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ONTOLOGY REPORT - ANNOTATIONS


Term:Disease Progression
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Accession:DOID:9000918 term browser browse the term
Definition:The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Synonyms:exact_synonym: Disease Exacerbation;   Disease Progressions
 primary_id: MESH:D018450;   RDO:0006470
For additional species annotation, visit the Alliance of Genome Resources.


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Disease Progression term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca13 ATP binding cassette subfamily A member 13 JBrowse link 14 89,384,512 89,876,748 RGD:11554173
G Abca7 ATP binding cassette subfamily A member 7 JBrowse link 7 12,742,433 12,762,423 RGD:11554173
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:11554173
G Abcb4 ATP binding cassette subfamily B member 4 JBrowse link 4 22,133,984 22,192,687 RGD:11554173
G Abcc1 ATP binding cassette subfamily C member 1 JBrowse link 10 549,537 672,235 RGD:11554173
G Abcc6 ATP binding cassette subfamily C member 6 JBrowse link 1 101,954,786 102,013,252 RGD:11554173
G Abcd4 ATP binding cassette subfamily D member 4 JBrowse link 6 108,315,026 108,329,550 RGD:11554173
G Abcf1 ATP binding cassette subfamily F member 1 JBrowse link 20 3,309,914 3,322,828 RGD:11554173
G Abcf2 ATP binding cassette subfamily F member 2 JBrowse link 4 7,122,850 7,135,607 RGD:11554173
G Abt1 activator of basal transcription 1 JBrowse link 17 43,946,118 43,948,224 RGD:11554173
G Acad8 acyl-CoA dehydrogenase family, member 8 JBrowse link 8 28,023,401 28,044,967 RGD:11554173
G Aldh7a1 aldehyde dehydrogenase 7 family, member A1 JBrowse link 18 51,619,007 51,651,267 RGD:11554173
G Amfr autocrine motility factor receptor JBrowse link 19 11,473,538 11,509,500 RGD:11554173
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 JBrowse link 15 27,849,943 27,852,083 RGD:11554173
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:11554173
G Arfgap2 ADP-ribosylation factor GTPase activating protein 2 JBrowse link 3 80,081,541 80,093,659 RGD:11554173
G Arg2 arginase 2 JBrowse link 6 102,311,097 102,338,406 RGD:11554173
G Atf2 activating transcription factor 2 JBrowse link 3 60,721,137 60,795,951 RGD:11554173
G Atp7b ATPase copper transporting beta JBrowse link 16 74,865,516 74,944,935 RGD:11554173
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:11554173
G Bmi1 BMI1 proto-oncogene, polycomb ring finger JBrowse link 17 85,360,439 85,370,283 RGD:11554173
G Bop1 BOP1 ribosomal biogenesis factor JBrowse link 7 117,514,529 117,538,342 RGD:11554173
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:11554173
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:11554173
G Ccne1 cyclin E1 JBrowse link 1 94,485,830 94,495,112 RGD:11554173
G Cct7 chaperonin containing TCP1 subunit 7 JBrowse link 4 117,235,023 117,252,265 RGD:11554173
G Cd274 CD274 molecule JBrowse link 1 247,519,890 247,539,659 RGD:11554173
G Cdh1 cadherin 1 JBrowse link 19 38,768,467 38,838,395 RGD:11554173
G Cdh2 cadherin 2 JBrowse link 18 8,146,971 8,366,037 RGD:11554173
G Cdkl2 cyclin dependent kinase like 2 JBrowse link 14 17,530,170 17,565,950 RGD:11554173
G Cga glycoprotein hormones, alpha polypeptide JBrowse link 5 50,362,491 50,393,368 RGD:11554173
G Chek2 checkpoint kinase 2 JBrowse link 12 51,845,574 51,878,098 RGD:11554173
G Clcn3 chloride voltage-gated channel 3 JBrowse link 16 32,448,821 32,520,649 RGD:11554173
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin JBrowse link 1 197,986,384 197,999,726 RGD:11554173
G Cnpy2 canopy FGF signaling regulator 2 JBrowse link 7 2,737,674 2,744,321 RGD:11554173
G Col7a1 collagen type VII alpha 1 chain JBrowse link 8 117,694,441 117,726,844 RGD:11554173
