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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Hemorrhagic Shock
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Accession:DOID:9001708 term browser browse the term
Definition:Acute hemorrhage or excessive fluid loss resulting in HYPOVOLEMIA.
Synonyms:primary_id: MESH:D012771
 alt_id: RDO:0006561
For additional species annotation, visit the Alliance of Genome Resources.


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Hemorrhagic Shock term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin treatment ISO
IEP
RGD PMID:18403050, PMID:15973109 RGD:7364987, RGD:7364990 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259
JBrowse link
G Aldh1a7 aldehyde dehydrogenase family 1, subfamily A7 severity IEP mRNA:decreased expression:liver RGD PMID:23810746, PMID:21643955 RGD:14367884, RGD:14367885 NCBI chr 1:240,584,233...240,601,843
Ensembl chr 1:240,562,423...240,601,744
JBrowse link
G Angpt1 angiopoietin 1 ISO RGD PMID:18344375 RGD:2316067 NCBI chr 7:81,338,327...81,592,459
Ensembl chr 7:81,342,280...81,592,206
JBrowse link
G Arg2 arginase 2 IEP protein:increased expression:aorta (rat) RGD PMID:20699748 RGD:4143274 NCBI chr 6:102,311,097...102,338,406
Ensembl chr 6:102,311,116...102,338,520
JBrowse link
G Bad BCL2-associated agonist of cell death IEP protein:decreased serine phosphorylation:lung RGD PMID:15345971 RGD:2292699 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bcl2 BCL2, apoptosis regulator IEP mRNA:increased expression:intestine RGD PMID:17693937 RGD:2293072 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 IEP protein:increased expression:liver, mitochondrion RGD PMID:17224795 RGD:1643525 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 IEP associated with Brain Injuries, Traumatic RGD PMID:29061477 RGD:13782298 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 IEP associated with Brain Injuries, Traumatic RGD PMID:29061477 RGD:13782298 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cfh complement factor H treatment ISO
IEP
RGD PMID:18403050, PMID:18496585, PMID:15973109 RGD:7364987, RGD:11041173, RGD:7364990 NCBI chr13:56,979,155...57,080,540
Ensembl chr13:56,978,607...57,080,622
JBrowse link
G Cnr1 cannabinoid receptor 1 IMP mRNA, protein:increased expression:aorta, mesenteric artery RGD PMID:19493421 RGD:2314664 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Cul5 cullin 5 IEP mRNA:altered expression:brain RGD PMID:12635525 RGD:2301433 NCBI chr 8:58,199,992...58,255,149
Ensembl chr 8:58,202,821...58,253,688
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 IEP
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:21192278, PMID:21168948 RGD:5128673 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21192278 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21192278 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Epo erythropoietin treatment ISO RGD PMID:20539178 RGD:10401059 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Esr1 estrogen receptor 1 severity IMP RGD PMID:20195535 RGD:4892252 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 IDA RGD PMID:16859701 RGD:8694176 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G F2 coagulation factor II IEP protein:decreased activity:blood (rat) RGD PMID:21550061 RGD:5132267 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G F8 coagulation factor VIII IEP protein:decreased expression:plasma RGD PMID:15748447 RGD:10450768 NCBI chr18:367,862...399,242
Ensembl chr18:367,862...399,242
JBrowse link
G Gfer growth factor, augmenter of liver regeneration ISO RGD PMID:23073658 RGD:9685733 NCBI chr10:14,059,347...14,061,703
Ensembl chr10:14,059,347...14,061,703
JBrowse link
G Gja1 gap junction protein, alpha 1 IEP RGD PMID:19077877 RGD:7207423 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Gja5 gap junction protein, alpha 5 IEP RGD PMID:19077877 RGD:7207423 NCBI chr 2:199,162,745...199,184,942
Ensembl chr 2:199,162,745...199,184,939
JBrowse link
G Hmox1 heme oxygenase 1 severity IMP
IEP
RGD PMID:20514418, PMID:20819606 RGD:10755719, RGD:10755727 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hp haptoglobin IEP RGD PMID:20016403 RGD:5147418 NCBI chr19:42,096,255...42,100,805
Ensembl chr19:42,097,995...42,100,804
