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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Hyperplasia
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Accession:DOID:9002221 term browser browse the term
Definition:An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
Synonyms:exact_synonym: Hyperplasias
 narrow_synonym: Columnar Cell Hyperplasia of the Breast;   Flat Urothelial Hyperplasia
 primary_id: MESH:D006965;   RDO:0001143
 xref: EFO:0000536;   EFO:1000199;   EFO:1000259;   NCI:C3113


show annotations for term's descendants           Sort by:
Hyperplasia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 ISO associated with Hyperinsulinism;DNA:missense mutations:exon:p.R1353P, p.R1421C, p.R1494W (human) RGD PMID:9769320 RGD:2325205 NCBI chr 1:105,734,992...105,816,272
Ensembl chr 1:96,598,647...96,679,510 		JBrowse link
G Adcyap1 adenylate cyclase activating polypeptide 1 ISO RGD PMID:14742740 RGD:2325255 NCBI chr 9:120,550,236...120,569,096
Ensembl chr 9:113,103,718...113,109,773 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20530298 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Apc APC regulator of WNT signaling pathway ISO RGD PMID:17596282 RGD:2317191 NCBI chr18:26,138,382...26,196,021
Ensembl chr18:25,864,222...25,922,696 		JBrowse link
G Ascl1 achaete-scute family bHLH transcription factor 1 IDA RGD PMID:12555267 RGD:704377 NCBI chr 7:23,790,642...23,793,509
Ensembl chr 7:21,903,126...21,905,993 		JBrowse link
G Asip agouti signaling protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:32937126 NCBI chr 3:163,933,768...164,021,377
Ensembl chr 3:143,555,696...143,561,171 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator ISO RGD PMID:7569956 RGD:734632 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Brca1 BRCA1, DNA repair associated ISO RGD PMID:11889595 RGD:2293156 NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,418,000...86,477,304 		JBrowse link
G Brd4 bromodomain containing 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25242322 NCBI chr 7:11,866,997...11,946,575
Ensembl chr 7:11,216,446...11,295,539 		JBrowse link
G Cav1 caveolin 1 ISO RGD PMID:12368209 RGD:8661765 NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Ccnb1 cyclin B1 IEP mRNA, protein:increased expression:thyroid gland RGD PMID:19298605 RGD:2314685 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12151359 PMID:21541686 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdc25a cell division cycle 25A ISO RGD PMID:17283130 RGD:2764000 NCBI chr 8:118,742,824...118,761,190
Ensembl chr 8:109,864,478...109,882,701 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A IEP protein:increased expression RGD PMID:23890812 RGD:13792775 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A treatment IEP RGD PMID:23427405 RGD:8552677 NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Clu clusterin ISO associated with Breast Diseases RGD PMID:10934144 RGD:8699513 NCBI chr15:44,336,619...44,375,861
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Col2a1 collagen type II alpha 1 chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:25481498 NCBI chr 7:130,977,561...131,006,627
Ensembl chr 7:129,098,786...129,127,546 		JBrowse link
G Csk C-terminal Src kinase IEP mRNA, protein:decreased expression:large intestine mucosa RGD PMID:15961079 RGD:5134365 NCBI chr 8:66,925,650...66,944,861
Ensembl chr 8:58,029,749...58,048,292 		JBrowse link
G Egfr epidermal growth factor receptor IEP protein:increased expression:carotid artery (rat) RGD PMID:21357274 RGD:5131466 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Fgf7 fibroblast growth factor 7 ISO mRNA:increased expression:distal colon (mouse) RGD PMID:10338516 RGD:126928149 NCBI chr 3:133,734,557...133,786,678
Ensembl chr 3:113,281,283...113,332,929 		JBrowse link
G Glp1r glucagon-like peptide 1 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:23471186 NCBI chr20:8,973,393...9,011,622
