PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: Toll-like receptor signaling pathway
Accession: PW:0000814
browse the term
Definition: Toll-like receptors represent a large and the better understood family of pattern recognition receptors that sense an array of exogenous structures, and recent evidence shows they can also recognize defective endogenous molecules. The intracellular signaling cascades they set in motion lead to the expression of inflammatory mediators.
Synonyms: related_synonym: TLR signaling pathway; Toll-Like Receptors Cascades
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Akt1
AKT serine/threonine kinase 1
IEA
KEGG
rno:04620
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
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Akt2
AKT serine/threonine kinase 2
IEA
KEGG
rno:04620
NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:82,883,547...82,933,817
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Akt3
AKT serine/threonine kinase 3
IEA
KEGG
rno:04620
NCBI chr13:91,475,839...91,758,060
Ensembl chr13:88,946,091...89,225,708
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Casp8
caspase 8
IEA
KEGG
rno:04620
NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542
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Ccl3
C-C motif chemokine ligand 3
IEA
KEGG
rno:04620
NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,451,388...68,452,938
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Ccl5
C-C motif chemokine ligand 5
IEA
KEGG
rno:04620
NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377
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Cd14
CD14 molecule
IEA ISO
KEGG RGD
PMID:22119168
rno:04620, RGD:7247704
NCBI chr18:28,609,558...28,611,409
Ensembl chr18:28,335,340...28,337,261
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Cd40
CD40 molecule
IEA
KEGG
rno:04620
NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:153,790,449...153,805,534
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Cd80
Cd80 molecule
IEA
KEGG
rno:04620
NCBI chr11:75,760,073...75,798,978
Ensembl chr11:62,254,624...62,292,030
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Cd86
CD86 molecule
IEA
KEGG
rno:04620
NCBI chr11:77,647,565...77,706,178
Ensembl chr11:64,163,828...64,200,818
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Chuk
component of inhibitor of nuclear factor kappa B kinase complex
IEA
KEGG
rno:04620
NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:242,959,760...242,995,065
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Ctsk
cathepsin K
IEA
KEGG
rno:04620
NCBI chr 2:185,747,548...185,758,512
Ensembl chr 2:183,058,569...183,069,550
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Cxcl10
C-X-C motif chemokine ligand 10
IEA
KEGG
rno:04620
NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,704,758...15,706,975
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Cxcl11
C-X-C motif chemokine ligand 11
IEA
KEGG
rno:04620
NCBI chr14:15,973,728...15,976,503
Ensembl chr14:15,689,424...15,692,271
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Cxcl9
C-X-C motif chemokine ligand 9
IEA
KEGG
rno:04620
NCBI chr14:16,007,166...16,012,077
Ensembl chr14:15,722,908...15,728,435
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Fadd
Fas associated via death domain
IEA
KEGG
rno:04620
NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:199,739,994...199,745,653
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
IEA
KEGG
rno:04620
NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036
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Ifna1
interferon, alpha 1
IEA
KEGG
rno:04620
NCBI chr 5:108,143,240...108,143,809
Ensembl chr 5:103,097,356...103,097,925
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Ifna2
interferon alpha 2
IEA
KEGG
rno:04620
NCBI chr 5:103,258,617...103,259,195
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Ifna4
interferon, alpha 4
IEA
KEGG
rno:04620
NCBI chr 5:108,115,064...108,116,010
Ensembl chr 5:103,069,483...103,070,052
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Ifna4l1
interferon, alpha 4 like 1
IEA
KEGG
rno:04620
NCBI chr 5:108,640,546...108,641,115
Ensembl chr 5:103,524,733...103,525,302
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Ifna5
interferon, alpha 5
IEA
KEGG
rno:04620
NCBI chr 5:108,233,736...108,234,314
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Ifnar1
interferon alpha and beta receptor subunit 1
IEA
KEGG
rno:04620
NCBI chr11:44,211,769...44,238,206
Ensembl chr11:30,725,790...30,749,979
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Ifnb1
interferon beta 1
IEA
KEGG
rno:04620
NCBI chr 5:108,066,650...108,067,487
Ensembl chr 5:103,020,969...103,021,523
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Ikbkb
inhibitor of nuclear factor kappa B kinase subunit beta
IEA
KEGG
rno:04620
NCBI chr16:76,021,968...76,075,717
