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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:diabetic neuropathy
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Accession:DOID:9743 term browser browse the term
Definition:Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)
Synonyms:exact_synonym: Asymmetric Diabetic Proximal Motor Neuropathy;   Diabetic Amyotrophy;   Diabetic Asymmetric Polyneuropathy;   Diabetic Mononeuropathies;   Diabetic Mononeuropathy;   Diabetic Mononeuropathy Simplex;   Diabetic Mononeuropathy Simplices;   Diabetic Neuralgia;   Diabetic Neuralgias;   Painful Diabetic Neuropathies;   diabetic amyotrophies;   diabetic asymmetric polyneuropathies;   diabetic neuropathies;   painful diabetic neuropathy;   symmetric diabetic proximal motor neuropathy
 primary_id: MESH:D003929
 xref: ICD9CM:250.6;   NCI:C26748
For additional species annotation, visit the Alliance of Genome Resources.


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diabetic neuropathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2b adrenoceptor alpha 2B ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism (human) RGD PMID:17516297 RGD:2313542 NCBI chr 3:119,805,941...119,809,987
Ensembl chr 3:119,805,941...119,809,987
JBrowse link
G Ager advanced glycosylation end product-specific receptor treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:22171162 RGD:8695979 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B susceptibility IDA
ISO
associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, Type 1;DNA:repeat:promoter:g.(CA)n (human)
RGD PMID:16900242, PMID:9489533 RGD:1626089, RGD:8548642 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member ISO associated with Diabetes Mellitus, Non-Insulin-Dependent RGD PMID:15318096 RGD:2311150 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
JBrowse link
G Alox15 arachidonate 15-lipoxygenase ISO RGD PMID:20724598 RGD:5509623 NCBI chr10:56,953,692...56,962,145
Ensembl chr10:56,953,691...56,962,161
JBrowse link
G Bad BCL2-associated agonist of cell death treatment IDA associated with Diabetes Mellitus, Experimental RGD PMID:24288572 RGD:10053667 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bdkrb1 bradykinin receptor B1 IMP RGD PMID:20587056 RGD:5129222 NCBI chr 6:129,437,423...129,441,553
Ensembl chr 6:129,438,158...129,440,574
JBrowse link
G Bdnf brain-derived neurotrophic factor IMP associated with Diabetes Mellitus, Experimental RGD PMID:20557422 RGD:4891134 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Becn1 beclin 1 treatment IEP associated with Diabetes Mellitus, Experimental RGD PMID:25824552 RGD:11561957 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Casp3 caspase 3 IEP
ISO
associated with Diabetes Mellitus, Experimental;protein:increased expresssion:sciatic nerve
CTD Direct Evidence: marker/mechanism
CTD PMID:12502508, PMID:19555701 RGD:2311441 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase ISO CTD Direct Evidence: marker/mechanism CTD PMID:10780678 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cav1 caveolin 1 ISO associated with Diabetes Mellitus, Experimental RGD PMID:19675140 RGD:8661787 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO associated with Diabetes Mellitus;protein:increased expression:serum RGD PMID:19276232 RGD:2307060 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Cd63 Cd63 molecule ISO associated with Diabetes Mellitus, Insulin-Dependent; protein:increased expression:platelet RGD PMID:10547212 RGD:2314203 NCBI chr 7:3,320,250...3,335,583
Ensembl chr 7:3,320,103...3,335,582
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 ISO CTD Direct Evidence: therapeutic CTD PMID:20624991 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
JBrowse link
G Cnr1 cannabinoid receptor 1 IDA associated with Diabetes Mellitus, Experimental RGD PMID:18810243 RGD:2314631 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Epo erythropoietin ISO associated with Diabetes Mellitus, Experimental; RGD PMID:14718663 RGD:2313898 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G F7 coagulation factor VII ISO associated with Diabetes Mellitus, Insulin-Dependent; protein:altered expression:plasma (human) RGD PMID:10468085 RGD:2312401 NCBI chr16:81,824,610...81,834,923
Ensembl chr16:81,824,111...81,834,945
JBrowse link
G Fgf2 fibroblast growth factor 2 ISO associated with Diabetes Mellitus, Experimental RGD PMID:16644707 RGD:2315860 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 ISO associated with Diabetes Mellitus,Insulin-Dependent;protein:increased activity:serum RGD PMID:11311965 RGD:2315614 NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068
JBrowse link
G Ghrl ghrelin and obestatin prepropeptide ISO associated with Diabetes Mellitus, Experimental RGD PMID:19733151 RGD:2313744 NCBI chr 4:145,674,157...145,678,066
Ensembl chr 4:145,674,157...145,678,066
JBrowse link
G Grm5 glutamate metabotropic receptor 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19840219 NCBI chr 1:151,207,846...151,785,038
Ensembl chr 1:151,439,409...151,783,392
