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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Experimental Colitis
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Accession:DOID:9000099 term browser browse the term
Definition:Colitis induced experimentally in laboratory animals by administration of various agents such as dextran sulfate sodium (DSS), 2,4,6-trinitrobenzene sulfonic acid (TNBS), or acetic acid. Experimental colitis can also be induced by a procedure like colon diversion or radiation treatment.


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Experimental Colitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme treatment ISO RGD PMID:24239644 PMID:17342403 RGD:40400720, RGD:40400748 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Acer3 alkaline ceramidase 3 severity ISO mRNA,protein:decreased expression, decreased activity:colon: RGD PMID:26938296 PMID:26938296 RGD:35673322, RGD:35673322 NCBI chr 1:152,504,180...152,606,596
Ensembl chr 1:152,504,186...152,606,591 		JBrowse link
G Adam17 ADAM metallopeptidase domain 17 treatment IEP RGD PMID:11884025 RGD:632022 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639 		JBrowse link
G Adrb3 adrenoceptor beta 3 no_association IEP mRNA:unaltered expression:colon (rat) RGD PMID:11803250 RGD:5684894 NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552 		JBrowse link
G Ager advanced glycosylation end product-specific receptor treatment IEP RGD PMID:29572553 RGD:152995414 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 treatment IEP RGD PMID:29572553 RGD:152995414 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Atm ATM serine/threonine kinase exacerbates ISO RGD PMID:20179206 RGD:126781749 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha treatment IEP RGD PMID:25689466 RGD:13703055 NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794 		JBrowse link
G Bcl2 BCL2, apoptosis regulator treatment IEP RGD PMID:29572553 RGD:152995414 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 exacerbates ISO RGD PMID:26037070 RGD:11537970 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Cd68 Cd68 molecule treatment ISO RGD PMID:25004394 RGD:40925931 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit treatment IMP RGD PMID:29572553 RGD:152995414 NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240 		JBrowse link
G Csf1r colony stimulating factor 1 receptor ameliorates ISO RGD PMID:23451116 RGD:150524300 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415 		JBrowse link
G Csf3 colony stimulating factor 3 treatment ISO RGD PMID:16689657 RGD:11039462 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603 		JBrowse link
G Ereg epiregulin ISO protein:increased expression:colonic mucosa (mouse) RGD PMID:20498653 RGD:39457688 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit treatment ISO RGD PMID:31160593 RGD:126779602 NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362 		JBrowse link
G Fas Fas cell surface death receptor treatment IDA RGD PMID:22368862 RGD:10054108 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fgf10 fibroblast growth factor 10 treatment ISO
IDA		 human protein in mouse model
human protein in mouse model with bacterial delivery system
human gene product in mouse model		 RGD PMID:10381813 PMID:19736360 PMID:23676805 PMID:11952999 RGD:126928132, RGD:126928133, RGD:127284855, RGD:127284874 NCBI chr 2:50,801,171...50,878,218
Ensembl chr 2:50,800,992...50,876,866 		JBrowse link
G Fgf7 fibroblast growth factor 7 treatment ISO human protein in mouse model RGD PMID:10219846 RGD:126928136 NCBI chr 3:113,280,448...113,333,279
Ensembl chr 3:113,281,283...113,332,929 		JBrowse link
G Foxp3 forkhead box P3 treatment ISO
IDA		 protein:increased expression:colon:
mRNA:increased expression:mucosa:		 RGD PMID:26925602 PMID:17229795 PMID:27498708 PMID:28733028 RGD:38455994, RGD:38455995, RGD:14975101, RGD:38549362 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Hamp hepcidin antimicrobial peptide IEP protein:increased expression:colon RGD PMID:24764672 RGD:11041628 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891 		JBrowse link
G Hmgb1 high mobility group box 1 treatment IEP RGD PMID:29572553 RGD:152995414 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Hsf1 heat shock transcription factor 1 IEP protein:increased acetylation:colon (rat) RGD PMID:25608526 RGD:10402402 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Icam1 intercellular adhesion molecule 1 treatment IMP
IEP		 RGD PMID:10092309 PMID:29572553 RGD:11522714, RGD:152995414 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifng interferon gamma IEP
ISO		 protein:increased expression:plasma: RGD PMID:15030379 PMID:27498708 RGD:10755756, RGD:14975101 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Ifngr1 interferon gamma receptor 1 ameliorates ISO RGD PMID:25918247 RGD:124715468 NCBI chr 1:14,333,167...14,351,799
Ensembl chr 1:14,333,187...14,351,785 		JBrowse link
G Il10 interleukin 10 treatment ISO
IEP		 associated with Helicobacter Infections RGD PMID:16982822 PMID:25727887 PMID:27815529 PMID:29572553 RGD:11049170, RGD:11049485, RGD:14975260, RGD:152995414 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta treatment ISO RGD PMID:31175857 RGD:14975282 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1rn interleukin 1 receptor antagonist treatment ISO human protein in a rat model RGD PMID:8978354 RGD:8551835 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Il2 interleukin 2 IEP RGD PMID:16630696 RGD:8662978 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il23a interleukin 23 subunit alpha severity ISO mRNA:increased expression:colon (mouse) RGD PMID:24028683 RGD:39458035 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923 		JBrowse link
