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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:transitional cell carcinoma
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Accession:DOID:2671 term browser browse the term
Definition:A carcinoma that derives_from transitional epithelial cells. (DO)
Synonyms:exact_synonym: TCC;   transitional carcinoma;   transitional cell carcinomas;   transitional cell tumor;   urothelial carcinoma;   urothelial cell carcinoma
 narrow_synonym: invasive transitional cell carcinoma;   transitional cell carcinoma of the bladder
 related_synonym: transitional cell neoplasm
 primary_id: MESH:D002295
 alt_id: OMIA:001512
 xref: GARD:7794;   NCI:C128126;   NCI:C2930;   NCI:C6783
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
 
transitional cell carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 ISO ClinVar Annotator: match by term: Transitional cell carcinoma of the bladder ClinVar PMID:17611497 PMID:18256540 PMID:18392055 PMID:18504432 PMID:18611285 More... NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Ambp alpha-1-microglobulin/bikunin precursor ISO CTD Direct Evidence: therapeutic CTD PMID:14644129 NCBI chr 5:76,568,094...76,578,416
Ensembl chr 5:76,568,094...76,578,331 		JBrowse link
G Angpt1 angiopoietin 1 disease_progression ISO RGD PMID:15517881 RGD:2293863 NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067 		JBrowse link
G Angpt2 angiopoietin 2 disease_progression ISO RGD PMID:15705099 RGD:2293853 NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804 		JBrowse link
G Anxa1 annexin A1 severity IEP mRNA, protein:increased expression:urinary bladder RGD PMID:17994624 RGD:2306889 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17133271 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Apc APC regulator of WNT signaling pathway ISO DNA:methylation: : RGD PMID:21599969 RGD:7242057 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696 		JBrowse link
G Apoa1 apolipoprotein A1 severity IEP
ISO		 mRNA:decreased expression:urinary bladder
protein:increased expression:urine		 RGD PMID:19399409 PMID:21496341 RGD:2325183, RGD:7241214 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Areg amphiregulin ISO mRNA:increased expression:urinary bladder RGD PMID:16469638 RGD:2289980 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535 		JBrowse link
G Arid1a AT-rich interaction domain 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:21822268 NCBI chr 5:145,908,181...145,981,609
Ensembl chr 5:145,908,181...145,985,564 		JBrowse link
G Bcl2 BCL2, apoptosis regulator ISO RGD PMID:18047955 RGD:1643477 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 ISO RGD PMID:18047955 RGD:1643477 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 disease_progression ISO mRNA:increased expression:urine
protein:increased expression:urinary bladder		 RGD PMID:17559031 PMID:17828507 PMID:18172282 RGD:2298937, RGD:2293099, RGD:2293093 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO ClinVar Annotator: match by term: Transitional cell carcinoma of the bladder ClinVar PMID:12068308 PMID:12460918 PMID:12460919 PMID:12960123 PMID:14612909 More... NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463 		JBrowse link
G Brd4 bromodomain containing 4 disease_progression ISO mRNA,protein:increased expression:bladder: RGD PMID:25120803 RGD:9586352 NCBI chr 7:11,216,446...11,296,029
Ensembl chr 7:11,216,446...11,295,539 		JBrowse link
G Bsg basigin (Ok blood group) disease_progression ISO RGD PMID:17671123 RGD:2289051 NCBI chr 7:9,993,170...10,000,387
Ensembl chr 7:9,993,170...10,000,387 		JBrowse link
G Ca9 carbonic anhydrase 9 disease_progression ISO RGD PMID:15069539 RGD:2298947 NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838 		JBrowse link
G Casp3 caspase 3 ISO RGD PMID:18172282 RGD:2293093 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cav1 caveolin 1 disease_progression ISO protein:increased expression:urinary bladder RGD PMID:16328005 RGD:2289103 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Cbx7 chromobox 7 severity ISO mRNA:decreased expression:urinary bladder: RGD PMID:18984978 RGD:9587361 NCBI chr 7:111,460,656...111,479,231
Ensembl chr 7:111,460,656...111,477,973 		JBrowse link
G Ccnd1 cyclin D1 IEP
ISO		 mRNA, protein:increased expression:urinary bladder