G Cops7a COP9 signalosome subunit 7A JBrowse link 4 157,479,549 157,486,944 RGD:11554173
G Cpsf1 cleavage and polyadenylation specific factor 1 JBrowse link 7 117,661,779 117,672,373 RGD:11554173
G Crybg1 crystallin beta-gamma domain containing 1 JBrowse link 20 48,927,942 49,123,724 RGD:11554173
G Csta cystatin A JBrowse link 11 67,555,792 67,566,980 RGD:11554173
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:11554173
G Ctsb cathepsin B JBrowse link 15 46,316,741 46,337,613 RGD:11554173
G Ctsc cathepsin C JBrowse link 1 151,918,514 151,949,979 RGD:11554173
G Ddb1 damage-specific DNA binding protein 1 JBrowse link 1 226,657,561 226,683,356 RGD:11554173
G Ddx58 DEXD/H-box helicase 58 JBrowse link 5 56,486,584 56,536,898 RGD:11554173
G Dpagt1 dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 JBrowse link 8 48,657,779 48,664,531 RGD:11554173
G E2f2 E2F transcription factor 2 JBrowse link 5 154,516,611 154,540,228 RGD:11554173
G E2f4 E2F transcription factor 4 JBrowse link 19 37,252,828 37,260,239 RGD:11554173
G E2f5 E2F transcription factor 5 JBrowse link 2 88,350,764 88,366,913 RGD:11554173
G E2f7 E2F transcription factor 7 JBrowse link 7 53,275,659 53,318,261 RGD:11554173
G E2f8 E2F transcription factor 8 JBrowse link 1 104,185,436 104,203,683 RGD:11554173
G Ednra endothelin receptor type A JBrowse link 19 33,928,356 33,991,703 RGD:11554173
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:11554173
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:11554173
G Epha2 Eph receptor A2 JBrowse link 5 159,845,773 159,874,203 RGD:11554173
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link 10 86,367,596 86,391,728 RGD:11554173
G Erbb3 erb-b2 receptor tyrosine kinase 3 JBrowse link 7 2,989,202 3,010,610 RGD:11554173
G Esr1 estrogen receptor 1 JBrowse link 1 41,192,029 41,594,799 RGD:11554173
G Exosc5 exosome component 5 JBrowse link 1 82,452,104 82,461,607 RGD:11554173
G Fam168a family with sequence similarity 168, member A JBrowse link 1 165,723,278 165,880,612 RGD:11554173
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:11554173
G Fgf2 fibroblast growth factor 2 JBrowse link 2 124,081,072 124,134,133 RGD:11554173
G Fkbp2 FKBP prolyl isomerase 2 JBrowse link 1 222,232,349 222,235,113 RGD:11554173
G Flt1 Fms related receptor tyrosine kinase 1 JBrowse link 12 9,033,993 9,205,886 RGD:11554173
G Gja1 gap junction protein, alpha 1 JBrowse link 20 37,876,650 37,889,097 RGD:11554173
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:11554173
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:11554173
G Hikeshi heat shock protein nuclear import factor JBrowse link 1 154,147,098 154,170,429 RGD:11554173
G Hnrnpl heterogeneous nuclear ribonucleoprotein L JBrowse link 1 86,994,090 87,006,776 RGD:11554173
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:11554173
G Idh3b isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta JBrowse link 3 122,808,564 122,813,638 RGD:11554173
G Il1a interleukin 1 alpha JBrowse link 3 121,824,712 121,836,122 RGD:11554173
G Il1rap interleukin 1 receptor accessory protein JBrowse link 11 77,456,648 77,593,208 RGD:11554173
G Ing1 inhibitor of growth family, member 1 JBrowse link 16 83,277,055 83,278,120 RGD:11554173
G Kdm1a lysine demethylase 1A JBrowse link 5 154,909,003 154,965,171 RGD:11554173
G Keap1 Kelch-like ECH-associated protein 1 JBrowse link 8 22,250,518 22,259,868 RGD:11554173
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:11554173
G Lamc2 laminin subunit gamma 2 JBrowse link 13 70,566,643 70,632,126 RGD:11554173
G LOC100361854 ribosomal protein S26-like JBrowse link X 115,495,660 115,496,062 RGD:11554173
G M6pr mannose-6-phosphate receptor, cation dependent JBrowse link 4 155,084,755 155,093,896 RGD:11554173
