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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Binge Drinking
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Accession:DOID:9006302 term browser browse the term
Definition:Drinking an excessive amount of ALCOHOLIC BEVERAGES in a short period of time.
Synonyms:primary_id: MESH:D063425;   RDO:0012117


show annotations for term's descendants           Sort by:
Binge Drinking term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase IEP mRNA:decreased expression:basal forebrain cholinergic neurons RGD PMID:37402853 RGD:597538603 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410 		JBrowse link
G Adh1c alcohol dehydrogenase 1C (class I), gamma polypeptide IEP mRNA:altered exxpression:liver (rat) RGD PMID:23413777 RGD:405100715 NCBI chr 2:229,470,703...229,482,291
Ensembl chr 2:229,470,703...229,482,291 		JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide IEP mRNA:altered exxpression:liver (rat) RGD PMID:23413777 RGD:405100715 NCBI chr 2:229,622,092...229,640,120
Ensembl chr 2:229,622,095...229,641,879 		JBrowse link
G Aqp4 aquaporin 4 IEP protein:increased expression:hippocampus RGD PMID:23102656 RGD:598092481 NCBI chr18:6,782,389...6,799,034
Ensembl chr18:6,782,389...6,799,098 		JBrowse link
G Bdnf brain-derived neurotrophic factor IEP protein:altered expression:amygdala, pyriform cortex, bed nucleus of stria terminalis
associated with Marchigian Sardinian alcohol-preferring rats; mRNA: increased expression:amygdala 		RGD PMID:23588198 PMID:33671048 RGD:405849391, RGD:616390065 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657 		JBrowse link
G Ca3 carbonic anhydrase 3 IEP associated with Alcoholic Liver Diseases;protein:decreased expression:liver RGD PMID:22545783 RGD:7495839 NCBI chr 2:88,491,666...88,501,299
Ensembl chr 2:88,491,670...88,500,524 		JBrowse link
G Casp3 caspase 3 IEP protein:increased expression:hippocampus RGD PMID:23102656 RGD:598092481 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IEP mRNA:increased expression:frontal cortex
mRNA:increased expression:basal forebrain cholinergic neurons 		RGD PMID:23867237 PMID:37402853 RGD:597538460, RGD:597538603 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Chat choline O-acetyltransferase IEP mRNA:decreased expression:basal forebrain cholinergic neurons RGD PMID:37402853 RGD:597538603 NCBI chr16:7,663,665...7,723,416
Ensembl chr16:7,663,665...7,723,416 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit IEP mRNA:decreased expression:basal forebrain cholinergic neurons RGD PMID:37402853 RGD:597538603 NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:126,123,425...126,446,858 		JBrowse link
G Crh corticotropin releasing hormone IEP mRNA: altered expression:amygdala, bed nucleus of stria terminalis RGD PMID:33671048 RGD:616390065 NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 IEP mRNA:decreased expression:adenohypophysis RGD PMID:11045867 RGD:407431640 NCBI chr10:89,540,192...89,583,466
Ensembl chr10:89,540,192...89,583,466 		JBrowse link
G Csf1r colony stimulating factor 1 receptor IEP protein:increased expression:hypothalamic microglia RGD PMID:30737481 RGD:598092506 NCBI chr18:56,834,152...56,860,804
Ensembl chr18:56,817,049...56,860,806 		JBrowse link
G Cybb cytochrome b-245 beta chain IEP mRNA:increased expression:frontal cortex RGD PMID:23867237 RGD:597538460 NCBI chr  X:16,030,596...16,065,065
Ensembl chr  X:16,030,596...16,065,065 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 ISO
IEP 		protein:increased expression, increased nitration
mRNA:altered exxpression:liver (rat)
associated with Alcoholic Liver Diseases;protein:increased expression:liver 		RGD PMID:25236742 PMID:25236742 PMID:29404485 PMID:23413777 PMID:22545783 RGD:14700891, RGD:14700891, RGD:14700911, RGD:405100715, RGD:7495839 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495 		JBrowse link
G Dnmt1 DNA methyltransferase 1 ISO protein:increased expression:nucleus accumbens: RGD PMID:23423140 RGD:9588287 NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:27,716,797...27,763,119 		JBrowse link
