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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:leptospirosis
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Accession:DOID:2297 term browser browse the term
Definition:A primary bacterial infectious disease that involves systemic infection, has_material_basis_in Leptospira, which is transmitted by contact with water, food, or soil containing urine from the infected animals. The infection has symptom jaundice, has symptom chills, has symptom fever, has symptom muscle pain, and has symptom hepatomegaly. (DO)
Synonyms:exact_synonym: Fort Bragg fever;   Stuttgart disease;   cane cutter fever;   leptospira canicola infection;   leptospira canicola infections;   leptospiroses;   leptospirosis canicola;   leptospirosis canicolas;   leptospirosis icterohaemorrhagica;   mud fever;   nanukayami fever;   rat catcher's yellows;   rice field fever;   spirochetal jaundice
 primary_id: MESH:D007922
 xref: EFO:0007344;   GARD:7881;   ICD10CM:A27;   ICD10CM:A27.0;   ICD9CM:100;   ICD9CM:100.0;   NCI:C84825
For additional species annotation, visit the Alliance of Genome Resources.


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leptospirosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase IEP RGD PMID:21921108 RGD:5688128 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Ada adenosine deaminase IEP RGD PMID:21320715 RGD:5128858 NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088 		JBrowse link
G Bche butyrylcholinesterase IEP protein:increased expression:serum RGD PMID:21921108 RGD:5688128 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G F2 coagulation factor II, thrombin severity ISO protein:increased expression:blood plasma (human) RGD PMID:18171258 PMID:20002620 RGD:40818429, RGD:40819859 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G Il1b interleukin 1 beta ISO mRNA, protein:increased expression:kidney (mouse) RGD PMID:22323544 RGD:7175257 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Mbl2 mannose binding lectin 2 severity ISO protein:increased expression:serum RGD PMID:19330263 RGD:6903260 NCBI chr 1:228,016,439...228,024,736 JBrowse link
G Tlr2 toll-like receptor 2 ISO RGD PMID:19635914 RGD:7240557 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr4 toll-like receptor 4 ISO RGD PMID:19635914 PMID:16428731 RGD:7240557, RGD:7241090 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19137
    disease by infectious agent 2252
      Bacterial Infections and Mycoses 1118
        bacterial infectious disease 824
          primary bacterial infectious disease 198
            leptospirosis 8
              Weil Disease 0
paths to the root