G Il25 interleukin 25 treatment ISO RGD PMID:19118508 RGD:39456129 NCBI chr15:28,408,766...28,412,157
Ensembl chr15:28,408,842...28,411,893 		JBrowse link
G Il33 interleukin 33 severity
treatment		 ISO RGD PMID:25112700 PMID:28423665 RGD:39938951, RGD:39939041 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373 		JBrowse link
G Il6 interleukin 6 treatment IEP
IDA
ISO		 RGD PMID:16630696 PMID:16133010 PMID:27096537 RGD:8662978, RGD:11062139, RGD:11062146 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Irf9 interferon regulatory factor 9 ameliorates ISO RGD PMID:25918247 RGD:124715468 NCBI chr15:29,095,474...29,101,924
Ensembl chr15:29,095,789...29,101,236 		JBrowse link
G Itga2 integrin subunit alpha 2 treatment ISO RGD PMID:16534417 RGD:11530069 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481 		JBrowse link
G Itga4 integrin subunit alpha 4 IEP protein:increased expression:colon (rat) RGD PMID:12183646 RGD:729408 NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715 		JBrowse link
G Jak2 Janus kinase 2 treatment IEP RGD PMID:29572553 RGD:152995414 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 IEP mRNA, protein:increased expression:colon RGD PMID:23986198 RGD:10412026 NCBI chr15:302,480...1,007,675
Ensembl chr15:302,214...1,001,198 		JBrowse link
G Kdr kinase insert domain receptor ISO protein:increased expression:colon RGD PMID:19013462 RGD:5684406 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Kl Klotho ISO mRNA:decreased expression:kidney: RGD PMID:20004202 RGD:10403055 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 treatment IEP RGD PMID:27028006 RGD:13800882 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 treatment IDA RGD PMID:29037916 RGD:13800567 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mif macrophage migration inhibitory factor severity ISO RGD PMID:15807847 RGD:36947390 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504 		JBrowse link
G Mir146a microRNA 146a ISO miRNA:increased expression:colon, small intestine (mouse) RGD PMID:24092752 RGD:126925183 NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610 		JBrowse link
G Mir155 microRNA 155 treatment ISO
IMP		 associated with Helicobacter Infections RGD PMID:30927737 PMID:28246471 PMID:21880981 PMID:30253332 PMID:28752563 More... RGD:21079443, RGD:21079463, RGD:21079473, RGD:21081536, RGD:24922208, RGD:25314295 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718 		JBrowse link
G Mir21 microRNA 21 ameliorates ISO RGD PMID:23826144 RGD:41404691 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mmp2 matrix metallopeptidase 2 treatment IEP RGD PMID:23323009 RGD:13207328 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 treatment IEP RGD PMID:23323009 RGD:13207328 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase treatment IEP RGD PMID:29572553 RGD:152995414 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor exacerbates ISO RGD PMID:25362351 RGD:150521530 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 treatment IEP RGD PMID:22350949 RGD:10412739 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha treatment IDA RGD PMID:21642017 RGD:10413866 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 IEP protein:increased expression:colonic mucosa: RGD PMID:22997830 RGD:13204727 NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177 		JBrowse link
G Npy neuropeptide Y treatment IMP RGD PMID:20533056 RGD:10448943 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Pdgfra platelet derived growth factor receptor alpha treatment IEP RGD PMID:24115822 RGD:11080973 NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta treatment IEP RGD PMID:24115822 RGD:11080973 NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
G Phex phosphate regulating endopeptidase X-linked ISO mRNA:decreased expression:bone: RGD PMID:16890604 RGD:11556253 NCBI chr  X:37,607,553...37,856,183
Ensembl chr  X:37,610,760...37,854,469 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma susceptibility ISO RGD PMID:20347874 RGD:38599183 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043 		JBrowse link
G Ptger4 prostaglandin E receptor 4 treatment IMP RGD PMID:12100473 RGD:727388 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit treatment IEP RGD PMID:29572553 RGD:152995414 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rnasel ribonuclease L severity ISO RGD PMID:23567782 RGD:40902808 NCBI chr13:65,894,990...65,910,354
Ensembl chr13:65,901,459...65,908,704 		JBrowse link
G Slc11a1 solute carrier family 11 member 1 ISO RGD PMID:19116231 RGD:5684934 NCBI chr 9:75,957,193...75,968,115
Ensembl chr 9:75,957,316...75,968,101 		JBrowse link
G Smad4 SMAD family member 4 susceptibility ISO RGD PMID:23090737 RGD:12880038 NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 treatment IEP RGD PMID:29572553 RGD:152995414 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787 		JBrowse link
G Tnf tumor necrosis factor treatment IMP
IEP		 RGD PMID:21296062 PMID:29572553 RGD:8661763, RGD:152995414 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A treatment IMP RGD PMID:21296062 RGD:8661763 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO protein:increased expression:colon RGD PMID:19013462 RGD:5684406 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19102
    Animal Diseases 1752
      Animal Disease Models 1699
        Experimental Colitis 68
Path 2
Term Annotations click to browse term
  disease 19102
    Pathological Conditions, Signs and Symptoms 13607
      Pathologic Processes 8259
        Inflammation 2834
          gastroenteritis 568
            inflammatory bowel disease 485
              colitis 256
                Experimental Colitis 68
paths to the root