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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:toxoplasmosis
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Accession:DOID:9965 term browser browse the term
Definition:A coccidiosis that has_material_basis_in protozoan Toxoplasma gondii. The parasite effects most genera of warm-blooded animals, including humans, but the primary host is the felid (cat) family. Animals are infected by eating infected meat, by ingestion of feces of a cat that has itself recently been infected, or transmission_by mother to fetus. The symptoms include bilateral, nontender cervical or axillary lymphadenopathy, fever, malaise, myalgia, hepatosplenomegaly, anemia and leukopenia. (DO)
Synonyms:exact_synonym: Toxoplasma gondii infection;   Toxoplasma gondii infections;   disseminated toxoplasmosis;   toxoplasmoses
 primary_id: MESH:D014123
 xref: EFO:0007517;   ICD10CM:B58;   ICD9CM:130;   NCI:C3418


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toxoplasmosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator IEP RGD PMID:24812878 RGD:10054127 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Il27 interleukin 27 susceptibility ISO RGD PMID:31548322 PMID:22981537 RGD:126790501, RGD:126790522 NCBI chr 1:190,603,684...190,609,292
Ensembl chr 1:181,173,372...181,178,582 		JBrowse link
G Nfkbia NFKB inhibitor alpha exacerbates ISO human gene in a mouse model RGD PMID:12626571 RGD:126925984 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Ucp2 uncoupling protein 2 susceptibility ISO RGD PMID:11101840 RGD:737759 NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:154,839,209...154,845,611 		JBrowse link
Animal Toxoplasmosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl5 C-C motif chemokine ligand 5 IEP mRNA, protein:increased expression:blood vessel endothelial cell RGD PMID:15710456 RGD:2307183 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 ISO RGD PMID:19741601 RGD:8661685 NCBI chr 8:132,611,883...132,619,106
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
G Cd209d CD209d molecule treatment ISO RGD PMID:32391004 RGD:39939012 NCBI chr12:6,689,002...6,695,452
Ensembl chr12:1,891,113...1,901,171 		JBrowse link
G Foxp3 forkhead box P3 ISO mRNA:decreased expression:placenta: RGD PMID:21923716 RGD:38501105 NCBI chr  X:17,580,380...17,601,181
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 ISO RGD PMID:8881756 RGD:12910478 NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:56,579,201...56,589,662 		JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 ISO RGD PMID:31231617 RGD:39939039 NCBI chr16:74,133,259...74,145,328
Ensembl chr16:67,430,578...67,442,730 		JBrowse link
G Il17a interleukin 17A ISO mRNA,protein:increased expression:placenta: RGD PMID:21923716 RGD:38501105 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il21 interleukin 21 ISO RGD PMID:23667536 RGD:127285360 NCBI chr 2:122,045,240...122,055,142
Ensembl chr 2:120,119,444...120,126,996 		JBrowse link
G Il23a interleukin 23 subunit alpha ISO RGD PMID:15265921 RGD:39457943 NCBI chr 7:1,306,320...1,308,434
Ensembl chr 7:721,809...723,923 		JBrowse link
G Il2rb interleukin 2 receptor subunit beta ameliorates ISO RGD PMID:11286020 RGD:42724468 NCBI chr 7:111,913,828...111,928,537
Ensembl chr 7:110,033,341...110,048,054 		JBrowse link
G Il6 interleukin 6 ISO mRNA:increased expression:placenta: RGD PMID:21923716 RGD:38501105 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ldlr low density lipoprotein receptor ISO RGD PMID:18316222 RGD:5490254 NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Mir146a microRNA 146a ameliorates ISO RGD PMID:24582962 RGD:126925172 NCBI chr10:28,349,996...28,350,090
Ensembl chr10:27,848,516...27,848,610 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 ISO RGD PMID:25855987 RGD:11057198 NCBI chr 3:62,098,739...62,115,926
Ensembl chr 3:41,689,851...41,697,877 		JBrowse link
G Rorc RAR-related orphan receptor C ISO mRNA:increased expression:placenta: RGD PMID:21923716 RGD:38501105 NCBI chr 2:184,698,779...184,723,942
Ensembl chr 2:182,009,286...182,034,907 		JBrowse link
G Sting1 stimulator of interferon response cGAMP interactor 1 severity ISO RGD PMID:31416833 RGD:39128220 NCBI chr18:27,606,196...27,612,544
Ensembl chr18:27,332,119...27,338,335 		JBrowse link
Cerebral Toxoplasmosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nfkb1 nuclear factor kappa B subunit 1 severity ISO RGD PMID:20156658 RGD:40902838 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
congenital toxoplasmosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RT1-Ba RT1 class II, locus Ba susceptibility ISO DNA:polymorphisms: :HLA-DQA1*01:03, HLA-DQA1*03:02 (human) RGD PMID:26856406 RGD:126928144 NCBI chr20:4,577,057...4,581,650
Ensembl chr20:4,575,134...4,579,744 		JBrowse link
Ocular Toxoplasmosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 ISO RGD PMID:22740770 RGD:7421536 NCBI chr 1:227,287,713...227,306,739
Ensembl chr 1:217,861,175...217,877,343 		JBrowse link
G Il10 interleukin 10 ISO RGD PMID:19026704 RGD:7365028 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il17a interleukin 17A treatment ISO protein:increased expression:aqueous humor (human) RGD PMID:22927448 PMID:22927448 RGD:8698652, RGD:8698652 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il27 interleukin 27 disease_progression ISO mRNA:increased expression:eye, cervical lymph node (mouse) RGD PMID:29779048 RGD:126790500 NCBI chr 1:190,603,684...190,609,292
Ensembl chr 1:181,173,372...181,178,582 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 susceptibility ISO DNA:snp:3' utr:g.*397A>C (rs3135499)(human) RGD PMID:23100559 RGD:8547527 NCBI chr19:34,555,832...34,596,281
Ensembl chr19:18,382,439...18,417,177 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19140
    disease by infectious agent 2255
      parasitic infectious disease 329
        parasitic protozoa infectious disease 177
          coccidiosis 38
            toxoplasmosis 36
              Animal Toxoplasmosis 16
              Cerebral Toxoplasmosis 1
              Ocular Toxoplasmosis 5
              congenital toxoplasmosis 1
paths to the root