JBrowse link
G Hgf hepatocyte growth factor ISO associated with Diabetes Mellitus, Experimental
CTD Direct Evidence: therapeutic
CTD PMID:26000320, PMID:15734864 RGD:2313570 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Hhip Hedgehog-interacting protein IEP RGD PMID:19515211 RGD:11552601 NCBI chr19:31,525,134...31,614,487
Ensembl chr19:31,524,671...31,614,246
JBrowse link
G Ifng interferon gamma ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism: :874A>T (human) RGD PMID:19608431 RGD:2311489 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igf1 insulin-like growth factor 1 treatment IMP
ISO
associated with Diabetes Mellitus, Experimental
protein:decreased expression:serum
RGD PMID:19264110, PMID:18545223, PMID:17194636 RGD:2306687, RGD:8549454, RGD:2313764 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Il1b interleukin 1 beta treatment IEP RGD PMID:23280817 RGD:7401217 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Insr insulin receptor IDA
ISO
associated with Diabetes Mellitus, Experimental;protein:decreased phosphorylation:sciatic nerve
CTD Direct Evidence: marker/mechanism
CTD PMID:18331706, PMID:18331706 RGD:2307344 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
JBrowse link
G Lepr leptin receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:24263156 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 IEP associated with Diabetes Mellitus, Experimental;protein:increased expression:cerebellum, Purkinje cell RGD PMID:24810053 RGD:13462056 NCBI chr 7:132,857,311...133,018,549
Ensembl chr 7:132,857,628...133,018,584
JBrowse link
G Mapk14 mitogen activated protein kinase 14 IDA associated with Diabetes Mellitus, Experimental RGD PMID:18579738 RGD:2311567 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mbp myelin basic protein IEP associated with Diabetes Mellitus, Experimental; protein:decreased expression:sciatic nerve: RGD PMID:23735240 RGD:7327194 NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310
JBrowse link
G Mme membrane metallo-endopeptidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:20148083 NCBI chr 2:153,799,203...153,880,910
Ensembl chr 2:153,803,349...153,880,738
JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20213226 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20213226 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpz myelin protein zero treatment IEP associated with Diabetes Mellitus, Experimental RGD PMID:22158827 RGD:9685782 NCBI chr13:89,524,204...89,530,070
Ensembl chr13:89,524,329...89,530,068
JBrowse link
G Ngf nerve growth factor IEP mRNA,protein:decreased expression:sciatic nerve RGD PMID:12469361 RGD:5508379 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Ngfr nerve growth factor receptor IEP mRNA,protein:decreased expression:dorsal root ganglia (GK/KyoSwe) RGD PMID:12469361 RGD:5508379 NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061
JBrowse link
G Nos2 nitric oxide synthase 2 ISO associated with Diabetes Mellitus, Experimental RGD PMID:18802679 RGD:2313218 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nrg1 neuregulin 1 treatment IEP associated with Diabetes Mellitus, Experimental RGD PMID:24288572 RGD:10053667 NCBI chr16:62,969,573...64,065,063
Ensembl chr16:63,837,216...64,057,434
JBrowse link
G Ntf3 neurotrophin 3 ISO CTD Direct Evidence: therapeutic CTD PMID:11779407 NCBI chr 4:158,636,883...158,705,886
Ensembl chr 4:158,636,884...158,705,886
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 IEP mRNA,protein:decreased expression:dorsal root ganglia RGD PMID:12469361 RGD:5508379 NCBI chr 2:187,143,568...187,160,373
Ensembl chr 2:187,143,568...187,160,373
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 ISO RGD PMID:17976390, PMID:21978940 RGD:5510012, RGD:5683915 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pgf placental growth factor ISO associated with Diabetes Mellitus, Experimental RGD PMID:21056561 RGD:6483583 NCBI chr 6:108,994,016...109,004,598
Ensembl chr 6:108,994,018...109,004,598
JBrowse link
G Plat plasminogen activator, tissue type ISO RGD PMID:17636064 RGD:2311667 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IMP
IEP
mRNA, protein:increased expression:peripheral nerve RGD PMID:17720896, PMID:21951301 RGD:1642588, RGD:5508311 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Retn resistin ISO associated with Diabetes Mellitus, Type 2 RGD PMID:17919381 RGD:7207161 NCBI chr12:2,201,909...2,203,649
Ensembl chr12:2,201,891...2,204,249
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16696316 NCBI chr 1:24,185,451...24,302,309
Ensembl chr 1:24,185,435...24,302,298
JBrowse link
G Sord sorbitol dehydrogenase resistance IDA RGD PMID:15755558 RGD:1601362 NCBI chr 3:114,176,127...114,207,368
Ensembl chr 3:114,176,309...114,207,366
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 IEP associated with Diabetes Mellitus, Insulin-Dependent RGD PMID:19423844 RGD:2308808 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Tgfb1 transforming growth factor, beta 1 IEP
ISO
associated with Diabetes Mellitus, Experimental;mRNA:increased expression:dorsal root ganglion
