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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:diabetic neuropathy
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Accession:DOID:9743 term browser browse the term
Definition:Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)
Synonyms:exact_synonym: Asymmetric Diabetic Proximal Motor Neuropathy;   Diabetic Amyotrophy;   Diabetic Asymmetric Polyneuropathy;   Diabetic Mononeuropathies;   Diabetic Mononeuropathy;   Diabetic Mononeuropathy Simplex;   Diabetic Mononeuropathy Simplices;   Diabetic Neuralgia;   Diabetic Neuralgias;   Painful Diabetic Neuropathies;   diabetic amyotrophies;   diabetic asymmetric polyneuropathies;   diabetic neuropathies;   painful diabetic neuropathy;   symmetric diabetic proximal motor neuropathy
 primary_id: MESH:D003929
 xref: ICD9CM:250.6;   NCI:C26748
For additional species annotation, visit the Alliance of Genome Resources.



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diabetic neuropathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2b adrenoceptor alpha 2B ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism (human) RGD PMID:17516297 RGD:2313542 NCBI chr 3:114,585,174...114,589,220
Ensembl chr 3:114,585,169...114,589,355
JBrowse link
G Ager advanced glycosylation end product-specific receptor treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:22171162 RGD:8695979 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B susceptibility IDA
ISO
associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, Type 1;DNA:repeat:promoter:g.(CA)n (human)
RGD PMID:16900242 PMID:9489533 RGD:1626089, RGD:8548642 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member ISO associated with Diabetes Mellitus, Non-Insulin-Dependent RGD PMID:15318096 RGD:2311150 NCBI chr12:34,949,549...34,982,527 JBrowse link
G Alox15 arachidonate 15-lipoxygenase ISO RGD PMID:20724598 RGD:5509623 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874
JBrowse link
G Bad BCL2-associated agonist of cell death treatment IDA associated with Diabetes Mellitus, Experimental RGD PMID:24288572 RGD:10053667 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bdkrb1 bradykinin receptor B1 IMP RGD PMID:20587056 RGD:5129222 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747
JBrowse link
G Bdnf brain-derived neurotrophic factor IMP associated with Diabetes Mellitus, Experimental RGD PMID:20557422 RGD:4891134 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Becn1 beclin 1 treatment IEP associated with Diabetes Mellitus, Experimental RGD PMID:25824552 RGD:11561957 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Casp3 caspase 3 IEP
ISO
associated with Diabetes Mellitus, Experimental;protein:increased expresssion:sciatic nerve
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:12502508 PMID:19555701 RGD:2311441 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase ISO CTD Direct Evidence: marker/mechanism CTD PMID:10780678 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cav1 caveolin 1 ISO associated with Diabetes Mellitus, Experimental RGD PMID:19675140 RGD:8661787 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO associated with Diabetes Mellitus;protein:increased expression:serum RGD PMID:19276232 RGD:2307060 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Cd63 Cd63 molecule ISO associated with Diabetes Mellitus, Insulin-Dependent; protein:increased expression:platelet RGD PMID:10547212 RGD:2314203 NCBI chr 7:1,325,108...1,340,447
Ensembl chr 7:1,325,103...1,399,178
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 ISO CTD Direct Evidence: therapeutic CTD PMID:20624991 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
JBrowse link
G Cnr1 cannabinoid receptor 1 IDA associated with Diabetes Mellitus, Experimental RGD PMID:18810243 RGD:2314631 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
JBrowse link
G Epo erythropoietin ISO associated with Diabetes Mellitus, Experimental; RGD PMID:14718663 RGD:2313898 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
JBrowse link
G F7 coagulation factor VII ISO associated with Diabetes Mellitus, Insulin-Dependent; protein:altered expression:plasma (human) RGD PMID:10468085 RGD:2312401 NCBI chr16:76,489,779...76,500,636
Ensembl chr16:76,489,717...76,500,610
JBrowse link
G Fgf2 fibroblast growth factor 2 ISO associated with Diabetes Mellitus, Experimental RGD PMID:16644707 RGD:2315860 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 ISO associated with Diabetes Mellitus,Insulin-Dependent;protein:increased activity:serum RGD PMID:11311965 RGD:2315614 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
JBrowse link
G Ghrl ghrelin and obestatin prepropeptide ISO associated with Diabetes Mellitus, Experimental RGD PMID:19733151 RGD:2313744 NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621
JBrowse link
