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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:endometrial cancer pathway
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Accession:PW:0000611 term browser browse the term
Definition:Endometrial cancer affects the lining of the uterus, or endometrium. Hormonal and genetic alterations play a role in the development of this carcinoma type. Mutations in genes acting in several pathways have been associated with the condition and its types.
Synonyms:related_synonym: KEGG:05213;   endometrial neoplasm pathway
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endometrial cancer pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 IEA KEGG rno:05213 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 severity IEA
ISO		 KEGG
RGD		 PMID:22146979 rno:05213, RGD:13432140 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 IEA KEGG rno:05213 NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708 		JBrowse link
G Apc APC regulator of WNT signaling pathway IEA
ISO		 KEGG
RGD		 PMID:12439748 rno:05213, RGD:13432145 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696 		JBrowse link
G Apc2 APC regulator of WNT signaling pathway 2 IEA KEGG rno:05213 NCBI chr 7:9,392,336...9,414,364
Ensembl chr 7:9,392,336...9,414,310 		JBrowse link
G Axin1 axin 1 IEA KEGG rno:05213 NCBI chr10:15,163,477...15,215,615
Ensembl chr10:15,163,684...15,215,615 		JBrowse link
G Axin2 axin 2 IEA
ISO		 KEGG
RGD		 PMID:25144715 rno:05213, RGD:13432159 NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231 		JBrowse link
G Bad BCL2-associated agonist of cell death IEA
ISO		 KEGG
RGD		 PMID:12790783 rno:05213, RGD:13432162 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase IEA KEGG rno:05213 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463 		JBrowse link
G Casp9 caspase 9 IEA
ISO		 KEGG
RGD		 PMID:17121923 rno:05213, RGD:13432196 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccnd1 cyclin D1 IEA KEGG rno:05213 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdh1 cadherin 1 IEA KEGG rno:05213 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Ctnna1 catenin alpha 1 IEA KEGG rno:05213 NCBI chr18:26,728,246...26,860,911
Ensembl chr18:26,728,485...26,860,910 		JBrowse link
G Ctnna2 catenin alpha 2 IEA KEGG rno:05213 NCBI chr 4:109,294,249...110,443,409
Ensembl chr 4:109,293,978...110,443,522 		JBrowse link
G Ctnna3 catenin alpha 3 IEA KEGG rno:05213 NCBI chr20:23,614,469...25,200,026
Ensembl chr20:23,623,560...25,199,978 		JBrowse link
G Ctnnb1 catenin beta 1 ISO
IEA		 KEGG
RGD		 PMID:19078924 rno:05213, RGD:4143515 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Egf epidermal growth factor IEA KEGG rno:05213 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfr epidermal growth factor receptor IEA KEGG rno:05213 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Elk1 ETS transcription factor ELK1 IEA KEGG rno:05213 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 ISO
IEA		 KEGG
RGD		 PMID:19078924 rno:05213, RGD:4143515 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Foxo3 forkhead box O3 IEA KEGG rno:05213 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Grb2 growth factor receptor bound protein 2 IEA KEGG rno:05213 NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta IEA KEGG rno:05213 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hras HRas proto-oncogene, GTPase IEA KEGG rno:05213 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Ilk integrin-linked kinase IEA KEGG rno:05213 NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140 		JBrowse link
G Kras KRAS proto-oncogene, GTPase ISO
IEA		 KEGG
RGD		 PMID:19078924 rno:05213, RGD:4143515 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Lef1 lymphoid enhancer binding factor 1 IEA KEGG rno:05213 NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 IEA KEGG rno:05213 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 IEA KEGG rno:05213 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 IEA KEGG rno:05213 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 IEA KEGG rno:05213 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mlh1 mutL homolog 1 ISO
IEA		 KEGG
RGD		 PMID:19078924 rno:05213, RGD:4143515 NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617 		JBrowse link
G Msh6 mutS homolog 6 ISO RGD PMID:19078924 RGD:4143515 NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor IEA KEGG rno:05213 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nras NRAS proto-oncogene, GTPase IEA KEGG rno:05213 NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 IEA KEGG rno:05213 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO
IEA		 KEGG
RGD		 PMID:19078924 rno:05213, RGD:4143515 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta IEA KEGG rno:05213 NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta IEA KEGG rno:05213 NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 IEA KEGG rno:05213 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 IEA KEGG rno:05213 NCBI chr16:18,665,517...18,674,067
Ensembl chr16:18,665,457...18,674,065 		JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 IEA KEGG rno:05213 NCBI chr 5:129,700,925...129,772,591
Ensembl chr 5:129,701,229...129,772,583 		JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 IEA KEGG rno:05213 NCBI chr10:53,132,585...53,200,663
Ensembl chr10:53,132,603...53,199,374 		JBrowse link
G Pten phosphatase and tensin homolog ISO
IEA		 KEGG
RGD		 PMID:19078924 rno:05213, RGD:4143515 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase IEA KEGG rno:05213 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 IEA KEGG rno:05213 NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107 		JBrowse link
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 IEA KEGG rno:05213 NCBI chr 6:88,042,966...88,156,140
Ensembl chr 6:88,042,966...88,156,692 		JBrowse link
G Tcf3 transcription factor 3 IEA KEGG rno:05213 NCBI chr 7:9,280,571...9,302,315
Ensembl chr 7:9,280,571...9,302,314 		JBrowse link
G Tcf7 transcription factor 7 IEA KEGG rno:05213 NCBI chr10:36,423,443...36,454,350
Ensembl chr10:36,423,445...36,453,535 		JBrowse link
G Tcf7l2 transcription factor 7 like 2 IEA KEGG rno:05213 NCBI chr 1:254,785,956...254,978,967
Ensembl chr 1:254,786,091...254,978,967 		JBrowse link
G Tp53 tumor protein p53 ISO
IEA		 KEGG
RGD		 PMID:19078924 rno:05213, RGD:4143515 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    disease pathway 1954
      cancer pathway 369
        urogenital cancer pathway 159
          endometrial cancer pathway 51
paths to the root