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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:urinary tract infection
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Accession:DOID:0080784 term browser browse the term
Definition:An urinary system disease that is characterized by an infection in any part of the urinary system, including the kidneys, ureters, bladder or urethra. (DO)
Synonyms:exact_synonym: UTI;   urinary tract infections
 primary_id: MESH:D014552
For additional species annotation, visit the Alliance of Genome Resources.



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urinary tract infection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcr1 C-X-C motif chemokine receptor 1 ISO RGD PMID:21151974 RGD:7207862 NCBI chr 9:75,768,124...75,771,122
Ensembl chr 9:75,766,770...75,771,084
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 ISO RGD PMID:18401338 RGD:7257688 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B ISO DNA: SNP: :g.1267A>G RGD PMID:20379347 RGD:7242733 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
JBrowse link
G Il18 interleukin 18 IEP protein:increased expression:urine RGD PMID:19171043 RGD:2311084 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1a interleukin 1 alpha IEP
ISO
protein:increased expression:urine RGD PMID:19171043 PMID:21690238 RGD:2311084, RGD:6907113 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta IEP
ISO
protein:increased expression:urine RGD PMID:19171043 PMID:20886104 RGD:2311084, RGD:7175340 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Lcn2 lipocalin 2 disease_progression
ameliorates
treatment
ISO protein:increased expression:urine: RGD PMID:25398327 PMID:24937428 PMID:24937428 PMID:24937428 RGD:126779559, RGD:126779579, RGD:126779579, RGD:126779579 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Nos2 nitric oxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:9011564 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Pomc proopiomelanocortin ISO CTD Direct Evidence: marker/mechanism CTD PMID:6254450 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Tlr2 toll-like receptor 2 susceptibility ISO DNA:polymorphism: :p.R753Q (human) RGD PMID:18001294 RGD:7240561 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tlr4 toll-like receptor 4 susceptibility ISO DNA:snp:cds:p.D299G (human) RGD PMID:19543401 RGD:7246906 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
bacteriuria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec4m C-type lectin domain family 4 member M ISO associated with Escherichia Coli Infections RGD PMID:31998663 RGD:41410804 NCBI chr12:1,915,902...1,924,529
Ensembl chr12:1,915,919...1,924,539
JBrowse link
urinary schistosomiasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd1d1 CD1d1 molecule ISO protein:increased expression:B cell (human) RGD PMID:22347409 RGD:127345101 NCBI chr 2:172,423,582...172,427,089
Ensembl chr 2:172,423,582...172,427,089
JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 susceptibility ISO DNA:SNPs:multiple:Gabonese(human) RGD PMID:22288822 RGD:7204674 NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963
JBrowse link
G Il5 interleukin 5 resistance ISO RGD PMID:9697734 RGD:7241010 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Stat6 signal transducer and activator of transcription 6 severity ISO DNA:SNP:enhancer: (rs324013) RGD PMID:18273035 RGD:7243977 NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18032
    disease of anatomical entity 17412
      Urogenital Diseases 4683
        urinary system disease 2383
          urinary tract infection 16
            acute gonococcal cystitis 0
            bacteriuria 1
            pyuria 0
            sparganosis 0
            urinary schistosomiasis 4
paths to the root