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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Oral Lichen Planus
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Accession:DOID:9003036 term browser browse the term
Definition:Oral lesions accompanying cutaneous lichen planus or often occurring alone. The buccal mucosa, lips, gingivae, floor of the mouth, and palate are usually affected (in a descending order of frequency). Typically, oral lesions consist of radiating white or gray, velvety, threadlike lines, arranged in a reticular pattern, at the intersection of which there may be minute, white, elevated dots or streaks (Wickham's striae). (Jablonski, Illustrated Dictionary of Dentistry)
Synonyms:primary_id: MESH:D017676
 xref: EFO:0008517


show annotations for term's descendants           Sort by:
Oral Lichen Planus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 ISO protein:increased expression:mouth mucosa: RGD PMID:16393252 RGD:9068457 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 ISO RGD PMID:16454813 RGD:7483584 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 ISO protein:increased expression:blood, T cell RGD PMID:23490419 RGD:8551821 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260 		JBrowse link
G Ccr6 C-C motif chemokine receptor 6 ISO RGD PMID:16454813 RGD:7483584 NCBI chr 1:52,474,477...52,508,301
Ensembl chr 1:52,474,168...52,498,603 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A ISO protein:increased expression:mucosa: RGD PMID:12076323 RGD:8662419 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Dnmt1 DNA methyltransferase 1 ISO protein:increased expression:mouth mucosa: RGD PMID:22236544 RGD:9589075 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659 		JBrowse link
G Dnmt3b DNA methyltransferase 3 beta susceptibility ISO protein:increased expression:mouth mucosa:
DNA:polymorphism: :C46359T(human)		 RGD PMID:22236544 PMID:22236544 RGD:9589075, RGD:9589075 NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124 		JBrowse link
G Il18 interleukin 18 no_association ISO DNA:SNPs, haplotypes:promoter:-137G>C (rs187238), -607C>A (rs1946518) (human)
DNA:SNPs:promoter, intron:-656G>T (rs1946519), 1248A>G (rs189667) (human)		 RGD PMID:17854431 PMID:17854431 RGD:8655868, RGD:8655868 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1a interleukin 1 alpha treatment ISO RGD PMID:16476030 RGD:7794728 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il2 interleukin 2 ISO RGD PMID:1666936 RGD:8693327 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Mir155 microRNA 155 ISO miRNA:increased expression:blood RGD PMID:29813046 PMID:29276184 RGD:21081545, RGD:24922205 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718 		JBrowse link
G Mir19a microRNA 19a ISO RGD PMID:29813046 RGD:21081545 NCBI chr15:92,180,912...92,180,993
Ensembl chr15:92,180,912...92,180,993 		JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO RGD PMID:22554030 RGD:8656000 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Tlr2 toll-like receptor 2 ISO protein:increased expression:monocyte,buccal mucosa: RGD PMID:21544941 RGD:8553047 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr4 toll-like receptor 4 ISO protein:increased expression:oral epithelium: RGD PMID:22672741 RGD:7777153 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tlr9 toll-like receptor 9 ISO protein:increased expression:oral epithelium: RGD PMID:22672741 RGD:7777153 NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796 		JBrowse link
G Tp53 tumor protein p53 ISO DNA:mutations: :
protein:increased expression:epithelium		 RGD PMID:12120703 PMID:16393253 RGD:8547838, RGD:8547841 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 21128
    sensory system disease 6940
      mouth disease 1012
        Oral Lichen Planus 17
Path 2
Term Annotations click to browse term
  disease 21128
    Pathological Conditions, Signs and Symptoms 13331
      Signs and Symptoms 10807
        Neurologic Manifestations 10039
          sensory system disease 6940
            skin disease 3960
              Papulosquamous Skin Diseases 169
                lichen disease 26
                  lichen planus 23
                    Oral Lichen Planus 17
paths to the root