh complement factor H ISO DNA:SNPs,Haplotype:: RGD PMID:17517971 PMID:17517971 RGD:7364995, RGD:7364995 NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838 		JBrowse link
Glomerulopathy with Giant Fibrillar Deposits term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase ISO ClinVar Annotator: match by term: Glomerulopathy with fibronectin deposits 2 ClinVar PMID:25741868 PMID:28492532 PMID:29100092 PMID:32200603 NCBI chr 9:73,164,846...73,184,897
Ensembl chr 9:73,164,846...73,184,889 		JBrowse link
G Fn1 fibronectin 1 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Glomerulopathy with fibronectin deposits 2		 OMIM
CTD
ClinVar		 PMID:1544672 PMID:7564073 PMID:7747733 PMID:9536098 PMID:12042895 More... NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Inf2 inverted formin 2 ISO ClinVar Annotator: match by term: Glomerulopathy with fibronectin deposits 2 ClinVar PMID:25741868 NCBI chr 6:131,649,162...131,675,944
Ensembl chr 6:131,649,211...131,675,941 		JBrowse link
hypotrichosis-lymphedema-telangiectasia-renal defect syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sox18 SRY-box transcription factor 18 ISO ClinVar Annotator: match by term: Hypotrichosis-lymphedema-telangiectasia-renal defect syndrome OMIM
ClinVar		 PMID:2484451 PMID:12740761 PMID:24697860 PMID:25741868 PMID:28492532 More... NCBI chr 3:168,785,488...168,787,290
Ensembl chr 3:168,785,490...168,787,290 		JBrowse link
nephrotic syndrome type 7 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dgke diacylglycerol kinase epsilon ISO ClinVar Annotator: match by term: AHUS, SUSCEPTIBILITY TO, 7 | ClinVar Annotator: match by term: DGKE-related condition | ClinVar Annotator: match by term: Hemolytic uremic syndrome with DGKE deficiency | ClinVar Annotator: match by term: Immunoglobulin-mediated membranoproliferative glomerulonephritis | ClinVar Annotator: match by term: Nephrotic syndrome, type 7 ClinVar
OMIM		 PMID:23274426 PMID:23542698 PMID:24747643 PMID:25135762 PMID:25349199 More... NCBI chr10:73,853,030...73,877,334
Ensembl chr10:73,855,583...73,877,100 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19050
    disease of anatomical entity 18384
      immune system disease 4930
        membranoproliferative glomerulonephritis 40
          C3 Glomerulopathy 3 1
          Glomerulonephritis with Isolated C3 Deposits and Factor H Deficiency 1
          Glomerulonephritis with Isolated C3 Deposits and Factor I Deficiency 0
          Glomerulopathy with Giant Fibrillar Deposits 3
          Membranoproliferative Glomerulonephritis, X-Linked 0
          hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 1
          nephrotic syndrome type 7 1
Path 2
Term Annotations click to browse term
  disease 19050
    disease of anatomical entity 18384
      Urogenital Diseases 5275
        urinary system disease 2830
          kidney disease 2579
            nephritis 488
              glomerulonephritis 427
                mesangial proliferative glomerulonephritis 51
                  Chronic Mesangial Proliferative Glomerulonephritis 42
                    membranoproliferative glomerulonephritis 40
                      C3 Glomerulopathy 3 1
                      Glomerulonephritis with Isolated C3 Deposits and Factor H Deficiency 1
                      Glomerulonephritis with Isolated C3 Deposits and Factor I Deficiency 0
                      Glomerulopathy with Giant Fibrillar Deposits 3
                      Membranoproliferative Glomerulonephritis, X-Linked 0
                      hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 1
                      nephrotic syndrome type 7 1
paths to the root