G Grm5 glutamate metabotropic receptor 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19840219 NCBI chr 1:141,310,069...141,884,980
Ensembl chr 1:141,312,368...141,882,274
JBrowse link
G Hgf hepatocyte growth factor ISO associated with Diabetes Mellitus, Experimental
CTD Direct Evidence: therapeutic
CTD
RGD
PMID:26000320 PMID:15734864 RGD:2313570 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Hhip Hedgehog-interacting protein IEP RGD PMID:19515211 RGD:11552601 NCBI chr19:27,863,684...27,952,528
Ensembl chr19:27,863,213...27,952,528
JBrowse link
G Ifng interferon gamma ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism: :874A>T (human) RGD PMID:19608431 RGD:2311489 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igf1 insulin-like growth factor 1 treatment IMP
ISO
associated with Diabetes Mellitus, Experimental
protein:decreased expression:serum
RGD PMID:19264110 PMID:18545223 PMID:17194636 RGD:2306687, RGD:8549454, RGD:2313764 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Il1b interleukin 1 beta treatment IEP RGD PMID:23280817 RGD:7401217 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Insr insulin receptor IDA
ISO
associated with Diabetes Mellitus, Experimental;protein:decreased phosphorylation:sciatic nerve
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:18331706 PMID:18331706 RGD:2307344 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
JBrowse link
G Lepr leptin receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:24263156 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 IEP associated with Diabetes Mellitus, Experimental;protein:increased expression:cerebellum, Purkinje cell RGD PMID:24810053 RGD:13462056 NCBI chr 7:122,826,712...122,987,711
Ensembl chr 7:122,826,696...122,987,703
JBrowse link
G Mapk14 mitogen activated protein kinase 14 IDA associated with Diabetes Mellitus, Experimental RGD PMID:18579738 RGD:2311567 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mbp myelin basic protein IEP associated with Diabetes Mellitus, Experimental; protein:decreased expression:sciatic nerve: RGD PMID:23735240 RGD:7327194 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404
JBrowse link
G Mme membrane metallo-endopeptidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:20148083 NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792
JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20213226 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20213226 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpz myelin protein zero treatment IEP associated with Diabetes Mellitus, Experimental RGD PMID:22158827 RGD:9685782 NCBI chr13:83,570,811...83,576,680
Ensembl chr13:83,570,811...83,576,679
JBrowse link
G Ngf nerve growth factor IEP mRNA,protein:decreased expression:sciatic nerve RGD PMID:12469361 RGD:5508379 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Ngfr nerve growth factor receptor IEP mRNA,protein:decreased expression:dorsal root ganglia (GK/KyoSwe) RGD PMID:12469361 RGD:5508379 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
JBrowse link
G Nos2 nitric oxide synthase 2 ISO associated with Diabetes Mellitus, Experimental RGD PMID:18802679 RGD:2313218 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nrg1 neuregulin 1 treatment IEP associated with Diabetes Mellitus, Experimental RGD PMID:24288572 RGD:10053667 NCBI chr16:59,250,658...60,303,024
Ensembl chr16:59,250,854...60,296,884
JBrowse link
G Ntf3 neurotrophin 3 ISO CTD Direct Evidence: therapeutic CTD PMID:11779407 NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 IEP mRNA,protein:decreased expression:dorsal root ganglia RGD PMID:12469361 RGD:5508379 NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 ISO RGD PMID:17976390 PMID:21978940 RGD:5510012, RGD:5683915 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pgf placental growth factor ISO associated with Diabetes Mellitus, Experimental RGD PMID:21056561 RGD:6483583 NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685
JBrowse link
G Plat plasminogen activator, tissue type ISO RGD PMID:17636064 RGD:2311667 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IMP
IEP
mRNA, protein:increased expression:peripheral nerve RGD PMID:17720896 PMID:21951301 RGD:1642588, RGD:5508311 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Retn resistin ISO associated with Diabetes Mellitus, Type 2 RGD PMID:17919381 RGD:7207161 NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16696316 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
JBrowse link
G Sord sorbitol dehydrogenase resistance IDA RGD PMID:15755558 RGD:1601362 NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 IEP associated with Diabetes Mellitus, Insulin-Dependent RGD PMID:19423844 RGD:2308808 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Tgfb1 transforming growth factor, beta 1 IEP
ISO
associated with Diabetes Mellitus, Experimental;mRNA:increased expression:dorsal root ganglion