CTD Direct Evidence: marker/mechanism
CTD PMID:16696316, PMID:18406405 RGD:2302086 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfb2 transforming growth factor, beta 2 IEP associated with Diabetes Mellitus, Experimental;mRNA:increased expression:dorsal root ganglion RGD PMID:18406405 RGD:2302086 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Tgfb3 transforming growth factor, beta 3 IEP associated with Diabetes Mellitus, Experimental;mRNA:increased expression:sciatic nerve RGD PMID:18406405 RGD:2302086 NCBI chr 6:109,913,757...109,936,217
Ensembl chr 6:109,913,757...109,935,533
JBrowse link
G Tlr4 toll-like receptor 4 susceptibility ISO
IDA
associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphisms: :p.N299G, p.T399I (human)
CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, Experimental;
CTD PMID:14693986, PMID:14693986, PMID:22910613 RGD:2312493, RGD:7777098 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor treatment IEP RGD PMID:23280817 RGD:7401217 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 IMP RGD PMID:22133672 RGD:10043378 NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485
JBrowse link
G Ucp2 uncoupling protein 2 susceptibility ISO associated with Diabetes Mellitus, Insulin-Dependent;DNA:polymorphism:promoter:-866G>A (rs659366)(human) RGD PMID:16373902 RGD:2313516 NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744
JBrowse link
G Ucp3 uncoupling protein 3 susceptibility ISO associated with Diabetes Mellitus, Insulin-Dependent;DNA:polymorphism:promoter:-55C>T (human) RGD PMID:16373902 RGD:2313516 NCBI chr 1:165,482,912...165,495,895
Ensembl chr 1:165,482,155...165,496,206
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent RGD PMID:19414982 RGD:2312761 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vegfa vascular endothelial growth factor A treatment ISO associated with Diabetes Mellitus, Experimental; RGD PMID:26201024 RGD:11079183 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
Diabetic Foot term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing ISO protein:decreased expression:plasma RGD PMID:20836881 RGD:5686889 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Ager advanced glycosylation end product-specific receptor ISO associated with Diabetes Mellitus, Type 2;protein:decreased expression:blood RGD PMID:21941211 RGD:6767555 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
JBrowse link
G Crp C-reactive protein disease_progression ISO protein:increased expression:blood: RGD PMID:22712631 RGD:6906887 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Gja1 gap junction protein, alpha 1 ISO protein:increased expression:dermis RGD PMID:22455314 RGD:7207269 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B severity ISO DNA:polymorphism: :1538G>A (human) RGD PMID:19731315 RGD:8662463 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Igf1 insulin-like growth factor 1 ISO protein:decreased expression:fibroblast of dermis,stratum basale of epidermis: RGD PMID:10727985 RGD:8549356 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Il15 interleukin 15 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:decreased expression:dermis, endothelial cell RGD PMID:17014667 RGD:2313575 NCBI chr19:23,542,606...23,624,366
Ensembl chr19:23,542,889...23,554,594
JBrowse link
G Mbl2 mannose binding lectin 2 ISO protein:increased expression:serum: RGD PMID:19997692 RGD:8694068 NCBI chr 1:248,435,069...248,442,669
Ensembl chr 1:248,723,397...248,729,962
JBrowse link
G Mmp9 matrix metallopeptidase 9 severity ISO RGD PMID:22688339 RGD:8547813 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Plat plasminogen activator, tissue type ISO RGD PMID:17275886 RGD:2311669 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Ptx3 pentraxin 3 ISO protein:decreased expression:plasma (human) RGD PMID:30767386 RGD:38501100 NCBI chr 2:158,097,843...158,103,653
Ensembl chr 2:158,097,843...158,103,653
JBrowse link
G Tlr4 toll-like receptor 4 susceptibility ISO DNA:SNPs,haplotype: :rs4986790,rs4986791,rs10759931,rs1927911(human); RGD PMID:23936790 RGD:7777174 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16023
    disease of anatomical entity 15278
      nervous system disease 10897
        peripheral nervous system disease 2500
          diabetic neuropathy 67
            Diabetic Foot 12
            Herrmann Syndrome 0
            diabetic autonomic neuropathy 0
            diabetic polyneuropathy 0
Path 2
Term Annotations click to browse term
  disease 16023
    Nutritional and Metabolic Diseases 4727
      disease of metabolism 4727
        acquired metabolic disease 2786
          carbohydrate metabolism disease 1757
            glucose metabolism disease 1757
              diabetes mellitus 1371
                Diabetes Complications 405
                  diabetic neuropathy 67
                    Diabetic Foot 12
                    Herrmann Syndrome 0
                    diabetic autonomic neuropathy 0
                    diabetic polyneuropathy 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.