RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Binge Drinking
Accession: DOID:9006302
browse the term
Definition: Drinking an excessive amount of ALCOHOLIC BEVERAGES in a short period of time.
Synonyms: primary_id: MESH:D063425 ; RDO:0012117
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Adh1c
alcohol dehydrogenase 1C (class I), gamma polypeptide
IEP
mRNA:altered exxpression:liver (rat)
RGD
PMID:23413777
RGD:405100715
NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
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Adh4
alcohol dehydrogenase 4 (class II), pi polypeptide
IEP
mRNA:altered exxpression:liver (rat)
RGD
PMID:23413777
RGD:405100715
NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591
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Bdnf
brain-derived neurotrophic factor
IEP
protein:altered expression:amygdala, pyriform cortex, bed nucleus of stria terminalis
RGD
PMID:23588198
RGD:405849391
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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Car3
carbonic anhydrase 3
IEP
associated with Alcoholic Liver Diseases;protein:decreased expression:liver
RGD
PMID:22545783
RGD:7495839
NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
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Crhr1
corticotropin releasing hormone receptor 1
IEP
mRNA:decreased expression:adenohypophysis
RGD
PMID:11045867
RGD:407431640
NCBI chr10:89,040,186...89,083,481
Ensembl chr10:89,040,203...89,083,481
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
ISO IEP
protein:increased expression, increased nitration mRNA:altered exxpression:liver (rat) associated with Alcoholic Liver Diseases;protein:increased expression:liver
RGD
PMID:25236742 PMID:25236742 PMID:29404485 PMID:23413777 PMID:22545783
RGD:14700891 , RGD:14700891 , RGD:14700911 , RGD:405100715 , RGD:7495839
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Dnmt1
DNA methyltransferase 1
ISO
protein:increased expression:nucleus accumbens:
RGD
PMID:23423140
RGD:9588287
NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
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Drd1
dopamine receptor D1
IEP
associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat)
RGD
PMID:23413777
RGD:405100715
NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
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Drd2
dopamine receptor D2
IEP
mRNA:altered exxpression:spleen (rat)
RGD
PMID:23413777
RGD:405100715
NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
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Drd3
dopamine receptor D3
IEP
associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat)
RGD
PMID:23413777
RGD:405100715
NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
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Drd4
dopamine receptor D4
susceptibility
ISO IEP
DNA:repeats:exon: mRNA:altered exxpression:spleen (rat)
RGD
PMID:19393859 PMID:23413777
RGD:401960068 , RGD:405100715
NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553
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Efhd2
EF-hand domain family, member D2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:28397836
NCBI chr 5:154,160,945...154,176,980
Ensembl chr 5:154,160,946...154,176,980
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
IEP
protein:increased expression:prefrontal cortex
RGD
PMID:29407478
RGD:405295494
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Gabra1
gamma-aminobutyric acid type A receptor subunit alpha 1
IEP
associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat)
RGD
PMID:23413777
RGD:405100715
NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
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Gabra2
gamma-aminobutyric acid type A receptor subunit alpha 2
IEP
associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat)
RGD
PMID:23413777
RGD:405100715
NCBI chr14:37,097,251...37,230,030
Ensembl chr14:37,097,279...37,228,944
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Gabra3
gamma-aminobutyric acid type A receptor subunit alpha 3
IEP
associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat)
RGD
PMID:23413777
RGD:405100715
NCBI chr X:150,244,745...150,501,566
Ensembl chr X:150,261,607...150,501,559
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Gabra6
gamma-aminobutyric acid type A receptor subunit alpha6
IEP
mRNA:altered exxpression:spleen (rat)
RGD
PMID:23413777
RGD:405100715
NCBI chr10:26,810,411...26,825,768
Ensembl chr10:26,810,423...26,825,769
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Gdnf
glial cell derived neurotrophic factor
IMP IEP
protein:altered expression:amygdala, pyriform cortex, bed nucleus of stria terminalis
RGD
PMID:23298382 PMID:23588198
RGD:405849390 , RGD:405849391
NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209
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Gpx1
glutathione peroxidase 1
IEP
protein:decreased expression:liver
RGD
PMID:25864381
RGD:401827870
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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Gpx3
glutathione peroxidase 3
IEP
protein:decreased expression:serum
RGD
PMID:25864381
RGD:401827870
NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
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Gpx4
glutathione peroxidase 4
IEP
protein:decreased expression:liver
RGD
PMID:25864381
RGD:401827870
NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
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Grm2
glutamate metabotropic receptor 2
IEP
associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat)
RGD
PMID:23413777
RGD:405100715
NCBI chr 8:107,280,099...107,293,159
Ensembl chr 8:107,280,099...107,293,146
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Grm5
glutamate metabotropic receptor 5
IEP
associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat)
RGD
PMID:23413777
RGD:405100715
NCBI chr 1:141,310,069...141,884,980
Ensembl chr 1:141,312,368...141,882,274
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Mir125a
microRNA 125a
IEP
RNA:decreased expression:neuron
RGD
PMID:27085842
RGD:26884454
NCBI chr 1:58,677,626...58,677,710
Ensembl chr 1:58,677,626...58,677,710
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Mir223
microRNA 223
ISO
RNA:increased expression:serum RNA:increased expression:serum, neutrophil,liver
RGD
PMID:27679493 PMID:27679493
RGD:21408575 , RGD:21408575
NCBI chr X:61,141,887...61,141,996
Ensembl chr X:61,141,887...61,141,996
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Npy1r
neuropeptide Y receptor Y1
ameliorates
ISO
protein:decreased expression:central amygdaloid nucleus (mouse)
RGD
PMID:30647448 PMID:22218088
RGD:402463940 , RGD:405096664
NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
treatment
IMP
RGD
PMID:22500955
RGD:408361838
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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Oprl1
opioid related nociceptin receptor 1
ISO
RGD
PMID:29197086
RGD:14348965
NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:168,834,003...168,839,920
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Per2
period circadian regulator 2
ISO
DNA, mRNA:hypermethylation, decreased expression:blood
RGD
PMID:30597578
RGD:405878075
NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459
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Pomc
proopiomelanocortin
ISO IEP
DNA, mRNA:hypermethylation, decreased expression:blood mRNA:decreased expression:hypothalamus protein:decreased expression:central amygdaloid nucleus, arcuate and paraventricular nucleus of hypothalamus
RGD
PMID:30597578 PMID:11045867 PMID:23792540
RGD:405878075 , RGD:407431640 , RGD:407571694
NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
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Sirt1
sirtuin 1
IEP
RGD
PMID:24416161
RGD:9495933
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
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Slc23a2
solute carrier family 23 member 2
IEP
RGD
PMID:27085842
RGD:26884454
NCBI chr 3:119,302,651...119,395,289
Ensembl chr 3:119,302,666...119,460,343
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