Ensembl chr20:8,972,004...9,010,241 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:20526721 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmox1 heme oxygenase 1 ISO CTD Direct Evidence: therapeutic CTD PMID:19234301 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20864298 NCBI chr12:26,430,640...26,432,301
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta IMP RGD PMID:15939736 RGD:7495757 NCBI chr16:76,021,968...76,075,717
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il13 interleukin 13 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19342650 NCBI chr10:38,290,926...38,293,483
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il9 interleukin 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19342650 NCBI chr17:8,117,028...8,120,151
Ensembl chr17:8,111,772...8,114,895 		JBrowse link
G Kcnk1 potassium two pore domain channel subfamily K member 1 ISO CTD Direct Evidence: therapeutic CTD PMID:23291559 NCBI chr19:70,856,985...70,895,053
Ensembl chr19:53,959,657...53,997,724 		JBrowse link
G Kdm1a lysine demethylase 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:22493729 NCBI chr 5:154,066,436...154,121,913
Ensembl chr 5:148,782,976...148,838,319 		JBrowse link
G Ldlr low density lipoprotein receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:9207284 NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Lep leptin ISO CTD Direct Evidence: marker/mechanism CTD PMID:27712037 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Mapk6 mitogen-activated protein kinase 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22561872 NCBI chr 8:85,027,141...85,050,236
Ensembl chr 8:76,146,690...76,169,720 		JBrowse link
G Mat1a methionine adenosyltransferase 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:12060674 NCBI chr16:17,017,168...17,035,368
Ensembl chr16:16,983,022...17,001,274 		JBrowse link
G Mir340 microRNA 340 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25926378 NCBI chr10:34,894,650...34,894,747
Ensembl chr10:34,393,568...34,393,665 		JBrowse link
G Mmp1 matrix metallopeptidase 1 IDA Intimal Hyperplasia RGD PMID:22860019 RGD:7207219 NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mmp2 matrix metallopeptidase 2 IEP protein:increased expression:serum RGD PMID:19726059 RGD:2325718 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15728660 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mycn MYCN proto-oncogene, bHLH transcription factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:25174395 NCBI chr 6:41,446,683...41,452,584
Ensembl chr 6:35,717,764...35,723,590 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 ISO CTD Direct Evidence: therapeutic CTD PMID:19234301 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19336973 NCBI chr 4:148,030,237...148,037,599
Ensembl chr 4:146,474,750...146,484,766 		JBrowse link
G Pam peptidylglycine alpha-amidating monooxygenase IEP protein:increased expression:lung, alveolus (rat) RGD PMID:11742033 RGD:6483575 NCBI chr 9:105,445,812...105,719,287
Ensembl chr 9:98,122,916...98,271,965 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:22729222 PMID:22214849 RGD:13207413 NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Prg4 proteoglycan 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10545950 NCBI chr13:65,037,363...65,054,764
Ensembl chr13:62,487,257...62,504,119 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12151359 PMID:17093206 PMID:22561872 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rln3 relaxin 3 ISO CTD Direct Evidence: therapeutic CTD PMID:16112403 NCBI chr19:24,107,401...24,109,432
Ensembl chr19:24,107,401...24,109,886 		JBrowse link
G Tcf7l2 transcription factor 7 like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21383188 NCBI chr 1:264,791,335...264,984,225