G Drd1 dopamine receptor D1 IEP associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,545,111...10,567,166 		JBrowse link
G Drd2 dopamine receptor D2 IEP mRNA:altered exxpression:spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339 		JBrowse link
G Drd3 dopamine receptor D3 IEP associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr11:70,385,586...70,437,793
Ensembl chr11:70,385,586...70,446,760 		JBrowse link
G Drd4 dopamine receptor D4 susceptibility ISO
IEP 		DNA:repeats:exon:
mRNA:altered exxpression:spleen (rat) 		RGD PMID:19393859 PMID:23413777 RGD:401960068, RGD:405100715 NCBI chr 1:205,825,937...205,829,124
Ensembl chr 1:205,826,049...205,830,458 		JBrowse link
G Efhd2 EF-hand domain family, member D2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28397836 NCBI chr 5:159,443,959...159,459,993
Ensembl chr 5:159,443,960...159,460,369 		JBrowse link
G Ehmt2 euchromatic histone lysine methyltransferase 2 IEP mRNA:increased expression:basal forebrain cholinergic neurons RGD PMID:37402853 RGD:597538603 NCBI chr20:3,924,263...3,941,238
Ensembl chr20:3,924,263...3,941,384 		JBrowse link
G Fn1 fibronectin 1 IEP mRNA:increased expression:frontal cortex RGD PMID:23867237 RGD:597538460 NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit IEP protein:increased expression:prefrontal cortex RGD PMID:29407478 RGD:405295494 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 IEP associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr10:27,096,731...27,152,563
Ensembl chr10:27,096,740...27,152,442 		JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 IEP associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr14:37,451,218...37,587,458
Ensembl chr14:37,450,683...37,587,457 		JBrowse link
G Gabra3 gamma-aminobutyric acid type A receptor subunit alpha 3 IEP associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr  X:155,301,979...155,543,870
Ensembl chr  X:155,303,928...155,543,863 		JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 IEP mRNA:altered exxpression:spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr10:27,311,965...27,327,337
Ensembl chr10:27,311,979...27,327,234 		JBrowse link
G Gdnf glial cell derived neurotrophic factor IMP
IEP 		protein:altered expression:amygdala, pyriform cortex, bed nucleus of stria terminalis RGD PMID:23298382 PMID:23588198 RGD:405849390, RGD:405849391 NCBI chr 2:58,621,327...58,647,242
Ensembl chr 2:58,621,327...58,647,240 		JBrowse link
G Gpx1 glutathione peroxidase 1 IEP protein:decreased expression:liver RGD PMID:25864381 RGD:401827870 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581 		JBrowse link
G Gpx3 glutathione peroxidase 3 IEP protein:decreased expression:serum RGD PMID:25864381 RGD:401827870 NCBI chr10:39,529,335...39,537,406
Ensembl chr10:39,529,448...39,537,405 		JBrowse link
G Gpx4 glutathione peroxidase 4 IEP protein:decreased expression:liver RGD PMID:25864381 RGD:401827870 NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629 		JBrowse link
G Grm2 glutamate metabotropic receptor 2 IEP associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr 8:116,158,810...116,171,857
Ensembl chr 8:116,158,810...116,171,857 		JBrowse link
G Grm5 glutamate metabotropic receptor 5 IEP associated with human immunodeficiency virus infectious disease;mRNA:altered expression:liver,spleen (rat) RGD PMID:23413777 RGD:405100715 NCBI chr 1:150,722,711...151,297,585
Ensembl chr 1:150,733,678...151,296,649 		JBrowse link
G Hdac1 histone deacetylase 1 IEP protein:decreased expression:hypothalamic microglia RGD PMID:30737481 RGD:598092506 NCBI chr 5:147,138,328...147,165,387
Ensembl chr 5:147,138,156...147,165,387 		JBrowse link
G Hmgb1 high mobility group box 1 ISO
IEP 		mRNA, protein:increased expression:brain
mRNA:increased expression:basal forebrain cholinergic neurons 		RGD PMID:23206318 PMID:37402853 RGD:7175526, RGD:597538603 NCBI chr12:11,009,236...11,015,941
Ensembl chr16:39,039,050...39,041,327
Ensembl chr12:39,039,050...39,041,327 		JBrowse link
G Il18 interleukin 18 treatment IEP RGD PMID:29260441 RGD:598099561 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286 		JBrowse link