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:12151359 PMID:16896691 RGD:2289144 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccnd2 cyclin D2 IDA DNA:hypermethylation:urinary bladder, urine RGD PMID:17017434 RGD:2289150 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495 		JBrowse link
G Cd44 CD44 molecule (Indian blood group) ISO mRNA:splice variants:kidney pelvis, ureter RGD PMID:10022688 RGD:2289363 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cd82 Cd82 molecule ISO RGD PMID:17393117 RGD:2289390 NCBI chr 3:79,387,361...79,431,847
Ensembl chr 3:79,385,887...79,431,809 		JBrowse link
G Cd9 CD9 molecule disease_progression ISO protein:decreased expression:urinary bladder RGD PMID:17393117 RGD:2289390 NCBI chr 4:158,256,328...158,289,136
Ensembl chr 4:158,256,328...158,289,222 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 severity ISO RGD PMID:18245534 RGD:2701900 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 disease_progression ISO RGD PMID:15161057 RGD:2293580 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:12151359 PMID:18640142 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B disease_progression ISO RGD PMID:10886076 RGD:2293608 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A disease_progression ISO DNA:hypermethylation:promoter
ClinVar Annotator: match by term: Transitional cell carcinoma of the bladder		 ClinVar
RGD		 PMID:7780957 PMID:8521414 PMID:9324288 PMID:10491434 PMID:16234564 More... RGD:2289686 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Cdkn2a_v1 cyclin-dependent kinase inhibitor 2A, variant 1 disease_progression ISO DNA:hypermethylation:promoter RGD PMID:16316628 RGD:2289686
G Cdkn2a_v2 cyclin-dependent kinase inhibitor 2A, variant 2 disease_progression ISO DNA:hypermethylation:promoter RGD PMID:16316628 RGD:2289686
G Cdkn2b cyclin-dependent kinase inhibitor 2B ISO mRNA:decreased expression:urinary bladder RGD PMID:11720438 RGD:2289697 NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050 		JBrowse link
G Chd6 chromodomain helicase DNA binding protein 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21822268 NCBI chr 3:149,596,509...149,757,765
Ensembl chr 3:149,596,509...149,757,755 		JBrowse link
G Cnot9 CCR4-NOT transcription complex subunit 9 ISO ClinVar Annotator: match by term: Transitional cell carcinoma of the bladder ClinVar PMID:26619011 NCBI chr 9:76,084,269...76,109,111
Ensembl chr 9:76,084,334...76,109,100 		JBrowse link
G Crebbp CREB binding protein ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Transitional cell carcinoma of the bladder		 CTD
ClinVar		 PMID:21390126 PMID:21680795 PMID:21796119 PMID:21822268 PMID:22832583 More... NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888 		JBrowse link
G Csf3 colony stimulating factor 3 ISO CTD Direct Evidence: therapeutic CTD PMID:7525883 PMID:7543010 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603 		JBrowse link
G Ctnna1 catenin alpha 1 ISO RGD PMID:16426728 RGD:2298486 NCBI chr18:26,728,246...26,860,911
Ensembl chr18:26,728,485...26,860,910 		JBrowse link
G Ctnnb1 catenin beta 1 disease_progression ISO ClinVar Annotator: match by term: Transitional cell carcinoma of the bladder ClinVar
RGD		 PMID:9065402 PMID:9065403 PMID:9294210 PMID:9927029 PMID:10027390 More... RGD:2298486, RGD:2289818 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Ctsb cathepsin B ISO protein:increased expression:urinary bladder RGD PMID:15183956 RGD:2315615 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500 		JBrowse link
G Ctsh cathepsin H ISO protein:increased expression:urinary bladder RGD PMID:15183956 RGD:2315615 NCBI chr 8:90,608,941...90,627,824
Ensembl chr 8:90,608,941...90,627,824 		JBrowse link
G Dapk1 death associated protein kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17133271 NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991 		JBrowse link
G Daxx death-domain associated protein ISO RGD PMID:23819605 RGD:9587843 NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843 		JBrowse link
G Egfr epidermal growth factor receptor ISO mRNA:decreased expression:urinary bladder RGD PMID:16469638 PMID:3499520 RGD:2289980, RGD:10395259 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Ep300 E1A binding protein p300 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Transitional cell carcinoma of the bladder		 CTD
ClinVar		 PMID:21822268 PMID:26619011 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 severity ISO mRNA:increased expression:urinary bladder
ClinVar Annotator: match by term: Transitional cell carcinoma of the bladder
