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ONTOLOGY REPORT - ANNOTATIONS


Term:diffuse large B-cell lymphoma
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Accession:DOID:0050745 term browser browse the term
Definition:Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.
Synonyms:exact_synonym: Diffuse Histiocytic Lymphoma;   Diffuse Histiocytic Lymphomas;   Diffuse Large Cell Lymphoma;   Diffuse Large-Cell Lymphomas;   Histiocytic Lymphoma;   Histiocytic Lymphomas;   Large Lymphoid Lymphoma, Diffuse
 narrow_synonym: PCLBCL;   primary cutaneous large B-cell lymphoma
 primary_id: MESH:D016403;   RDO:0006954
 xref: GARD:3178
For additional species annotation, visit the Alliance of Genome Resources.


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diffuse large B-cell lymphoma term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:11554173
G Abcg2 ATP binding cassette subfamily G member 2 JBrowse link 4 88,765,441 88,890,268 RGD:11554173
G Alk ALK receptor tyrosine kinase JBrowse link 6 22,696,415 23,203,791 RGD:11554173
G B2m beta-2 microglobulin JBrowse link 3 114,087,287 114,093,311 RGD:11554173
G Bcas2 BCAS2, pre-mRNA processing factor JBrowse link 2 205,662,633 205,670,514 RGD:11554173
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:11554173
G Bcl2l2 Bcl2-like 2 JBrowse link 15 33,543,774 33,549,165 RGD:14394511
G Bcl6 BCL6, transcription repressor JBrowse link 11 80,255,790 80,279,075 RGD:1600111
RGD:11530023
G Card11 caspase recruitment domain family, member 11 JBrowse link 12 15,700,600 15,844,512 RGD:11100036
RGD:11554173
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:11554173
G Ccdc86 coiled-coil domain containing 86 JBrowse link 1 226,996,435 227,002,016 RGD:11554173
G Cd40 CD40 molecule JBrowse link 3 161,519,789 161,534,943 RGD:5490541
G Cd79a CD79a molecule JBrowse link 1 81,763,609 81,768,039 RGD:11554173
G Cd79b CD79b molecule JBrowse link 10 94,497,445 94,500,591 RGD:11554173
G Cdk1 cyclin-dependent kinase 1 JBrowse link 20 20,576,341 20,591,510 RGD:11554173
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:11554173
G Cltc clathrin heavy chain JBrowse link 10 74,014,560 74,070,578 RGD:11554173
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit JBrowse link 4 77,284,404 77,347,011 RGD:11554173
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:11554173
G Fcgr2a Fc fragment of IgG receptor IIa JBrowse link 13 91,146,878 91,163,691 RGD:11344967
G Gli1 GLI family zinc finger 1 JBrowse link 7 70,620,794 70,633,171 RGD:11554173
G Gstm1 glutathione S-transferase mu 1 JBrowse link 2 210,803,869 210,809,461 RGD:10450835
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:8547939
G Gstt1 glutathione S-transferase theta 1 JBrowse link 20 13,799,102 13,816,527 RGD:10450835
G Icam1 intercellular adhesion molecule 1 JBrowse link 8 22,035,287 22,047,049 RGD:11354982
G Il21r interleukin 21 receptor JBrowse link 1 196,996,405 197,024,185 RGD:1600111
G Immp2l inner mitochondrial membrane peptidase subunit 2 JBrowse link 6 60,958,351 61,859,457 RGD:11554173
G Irf4 interferon regulatory factor 4 JBrowse link 17 34,886,746 34,905,191 RGD:11530023
G Kmt2d lysine methyltransferase 2D JBrowse link 7 140,507,137 140,542,479 RGD:11554173
G Malt1 MALT1 paracaspase JBrowse link 18 61,108,712 61,162,446 RGD:11554173
G Mki67 marker of proliferation Ki-67 JBrowse link 1 207,993,895 208,020,454 RGD:6483541
G Mthfr methylenetetrahydrofolate reductase JBrowse link 5 164,844,642 164,864,360 RGD:6893517
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:11554173
G Myd88 MYD88, innate immune signal transduction adaptor JBrowse link 8 128,022,512 128,027,462 RGD:11554173
G Nectin2 nectin cell adhesion molecule 2 JBrowse link 1 80,631,449 80,666,617 RGD:11554173
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:2298905
G Nom1 nucleolar protein with MIF4G domain 1 JBrowse link 4 2,340,034 2,356,427 RGD:11554173
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:11554173
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:11554173
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta JBrowse link 8 107,275,849 107,381,088 RGD:11554173
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta JBrowse link 5 166,602,053 166,628,028 RGD:11554173
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma JBrowse link 6 51,465,696 51,501,234 RGD:11554173
G Prdx3 peroxiredoxin 3 JBrowse link 1 282,238,774 282,251,193 RGD:11554173
G Prdx4 peroxiredoxin 4 JBrowse link X 43,495,453 43,512,994 RGD:11554173
G Rangap1 RAN GTPase activating protein 1 JBrowse link 7 122,939,266 122,967,178 RGD:11554173
G Rps6kb1 ribosomal protein S6 kinase B1 JBrowse link 10 73,824,200 73,865,503 RGD:11554173
G Sec31a SEC31 homolog A, COPII coat complex component JBrowse link 14 10,854,713 10,909,579 RGD:11554173
G Skp2 S-phase kinase associated protein 2 JBrowse link 2 58,506,146 58,534,211 RGD:11554173
G Smurf2 SMAD specific E3 ubiquitin protein ligase 2 JBrowse link 10 95,018,050 95,118,107 RGD:13592920
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:11554173
G Sod3 superoxide dismutase 3 JBrowse link 14 60,958,583 60,971,143 RGD:11554173
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:13592920
G Txnip thioredoxin interacting protein JBrowse link 2 198,683,168 198,686,971 RGD:11554173

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15502
    disease of anatomical entity 14856
      hematopoietic system disease 1469
        leukocyte disease 472
          B-cell lymphoma 260
            diffuse large B-cell lymphoma 53
              Plasmablastic Lymphoma 0
              primary mediastinal B-cell lymphoma 0
              relapsed/refractory diffuse large B-cell lymphoma 0
Path 2
Term Annotations click to browse term
  disease 15502
    disease of anatomical entity 14856
      Immune & Inflammatory Diseases 3130
        immune system disease 2548
          primary immunodeficiency disease 988
            lymphoproliferative syndrome 640
              lymphoma 378
                non-Hodgkin lymphoma 329
                  B-cell lymphoma 260
                    diffuse large B-cell lymphoma 53
                      Plasmablastic Lymphoma 0
                      primary mediastinal B-cell lymphoma 0
                      relapsed/refractory diffuse large B-cell lymphoma 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.