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ONTOLOGY REPORT - ANNOTATIONS


Term:Kaposi's sarcoma
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Accession:DOID:8632 term browser browse the term
Definition:A multicentric, malignant neoplastic vascular proliferation characterized by the development of bluish-red cutaneous nodules, usually on the lower extremities, most often on the toes or feet, and slowly increasing in size and number and spreading to more proximal areas. The tumors have endothelium-lined channels and vascular spaces admixed with variably sized aggregates of spindle-shaped cells, and often remain confined to the skin and subcutaneous tissue, but widespread visceral involvement may occur. Kaposi's sarcoma occurs spontaneously in Jewish and Italian males in Europe and the United States. An aggressive variant in young children is endemic in some areas of Africa. A third form occurs in about 0.04% of kidney transplant patients. There is also a high incidence in AIDS patients. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, pp2105-7) HHV-8 is the suspected cause.
Synonyms:exact_synonym: KAPOSI SARCOMA, SUSCEPTIBILITY TO;   Kaposi sarcoma;   Kaposi's sarcoma of anus;   Kaposi's sarcoma of conjunctiva;   Kaposi's sarcoma of cornea;   Kaposi's sarcoma of esophagus;   Kaposi's sarcoma of gastrointestinal sites;   Kaposi's sarcoma of lung;   Kaposi's sarcoma of lymph nodes;   Kaposi's sarcoma of palate;   Kaposi's sarcoma of penis;   Kaposi's sarcoma of skin;   Kaposi's sarcoma of soft tissue;   Kaposi's sarcoma of soft tissues;   Kaposi's sarcoma of the CNS;   Kaposi's sarcoma of the gallbladder;   Kaposi's sarcoma of the prostate;   Kaposi's sarcoma, lung;   Kaposi's sarcoma, skin;   Kaposis sarcoma;   anal Kaposi's sarcoma;   cardiac Kaposi's sarcoma;   central nervous system Kaposi's sarcoma;   conjunctival Kaposi's sarcoma;   corneal Kaposi's sarcoma;   cutaneous Kaposi's sarcoma;   esophageal Kaposi's sarcoma;   gallbladder Kaposi's sarcoma;   gastric Kaposi's sarcoma;   intestinal Kaposi's sarcoma;   lymph node Kaposi's sarcoma;   lymphadenopathic Kaposi's sarcoma;   multiple idiopathic pigmented hemangiosarcoma;   palate Kaposi's sarcoma;   penis Kaposi's sarcoma;   prostate Kaposi's sarcoma;   pulmonary Kaposi's sarcoma;   soft tissue Kaposi's sarcoma
 narrow_synonym: Kaposi's sarcoma of central nervous system;   Kaposi's sarcoma of heart;   MCD;   MULTIPLE IDIOPATHIC PIGMENTED HEMANGIOSARCOMA, SUSCEPTIBILITY TO MULTICENTRIC CASTLEMAN DISEASE, SUSCEPTIBILITY TO
 related_synonym: African lymphadenopathic Kaposi's sarcoma;   Kaposi's sarcoma-associated herpesvirus (KSHV)
 primary_id: MESH:D012514
 alt_id: OMIM:148000;   RDO:0002749
 xref: GARD:6814;   ICD10CM:C46;   ICD10CM:C46.0;   ICD10CM:C46.1;   ICD10CM:C46.2;   ICD10CM:C46.3;   ICD10CM:C46.4;   ICD10CM:C46.5;   ICD10CM:C46.9;   ICD9CM:176;   ICD9CM:176.0;   ICD9CM:176.1;   ICD9CM:176.2;   ICD9CM:176.3;   ICD9CM:176.4;   ICD9CM:176.5;   ICD9CM:176.9;   NCI:C27500;   NCI:C3550;   NCI:C3551;   NCI:C4578;   NCI:C4579;   NCI:C5363;   NCI:C5523;   NCI:C5529;   NCI:C5602;   NCI:C5706;   NCI:C5842;   NCI:C6377;   NCI:C6749;   NCI:C7006;   NCI:C9087
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Kaposi's sarcoma term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:8554872
RGD:11554173
RGD:7240710
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:1331525
AIDS-Related Kaposi Sarcoma term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:11554173
Kaposiform Hemangioendothelioma term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fgf2 fibroblast growth factor 2 JBrowse link 2 124,081,072 124,134,133 RGD:8655667
G Gna14 G protein subunit alpha 14 JBrowse link 1 235,165,775 235,347,986 RGD:8554872

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15609
    disease of cellular proliferation 5822
      Neoplasms by Histologic Type 3638
        Vascular Tissue Neoplasms 124
          Kaposi's sarcoma 5
            AIDS-Related Kaposi Sarcoma 1
            Kaposiform Hemangioendothelioma 2
            Non-AIDS-Related Kaposi Sarcoma 0
            rectum Kaposi's sarcoma 0
Path 2
Term Annotations click to browse term
  disease 15609
    disease of anatomical entity 14966
      Skin and Connective Tissue Diseases 5231
        connective tissue disease 3934
          Connective Tissue Neoplasms 1360
            connective tissue cancer 1254
              Kaposi's sarcoma 5
                AIDS-Related Kaposi Sarcoma 1
                Kaposiform Hemangioendothelioma 2
                Non-AIDS-Related Kaposi Sarcoma 0
                rectum Kaposi's sarcoma 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.