Ensembl chr 1:254,786,091...254,978,967 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20172950 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 IEP mRNA:increased expression:bile duct, duct epithelial cell RGD PMID:12632524 RGD:1299231 NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 ISO CTD Direct Evidence: therapeutic CTD PMID:32535744 NCBI chr10:58,382,054...58,413,657
Ensembl chr10:57,883,546...57,913,296 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO associated with Breast Diseases;protein:increased expression:breast RGD PMID:19623180 RGD:2315458 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Zfp36 zinc finger protein 36 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15944294 NCBI chr 1:92,796,628...92,799,108
Ensembl chr 1:83,669,084...83,671,564 		JBrowse link
Epidermal Hyperplasia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor ISO RGD PMID:18208974 RGD:8695988 NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Srsf6 serine and arginine rich splicing factor 6 ISO human gene in a mouse model RGD PMID:24440982 RGD:11039481 NCBI chr 3:172,009,072...172,014,395
Ensembl chr 3:151,589,535...151,594,860 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO RGD PMID:23870655 RGD:8699499 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
hypoinsulinemic hypoglycemia with hemihypertrophy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt2 AKT serine/threonine kinase 2 ISO ClinVar Annotator: match by term: Hypoinsulinemic hypoglycemia and body hemihypertrophy | ClinVar Annotator: match by term: Hypoinsulinemic hypoglycemia and hemihypertrophy OMIM
ClinVar		 PMID:15166380 PMID:16722806 PMID:17327441 PMID:21518566 PMID:21979934 More... NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
Intimal Hyperplasia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr2 C-C motif chemokine receptor 2 ISO associated with Vascular System Injuries; RGD PMID:20836883 RGD:8661636 NCBI chr 8:132,611,883...132,619,106
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
G Cdk2 cyclin dependent kinase 2 treatment ISO RGD PMID:8104336 RGD:10448975 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 ISO RGD PMID:20836883 RGD:8661636 NCBI chr 8:128,661,294...128,679,048
Ensembl chr 8:119,782,595...119,800,014 		JBrowse link
G Dusp1 dual specificity phosphatase 1 treatment IEP RGD PMID:21964194 RGD:401976490 NCBI chr10:17,184,853...17,187,646 JBrowse link
G Egr1 early growth response 1 treatment IMP RGD PMID:23774133 RGD:10395302 NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Foxo3 forkhead box O3 ISO RGD PMID:15662024 RGD:10402197 NCBI chr20:47,251,968...47,348,254
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Icam1 intercellular adhesion molecule 1 treatment IMP RGD PMID:9118520 RGD:11520787 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Klf5 KLF transcription factor 5 IEP RGD PMID:11120052 RGD:1581748 NCBI chr15:82,472,081...82,487,267
Ensembl chr15:76,064,258...76,079,445 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 ameliorates
treatment		 IMP
IEP		 RGD PMID:23498803 PMID:21964194 RGD:401976463, RGD:401976490 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mdm2 MDM2 proto-oncogene treatment ISO RGD PMID:21498419 RGD:10412065 NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Mmp7 matrix metallopeptidase 7 IEP RGD PMID:20098355 RGD:9685369 NCBI chr 8:13,133,043...13,140,761
Ensembl chr 8:4,848,186...4,855,902 		JBrowse link
G Nos3 nitric oxide synthase 3 treatment ISO RGD PMID:9576106 RGD:11534002 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Npr2 natriuretic peptide receptor 2 ameliorates IMP RGD PMID:26410366 RGD:11528696 NCBI chr 5:62,678,197...62,697,360
Ensembl chr 5:57,883,171...57,901,580 		JBrowse link
G Nrp1 neuropilin 1 ameliorates IMP RGD PMID:26410366 RGD:11528696 NCBI chr19:73,256,557...73,411,705
Ensembl chr19:56,359,455...56,513,633 		JBrowse link
G Pcna proliferating cell nuclear antigen treatment IMP RGD PMID:8104336 RGD:10448975 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pdgfd platelet derived growth factor D IEP protein:increased expression:smooth muscle cell: RGD PMID:15752751 RGD:9854640 NCBI chr 8:11,773,335...12,007,277
