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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:pancreatic ductal carcinoma
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Accession:DOID:3587 term browser browse the term
Definition:Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.
Synonyms:exact_synonym: Duct Cell Carcinoma of the Pancreas;   Ductal Carcinoma of the Pancreas;   Pancreas Duct-Cell Carcinoma;   Pancreas Duct-Cell Carcinomas;   Pancreatic Duct Cell Carcinoma;   Pancreatic Ductal Carcinomas;   malignant neoplasm of duct of Wirsung;   pancreatic duct cancer
 primary_id: MESH:D021441
 alt_id: RDO:0007458
 xref: ICD10CM:C25.3;   ICD9CM:157.3
For additional species annotation, visit the Alliance of Genome Resources.


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pancreatic ductal carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme ISO mRNA, protein:increased expression:pancreas RGD PMID:17481528 RGD:2325211 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Ace2 angiotensin I converting enzyme 2 ISO protein:decreased expression:pancreas RGD PMID:19212105 RGD:2325210 NCBI chr  X:32,050,734...32,095,860
Ensembl chr  X:32,049,931...32,096,016
JBrowse link
G Adam8 ADAM metallopeptidase domain 8 disease_progression ISO mRNA:increased expression:pancreas RGD PMID:17979891 RGD:2325243 NCBI chr 1:212,317,510...212,332,895
Ensembl chr 1:212,317,848...212,330,349
JBrowse link
G Adam9 ADAM metallopeptidase domain 9 disease_progression ISO protein:altered localization:cytoplasm RGD PMID:14997207 RGD:2325249 NCBI chr16:71,810,377...71,887,926
Ensembl chr16:71,810,377...71,887,926
JBrowse link
G Agr2 anterior gradient 2, protein disulphide isomerase family member ISO mRNA:increased expression:pancreas RGD PMID:19609859 RGD:2325659 NCBI chr 6:55,465,782...55,487,087
Ensembl chr 6:55,465,782...55,487,714
JBrowse link
G Agtr1a angiotensin II receptor, type 1a ISO CTD Direct Evidence: marker/mechanism CTD PMID:17481528 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Alb albumin disease_progression ISO RGD PMID:19011933 RGD:2325677 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Anxa2 annexin A2 disease_progression ISO mRNA, protein:increased expression, altered localization:pancreas, plasma membrane RGD PMID:19260470, PMID:16450333 RGD:2317307, RGD:2325731 NCBI chr 8:75,687,134...75,723,589
Ensembl chr 8:75,687,100...75,723,594
JBrowse link
G Anxa5 annexin A5 ISO protein:increased expression:pancreas RGD PMID:19488907 RGD:2317538 NCBI chr 2:123,162,477...123,194,730
Ensembl chr 2:123,162,461...123,193,130
JBrowse link
G Anxa8 annexin A8 ISO mRNA:increased expression:pancreas RGD PMID:18223320 RGD:2325735 NCBI chr16:10,417,174...10,432,388
Ensembl chr16:10,417,185...10,432,393
JBrowse link
G Apoc1 apolipoprotein C1 ISO RGD PMID:15876873 RGD:2325793 NCBI chr 1:80,606,638...80,609,921
Ensembl chr 1:80,606,638...80,609,921
JBrowse link
G Arg2 arginase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23424623 NCBI chr 6:102,311,097...102,338,406
Ensembl chr 6:102,311,116...102,338,520
JBrowse link
G Bmi1 BMI1 proto-oncogene, polycomb ring finger ISO protein:increased expression:pancreas
protein:increased expression:exocrine pancreas:
RGD PMID:19585519, PMID:19585519 RGD:9491843, RGD:9491843 NCBI chr17:85,360,439...85,370,283
Ensembl chr17:85,364,483...85,368,208
JBrowse link
G Calr calreticulin ISO protein:increased expression:pancreatic duct RGD PMID:15289361 RGD:2326165 NCBI chr19:25,956,771...25,961,666
Ensembl chr19:25,956,771...25,961,666
JBrowse link
G Cbx7 chromobox 7 disease_progression ISO protein:decreased expression:pancreas RGD PMID:20185297 RGD:9587360 NCBI chr 7:121,136,067...121,153,503
Ensembl chr 7:121,136,058...121,153,383
JBrowse link
G Cckar cholecystokinin A receptor ISO mRNA:increased expression:pancreatic duct
