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RGD uses the Human Disease Ontology (DO, for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Bronchial Hyperreactivity
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Accession:DOID:9000772 term browser browse the term
Definition:Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.
Synonyms:exact_synonym: Bronchial Hyperreactivities
 primary_id: MESH:D016535
For additional species annotation, visit the Alliance of Genome Resources.

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Bronchial Hyperreactivity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam33 ADAM metallopeptidase domain 33 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17061022 PMID:15118671 RGD:1331525 NCBI chr 3:118,262,395...118,283,461
Ensembl chr 3:118,271,029...118,283,461
JBrowse link
G Calca calcitonin-related polypeptide alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:15127121 PMID:16777450 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 ISO associated with Gastrointestinal Diseases RGD PMID:15236177 RGD:4145432 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
JBrowse link
G Ccl12 C-C motif chemokine ligand 12 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12388339 NCBI chr10:67,070,230...67,071,780
Ensembl chr10:67,070,230...67,071,780
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 ISO CTD Direct Evidence: marker/mechanism CTD
PMID:12388339 PMID:19762564 RGD:4891460 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 ISO RGD PMID:18490489 RGD:5130980 NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 ISO RGD PMID:10438957 RGD:4145126 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
JBrowse link
G Cd14 CD14 molecule ISO associated with asthma; DNA:polymorphism:promoter:c. -159C>T (human) RGD PMID:17196641 RGD:4144784 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 ISO DNA:polymorphism:exon:49A>G (human) RGD PMID:12114354 RGD:4891522 NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12388339 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12388339 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cysltr1 cysteinyl leukotriene receptor 1 ISO associated with Respiratory Syncytial Virus Infections RGD PMID:16238585 RGD:4846883 NCBI chr  X:71,661,415...71,690,158
Ensembl chr  X:71,663,821...71,690,121
JBrowse link
G Dpp10 dipeptidyl peptidase like 10 ISO RGD PMID:19951440 RGD:4892274 NCBI chr13:34,584,420...36,269,619
Ensembl chr13:34,595,868...36,269,292
JBrowse link
G Esr1 estrogen receptor 1 ISO RGD PMID:16522460 RGD:4892312 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Gata3 GATA binding protein 3 IEP RGD PMID:20118299 RGD:5128801 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391
JBrowse link
G Hnmt histamine N-methyltransferase no_association ISO RGD PMID:15693910 RGD:5128888 NCBI chr 3:6,591,804...6,623,821
Ensembl chr 3:6,591,463...6,624,012
JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17014439 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifng interferon gamma IEP mRNA:increased expression:lung: RGD PMID:8690457 RGD:10755761 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 ISO RGD PMID:20406594 RGD:4140467 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il13 interleukin 13 susceptibility ISO DNA:SNP:promoter:-1055C>T (human)
associated with Eosinophilic enteropathy
CTD Direct Evidence: marker/mechanism
PMID:12654629 PMID:23434795 PMID:12669034 PMID:11588017 PMID:15236177 RGD:4761594, RGD:4765128, RGD:4145432 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il15 interleukin 15 ISO RGD PMID:18394133 RGD:4943853 NCBI chr19:25,640,013...25,706,818
Ensembl chr19:25,640,251...25,706,820
JBrowse link
G Il17a interleukin 17A ISO protein:increased expression:sputum RGD PMID:12814161 PMID:20413629 RGD:4889115, RGD:4888526 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il18 interleukin 18 ISO RGD PMID:11766995 RGD:4889856 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il18rap interleukin 18 receptor accessory protein ISO DNA:SNP: :rs1420106 (human) RGD PMID:18774397 RGD:5024946 NCBI chr 9:42,768,112...42,800,964
Ensembl chr 9:42,768,220...42,800,959
JBrowse link
G Il1b interleukin 1 beta ISO mRNA, protein:increased expression:lung RGD PMID:14754758 RGD:4143217 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:32777237 NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256
JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO CTD Direct Evidence: therapeutic CTD
PMID:14754758 PMID:14754758 RGD:4143217 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
JBrowse link
G Il21r interleukin 21 receptor ISO RGD PMID:17920666 RGD:6892942 NCBI chr 1:180,168,028...180,195,690
Ensembl chr 1:180,168,097...180,195,522
JBrowse link
G Il4r interleukin 4 receptor ISO RGD PMID:16890766 RGD:4890011 NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980
JBrowse link
G Il5 interleukin 5 treatment ISO RGD PMID:9712797 PMID:10471622 RGD:4890961, RGD:11354935 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Itgb3 integrin subunit beta 3 ISO DNA:SNPs: : RGD PMID:15817799 RGD:5037231 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
JBrowse link
G Mif macrophage migration inhibitory factor ISO RGD PMID:17373669 RGD:4891035 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO RGD PMID:19940022 RGD:5129522 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Ms4a2 membrane spanning 4-domains A2 susceptibility ISO DNA:polymorphism:CDS: E237G (human) RGD PMID:17430357 RGD:5131116 NCBI chr 1:208,440,179...208,448,716
Ensembl chr 1:208,440,361...208,448,310
JBrowse link
G Ngf nerve growth factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:22871964 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Nos1 nitric oxide synthase 1 ISO protein:increased expression:lung RGD PMID:19286931 RGD:5132864 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nos2 nitric oxide synthase 2 IEP
associated with reperfusion injury; mRNA:increased expression:lung
protein:increased expression:lung
protein:increased expression:lung, respiratory tract
associated with Reperfusion Injury
RGD PMID:20430162 PMID:19286931 PMID:11076311 PMID:17607157 RGD:4891490, RGD:5132864, RGD:4892083, RGD:4891947 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 ISO protein:decreased expression:lung RGD PMID:16714207 PMID:19286931 RGD:4892061, RGD:5132864 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17508966 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Scgb1a1 secretoglobin family 1A member 1 ISO RGD PMID:11597923 RGD:5144210 NCBI chr 1:205,977,060...205,980,610
Ensembl chr 1:205,977,060...205,980,610
JBrowse link
G Selp selectin P ISO atopy and bronchial hyperresponsiveness, OMIM:147050 RGD PMID:12929084 RGD:1599904 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845
JBrowse link
G Serpina1 serpin family A member 1 ISO DNA:mutation:cds:c.321C>A(human) RGD PMID:28947017 RGD:14695046 NCBI chr 6:122,866,314...122,888,339
Ensembl chr 6:122,866,312...122,888,339
JBrowse link
G Sftpa1 surfactant protein A1 ISO protein:decreased expression:lung RGD PMID:14748931 RGD:4143407 NCBI chr16:17,008,180...17,011,686
Ensembl chr16:17,008,180...17,011,685
JBrowse link
G Sftpb surfactant protein B ISO protein:decreased expression:lung RGD PMID:14748931 RGD:4143407 NCBI chr 4:104,359,303...104,368,439
Ensembl chr 4:104,359,396...104,368,436
JBrowse link
G Sftpc surfactant protein C ISO protein:decreased expression:lung RGD PMID:14748931 RGD:4143407 NCBI chr15:45,596,565...45,599,615
Ensembl chr15:45,596,574...45,610,777
JBrowse link
G Sftpd surfactant protein D ISO
protein:increased expression:lung RGD PMID:14748931 PMID:12882759 RGD:4143407, RGD:4144051 NCBI chr16:17,046,491...17,058,968
Ensembl chr16:17,046,483...17,059,927
JBrowse link
G Tac1 tachykinin, precursor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16777450 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
G Tacr1 tachykinin receptor 1 IMP
RGD PMID:18063836 PMID:15272104 RGD:5147833, RGD:5147834 NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733
JBrowse link
G Tlr4 toll-like receptor 4 ISO RGD PMID:20007931 RGD:4144229 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor ISO associated with asthma; DNA:polymorphism:promoter: c. -308A>G (human) RGD PMID:17196641 RGD:4144784 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19458046 NCBI chr 5:4,379,999...4,433,243
Ensembl chr 5:4,379,999...4,433,570
JBrowse link
G Vip vasoactive intestinal peptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:15127121 PMID:15144609 NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18145
    disease of anatomical entity 17519
      respiratory system disease 3381
        lower respiratory tract disease 2223
          bronchial disease 972
            Bronchial Hyperreactivity 52
paths to the root