G Il1b interleukin 1 beta IEP mRNA:increased expression:basal forebrain cholinergic neurons
mRNA:decreased expression:amygdala,prefrontal cortex 		RGD PMID:37402853 PMID:29458194 RGD:597538603, RGD:598092572 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 treatment IEP protein:increased expression:hypothalamic microglia
mRNA:increased expression:amygdala,hippocampus 		RGD PMID:30737481 PMID:29458194 PMID:29260441 RGD:598092506, RGD:598092572, RGD:598099561 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Lhx8 LIM homeobox 8 IEP mRNA:decreased expression:basal forebrain cholinergic neurons RGD PMID:37402853 RGD:597538603 NCBI chr 2:245,904,712...245,929,376
Ensembl chr 2:245,904,712...245,929,376 		JBrowse link
G Mecp2 methyl CpG binding protein 2 IEP protein:decreased expression:hypothalamic microglia RGD PMID:30737481 RGD:598092506 NCBI chr  X:156,932,481...156,995,981
Ensembl chr  X:156,941,234...156,943,560 		JBrowse link
G Mir125a microRNA 125a IEP RNA:decreased expression:neuron RGD PMID:27085842 RGD:26884454 NCBI chr 1:67,350,675...67,350,759
Ensembl chr 1:67,350,675...67,350,759 		JBrowse link
G Mir223 microRNA 223 ISO RNA:increased expression:serum
RNA:increased expression:serum, neutrophil,liver 		RGD PMID:27679493 PMID:27679493 RGD:21408575, RGD:21408575 NCBI chr  X:65,151,383...65,151,492
Ensembl chr  X:65,151,383...65,151,492 		JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II IEP mRNA:increased expression:frontal cortex RGD PMID:23867237 RGD:597538460 NCBI chr MT:7,006...7,689
Ensembl chr MT:6,991...7,674 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor IEP mRNA:increased expression:frontal cortex RGD PMID:23867237 RGD:597538460 NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:127,952,161...127,956,230 		JBrowse link
G Nfkbia NFKB inhibitor alpha IEP mRNA:increased expression:hippocampus RGD PMID:29458194 RGD:598092572 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Ngfr nerve growth factor receptor IEP mRNA:decreased expression:basal forebrain cholinergic neurons RGD PMID:37402853 RGD:597538603 NCBI chr10:81,012,077...81,030,305
Ensembl chr10:81,012,089...81,030,305 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 ameliorates ISO protein:decreased expression:central amygdaloid nucleus (mouse) RGD PMID:30647448 PMID:22218088 RGD:402463940, RGD:405096664 NCBI chr16:27,804,416...27,814,070
Ensembl chr16:27,804,416...27,813,387 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 treatment IMP RGD PMID:22500955 RGD:408361838 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 IEP associated with Wistar rats; mRNA: increased expression:amygdala RGD PMID:33671048 RGD:616390065 NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,564,570...5,874,628 		JBrowse link
G Ntsr2 neurotensin receptor 2 IEP mRNA,protein:altered expression:anterior paraventricular nucleus of thalamus RGD PMID:32623746 RGD:596948426 NCBI chr 6:45,153,095...45,159,783
Ensembl chr 6:45,153,095...45,159,783 		JBrowse link
G Oprk1 opioid receptor, kappa 1 IEP associated with Marchigian Sardinian alcohol-preferring rats; mRNA: altered expression:amygdala, bed nucleus of stria terminalis RGD PMID:33671048 RGD:616390065 NCBI chr 5:18,657,866...18,675,671
Ensembl chr 5:18,657,871...18,675,671 		JBrowse link
G Oprl1 opioid related nociceptin receptor 1 ISO
IEP 		associated with Marchigian Sardinian alcohol-preferring rats; mRNA: altered expression:amygdala, bed nucleus of stria terminalis RGD PMID:29197086 PMID:33671048 RGD:14348965, RGD:616390065 NCBI chr 3:189,209,495...189,225,406
Ensembl chr 3:189,212,175...189,217,426 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 IEP protein:increased expression:entorhinal cortex RGD PMID:23102656 RGD:598092481 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Pdyn prodynorphin IEP associated with Marchigian Sardinian alcohol-preferring rats; mRNA: decreased expression:amygdala RGD PMID:33671048 RGD:616390065 NCBI chr 3:137,354,161...137,366,503
Ensembl chr 3:137,354,161...137,366,503 		JBrowse link
G Per2 period circadian regulator 2 ISO DNA, mRNA:hypermethylation, decreased expression:blood RGD PMID:30597578 RGD:405878075 NCBI chr 9:99,454,828...99,497,069