protein:decreased expression:pancreas
RGD PMID:9239407, PMID:12851875 RGD:4110818, RGD:4110816 NCBI chr14:59,610,939...59,619,786
Ensembl chr14:59,611,434...59,619,783
JBrowse link
G Cckbr cholecystokinin B receptor ISO protein:decreased expression:pancreas RGD PMID:12851875 RGD:4110816 NCBI chr 1:170,262,218...170,272,298
Ensembl chr 1:170,262,156...170,272,298
JBrowse link
G Ccnd1 cyclin D1 severity ISO protein:increased expression:pancreas (human) RGD PMID:17420962 RGD:13462063 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cd40 CD40 molecule treatment ISO protein:increased expression:dendritic cell RGD PMID:21436454, PMID:23983255, PMID:20976171 RGD:5490301, RGD:11522743, RGD:5490524 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Cdk6 cyclin-dependent kinase 6 treatment ISO human cells in a mouse model RGD PMID:24389175 RGD:13782187 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A disease_progression ISO RGD PMID:17671118 RGD:8662851 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A ISO CTD Direct Evidence: marker/mechanism CTD PMID:24986516 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Cldn4 claudin 4 ISO RGD PMID:15693851 RGD:2317592 NCBI chr12:24,761,210...24,763,008
Ensembl chr12:24,761,210...24,763,005
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24979617 NCBI chr14:17,195,395...17,198,170
Ensembl chr14:17,195,014...17,198,291
JBrowse link
G Dnmt1 DNA methyltransferase 1 disease_progression ISO protein:increased expression:pancreas
CTD Direct Evidence: marker/mechanism
CTD PMID:29844410, PMID:19424621 RGD:9588974 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta disease_progression ISO RGD PMID:22919364 RGD:9589121 NCBI chr 3:149,131,541...149,170,061
Ensembl chr 3:149,131,785...149,208,786
JBrowse link
G Dtx1 deltex E3 ubiquitin ligase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr12:41,383,885...41,415,783
Ensembl chr12:41,385,241...41,414,754
JBrowse link
G Dtx4 deltex E3 ubiquitin ligase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr 1:228,729,842...228,759,783
Ensembl chr 1:228,732,985...228,755,866
JBrowse link
G Egf epidermal growth factor disease_progression ISO protein:increased expression: : RGD PMID:18505086 RGD:2317644 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Faslg Fas ligand ISO protein:increased expression:pancreas, liver RGD PMID:10547193, PMID:15375495 RGD:2317747, RGD:2317741 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fgf2 fibroblast growth factor 2 disease_progression ISO RGD PMID:12717266, PMID:18704599 RGD:2317758, RGD:2317756 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fscn1 fascin actin-bundling protein 1 disease_progression ISO protein:increased expression:pancreas RGD PMID:12109856 RGD:2317790 NCBI chr12:13,655,459...13,668,595
Ensembl chr12:13,656,554...13,668,515
JBrowse link
G Gpnmb glycoprotein nmb ISO CTD Direct Evidence: marker/mechanism CTD PMID:24979617 NCBI chr 4:78,694,447...78,715,685
Ensembl chr 4:78,694,447...78,715,683
JBrowse link
G Gstp1 glutathione S-transferase pi 1 resistance ISO DNA:methylation: :
mRNA, protein:increased expression:pancreas
RGD PMID:16537562, PMID:17265526, PMID:12488200 RGD:2317809, RGD:2317806, RGD:2317811 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hdac1 histone deacetylase 1 disease_progression ISO protein:increased expression:pancreas RGD PMID:19424621 RGD:9588974 NCBI chr 5:147,716,664...147,743,723
Ensembl chr 5:147,716,664...147,743,723
JBrowse link
G Heatr1 HEAT repeat containing 1 treatment ISO RGD PMID:26676747 RGD:10761108 NCBI chr17:66,446,135...66,488,303
Ensembl chr17:66,446,162...66,619,250
JBrowse link
G Hes1 hes family bHLH transcription factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr11:74,312,837...74,315,249
Ensembl chr11:74,312,806...74,315,248
JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr 2:95,320,147...95,322,701
Ensembl chr 2:95,320,283...95,322,696
JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr 1:29,191,170...29,201,257
Ensembl chr 1:29,191,192...29,201,531
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:17234771 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B ISO CTD Direct Evidence: marker/mechanism CTD PMID:17234771 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Igf1 insulin-like growth factor 1 ISO RGD PMID:20098680 RGD:2317639 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igf1r insulin-like growth factor 1 receptor ISO protein:increased expression:pancreas RGD PMID:14627343, PMID:14506643 RGD:2317649, RGD:2317652 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Il4 interleukin 4 ISO RGD PMID:17942922 RGD:2317264 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il4r interleukin 4 receptor ISO protein:increased expression:pancreas RGD PMID:17942922 RGD:2317264 NCBI chr 1:196,942,343...196,967,221
Ensembl chr 1:196,942,364...196,967,220
JBrowse link
G Ins2 insulin 2 ISO Glucagon/insulin RGD PMID:19571666 RGD:2317248 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Jag1 jagged canonical Notch ligand 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr 3:130,079,361...130,114,781
Ensembl chr 3:130,079,361...130,114,770
JBrowse link
G Jag2 jagged canonical Notch ligand 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr 6:137,711,144...137,733,331
Ensembl chr 6:137,711,155...137,733,026
JBrowse link
G Kdm2b lysine demethylase 2B severity ISO mRNA, protein:increased expression:pancreas (human) RGD PMID:23321669 RGD:9588253 NCBI chr12:39,021,924...39,161,954
Ensembl chr12:39,078,119...39,161,956
JBrowse link
G Kitlg KIT ligand ISO CTD Direct Evidence: marker/mechanism CTD PMID:24979617 NCBI chr 7:42,269,784...42,351,054
Ensembl chr 7:42,269,784...42,351,054
JBrowse link
G Kras KRAS proto-oncogene, GTPase ISO CTD Direct Evidence: marker/mechanism CTD PMID:25347530 PMID:30654191 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Krt7 keratin 7 disease_progression ISO RGD PMID:19260470 RGD:2317307 NCBI chr 7:143,059,731...143,075,907
Ensembl chr 7:143,059,764...143,075,907
JBrowse link
G L1cam L1 cell adhesion molecule severity ISO protein:increased expression:pancreas (human) RGD PMID:20162456 RGD:6483447 NCBI chr  X:156,901,244...156,928,064
Ensembl chr  X:156,909,913...156,928,057
JBrowse link
G Mapk3 mitogen activated protein kinase 3 treatment ISO human cells in mouse model RGD PMID:20179210 RGD:14348973 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mcm7 minichromosome maintenance complex component 7 ISO mRNA, protein:increased expression:pancreatic duct RGD PMID:15548371 RGD:2317697 NCBI chr12:19,306,615...19,313,877
Ensembl chr12:19,306,607...19,314,016
JBrowse link
G Mdm2 MDM2 proto-oncogene onset
severity
ISO DNA:snp:promoter, intron:IVS1+309T>G (human)
protein:increased expression:pancreas (human)
RGD PMID:19752772, PMID:15810085 RGD:2317414, RGD:2317416 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Men1 menin 1 ISO protein:decreased expression:pancreas RGD PMID:19170121 RGD:2317294 NCBI chr 1:221,704,394...221,710,343
Ensembl chr 1:221,704,493...221,710,331
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase ISO protein:increased expression:pancreatic duct (human) RGD PMID:7866999 RGD:2317530 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase susceptibility ISO DNA:missense mutation:cds:p.L84F rs12917 (human)
protein:increased activity, increased expression:ductal adenocarcinoma (human)
RGD PMID:16844323, PMID:9393761 RGD:2317648, RGD:2317664 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
JBrowse link
G Mir142 microRNA 142 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29844410 NCBI chr10:75,050,839...75,050,925
