Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:varicocele
go back to main search page
Accession:DOID:12337 term browser browse the term
Definition:A condition characterized by the dilated tortuous veins of the SPERMATIC CORD with a marked left-sided predominance. Adverse effect on male fertility occurs when varicocele leads to an increased scrotal (and testicular) temperature and reduced testicular volume.
Synonyms:exact_synonym: Scrotal varices;   Varicoceles
 primary_id: MESH:D014646;   RDO:0006802
 xref: ICD10CM:I86.1;   ICD9CM:456.4
For additional species annotation, visit the Alliance of Genome Resources.



show annotations for term's descendants           Sort by:
 
varicocele term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp9 caspase 9 IEP protein:increased expression:testis RGD PMID:19145435 RGD:2311432 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Fas Fas cell surface death receptor IEP protein:decreased expression:Leydig cell, spermatid RGD PMID:16616089 RGD:1600348 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha IEP protein:increased expression:epididymus (rat) RGD PMID:25095617 RGD:9068459 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmox1 heme oxygenase 1 severity ISO RGD PMID:15878918 RGD:1598403 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 IEP mRNA:increased expression:spermatid RGD PMID:15804863 RGD:1624240 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
JBrowse link
G Il1a interleukin 1 alpha IEP protein:increased expression:testis RGD PMID:16616101 RGD:2311094 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta IEP protein:increased expression:testis RGD PMID:16616101 RGD:2311094 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17427
    disease of anatomical entity 16758
      cardiovascular system disease 4538
        vascular disease 3457
          varicocele 7
Path 2
Term Annotations click to browse term
  disease 17427
    disease of anatomical entity 16758
      cardiovascular system disease 4538
        vascular disease 3457
          vein disease 111
            varicose veins 22
              pelvic varices 8
                varicocele 7
paths to the root