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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Spinal Cord Compression
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Accession:DOID:9001553 term browser browse the term
Definition:Acute and chronic conditions characterized by external mechanical compression of the SPINAL CORD due to extramedullary neoplasm; EPIDURAL ABSCESS; SPINAL FRACTURES; bony deformities of the vertebral bodies; and other conditions. Clinical manifestations vary with the anatomic site of the lesion and may include localized pain, weakness, sensory loss, incontinence, and impotence.
Synonyms:exact_synonym: Compressive Myelopathy;   Conus Medullaris Syndrome;   Conus Medullaris Syndromes;   Extramedullary Spinal Cord Compression;   Spinal Cord Compressions
 primary_id: MESH:D013117;   RDO:0006596
For additional species annotation, visit the Alliance of Genome Resources.


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Spinal Cord Compression term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 IEP mRNA, protein:increased expression, increased activity:spinal cord (rat) RGD PMID:22425718 RGD:10449098 NCBI chr 3:5,519,921...5,558,390
Ensembl chr 3:5,519,990...5,558,166
JBrowse link
G Amigo3 adhesion molecule with Ig like domain 3 IEP mRNA, protein:increased expression:dorsal root ganglion (rat) RGD PMID:23613963 RGD:14390159 NCBI chr 8:116,830,773...116,832,299 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IEP
ISO
mRNA, protein:increased expression:liver, serum (rat)
CTD Direct Evidence: marker/mechanism
CTD PMID:15135227, PMID:15855648 RGD:11526154 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Egr1 early growth response 1 IEP protein:increased expression:spinal cord dorsal horn (rat) RGD PMID:20675054 RGD:5131876 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Elane elastase, neutrophil expressed treatment IMP RGD PMID:9675307 RGD:10450552 NCBI chr 7:12,638,320...12,640,168
Ensembl chr 7:12,638,322...12,640,232
JBrowse link
G Epo erythropoietin IEP protein:increased expression:neuron, endothelium, glia: RGD PMID:15792521 RGD:11041719 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Epor erythropoietin receptor IEP protein:increased expression:neuron, endothelium, glia: RGD PMID:15792521 RGD:11041719 NCBI chr 8:22,969,737...22,974,468
Ensembl chr 8:22,969,745...22,974,321
JBrowse link
G Fas Fas cell surface death receptor treatment ISO human protein in a rat model
protein:increased expression:spinal cord:
RGD PMID:16689665, PMID:21490053, PMID:16202410 RGD:1582444, RGD:12904017, RGD:8663485 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand treatment ISO protein:increased expression:spinal cord: RGD PMID:21490053, PMID:21490053 RGD:12904017, RGD:12904017 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fgf2 fibroblast growth factor 2 IEP protein:increased expression:spinal cord RGD PMID:17244329 RGD:8655633 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fis1 fission, mitochondrial 1 treatment IEP RGD PMID:25595990 RGD:12437079 NCBI chr12:22,750,485...22,765,324
Ensembl chr12:22,750,485...22,765,308
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 IEP protein:decreased expression:spinal cord, thoracic vertebrae (rat) RGD PMID:20399821 RGD:2326108 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 ISO protein:increased expression:spinal cord (mouse) RGD PMID:21787762 RGD:6218959 NCBI chr10:38,601,624...38,642,397
Ensembl chr10:38,601,624...38,642,397
JBrowse link
G Il6 interleukin 6 IEP protein:increased expression:cerebrospinal fluid, serum RGD PMID:30327453 RGD:14975119 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G L1cam L1 cell adhesion molecule ISO RGD PMID:21671795 RGD:6483029 NCBI chr  X:156,901,244...156,928,064
Ensembl chr  X:156,909,913...156,928,057
JBrowse link
G Mt2A metallothionein 2A ISO mRNA:increased expression:spinal cord (mouse) RGD PMID:15592854 RGD:6483848 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Nos3 nitric oxide synthase 3 treatment IEP RGD PMID:29323048 RGD:13504709 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Plat plasminogen activator, tissue type ISO CTD Direct Evidence: marker/mechanism CTD PMID:12227717 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:15135227 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A IEP protein:increased expression:spinal cord (rat) RGD PMID:21224756 RGD:5130917 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B IEP
ISO
protein:increased expression:spinal cord (rat)
human protein in rat model
RGD PMID:21224756, PMID:21224756 RGD:5130917, RGD:5130917 NCBI chr 5:163,136,390...163,167,299
Ensembl chr 5:163,136,390...163,167,299
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16123
    Wounds and Injuries 855
      Spinal Cord Injuries 264
        Spinal Cord Compression 21
Path 2
Term Annotations click to browse term
  disease 16123
    disease of anatomical entity 15370
      nervous system disease 10975
        central nervous system disease 9096
          spinal cord disease 1456
            Spinal Cord Injuries 264
              Spinal Cord Compression 21
paths to the root