Ensembl chr10:75,050,832...75,050,942
JBrowse link
G Mir873 microRNA 873 ISO CTD Direct Evidence: therapeutic CTD PMID:30654191 NCBI chr 5:52,481,076...52,481,152
Ensembl chr 5:52,481,076...52,481,152
JBrowse link
G Mmp2 matrix metallopeptidase 2 severity ISO protein:increased expression:pancreas RGD PMID:17377415 RGD:2325746 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO protein:increased expression:pancreas, serum
protein:increased expression:blood
RGD PMID:18706098, PMID:20332475 RGD:2325844, RGD:2325830 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Msln mesothelin disease_progression ISO protein:increased secretion:serum
CTD Direct Evidence: marker/mechanism
DNA:hypomethylation:5'UTR
CTD PMID:14576474 PMID:21775916 PMID:25347530, PMID:19818733, PMID:12874021 RGD:2326055, RGD:2326065 NCBI chr10:15,119,700...15,129,129
Ensembl chr10:15,119,663...15,125,408
JBrowse link
G Muc1 mucin 1, cell surface associated disease_progression ISO protein:increased expression, altered localization:pancreas RGD PMID:14681945, PMID:19109152, PMID:18713982 RGD:2317983, RGD:2324616, RGD:2324633 NCBI chr 2:188,543,137...188,547,874
Ensembl chr 2:188,543,137...188,547,874
JBrowse link
G Muc3 mucin 3, intestinal disease_progression ISO mRNA:increased expression:pancreas RGD PMID:12657964 RGD:2324946 NCBI chr12:22,535,663...22,584,775 JBrowse link
G Muc4 mucin 4, cell surface associated disease_progression ISO mRNA:increased expression:pancreas
protein:increased expression:pancreas
RGD PMID:12657964, PMID:16049287 RGD:2324946, RGD:2324942 NCBI chr11:71,242,973...71,285,217
Ensembl chr11:71,243,334...71,284,939
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming disease_progression ISO mRNA:increased expression:pancreas RGD PMID:7657125, PMID:10227724 RGD:2324986, RGD:2324907 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Muc5b mucin 5B, oligomeric mucus/gel-forming ISO mRNA:increased expression:pancreas RGD PMID:7657125 RGD:2324986 NCBI chr 1:214,778,459...214,811,237
Ensembl chr 1:214,778,496...214,810,720
JBrowse link
G Ndrg1 N-myc downstream regulated 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16778198 NCBI chr 7:107,734,326...107,775,701
Ensembl chr 7:107,734,323...107,775,714
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21489257 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nme1 NME/NM23 nucleoside diphosphate kinase 1 ISO protein:increased expression:pancreas (human) RGD PMID:17492507 RGD:5132867 NCBI chr10:81,657,152...81,666,542
Ensembl chr10:81,657,153...81,666,523
JBrowse link
G Nos2 nitric oxide synthase 2 ISO RGD PMID:12660813 RGD:2325254 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Notch1 notch receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19208345, PMID:20484026, PMID:19028876 RGD:2325323, RGD:2325324 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
G Notch3 notch receptor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr 7:14,138,495...14,189,688
Ensembl chr 7:14,138,495...14,189,688
JBrowse link
G Notch4 notch receptor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19208345 NCBI chr20:4,329,794...4,353,868
Ensembl chr20:4,329,811...4,353,785
JBrowse link
G Ntrk3 neurotrophic receptor tyrosine kinase 3 disease_progression ISO protein:increased expression:pancreas RGD PMID:11295066, PMID:10209957 RGD:2325660, RGD:2325663 NCBI chr 1:139,890,537...140,262,503
Ensembl chr 1:139,890,560...140,262,503
JBrowse link
G Osm oncostatin M ISO CTD Direct Evidence: marker/mechanism CTD PMID:24979617 NCBI chr14:84,457,487...84,469,426
Ensembl chr14:84,465,515...84,470,409
JBrowse link
G Palld palladin, cytoskeletal associated protein ISO protein:increased expression, alternative form:pancreas, fibroblast RGD PMID:17404500 RGD:2325781 NCBI chr16:31,865,712...31,948,168 JBrowse link