G Mir100 microRNA 100 JBrowse link 8 45,746,948 45,747,027 RGD:11554173
G Mir145 microRNA 145 JBrowse link 18 56,969,907 56,969,994 RGD:11554173
G Mir196a microRNA 196a JBrowse link 7 144,584,235 144,584,344 RGD:11554173
G Mir200b microRNA 200b JBrowse link 5 173,490,144 173,490,238 RGD:11554173
G Mir200c microRNA 200c JBrowse link 4 157,236,786 157,236,854 RGD:11554173
G Mir21 microRNA 21 JBrowse link 10 73,902,210 73,902,301 RGD:11554173
G Mir346 microRNA 346 JBrowse link 16 11,250,054 11,250,151 RGD:11554173
G Mir34b microRNA 34b JBrowse link 8 55,492,542 55,492,625 RGD:11554173
G Mir99a microRNA 99a JBrowse link 11 16,052,153 16,052,233 RGD:11554173
G Mki67 marker of proliferation Ki-67 JBrowse link 1 207,993,895 208,020,454 RGD:11554173
G Mmp2 matrix metallopeptidase 2 JBrowse link 19 15,542,771 15,570,589 RGD:11554173
G Mrpl13 mitochondrial ribosomal protein L13 JBrowse link 7 95,288,400 95,309,997 RGD:11554173
G Mrps11 mitochondrial ribosomal protein S11 JBrowse link 1 140,477,645 140,487,249 RGD:11554173
G Mrps18b mitochondrial ribosomal protein S18B JBrowse link 20 3,344,870 3,350,929 RGD:11554173
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:11554173
G Naxd NAD(P)HX dehydratase JBrowse link 16 83,326,228 83,342,711 RGD:11554173
G Nbas NBAS subunit of NRZ tethering complex JBrowse link 6 38,474,773 38,777,146 RGD:11554173
G Ndufa2 NADH:ubiquinone oxidoreductase subunit A2 JBrowse link 18 29,585,671 29,587,760 RGD:11554173
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 JBrowse link 9 69,919,863 69,953,182 RGD:11554173
G Ndufv1 NADH:ubiquinone oxidoreductase core subunit V1 JBrowse link 1 219,254,293 219,259,328 RGD:11554173
G Nop56 NOP56 ribonucleoprotein JBrowse link 3 122,803,726 122,808,564 RGD:11554173
G Pa2g4 proliferation-associated 2G4 JBrowse link 7 2,979,587 2,987,055 RGD:11554173
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 JBrowse link X 37,329,779 37,343,410 RGD:11554173
G Phb prohibitin JBrowse link 10 83,476,107 83,488,878 RGD:11554173
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:11554173
G Plpp1 phospholipid phosphatase 1 JBrowse link 2 44,664,076 44,726,820 RGD:11554173
G Polr3k RNA polymerase III subunit K JBrowse link 3 177,374,812 177,379,009 RGD:11554173
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha JBrowse link 1 60,717,386 60,736,629 RGD:11554173
G Prdx3 peroxiredoxin 3 JBrowse link 1 282,238,774 282,251,193 RGD:11554173
G Prdx4 peroxiredoxin 4 JBrowse link X 43,495,453 43,512,994 RGD:11554173
G Prep prolyl endopeptidase JBrowse link 20 50,172,618 50,269,992 RGD:11554173
G Prkab1 protein kinase AMP-activated non-catalytic subunit beta 1 JBrowse link 12 46,316,298 46,326,789 RGD:11554173
G Prpf19 pre-mRNA processing factor 19 JBrowse link 1 226,947,065 226,958,147 RGD:11554173
G Psmd14 proteasome 26S subunit, non-ATPase 14 JBrowse link 3 47,578,449 47,673,330 RGD:11554173
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:11554173
G Ptov1 PTOV1, extended AT-hook containing adaptor protein JBrowse link 1 100,859,346 100,866,917 RGD:11554173
G Ptpa protein phosphatase 2 phosphatase activator JBrowse link 3 8,982,122 9,012,585 RGD:11554173
G Ptprf protein tyrosine phosphatase, receptor type, F JBrowse link 5 137,036,936 137,112,930 RGD:11554173
G Pus1 pseudouridine synthase 1 JBrowse link 12 51,936,721 51,945,930 RGD:11554173
G Rad23a RAD23 homolog A, nucleotide excision repair protein JBrowse link 19 25,949,488 25,956,677 RGD:11554173
G Ranbp10 RAN binding protein 10 JBrowse link 19 37,734,662 37,795,360 RGD:11554173
G Rap1gap Rap1 GTPase-activating protein JBrowse link 5 156,008,868 156,074,350 RGD:11554173
G Rchy1 ring finger and CHY zinc finger domain containing 1 JBrowse link 14 17,615,968 17,631,715 RGD:11554173
