RGD Reference Report - Eosinophil cationic protein in nasal secretion and in serum and myeloperoxidase in serum in respiratory syncytial virus bronchiolitis: relation to asthma and atopy.

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Eosinophil cationic protein in nasal secretion and in serum and myeloperoxidase in serum in respiratory syncytial virus bronchiolitis: relation to asthma and atopy.
Authors:	Sigurs, N Bjarnason, R Sigurbergsson, F
Citation:	Sigurs N, etal., Acta Paediatr. 1994 Nov;83(11):1151-5.
RGD ID:	5130995
Pubmed:	PMID:7841728 (View Abstract at PubMed)
Eosinophil cationic protein (ECP) in nasal secretions was determined in 34 infants with respiratory syncytial virus (RSV) bronchiolitis during the acute infection stage and one and six months later. ECP in serum was determined in 19 of these children at the same time. Myeloperoxidase (MPO) was determined in the same 19 children at the acute infection stage and after one month. All children were followed prospectively for two years after the infection with regard to the development of bronchial obstructive symptoms. Asthma, defined as three or more episodes of bronchial obstruction verified by a physician, developed in 18% of children and less severe obstructive symptoms in 29%. A screening test for food IgE antibodies in serum was performed six months and a skin prick test two years after the acute infection. Nasal ECP/albumin ratios after six months were significantly higher than during the acute RSV infection. MPO, but not ECP, levels in serum were significantly elevated at the time of acute infection compared with levels after one month. Nasal ECP/albumin ratios at the acute infection were compared to a control group of 27 infants with non-RSV upper respiratory tract infections and did not differ. It was not possible to predict, either from ECP/albumin ratios in nasal secretion or from ECP and MPO in serum, which children would develop asthma, other bronchial obstructive symptoms or positive IgE tests.

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Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
MPO	Human	Viral Bronchiolitis		IEP			RGD
Mpo	Mouse	Viral Bronchiolitis		ISO	MPO (Homo sapiens)		RGD
Mpo	Rat	Viral Bronchiolitis		ISO	MPO (Homo sapiens)		RGD

Objects Annotated

Genes (Rattus norvegicus)

Mpo (myeloperoxidase)

Genes (Mus musculus)

Mpo (myeloperoxidase)

Genes (Homo sapiens)

MPO (myeloperoxidase)

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Eosinophil cationic protein in nasal secretion and in serum and myeloperoxidase in serum in respiratory syncytial virus bronchiolitis: relation to asthma and atopy.