Ensembl chr 8:3,488,423...3,722,395 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta treatment IMP RGD PMID:10982551 RGD:10449504 NCBI chr18:56,770,348...56,809,228
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
G Pten phosphatase and tensin homolog ameliorates ISO associated with Carotid Artery Injuries, human gene in a rat model RGD PMID:15569824 RGD:127285607 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
MACROCEPHALY, NEURODEVELOPMENTAL DELAY, LYMPHOID HYPERPLASIA, AND PERSISTENT FETAL HEMOGLOBIN term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Zbtb7a zinc finger and BTB domain containing 7a ISO ClinVar Annotator: match by term: Macrocephaly, neurodevelopmental delay, lymphoid hyperplasia, and persistent fetal hemoglobin OMIM
ClinVar		 PMID:25741868 PMID:31645653 PMID:34515416 NCBI chr 7:9,211,733...9,229,273
Ensembl chr 7:8,563,779...8,576,539 		JBrowse link
Neointima term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor treatment ISO RGD PMID:24132651 RGD:8695998 NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Agt angiotensinogen ISO CTD Direct Evidence: marker/mechanism CTD PMID:19258495 PMID:29609002 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO RGD PMID:25751394 RGD:329328927 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Anxa2 annexin A2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21204247 NCBI chr 8:78,986,252...79,022,638
Ensembl chr 8:70,105,253...70,141,658 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 treatment ISO RGD PMID:23535897 RGD:13782090 NCBI chr12:39,733,519...39,782,942
Ensembl chr12:34,072,683...34,122,101 		JBrowse link
G Atp7a ATPase copper transporting alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:20671235 NCBI chr  X:75,159,635...75,267,094
Ensembl chr  X:71,094,202...71,198,354 		JBrowse link
G Axl Axl receptor tyrosine kinase IEP RGD PMID:9758639 RGD:631894 NCBI chr 1:90,392,864...90,424,123
Ensembl chr 1:81,265,088...81,296,265 		JBrowse link
G Becn1 beclin 1 IMP RGD PMID:25238224 RGD:11558011 NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Carmn cardiac mesoderm enhancer-associated non-coding RNA exacerbates
ameliorates		 ISO
IDA		 RGD PMID:34694145 PMID:34694145 RGD:155883160, RGD:155883160 NCBI chr18:55,097,848...55,118,769
Ensembl chr18:55,095,230...55,118,825 		JBrowse link
G Clu clusterin ISO RGD PMID:19696405 PMID:20032585 RGD:8699512, RGD:9068412 NCBI chr15:44,336,619...44,375,861
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Cybb cytochrome b-245 beta chain treatment IMP RGD PMID:20485380 RGD:11040762 NCBI chr  X:16,030,596...16,065,065
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Drd4 dopamine receptor D4 treatment IDA associated with type 2 diabetes mellitus RGD PMID:24888351 RGD:13506962 NCBI chr 1:205,825,937...205,829,124
Ensembl chr 1:196,396,366...196,399,553 		JBrowse link
G Ece1 endothelin converting enzyme 1 IEP mRNA:increased expression:carotid artery RGD PMID:8575076 RGD:7244170 NCBI chr 5:155,361,031...155,462,723
Ensembl chr 5:150,077,644...150,179,371 		JBrowse link
G Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 treatment ISO RGD PMID:18485080 RGD:9685444 NCBI chr 1:249,374,810...249,502,310
Ensembl chr 1:239,425,430...239,552,317 		JBrowse link
G Epc1 enhancer of polycomb homolog 1 treatment ISO RGD PMID:22398275 RGD:9587795 NCBI chr17:59,198,513...59,289,535
Ensembl chr17:54,503,358...54,594,425 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 IEP RGD PMID:17438359 RGD:2289992 NCBI chr 9:76,973,386...78,045,633
Ensembl chr 9:69,531,481...70,596,595 		JBrowse link
G F3 coagulation factor III, tissue factor treatment IEP RGD PMID:22140576 RGD:11341672 NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Fgf2 fibroblast growth factor 2 IEP RGD PMID:8808969 RGD:8655643 NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 IDA RGD PMID:15072997 RGD:10402089 NCBI chr16:73,194,631...73,249,855
