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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Binge Drinking
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Accession:DOID:9006302 term browser browse the term
Definition:Drinking an excessive amount of ALCOHOLIC BEVERAGES in a short period of time.
Synonyms:primary_id: MESH:D063425;   RDO:0012117


show annotations for term's descendants           Sort by:
Binge Drinking term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh1c alcohol dehydrogenase 1C (class I), gamma polypeptide IEP mRNA:altered exxpression:liver (rat) RGD PMID:23413777 RGD:405100715 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892 		JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide IEP mRNA:altered exxpression:liver (rat) RGD PMID:23413777 RGD:405100715 NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591 		JBrowse link
G Bdnf brain-derived neurotrophic factor IEP protein:altered expression:amygdala, pyriform cortex, bed nucleus of stria terminalis RGD PMID:23588198 RGD:405849391 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Car3 carbonic anhydrase 3 IEP associated with Alcoholic Liver Diseases;protein:decreased expression:liver RGD PMID:22545783 RGD:7495839 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 IEP mRNA:decreased expression:adenohypophysis RGD PMID:11045867 RGD:407431640 NCBI chr10:89,040,186...89,083,481
Ensembl chr10:89,040,203...89,083,481 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 ISO
IEP		 protein:increased expression, increased nitration
mRNA:altered exxpression:liver (rat)
associated with Alcoholic Liver Diseases;protein:increased expression:liver		 RGD PMID:25236742 PMID:25236742 PMID:29404485 PMID:23413777 PMID:22545783 RGD:14700891, RGD:14700891, RGD:14700911, RGD:405100715, RGD:7495839 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Dnmt1 DNA methyltransferase 1 ISO protein:increased expression:nucleus accumbens: RGD PMID:23423140 RGD:9588287 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659 		JBrowse link
G Drd1 dopamine receptor D1 IEP associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd2 dopamine receptor D2 IEP mRNA:altered exxpression:spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Drd3 dopamine receptor D3 IEP associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596 		JBrowse link
G Drd4 dopamine receptor D4 susceptibility ISO
IEP		 DNA:repeats:exon:
mRNA:altered exxpression:spleen (rat)		 RGD PMID:19393859 PMID:23413777 RGD:401960068, RGD:405100715 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553 		JBrowse link
G Efhd2 EF-hand domain family, member D2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28397836 NCBI chr 5:154,160,945...154,176,980
Ensembl chr 5:154,160,946...154,176,980 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit IEP protein:increased expression:prefrontal cortex RGD PMID:29407478 RGD:405295494 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 IEP associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864 		JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 IEP associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr14:37,097,251...37,230,030
Ensembl chr14:37,097,279...37,228,944 		JBrowse link
G Gabra3 gamma-aminobutyric acid type A receptor subunit alpha 3 IEP associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr  X:150,244,745...150,501,566
Ensembl chr  X:150,261,607...150,501,559 		JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 IEP mRNA:altered exxpression:spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr10:26,810,411...26,825,768
Ensembl chr10:26,810,423...26,825,769 		JBrowse link
G Gdnf glial cell derived neurotrophic factor IMP
IEP		 protein:altered expression:amygdala, pyriform cortex, bed nucleus of stria terminalis RGD PMID:23298382 PMID:23588198 RGD:405849390, RGD:405849391 NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209 		JBrowse link
G Gpx1 glutathione peroxidase 1 IEP protein:decreased expression:liver RGD PMID:25864381 RGD:401827870 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gpx3 glutathione peroxidase 3 IEP protein:decreased expression:serum RGD PMID:25864381 RGD:401827870 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035 		JBrowse link
G Gpx4 glutathione peroxidase 4 IEP protein:decreased expression:liver RGD PMID:25864381 RGD:401827870 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Grm2 glutamate metabotropic receptor 2 IEP associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr 8:107,280,099...107,293,159
Ensembl chr 8:107,280,099...107,293,146 		JBrowse link
G Grm5 glutamate metabotropic receptor 5 IEP associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr 1:141,310,069...141,884,980
Ensembl chr 1:141,312,368...141,882,274 		JBrowse link
G Mir125a microRNA 125a IEP RNA:decreased expression:neuron RGD PMID:27085842 RGD:26884454 NCBI chr 1:58,677,626...58,677,710
Ensembl chr 1:58,677,626...58,677,710 		JBrowse link
G Mir223 microRNA 223 ISO RNA:increased expression:serum
RNA:increased expression:serum, neutrophil,liver		 RGD PMID:27679493 PMID:27679493 RGD:21408575, RGD:21408575 NCBI chr  X:61,141,887...61,141,996
Ensembl chr  X:61,141,887...61,141,996 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 ameliorates ISO protein:decreased expression:central amygdaloid nucleus (mouse) RGD PMID:30647448 PMID:22218088 RGD:402463940, RGD:405096664 NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 treatment IMP RGD PMID:22500955 RGD:408361838 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Oprl1 opioid related nociceptin receptor 1 ISO RGD PMID:29197086 RGD:14348965 NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:168,834,003...168,839,920 		JBrowse link
G Per2 period circadian regulator 2 ISO DNA, mRNA:hypermethylation, decreased expression:blood RGD PMID:30597578 RGD:405878075 NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459 		JBrowse link
G Pomc proopiomelanocortin ISO
IEP		 DNA, mRNA:hypermethylation, decreased expression:blood
mRNA:decreased expression:hypothalamus
protein:decreased expression:central amygdaloid nucleus, arcuate and paraventricular nucleus of hypothalamus		 RGD PMID:30597578 PMID:11045867 PMID:23792540 RGD:405878075, RGD:407431640, RGD:407571694 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Sirt1 sirtuin 1 IEP RGD PMID:24416161 RGD:9495933 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slc23a2 solute carrier family 23 member 2 IEP RGD PMID:27085842 RGD:26884454 NCBI chr 3:119,302,651...119,395,289
Ensembl chr 3:119,302,666...119,460,343 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19099
    Chemically-Induced Disorders 1420
      substance-related disorder 748
        Alcohol-Related Disorders 451
          Binge Drinking 33
Path 2
Term Annotations click to browse term
  disease 19099
    disease of anatomical entity 18440
      nervous system disease 14334
        central nervous system disease 12604
          brain disease 11833
            disease of mental health 8425
              substance-related disorder 748
                Alcohol-Related Disorders 451
                  Binge Drinking 33
paths to the root