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A IEP mRNA:increased expression:liver RGD PMID:22266570 RGD:7257601 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO mRNA, protein:increased expression:lung (mouse)
CTD Direct Evidence: marker/mechanism
CTD PMID:21192278, PMID:19828841 RGD:4145497 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma IEP protein:increased expression:plasma RGD PMID:19439114 RGD:2311495 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 IEP protein:increased expression:serum, lymph RGD PMID:19160132 RGD:2311060 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il18 interleukin 18 ISO protein:increased expression:plasma RGD PMID:23589298 RGD:14695541 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1a interleukin 1 alpha IEP mRNA:increased expression:lung RGD PMID:15580020 RGD:2311100 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta severity IEP mRNA:increased expression:lung
protein:increased expression:kidney, serum (rat)
RGD PMID:15580020, PMID:21336199, PMID:17545943 RGD:2311100, RGD:7175325, RGD:1626655 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il4 interleukin 4 treatment IEP RGD PMID:24986445 RGD:10402801 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il6 interleukin 6 IEP
ISO
protein:increased expression:plasma
CTD Direct Evidence: marker/mechanism
CTD PMID:21192278, PMID:21168948 RGD:5128673 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapk1 mitogen activated protein kinase 1 IEP protein: increased expression: lung and liver RGD PMID:22392145 RGD:7244173 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mpo myeloperoxidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:21192278 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mtor mechanistic target of rapamycin kinase treatment IDA RGD PMID:24204984 RGD:10041042 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor treatment IDA RGD PMID:22113495 RGD:7240568 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nos2 nitric oxide synthase 2 IEP mRNA, protein:increased expression:multiple RGD PMID:15854664 RGD:1580937 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 treatment IEP mRNA:increased expression: :multiple RGD PMID:15854664, PMID:29122552 RGD:1580937, RGD:13450929 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Otc ornithine transcarbamylase IEP protein:increased activity:serum (rat) RGD PMID:17224795 RGD:1643525 NCBI chr  X:13,524,804...13,601,074
Ensembl chr  X:13,524,607...13,601,069
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit IEP
ISO
protein:increased phosphorylation, altered location:nucleus, endothelial cell, lung
protein:increased phosphorylation:nucleus, liver
RGD PMID:17950078, PMID:17950083, PMID:18469645 RGD:2298842, RGD:2298841, RGD:2298781 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Sirt1 sirtuin 1 treatment IMP
IEP
protein:decreased expression:heart left ventricle RGD PMID:22113495, PMID:21554952 RGD:7240568, RGD:9585770 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Slc9a1 solute carrier family 9 member A1 IMP
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:17724433, PMID:19384202 RGD:6771334 NCBI chr 5:151,573,122...151,626,360
Ensembl chr 5:151,573,092...151,627,316
JBrowse link
G Sod2 superoxide dismutase 2 treatment IEP RGD PMID:26073907 RGD:26923954 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tfam transcription factor A, mitochondrial IEP RGD PMID:22469910 RGD:6767567 NCBI chr20:18,594,057...18,606,106
Ensembl chr20:18,594,037...18,606,151
JBrowse link
G Tlr4 toll-like receptor 4 severity ISO RGD PMID:25049041 RGD:14697700 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor treatment IDA
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:21192278, PMID:24315526 RGD:10450602 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vwf von Willebrand factor IEP protein:decreased expression:plasma RGD PMID:15748447 RGD:10450768 NCBI chr 4:158,085,059...158,219,525
Ensembl chr 4:158,088,505...158,219,523
JBrowse link

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  disease 16918
    Pathological Conditions, Signs and Symptoms 9887
      Pathologic Processes 6539
        Hemorrhage 259
          Hemorrhagic Shock 49
            Hemorrhagic Shock and Encephalopathy Syndrome 0
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