G Pax6 paired box 6 ISO protein:increased expression:pancreatic duct (human) RGD PMID:17849422 RGD:8552381 NCBI chr 3:95,700,241...95,728,682
Ensembl chr 3:95,707,386...95,728,624
JBrowse link
G Pms1 PMS1 homolog 1, mismatch repair system component ISO protein:increased expression:pancreatic duct RGD PMID:15856462 RGD:2324870 NCBI chr 9:53,120,656...53,206,520
Ensembl chr 9:53,120,656...53,206,516
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma disease_progression ISO RGD PMID:19396032 RGD:2317461 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO RGD PMID:18670639 RGD:2317185 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rnf2 ring finger protein 2 ISO protein:increased expression:pancreas RGD PMID:19585519 RGD:9491843 NCBI chr13:68,829,714...68,859,920
Ensembl chr13:68,830,620...68,858,809
JBrowse link
G Rxra retinoid X receptor alpha severity ISO RGD PMID:19396032 RGD:2317461 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Serpina1 serpin family A member 1 ISO mRNA, protein:increased expression:pancreas RGD PMID:12488200 RGD:2317811 NCBI chr 6:127,610,241...127,632,265
Ensembl chr 6:127,610,243...127,632,265
JBrowse link
G Slc2a2 solute carrier family 2 member 2 ISO protein:increased expression:pancreatic duct RGD PMID:19252908 RGD:2324975 NCBI chr 2:114,413,427...114,445,418
Ensembl chr 2:114,413,410...114,445,395
JBrowse link
G Smad4 SMAD family member 4 disease_progression ISO RGD PMID:15173084 RGD:21066334 NCBI chr18:69,626,682...69,657,373
Ensembl chr18:69,627,757...69,671,199
JBrowse link
G Smo smoothened, frizzled class receptor ISO RGD PMID:16826192 RGD:2324981 NCBI chr 4:57,019,941...57,041,779
Ensembl chr 4:57,019,941...57,042,770
JBrowse link
G Stk11 serine/threonine kinase 11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26887594 NCBI chr 7:12,440,751...12,457,513
Ensembl chr 7:12,440,751...12,457,513
JBrowse link
G Tgfb1 transforming growth factor, beta 1 disease_progression ISO RGD PMID:16101174 RGD:2325019 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 disease_progression ISO mRNA:increased expresssion:pancreas RGD PMID:17114585, PMID:10547197 RGD:2317498, RGD:2317500 NCBI chr 8:124,310,288...124,399,345
Ensembl chr 8:124,312,754...124,399,494
JBrowse link
G Thbs1 thrombospondin 1 disease_progression ISO DNA:hypermethylation:promoter (human) RGD PMID:12429967, PMID:19065635 RGD:2325025, RGD:2325022 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
JBrowse link
G Tmprss3 transmembrane serine protease 3 ISO RGD PMID:14695172 RGD:2325152 NCBI chr20:9,910,522...9,929,705
Ensembl chr20:9,910,522...9,929,705
JBrowse link
G Tp53 tumor protein p53 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29844410 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tsc2 TSC complex subunit 2 severity ISO RGD PMID:16213898 RGD:11568674 NCBI chr10:13,962,006...13,996,684
Ensembl chr10:13,961,947...13,996,584
JBrowse link
G Tymp thymidine phosphorylase disease_progression ISO RGD PMID:19760965 RGD:2325155 NCBI chr 7:130,342,481...130,347,845
Ensembl chr 7:130,342,483...130,347,587
JBrowse link
G Vegfa vascular endothelial growth factor A ISO CTD Direct Evidence: marker/mechanism CTD PMID:17481528 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vhl von Hippel-Lindau tumor suppressor ISO DNA:hypermethylation:promoter (human) RGD PMID:19065635 RGD:2325022 NCBI chr 4:145,580,869...145,587,835
Ensembl chr 4:145,580,799...145,587,845
JBrowse link
pancreatic ductal adenocarcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agr2 anterior gradient 2, protein disulphide isomerase family member ISO protein:increased expression:pancreas RGD PMID:19714807 RGD:2325658 NCBI chr 6:55,465,782...55,487,087
Ensembl chr 6:55,465,782...55,487,714
JBrowse link
