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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Viral Bronchiolitis
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Accession:DOID:9006928 term browser browse the term
Definition:An acute inflammatory disease of the lower RESPIRATORY TRACT, caused by paramyxoviruses, occurring primarily in infants and young children; the viruses most commonly implicated are PARAINFLUENZA VIRUS TYPE 3; RESPIRATORY SYNCYTIAL VIRUS, HUMAN; and METAPNEUMOVIRUS.
Synonyms:exact_synonym: Viral Bronchiolitides
 primary_id: MESH:D001990


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Viral Bronchiolitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam33 ADAM metallopeptidase domain 33 susceptibility ISO DNA:SNP: :rs2787094 c.2891G>C (human) RGD PMID:19258923 RGD:4142862 NCBI chr 3:118,262,395...118,283,456
Ensembl chr 3:118,271,029...118,283,461 		JBrowse link
G Bcl2 BCL2, apoptosis regulator severity ISO protein:increased expression:natural killer cell, T cell (human) RGD PMID:26541527 RGD:40902860 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 severity ISO protein:increased expression:natural killer cell,t cell (human) RGD PMID:26541527 RGD:40902860 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G C3 complement C3 resistance ISO RGD PMID:19258923 PMID:12235218 RGD:4142862, RGD:5129513 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G Casp1 caspase 1 ISO RGD PMID:15196254 RGD:5130189 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Cat catalase ISO protein:decreased expression:nasal mucus RGD PMID:21471094 RGD:5130770 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 susceptibility ISO protein:increased secretion:serum (human)
DNA:snp:5' utr:g.-28C>G (human)		 RGD PMID:19005677 PMID:19099677 RGD:4891884, RGD:4891881 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Cd14 CD14 molecule ISO DNA:polymorphism:promoter:c.-550C>T (human) RGD PMID:17471431 RGD:4144210 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
G Cd274 CD274 molecule treatment ISO mRNA:increased expression:lung RGD PMID:22797302 PMID:22797302 RGD:40818270, RGD:40818270 NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450 		JBrowse link
G Csf2 colony stimulating factor 2 ISO protein:increased expression:nasal mucus RGD PMID:20088864 RGD:4143440 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 ISO DNA:SNP: :p.T280M (human) RGD PMID:18257903 PMID:16645504 RGD:4891891, RGD:4891905 NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 IEP
ISO		 mRNA:increased expression:lung
protein:increased expression:plasma		 RGD PMID:12909590 PMID:20561238 RGD:2311388, RGD:5135493 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 ISO RGD PMID:20561238 RGD:5135493 NCBI chr  X:66,844,318...66,846,969
Ensembl chr  X:66,844,318...66,846,969 		JBrowse link
G Fas Fas cell surface death receptor severity ISO mRNA:increased expression:peripheral blood mononuclear cell (human) RGD PMID:26541527 RGD:40902860 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 severity ISO mRNA:increased expression:peripheral blood mononuclear cell (human) RGD PMID:26541527 RGD:40902860 NCBI chr12:7,623,930...7,699,474
Ensembl chr12:7,623,930...7,699,474 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase severity ISO mRNA:increased expression:peripheral blood mononuclear cell (human) RGD PMID:26541527 RGD:40902860 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235 		JBrowse link
G Ifnl1 interferon, lambda 1 exacerbates ISO associated with respiratory syncytial virus infectious disease;mRNA:increased expression:mucosa of nasopharynx (human) RGD PMID:24389019 RGD:126848743 NCBI chr 1:83,798,651...83,800,297
Ensembl chr 1:83,798,703...83,800,235 		JBrowse link
G Il15 interleukin 15 severity ISO mRNA,protein:increased expression:peripheral blood mononuclear cell,serum,dendritic cell (human) RGD PMID:26541527 RGD:40902860 NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820 		JBrowse link
G Il17a interleukin 17A susceptibility ISO DNA:SNP: :rs7747909(human) RGD PMID:17703412 RGD:4889847 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il1rn interleukin 1 receptor antagonist susceptibility ISO DNA:SNP: :c.390T>C (rs315952) (human) RGD PMID:19258923 RGD:4142862 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Il33 interleukin 33 ISO protein:increased expression:nasal mucus RGD PMID:28471975 RGD:38596342 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373 		JBrowse link
