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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Retina Reperfusion Injury
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Accession:DOID:9001725 term browser browse the term
Definition:Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the retina, including swelling; hemorrhage; necrosis; and damage from free radicals.
Synonyms:exact_synonym: RIRI;   Retinal Ischemia-Reperfusion Injury
 primary_id: RDO:9000042
For additional species annotation, visit the Alliance of Genome Resources.


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Retina Reperfusion Injury term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apaf1 apoptotic peptidase activating factor 1 treatment IDA RGD PMID:22143029 RGD:5686888 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Bad BCL2-associated agonist of cell death treatment IDA RGD PMID:23056591 RGD:10053711 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bax BCL2 associated X, apoptosis regulator treatment IEP RGD PMID:23056591 RGD:10053711 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator treatment IDA RGD PMID:25535961 RGD:11522737 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 treatment IEP RGD PMID:23056591 RGD:10053711 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bdnf brain-derived neurotrophic factor ISO RGD PMID:10549664 RGD:8655861 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Casp7 caspase 7 IEP RGD PMID:20702827 RGD:5684535 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Cat catalase treatment IEP protein:decreased expression,decreased activity:retina: RGD PMID:22509733 RGD:9068919 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 treatment IDA RGD PMID:24325836 RGD:11526144 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Clu clusterin IEP RGD PMID:15139011 RGD:1581194 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Cntf ciliary neurotrophic factor treatment IDA RGD PMID:8125754 RGD:8655591 NCBI chr 1:229,599,009...229,601,032
Ensembl chr 1:229,599,009...229,601,032
JBrowse link
G Dusp1 dual specificity phosphatase 1 treatment IMP RGD PMID:21094639 RGD:7495849 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G Fgf2 fibroblast growth factor 2 treatment IEP
ISO
RGD PMID:9561364, PMID:8125754, PMID:14975212 RGD:8554857, RGD:8655591, RGD:8655585 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Hdac2 histone deacetylase 2 treatment ISO RGD PMID:23696608 RGD:9590210 NCBI chr20:43,084,870...43,108,198
Ensembl chr20:43,084,870...43,108,198
JBrowse link
G Hgf hepatocyte growth factor treatment ISO
IEP
mRNA,protein:increased expression:retina: RGD PMID:11818401, PMID:11818401 RGD:8548551, RGD:8548551 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Hmgb1 high mobility group box 1 IDA RGD PMID:21999229 RGD:10402064 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hmox1 heme oxygenase 1 IEP associated with Glaucoma RGD PMID:20357190 RGD:4145289 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 IDA RGD PMID:21310899 RGD:10402767 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Icam1 intercellular adhesion molecule 1 treatment IMP
IEP
associated with Hypertension RGD PMID:10235552, PMID:15007035 RGD:8547704, RGD:8547707 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il1a interleukin 1 alpha IEP RGD PMID:7890488 RGD:7401191 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta IEP RGD PMID:7890488 RGD:7401191 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 IEP mRNA:increased expression:retina: RGD PMID:16530172 RGD:7829807 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Kcnj10 potassium inwardly-rectifying channel, subfamily J, member 10 IEP
ISO
mRNA:decreased expression:retina
protein:decreased expression:retina, blood vessel
RGD PMID:16330144, PMID:20132867 RGD:8662868, RGD:8662890 NCBI chr13:90,722,945...90,753,338
Ensembl chr13:90,723,092...90,752,581
JBrowse link
G Lpar1 lysophosphatidic acid receptor 1 IEP protein:increased expression:retina RGD PMID:17026968 RGD:2317696 NCBI chr 5:75,557,038...75,678,067
Ensembl chr 5:75,557,042...75,676,584
JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 IEP RGD PMID:19668425 RGD:7495824 NCBI chr10:52,196,121...52,301,887
Ensembl chr10:52,196,124...52,290,657
JBrowse link
G Nos3 nitric oxide synthase 3 treatment IEP
IDA
mRNA:altered expression:retina (rat)
protein:increased expression:retinal vasculature, retinal ganglion cell layer (rat)
RGD PMID:9950605, PMID:11496119, PMID:12634478 RGD:7771570, RGD:7775036, RGD:7775037 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase IEP protein:increased expression:retina, cytosol (rat) RGD PMID:19122832 RGD:13208943 NCBI chr11:74,717,600...74,793,902
Ensembl chr11:74,720,254...74,793,803
JBrowse link
G Ren renin treatment IMP RGD PMID:24709336 RGD:11039406 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Rnf2 ring finger protein 2 IEP RGD PMID:20740046 RGD:9491844 NCBI chr13:68,829,714...68,859,920
Ensembl chr13:68,830,620...68,858,809
JBrowse link
G Serpinf1 serpin family F member 1 ISO human protein in a mouse model RGD PMID:16822505 RGD:8554871 NCBI chr10:62,241,750...62,254,145
Ensembl chr10:62,241,756...62,254,287
JBrowse link
G Sod2 superoxide dismutase 2 treatment IEP
ISO
protein:decreased activity:retina: RGD PMID:22240151, PMID:22240151 RGD:8158043, RGD:8158043 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Stat3 signal transducer and activator of transcription 3 treatment IDA RGD PMID:21858029 RGD:8694310 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tlr4 toll-like receptor 4 ISO RGD PMID:21031135 RGD:7794771 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor IEP
IMP
IDA
protein:increased expression:retina: RGD PMID:18660426, PMID:18660426, PMID:18660426 RGD:7387281, RGD:7387281, RGD:7387281 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vegfa vascular endothelial growth factor A IDA RGD PMID:17591953 RGD:7421609 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Xdh xanthine dehydrogenase treatment IMP RGD PMID:9288448 RGD:13210506 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16122
    sensory system disease 5248
      eye disease 2673
        retinal disease 780
          Retina Reperfusion Injury 36
Path 2
Term Annotations click to browse term
  disease 16122
    disease of anatomical entity 15369
      nervous system disease 10977
        sensory system disease 5248
          eye disease 2673
            retinal disease 780
              Retina Reperfusion Injury 36
paths to the root