Ensembl chr16:66,494,042...66,547,350 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 treatment IEP
IMP		 mRNA,protein:increased expression:smooth muscle cell: RGD PMID:9400373 PMID:22814749 RGD:10402128, RGD:10402146 NCBI chr12:12,333,050...12,504,750
Ensembl chr12:7,297,292...7,468,626 		JBrowse link
G Foxo4 forkhead box O4 ISO protein:increased expression:smooth muscle cell: RGD PMID:17242183 PMID:16054032 RGD:10402361, RGD:10402362 NCBI chr  X:70,425,218...70,432,120
Ensembl chr  X:66,385,558...66,392,115 		JBrowse link
G Gas6 growth arrest specific 6 IEP RGD PMID:9758639 RGD:631894 NCBI chr16:82,747,676...82,778,090
Ensembl chr16:76,045,426...76,075,904 		JBrowse link
G Gata2 GATA binding protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28569748 NCBI chr 4:122,211,501...122,225,058
Ensembl chr 4:120,658,986...120,667,761 		JBrowse link
G Hmox1 heme oxygenase 1 treatment IMP RGD PMID:21804207 RGD:10755571 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Igf1 insulin-like growth factor 1 ISO associated with Hypertension RGD PMID:12791939 RGD:1580477 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 ISO associated with Vascular System Injuries RGD PMID:23657573 RGD:11049552 NCBI chr 1:144,088,788...144,178,989
Ensembl chr 1:134,679,586...134,769,755 		JBrowse link
G Irf8 interferon regulatory factor 8 ameliorates ISO associated with Carotid Artery Injuries RGD PMID:24248596 RGD:329902075 NCBI chr19:65,699,284...65,721,066
Ensembl chr19:48,790,588...48,811,829 		JBrowse link
G Klf5 KLF transcription factor 5 IEP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16224062 PMID:10417400 RGD:1581746 NCBI chr15:82,472,081...82,487,267
Ensembl chr15:76,064,258...76,079,445 		JBrowse link
G Lgals3 galectin 3 IEP mRNA:increased expression:thoracic aorta RGD PMID:9688561 RGD:9685205 NCBI chr15:23,099,795...23,111,731
Ensembl chr15:20,607,692...20,632,025 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 treatment IMP RGD PMID:14638553 RGD:10412321 NCBI chr 1:16,505,387...16,723,899
Ensembl chr 1:14,685,492...14,904,800 		JBrowse link
G Mir125a microRNA 125a treatment IMP RGD PMID:30156956 RGD:26884369 NCBI chr 1:67,350,675...67,350,759
Ensembl chr 1:58,677,626...58,677,710 		JBrowse link
G Mir126b microRNA 126b ameliorates IDA RGD PMID:31964421 RGD:401850783 NCBI chr 3:29,813,174...29,813,246 JBrowse link
G Mmp2 matrix metallopeptidase 2 treatment ISO
IEP		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:17964422 PMID:23344254 RGD:13207403 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 treatment ISO
IEP		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:17964422 PMID:23344254 RGD:13207403 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Myb MYB proto-oncogene, transcription factor treatment IMP RGD PMID:10438864 RGD:11532744 NCBI chr 1:17,759,309...17,793,306
Ensembl chr 1:15,939,761...15,973,057 		JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone dehydrogenase 2 IMP RGD PMID:22508052 RGD:11073699 NCBI chr17:31,114,825...31,144,062
Ensembl chr17:30,909,187...30,938,320 		JBrowse link
G Nrg1 neuregulin 1 IEP RGD PMID:17438359 RGD:2289992 NCBI chr16:65,954,084...67,007,484
Ensembl chr16:59,250,854...60,296,884 		JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 IDA
IMP		 RGD PMID:22922962 PMID:19359598 RGD:10041068, RGD:11533945 NCBI chr 1:161,522,399...161,637,623
Ensembl chr 1:152,111,188...152,226,383 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 IMP RGD PMID:15044192 RGD:10413907 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pdgfb platelet derived growth factor subunit B IEP RGD PMID:8585266 RGD:10449489 NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:111,540,345...111,557,984 		JBrowse link
G Pdgfra platelet derived growth factor receptor alpha treatment IEP associated with Carotid Artery Injuries RGD PMID:9323080 RGD:11087557 NCBI chr14:33,360,027...33,408,604