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:16696316 PMID:18406405 RGD:2302086 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfb2 transforming growth factor, beta 2 IEP associated with Diabetes Mellitus, Experimental;mRNA:increased expression:dorsal root ganglion RGD PMID:18406405 RGD:2302086 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
G Tgfb3 transforming growth factor, beta 3 IEP associated with Diabetes Mellitus, Experimental;mRNA:increased expression:sciatic nerve RGD PMID:18406405 RGD:2302086 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564
JBrowse link
G Tlr4 toll-like receptor 4 susceptibility ISO
IDA
associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphisms: :p.N299G, p.T399I (human)
CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, Experimental;
CTD
RGD
PMID:14693986 PMID:14693986 PMID:22910613 RGD:2312493, RGD:7777098 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor treatment IEP RGD PMID:23280817 RGD:7401217 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 IMP RGD PMID:22133672 RGD:10043378 NCBI chr 5:4,379,999...4,433,243
Ensembl chr 5:4,379,999...4,433,570
JBrowse link
G Ucp2 uncoupling protein 2 susceptibility ISO associated with Diabetes Mellitus, Insulin-Dependent;DNA:polymorphism:promoter:-866G>A (rs659366)(human) RGD PMID:16373902 RGD:2313516 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
JBrowse link
G Ucp3 uncoupling protein 3 susceptibility ISO associated with Diabetes Mellitus, Insulin-Dependent;DNA:polymorphism:promoter:-55C>T (human) RGD PMID:16373902 RGD:2313516 NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent RGD PMID:19414982 RGD:2312761 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vegfa vascular endothelial growth factor A treatment ISO associated with Diabetes Mellitus, Experimental; RGD PMID:26201024 RGD:11079183 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
Diabetic Foot term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing ISO protein:decreased expression:plasma RGD PMID:20836881 RGD:5686889 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Ager advanced glycosylation end product-specific receptor ISO associated with Diabetes Mellitus, Type 2;protein:decreased expression:blood RGD PMID:21941211 RGD:6767555 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Crp C-reactive protein disease_progression ISO protein:increased expression:blood: RGD PMID:22712631 RGD:6906887 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Gja1 gap junction protein, alpha 1 ISO protein:increased expression:dermis RGD PMID:22455314 RGD:7207269 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B severity ISO DNA:polymorphism: :1538G>A (human) RGD PMID:19731315 RGD:8662463 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
JBrowse link
G Igf1 insulin-like growth factor 1 ISO protein:decreased expression:fibroblast of dermis,stratum basale of epidermis: RGD PMID:10727985 RGD:8549356 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Il15 interleukin 15 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:decreased expression:dermis, endothelial cell RGD PMID:17014667 RGD:2313575 NCBI chr19:25,640,013...25,706,818
Ensembl chr19:25,640,251...25,706,820
JBrowse link
G Mbl2 mannose binding lectin 2 ISO protein:increased expression:serum: RGD PMID:19997692 RGD:8694068 NCBI chr 1:228,016,439...228,024,736 JBrowse link
G Mmp9 matrix metallopeptidase 9 severity ISO RGD PMID:22688339 RGD:8547813 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Plat plasminogen activator, tissue type ISO RGD PMID:17275886 RGD:2311669 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Ptx3 pentraxin 3 ISO protein:decreased expression:plasma (human) RGD PMID:30767386 RGD:38501100 NCBI chr 2:150,487,513...150,493,323
Ensembl chr 2:150,487,513...150,493,323
JBrowse link
G Tlr4 toll-like receptor 4 susceptibility ISO DNA:SNPs,haplotype: :rs4986790,rs4986791,rs10759931,rs1927911(human); RGD PMID:23936790 RGD:7777174 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17251
    disease of anatomical entity 16595
      nervous system disease 12130
        peripheral nervous system disease 2557
          diabetic neuropathy 67
            Diabetic Foot 12
            Herrmann Syndrome 0
            diabetic autonomic neuropathy 0
            diabetic polyneuropathy 0
Path 2
Term Annotations click to browse term
  disease 17251
    Nutritional and Metabolic Diseases 5548
      disease of metabolism 5548
        acquired metabolic disease 2896
          carbohydrate metabolism disease 1801
            glucose metabolism disease 1801
              diabetes mellitus 1407
                Diabetes Complications 415
                  diabetic neuropathy 67
                    Diabetic Foot 12
                    Herrmann Syndrome 0
                    diabetic autonomic neuropathy 0
                    diabetic polyneuropathy 0
paths to the root