Ensembl chr 9:99,454,830...99,496,993 		JBrowse link
G Pla2g4a phospholipase A2 group 4A IEP protein:increased expression:hippocampus, entorhinal cortex RGD PMID:23102656 RGD:598092481 NCBI chr13:64,427,921...64,572,352
Ensembl chr13:64,427,916...64,589,641 		JBrowse link
G Pla2g6 phospholipase A2 group VI IEP protein:decreased expression:hippocampus, entorhinal cortex RGD PMID:23102656 RGD:598092481 NCBI chr 7:112,731,803...112,771,978
Ensembl chr 7:112,731,803...112,771,609 		JBrowse link
G Pnoc prepronociceptin IEP associated with Marchigian Sardinian alcohol-preferring rats; mRNA: decreased expression:amygdala, bed nucleus of stria terminalis RGD PMID:33671048 RGD:616390065 NCBI chr15:43,800,240...43,827,841
Ensembl chr15:43,800,246...43,827,470 		JBrowse link
G Pomc proopiomelanocortin ISO
IEP 		DNA, mRNA:hypermethylation, decreased expression:blood
mRNA:decreased expression:hypothalamus
protein:decreased expression:central amygdaloid nucleus, arcuate and paraventricular nucleus of hypothalamus 		RGD PMID:30597578 PMID:11045867 PMID:23792540 RGD:405878075, RGD:407431640, RGD:407571694 NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit treatment IEP RGD PMID:29260441 RGD:598099561 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Rest RE1-silencing transcription factor IEP mRNA:increased expression:basal forebrain cholinergic neurons RGD PMID:37402853 RGD:597538603 NCBI chr14:31,213,415...31,233,451
Ensembl chr14:31,213,415...31,248,662 		JBrowse link
G S100b S100 calcium binding protein B IEP mRNA:increased expression:frontal cortex RGD PMID:23867237 RGD:597538460 NCBI chr20:12,372,345...12,381,159
Ensembl chr20:12,372,348...12,381,081 		JBrowse link
G Sirt1 sirtuin 1 IEP protein:decreased expression:hypothalamic microglia RGD PMID:24416161 PMID:30737481 RGD:9495933, RGD:598092506 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000 		JBrowse link
G Slc18a3 solute carrier family 18 member A3 IEP mRNA:decreased expression:basal forebrain cholinergic neurons RGD PMID:37402853 RGD:597538603 NCBI chr16:7,719,953...7,722,814 JBrowse link
G Slc23a2 solute carrier family 23 member 2 IEP RGD PMID:27085842 RGD:26884454 NCBI chr 3:139,755,583...139,913,304
Ensembl chr 3:139,755,584...139,847,343 		JBrowse link
G Tlr2 toll-like receptor 2 sexual_dimorphism ISO mRNA, protein:increased expression:brain
mRNA:increased expression:adipose tissue 		RGD PMID:23206318 PMID:27711160 RGD:7175526, RGD:407424601 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194 		JBrowse link
G Tlr3 toll-like receptor 3 ISO mRNA, protein:increased expression:brain RGD PMID:23206318 RGD:7175526 NCBI chr16:53,554,916...53,572,321
Ensembl chr16:53,555,131...53,568,385 		JBrowse link
G Tlr4 toll-like receptor 4 ISO
IEP 		mRNA, protein:increased expression:brain
protein:increased expression:hypothalamic microglia 		RGD PMID:23206318 PMID:30737481 RGD:7175526, RGD:598092506 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007 		JBrowse link
G Tnf tumor necrosis factor IEP mRNA:increased expression:frontal cortex
protein:increased expression:hypothalamic microglia
mRNA:decreased expression:amygdala,prefrontal cortex, PVN, hippocampus 		RGD PMID:23867237 PMID:30737481 PMID:29458194 RGD:597538460, RGD:598092506, RGD:598092572 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tph2 tryptophan hydroxylase 2 susceptibility ISO DNA:SNPs: :rs7963717, rs11178999, rs17110451 RGD PMID:29697747 RGD:597621695 NCBI chr 7:52,571,909...52,676,305
Ensembl chr 7:52,571,911...52,675,639 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19154
    Chemically-Induced Disorders 1508
      substance-related disorder 846
        Alcohol-Related Disorders 543
          Binge Drinking 73
Path 2
Term Annotations click to browse term
  disease 19154
    disease of anatomical entity 18461
      nervous system disease 14368
        central nervous system disease 12644
          brain disease 11865
            disease of mental health 8493
              substance-related disorder 846
                Alcohol-Related Disorders 543
                  Binge Drinking 73
paths to the root