G Rpl13 ribosomal protein L13 JBrowse link 19 55,917,489 55,920,040 RGD:11554173
G Rpl15 ribosomal protein L15 JBrowse link 15 8,188,717 8,192,153 RGD:11554173
G Rpl18 ribosomal protein L18 JBrowse link 1 101,700,910 101,703,551 RGD:11554173
G Rps15 ribosomal protein S15 JBrowse link 7 12,282,134 12,283,573 RGD:11554173
G Rps19 ribosomal protein S19 JBrowse link 1 81,750,873 81,756,629 RGD:11554173
G Rps21-ps1 ribosomal protein S21, pseudogene 1 JBrowse link 5 159,606,647 159,606,990 RGD:11554173
G Rps6 ribosomal protein S6 JBrowse link 5 105,197,821 105,200,681 RGD:11554173
G Rrm1 ribonucleotide reductase catalytic subunit M1 JBrowse link 1 167,538,387 167,562,688 RGD:11554173
G Rrp9 ribosomal RNA processing 9, U3 small nucleolar RNA binding protein JBrowse link 8 115,179,899 115,188,551 RGD:11554173
G Rxrb retinoid X receptor beta JBrowse link 20 3,822,673 3,829,138 RGD:11554173
G Serbp1 Serpine1 mRNA binding protein 1 JBrowse link 4 98,027,563 98,044,717 RGD:11554173
G Snrpb small nuclear ribonucleoprotein polypeptides B and B1 JBrowse link 3 122,696,125 122,703,734 RGD:11554173
G Snx5 sorting nexin 5 JBrowse link 3 138,378,032 138,397,944 RGD:11554173
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:11554173
G Sod3 superoxide dismutase 3 JBrowse link 14 60,958,583 60,971,143 RGD:11554173
G Srebf2 sterol regulatory element binding transcription factor 2 JBrowse link 7 123,381,082 123,438,605 RGD:11554173
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:11554173
G Suclg1 succinate-CoA ligase GDP/ADP-forming subunit alpha JBrowse link 4 101,181,315 101,210,692 RGD:11554173
G Sympk symplekin JBrowse link 1 79,931,097 79,959,461 RGD:11554173
G Taf15 TATA-box binding protein associated factor 15 JBrowse link 10 70,689,863 70,721,892 RGD:11554173
G Tert telomerase reverse transcriptase JBrowse link 1 32,250,876 32,275,330 RGD:11554173
G Tmem63a transmembrane protein 63a JBrowse link 13 99,219,585 99,253,176 RGD:11554173
G Tnfsf8 TNF superfamily member 8 JBrowse link 5 79,664,779 79,691,547 RGD:11554173
G Top1 DNA topoisomerase I JBrowse link 3 156,635,688 156,717,686 RGD:11554173
G Top2a DNA topoisomerase II alpha JBrowse link 10 86,901,467 86,930,947 RGD:11554173
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:11554173
G Trap1 TNF receptor-associated protein 1 JBrowse link 10 11,724,032 11,757,682 RGD:11554173
G Txnip thioredoxin interacting protein JBrowse link 2 198,683,168 198,686,971 RGD:11554173
G Ubxn1 UBX domain protein 1 JBrowse link 1 225,067,953 225,071,944 RGD:11554173
G Urm1 ubiquitin related modifier 1 JBrowse link 3 8,389,024 8,405,868 RGD:11554173
G Vcp valosin-containing protein JBrowse link 5 58,426,548 58,445,953 RGD:11554173
G Vegfb vascular endothelial growth factor B JBrowse link 1 222,237,000 222,242,786 RGD:11554173
G Wdr46 WD repeat domain 46 JBrowse link 20 5,447,860 5,455,632 RGD:11554173
G Xpc XPC complex subunit, DNA damage recognition and repair factor JBrowse link 4 123,134,457 123,161,985 RGD:11554173
G Yap1 Yes1 associated transcriptional regulator JBrowse link 8 6,133,014 6,204,240 RGD:11554173
G Yy1 YY1 transcription factor JBrowse link 6 132,702,443 132,726,848 RGD:11554173
G Zeb1 zinc finger E-box binding homeobox 1 JBrowse link 17 54,656,627 54,714,920 RGD:11554173
G Zeb2 zinc finger E-box binding homeobox 2 JBrowse link 3 29,857,289 29,985,932 RGD:11554173
G Zfp593 zinc finger protein 593 JBrowse link 5 152,462,522 152,464,850 RGD:11554173

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  disease 15849
    Pathological Conditions, Signs and Symptoms 8392
      Pathologic Processes 5449
        Disease Attributes 544
          Disease Progression 162
            Remission, Spontaneous 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.