G Il4r interleukin 4 receptor susceptibility ISO associated with respiratory syncystial virus infection; DNA:polymorphism:cds:p. Q551R (human)
DNA:SNPs: :rs1805011,rs2057768 (human)		 RGD PMID:12508140 PMID:17703412 PMID:20404812 RGD:4890022, RGD:4889847, RGD:4889996 NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980 		JBrowse link
G Il6 interleukin 6 ISO mRNA, protein:increased expression:respiratory system fluid/secretion RGD PMID:14738241 RGD:5128668 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Il9 interleukin 9 ISO RGD PMID:15051283 RGD:5128692 NCBI chr17:8,111,772...8,114,895
Ensembl chr17:8,111,772...8,114,895 		JBrowse link
G Jak3 Janus kinase 3 severity ISO mRNA:increased expression:peripheral blood mononuclear cell (human) RGD PMID:26541527 RGD:40902860 NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536 		JBrowse link
G Klrk1 killer cell lectin like receptor K1 susceptibility ISO DNA:SNP,haplotypes:3'utr: (rs10772271) (human) RGD PMID:29967528 RGD:39128159 NCBI chr 4:163,079,887...163,092,434
Ensembl chr 4:163,081,927...163,092,459 		JBrowse link
G Mpo myeloperoxidase ISO RGD PMID:7841728 RGD:5130995 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Muc1 mucin 1, cell surface associated severity ISO protein:increased expression:serum RGD PMID:19856476 RGD:5131164 NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 severity ISO mRNA:increased expression:peripheral blood mononuclear cell (human) RGD PMID:26541527 RGD:40902860 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha susceptibility ISO associated with respiratory syncytial virus infectious disease;DNA:SNP:promoter: (rs2233406) (human) RGD PMID:23487427 RGD:40902982 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 susceptibility ISO DNA:SNP: :rs1060826(human) RGD PMID:17703412 RGD:4889847 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Pdcd1 programmed cell death 1 ISO protein:increased expression:CD8 T cell RGD PMID:22797302 RGD:40818270 NCBI chr 9:94,418,786...94,431,945
Ensembl chr 9:94,418,791...94,431,937 		JBrowse link
G Postn periostin ISO mRNA,protein:increased expression:nasal mucus RGD PMID:28471975 RGD:38596342 NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A severity ISO mRNA:increased expression:peripheral blood mononuclear cell (human) RGD PMID:26541527 RGD:40902860 NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866 		JBrowse link
G Tlr4 toll-like receptor 4 ISO protein:increased expression:monocyte
protein:decreased expression:neutrophil		 RGD PMID:14738455 PMID:19497921 RGD:4144819, RGD:4144183 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tlr5 toll-like receptor 5 susceptibility ISO DNA:snp:cds:p.F616L rs5744174 (human) RGD PMID:19258923 RGD:4142862 NCBI chr13:94,634,778...94,658,992
Ensembl chr13:94,634,801...94,657,738 		JBrowse link
G Tnf tumor necrosis factor susceptibility ISO DNA:SNP: :rs1799724(human)
protein:increased expression:nasal lavage fluid
DNA:polymorphism:promoter: c. -308A>G (human)		 RGD PMID:17703412 PMID:20088864 PMID:19849941 RGD:4889847, RGD:4143440, RGD:4143441 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b severity ISO mRNA:increased expression:peripheral blood mononuclear cell (human) RGD PMID:26541527 RGD:40902860 NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467 		JBrowse link
G Tslp thymic stromal lymphopoietin severity ISO mRNA, protein:increased expression:nasal mucus (human) RGD PMID:28471975 RGD:38596342 NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548 		JBrowse link
G Vdr vitamin D receptor susceptibility ISO DNA:SNP (human)
DNA:SNP: :rs10735810 (human)		 RGD PMID:18266602 PMID:17703412 RGD:4889843, RGD:4889847 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19100
    disease by infectious agent 2253
      viral infectious disease 1717
        Viral Bronchiolitis 40
Path 2
Term Annotations click to browse term
  disease 19100
    disease of anatomical entity 18440
      respiratory system disease 5243
        lower respiratory tract disease 2360
          lung disease 2321
            obstructive lung disease 479
              bronchitis 92
                bronchiolitis 78
                  Viral Bronchiolitis 40
paths to the root