Ensembl chr16:69,319,554...69,373,250
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Ikbke
inhibitor of nuclear factor kappa B kinase subunit epsilon
IEA
KEGG
rno:04620
NCBI chr13:45,264,404...45,290,737
Ensembl chr13:42,712,159...42,737,143
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Ikbkg
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
IEA
KEGG
rno:04620
NCBI chr X:157,358,279...157,397,563
Ensembl chr X:152,216,596...152,239,499
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Il12a
interleukin 12A
IEA
KEGG
rno:04620
NCBI chr 2:155,275,734...155,282,997
Ensembl chr 2:152,965,769...152,972,734
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Il12b
interleukin 12B
IEA
KEGG
rno:04620
NCBI chr10:29,390,300...29,405,194
Ensembl chr10:28,893,008...28,902,903
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Il1b
interleukin 1 beta
IEA
KEGG
rno:04620
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
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Il6
interleukin 6
IEA
KEGG
rno:04620
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
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Irak1
interleukin-1 receptor-associated kinase 1
ISO IEA
KEGG RGD
PMID:21235323
rno:04620, RGD:5685014
NCBI chr X:156,919,927...156,929,825
Ensembl chr X:151,768,777...151,778,521
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Irak2
interleukin-1 receptor-associated kinase 2
ISO
RGD
PMID:21235323
RGD:5685014
NCBI chr 4:148,341,704...148,398,211
Ensembl chr 4:146,786,100...146,842,602
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Irak3
interleukin-1 receptor-associated kinase 3
ISO
RGD
PMID:28954388
RGD:34888230
NCBI chr 7:57,538,522...57,600,166
Ensembl chr 7:55,653,962...55,713,121
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Irak4
interleukin-1 receptor-associated kinase 4
ISO IEA
KEGG RGD
PMID:21235323
rno:04620, RGD:5685014
NCBI chr 7:127,561,777...127,588,762
Ensembl chr 7:125,682,488...125,717,837
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Irf3
interferon regulatory factor 3
ISO IEA
KEGG RGD
PMID:21235323
rno:04620, RGD:5685014
NCBI chr 1:104,616,608...104,621,402
Ensembl chr 1:95,479,821...95,484,935
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Irf5
interferon regulatory factor 5
IEA
KEGG
rno:04620
NCBI chr 4:59,092,914...59,104,596
Ensembl chr 4:58,127,640...58,139,267
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Irf7
interferon regulatory factor 7
IEA
KEGG
rno:04620
NCBI chr 1:205,796,956...205,800,543
Ensembl chr 1:196,367,361...196,370,832
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
IEA
KEGG
rno:04620
NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656
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Lbp
lipopolysaccharide binding protein
IEA ISO
KEGG RGD
PMID:22119168
rno:04620, RGD:7247704
NCBI chr 3:167,373,786...167,400,941
Ensembl chr 3:146,954,015...146,981,586
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Ly96
lymphocyte antigen 96
ISO IEA
KEGG RGD
PMID:21741580 PMID:22119168
rno:04620, RGD:5685019 , RGD:7247704
NCBI chr 5:7,365,536...7,397,864
Ensembl chr 5:2,582,254...2,612,386
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Map2k1
mitogen activated protein kinase kinase 1
IEA
KEGG
rno:04620
NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:64,683,449...64,755,147
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Map2k2
mitogen activated protein kinase kinase 2
IEA
KEGG
rno:04620
NCBI chr 7:9,241,449...9,264,216
Ensembl chr 7:8,580,905...8,610,243
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Map2k3
mitogen activated protein kinase kinase 3
IEA
KEGG
rno:04620
NCBI chr10:46,107,639...46,128,986
Ensembl chr10:45,607,163...45,629,492
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Map2k4
mitogen activated protein kinase kinase 4
IEA
KEGG
rno:04620
NCBI chr10:50,842,348...50,947,063
Ensembl chr10:50,344,915...50,447,993
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Map2k6
mitogen-activated protein kinase kinase 6
IEA
KEGG
rno:04620
NCBI chr10:95,872,747...95,987,747
Ensembl chr10:95,373,204...95,488,293
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Map2k7
mitogen activated protein kinase kinase 7
IEA
KEGG
rno:04620
NCBI chr12:7,389,032...7,398,377
Ensembl chr12:2,591,219...2,604,222
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Map3k7
mitogen activated protein kinase kinase kinase 7
ISO IEA
KEGG RGD
PMID:21235323
rno:04620, RGD:5685014
NCBI chr 5:51,149,524...51,212,012
Ensembl chr 5:46,357,931...46,415,597
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Map3k8
mitogen-activated protein kinase kinase kinase 8
IEA
KEGG
rno:04620
NCBI chr17:58,078,175...58,098,455
Ensembl chr17:53,383,131...53,403,216
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Mapk1
mitogen activated protein kinase 1
IEA
KEGG
rno:04620
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