Ensembl chr14:33,005,839...33,054,335 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta treatment IEP associated with Carotid Artery Injuries RGD PMID:9323080 RGD:11087557 NCBI chr18:56,770,348...56,809,228
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 ISO RGD PMID:20307651 RGD:8693429 NCBI chr 8:27,465,538...27,477,016
Ensembl chr 8:19,189,373...19,200,785 		JBrowse link
G Pkn1 protein kinase N1 ameliorates IMP RGD PMID:22893700 RGD:243065233 NCBI chr19:41,346,855...41,374,832
Ensembl chr19:24,442,122...24,470,107 		JBrowse link
G Poldip2 DNA polymerase delta interacting protein 2 ISO RGD PMID:30237457 RGD:124713557 NCBI chr10:63,905,287...63,915,655
Ensembl chr10:63,407,213...63,417,605 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta IMP associated with Carotid Artery Injuries RGD PMID:22922962 RGD:10041068 NCBI chr15:44,536,275...44,656,754
Ensembl chr15:40,360,723...40,481,282 		JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C treatment IEP associated with Diabetes Mellitus, Type 2 RGD PMID:12377736 RGD:729766 NCBI chr13:52,147,717...52,259,810
Ensembl chr13:49,596,193...49,708,692 		JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29609002 NCBI chr 2:206,309,715...206,314,070
Ensembl chr 2:203,621,587...203,629,681 		JBrowse link
G Selp selectin P treatment IMP associated with Diabetes Mellitus, Type 2 RGD PMID:12377736 RGD:729766 NCBI chr13:79,009,379...79,044,994
Ensembl chr13:76,476,295...76,511,845 		JBrowse link
G Senp1 SUMO specific peptidase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28569748 NCBI chr 7:131,042,237...131,105,826
Ensembl chr 7:129,165,774...129,221,598 		JBrowse link
G Serpine1 serpin family E member 1 treatment IMP
ISO		 associated with Diabetes Mellitus, Type 2
human protein in rat model		 RGD PMID:18091579 PMID:19574558 RGD:8547879, RGD:8547913 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Spon2 spondin 2 ISO
IMP		 RGD PMID:25751394 PMID:25751394 RGD:329328927, RGD:329328927 NCBI chr14:81,713,070...81,742,510
Ensembl chr14:77,511,901...77,517,996 		JBrowse link
G Spon2em1Holi spondin 2; TALEN induced mutant1, Holi IMP RGD PMID:25751394 RGD:329328927
G Ssh1 slingshot protein phosphatase 1 IEP protein:increased expression:carotid artery RGD PMID:21868701 RGD:11535005 NCBI chr12:48,281,756...48,343,812
Ensembl chr12:42,621,135...42,683,274 		JBrowse link
G Stat4 signal transducer and activator of transcription 4 treatment IDA associated with Carotid Artery Injuries RGD PMID:16118253 RGD:5509614 NCBI chr 9:56,964,617...57,080,523
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Stim1 stromal interaction molecule 1 ameliorates IMP RGD PMID:19107116 RGD:151893459 NCBI chr 1:166,067,450...166,230,733
Ensembl chr 1:156,656,013...156,818,363 		JBrowse link
G Tfpi tissue factor pathway inhibitor treatment ISO
IEP		 RGD PMID:10521388 PMID:22140576 RGD:11060274, RGD:11341672 NCBI chr 3:89,939,862...89,989,253
Ensembl chr 3:69,533,156...69,576,880 		JBrowse link
G Timm44 translocase of inner mitochondrial membrane 44 treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:16186389 RGD:13463598 NCBI chr12:7,410,424...7,428,179
Ensembl chr12:2,612,581...2,629,351 		JBrowse link
G Yy1 YY1 transcription factor treatment IMP RGD PMID:21030713 RGD:9588268 NCBI chr 6:133,471,615...133,500,875
Ensembl chr 6:127,707,596...127,732,747 		JBrowse link
PINEAL HYPERPLASIA, INSULIN-RESISTANT DIABETES MELLITUS, AND SOMATIC ABNORMALITIES term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Insr insulin receptor ISO ClinVar Annotator: match by term: Mendenhall Syndrome | ClinVar Annotator: match by term: Pineal Hyperplasia, Insulin-Resistant Diabetes Mellitus, and Somatic Abnormalities | ClinVar Annotator: match by term: Rabson-Mendenhall syndrome OMIM
ClinVar		 PMID:2002058 PMID:2040394 PMID:2121734 PMID:2211730 PMID:2233914 More... NCBI chr12:5,991,135...6,129,275
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
Term paths to the root