G Akr7a2 aldo-keto reductase family 7, member A2 ISO protein:increased expression:pancreas RGD PMID:19077459 RGD:2325696 NCBI chr 5:157,759,448...157,768,473
Ensembl chr 5:157,759,416...157,768,471
JBrowse link
G Ccnd1 cyclin D1 severity ISO DNA:snp:exon:c.870G>A (human)
protein:increased expression:pancreas (human)
RGD PMID:25470788, PMID:22939953 RGD:13462050, RGD:13462062 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdk4 cyclin-dependent kinase 4 severity ISO protein:increased expression:pancreas, islet of Langerhans (human) RGD PMID:29735403 RGD:13781899 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G E2f1 E2F transcription factor 1 severity ISO protein:increased expression:pancreatic ductal cell, nucleus (human)
DNA:amplification: : (human)
RGD PMID:12650514, PMID:17233815, PMID:27573434 RGD:13838735, RGD:13838739, RGD:13838738 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 treatment ISO human cells in a mouse model RGD PMID:23535601 RGD:13504844 NCBI chr 1:263,246,248...263,269,762
Ensembl chr 1:263,246,248...263,269,762
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta susceptibility ISO RGD PMID:22264792 RGD:13838741 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Jak1 Janus kinase 1 ISO mRNA:decreased expression:pancreatic ductal cell (human) RGD PMID:28677798 RGD:13838745 NCBI chr 5:119,982,503...120,091,452
Ensembl chr 5:119,982,943...120,083,904
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 severity
disease_progression
ISO protein:increased phosphorylation:pancreas (mouse) RGD PMID:28837246, PMID:23237571 RGD:14348974, RGD:14348975 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mir155 microRNA 155 disease_progression ISO RGD PMID:28198398 RGD:25314300 NCBI chr11:24,176,603...24,176,667
Ensembl chr11:24,176,603...24,176,667
JBrowse link
G Pgf placental growth factor severity ISO associated with obesity RGD PMID:26861455 RGD:14349030 NCBI chr 6:108,994,016...109,004,598
Ensembl chr 6:108,994,018...109,004,598
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma ISO mRNA, protein:increased expression:pancreas (human) RGD PMID:20876794 RGD:14390130 NCBI chr 6:51,465,696...51,501,234
Ensembl chr 6:51,465,908...51,498,337
JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 severity ISO human cells in a mouse model RGD PMID:15591514 RGD:14390084 NCBI chr16:20,415,109...20,424,982
Ensembl chr16:20,416,432...20,424,980
JBrowse link
G Pld1 phospholipase D1 severity ISO protein:increased expression:pancreas (human) RGD PMID:27713167 RGD:14392801 NCBI chr 2:113,651,967...113,849,403
Ensembl chr 2:113,652,348...113,849,403
JBrowse link
G Rac1 Rac family small GTPase 1 ISO mRNA:increased expression:pancreas (human)
mRNA, protein:increased expression:pancreas (mouse)
RGD PMID:23334332, PMID:21684285 RGD:14392806, RGD:14392816 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Rala RAS like proto-oncogene A ISO mRNA:increased expression:pancreas (human) RGD PMID:29113235 RGD:14394418 NCBI chr17:49,676,073...49,729,133
Ensembl chr17:49,714,294...49,727,664
JBrowse link
G Smad2 SMAD family member 2 severity ISO RGD PMID:26908446 RGD:14394493 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16122
    disease of cellular proliferation 5907
      cancer 3745
        cell type cancer 2575
          carcinoma 2068
            pancreatic carcinoma 155
              pancreatic ductal carcinoma 114
                pancreatic ductal adenocarcinoma + 17
Path 2
Term Annotations click to browse term
  disease 16122
    disease of cellular proliferation 5907
      cancer 3745
        organ system cancer 3596
          endocrine gland cancer 1458
            pancreatic cancer 380
              pancreatic carcinoma 155
                pancreatic ductal carcinoma 114
                  pancreatic ductal adenocarcinoma + 17
paths to the root