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Mapk10
mitogen activated protein kinase 10
IEA
KEGG
rno:04620
NCBI chr14:6,802,247...7,094,103
Ensembl chr14:6,497,707...6,786,201
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Mapk11
mitogen-activated protein kinase 11
IEA
KEGG
rno:04620
NCBI chr 7:122,098,120...122,105,023
Ensembl chr 7:120,218,478...120,225,395
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Mapk12
mitogen-activated protein kinase 12
IEA
KEGG
rno:04620
NCBI chr 7:122,085,647...122,096,307
Ensembl chr 7:120,206,271...120,216,664
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Mapk13
mitogen activated protein kinase 13
IEA
KEGG
rno:04620
NCBI chr20:6,836,979...6,847,197
Ensembl chr20:6,835,320...6,844,222
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Mapk14
mitogen activated protein kinase 14
IEA
KEGG
rno:04620
NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,749,670...6,810,589
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Mapk3
mitogen activated protein kinase 3
IEA
KEGG
rno:04620
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
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Mapk8
mitogen-activated protein kinase 8
IEA
KEGG
rno:04620
NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981
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Mapk9
mitogen-activated protein kinase 9
IEA
KEGG
rno:04620
NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,169,675...34,210,178
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Myd88
MYD88, innate immune signal transduction adaptor
ISO IEA
KEGG RGD
PMID:21235323
rno:04620, RGD:5685014
NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:119,074,437...119,079,415
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Nfkb1
nuclear factor kappa B subunit 1
IEA
KEGG
rno:04620
NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404
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Nfkbia
NFKB inhibitor alpha
IEA
KEGG
rno:04620
NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941
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Pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
IEA
KEGG
rno:04620
NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:115,174,984...115,249,032
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Pik3cb
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
IEA
KEGG
rno:04620
NCBI chr 8:108,474,017...108,579,140
Ensembl chr 8:99,594,644...99,699,663
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Pik3cd
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
IEA
KEGG
rno:04620
NCBI chr 5:165,377,994...165,426,620
Ensembl chr 5:160,094,952...160,120,930
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Pik3r1
phosphoinositide-3-kinase regulatory subunit 1
IEA
KEGG
rno:04620
NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:32,882,032...32,963,631
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Pik3r2
phosphoinositide-3-kinase regulatory subunit 2
IEA
KEGG
rno:04620
NCBI chr16:18,699,389...18,708,045
Ensembl chr16:18,665,457...18,674,065
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Pik3r3
phosphoinositide-3-kinase regulatory subunit 3
IEA
KEGG
rno:04620
NCBI chr 5:134,936,790...135,009,303
Ensembl chr 5:129,701,229...129,772,583
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Pik3r5
phosphoinositide-3-kinase, regulatory subunit 5
IEA
KEGG
rno:04620
NCBI chr10:53,631,469...53,699,550
Ensembl chr10:53,132,603...53,199,374
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Rac1
Rac family small GTPase 1
IEA
KEGG
rno:04620
NCBI chr12:16,150,411...16,170,864
Ensembl chr12:11,036,698...11,057,251
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Rela
RELA proto-oncogene, NF-kB subunit
IEA
KEGG
rno:04620
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
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Ripk1
receptor interacting serine/threonine kinase 1
ISO IEA
KEGG RGD
PMID:21235323
rno:04620, RGD:5685014
NCBI chr17:31,044,983...31,077,167
Ensembl chr17:30,839,650...30,871,824
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Spp1
secreted phosphoprotein 1
IEA
KEGG
rno:04620
NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,308,885...5,315,162
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Stat1
signal transducer and activator of transcription 1
IEA
KEGG
rno:04620
NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:49,419,340...49,588,540
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Tab1
TGF-beta activated kinase 1/MAP3K7 binding protein 1
ISO
RGD
PMID:20940366
RGD:5685016
NCBI chr 7:113,556,157...113,587,351
Ensembl chr 7:111,686,371...111,707,058
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Tab2
TGF-beta activated kinase 1/MAP3K7 binding protein 2
ISO
RGD
PMID:20940366
RGD:5685016
NCBI chr 1:4,195,400...4,245,485
Ensembl chr 1:2,375,490...2,424,756
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Tab3
TGF-beta activated kinase 1 (MAP3K7) binding protein 3
ISO
RGD
PMID:20940366
RGD:5685016
NCBI chr X:53,923,473...53,995,777
Ensembl chr X:49,972,330...50,042,056
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Tbk1
TANK-binding kinase 1
ISO IEA
KEGG RGD
PMID:21235323
rno:04620, RGD:5685014
NCBI chr 7:58,963,319...58,996,357
Ensembl chr 7:57,077,830...57,110,892
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Ticam1
TIR domain containing adaptor molecule 1
ISO
RGD
PMID:21235323
RGD:5685014
NCBI chr 9:1,189,717...1,197,730
Ensembl chr 9:1,102,366...1,123,147
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Ticam2
TIR domain containing adaptor molecule 2
ISO IEA
KEGG RGD
PMID:21235323
rno:04620, RGD:5685014
NCBI chr18:41,481,057...41,498,065
Ensembl chr18:39,294,453...39,311,462
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Tirap
TIR domain containing adaptor protein
ISO IEA
KEGG RGD
PMID:21235323
rno:04620, RGD:5685014
NCBI chr 8:41,789,557...41,805,903
Ensembl chr 8:33,531,725...33,547,432
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Tlr1
toll-like receptor 1
IDA ISO
RGD
PMID:16973131 PMID:21235323
RGD:1643119 , RGD:5685014
NCBI chr14:43,737,761...43,750,389
Ensembl chr14:43,384,932...43,397,125
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Tlr2
toll-like receptor 2
IDA IMP ISO IEA
KEGG RGD
PMID:16973131 PMID:18353287 PMID:21235323
rno:04620, RGD:1643119 , RGD:5684896 , RGD:5685014
NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:169,197,419...169,206,630
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Tlr3
toll-like receptor 3
IDA ISO IEA
KEGG RGD
PMID:16973131 PMID:21235323
rno:04620, RGD:1643119 , RGD:5685014
NCBI chr16:53,554,916...53,572,321
Ensembl chr16:46,822,039...46,836,545
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Tlr4
toll-like receptor 4
IDA ISO IEA
KEGG RGD
PMID:16973131 PMID:21235323 PMID:22119168
rno:04620, RGD:1643119 , RGD:5685014 , RGD:7247704
NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628
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Tlr5
toll-like receptor 5
IDA ISO IEA
KEGG RGD
PMID:16973131 PMID:21235323
rno:04620, RGD:1643119 , RGD:5685014
NCBI chr13:97,166,430...97,190,642
Ensembl chr13:94,634,801...94,657,738
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Tlr6
toll-like receptor 6
IDA IMP ISO IEA
KEGG RGD
PMID:16973131 PMID:18353287 PMID:21235323
rno:04620, RGD:1643119 , RGD:5684896 , RGD:5685014
NCBI chr14:43,715,809...43,727,019
Ensembl chr14:43,362,164...43,375,685
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Tlr7
toll-like receptor 7
ISO IEA
KEGG RGD
PMID:21235323
rno:04620, RGD:5685014
NCBI chr X:30,644,324...30,670,796
Ensembl chr X:27,027,425...27,054,754
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Tlr8
toll-like receptor 8
ISO IEA
KEGG RGD
PMID:21235323
rno:04620, RGD:5685014
NCBI chr X:30,708,714...30,733,104
Ensembl chr X:27,091,778...27,116,549
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Tlr9
toll-like receptor 9
IDA ISO IEA
KEGG RGD
PMID:16973131 PMID:21235323
rno:04620, RGD:1643119 , RGD:5685014
NCBI chr 8:115,743,407...115,747,523
Ensembl chr 8:106,864,680...106,868,796
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Tnf
tumor necrosis factor
IEA
KEGG
rno:04620
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
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Tollip
toll interacting protein
IEA
KEGG
rno:04620
NCBI chr 1:206,391,120...206,413,809
Ensembl chr 1:196,950,771...196,983,625
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Tradd
TNFRSF1A-associated via death domain
ISO
RGD
PMID:21235323
RGD:5685014
NCBI chr19:50,046,057...50,048,158
Ensembl chr19:33,136,138...33,142,638
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Traf3
Tnf receptor-associated factor 3
ISO IEA
KEGG RGD
PMID:21235323
rno:04620, RGD:5685014
NCBI chr 6:136,025,097...136,128,363
Ensembl chr 6:130,206,484...130,305,481
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Traf6
TNF receptor associated factor 6
ISO IEA
KEGG RGD
PMID:21235323
rno:04620, RGD:5685014
NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:87,963,514...87,983,507
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Ube2n
ubiquitin-conjugating enzyme E2N
ISO
RGD
PMID:21235323
RGD:5685014
NCBI chr 7:32,041,190...32,071,252
Ensembl chr 7:30,154,616...30,184,355
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Ube2v1
ubiquitin conjugating enzyme E2 V1
ISO
RGD
PMID:21235323
RGD:5685014
NCBI chr 3:176,736,325...176,759,174
Ensembl chr 3:156,316,781...156,340,273
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Unc93b1
unc-93 homolog B1, TLR signaling regulator
ISO
RGD
PMID:21235323
RGD:5685014
NCBI chr 1:210,596,639...210,607,579
Ensembl chr 1:201,152,693...201,178,338
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all