protein:increased expression:urinary bladder		 ClinVar
RGD		 PMID:16397024 PMID:18413839 PMID:22046346 PMID:22908275 PMID:23220880 More... RGD:2298506, RGD:2289927 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 ISO ClinVar Annotator: match by term: Transitional cell carcinoma of the bladder
mRNA:increased expression:urinary bladder		 ClinVar
RGD		 PMID:26619011 PMID:16469638 PMID:14614020 RGD:2289980, RGD:2298506 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 ISO mRNA:increased expression:urinary bladder
mRNA:decreased expression:urinary bladder		 RGD PMID:14614020 PMID:16469638 RGD:2298506, RGD:2289980 NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595 		JBrowse link
G Espl1 extra spindle pole bodies like 1, separase ISO CTD Direct Evidence: marker/mechanism CTD PMID:24121792 NCBI chr 7:133,424,027...133,450,984
Ensembl chr 7:133,424,130...133,450,984 		JBrowse link
G Esr2 estrogen receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16700038 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Fas Fas cell surface death receptor disease_progression ISO protein:increased expression:urine
protein:decreased expression		 RGD PMID:16541433 PMID:12470426 PMID:16091761 RGD:2290058, RGD:2290077, RGD:2290075 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand disease_progression ISO RGD PMID:12470426 PMID:12651606 RGD:2290077, RGD:2290076 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fbxw7 F-box and WD repeat domain containing 7 ISO ClinVar Annotator: match by term: Transitional cell carcinoma of the bladder ClinVar PMID:25741868 PMID:26619011 NCBI chr 2:170,150,552...170,310,698
Ensembl chr 2:170,149,694...170,309,941 		JBrowse link
G Fgf1 fibroblast growth factor 1 disease_progression ISO protein:increased expression:urine, urinary bladder RGD PMID:7690426 RGD:2298518 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357 		JBrowse link
G Fgf2 fibroblast growth factor 2 ISO protein:decreased expression:urinary bladder RGD PMID:7549793 RGD:2298517 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 ISO ClinVar Annotator: match by term: Transitional cell carcinoma of the bladder ClinVar PMID:25705862 PMID:26619011 PMID:26942290 NCBI chr16:66,492,445...66,546,731
Ensembl chr16:66,494,042...66,547,350 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 ISO mRNA, protein:decreased expression:urinary bladder RGD PMID:9018118 RGD:2301194 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626 		JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 ISO ClinVar Annotator: match by term: Transitional cell carcinoma of the bladder
CTD Direct Evidence: marker/mechanism		 ClinVar
CTD
RGD		 PMID:1908846 PMID:7773297 PMID:8589699 PMID:8845844 PMID:8858131 More... RGD:2289866 NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341 		JBrowse link
G Ggh gamma-glutamyl hydrolase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19815704 NCBI chr 5:33,529,880...33,552,790
Ensembl chr 5:33,529,880...33,552,787 		JBrowse link
G Gpx1 glutathione peroxidase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15247771 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 onset ISO protein:increased expression:urinary bladder mucosa RGD PMID:9111645 PMID:18199464 RGD:2293800, RGD:2293824 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 ISO protein:increased expression:urinary bladder mucosa RGD PMID:9111645 RGD:2293800 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585 		JBrowse link
G H19 H19, imprinted maternally expressed transcript (non-protein coding) IEP mRNA:increased expression:urinary bladder RGD PMID:15378645 RGD:2306177 NCBI chr 1:197,730,698...197,733,374 JBrowse link
G Hras HRas proto-oncogene, GTPase ISO DNA, mRNA:mutation, increased expression:urinary bladder
ClinVar Annotator: match by term: Transitional cell carcinoma of the bladder
CTD Direct Evidence: marker/mechanism		 ClinVar
CTD
RGD		 PMID:1904555 PMID:3433577 PMID:3510078 PMID:11150980 PMID:12835555 More... RGD:2314836 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Hrh2 histamine receptor H 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:6224980 NCBI chr17:10,368,355...10,407,791
Ensembl chr17:10,368,298...10,407,631 		JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 ISO ClinVar Annotator: match by term: Transitional cell carcinoma of the bladder ClinVar PMID:18772396 PMID:19657110 PMID:19798509 PMID:19818334 PMID:20946881 More... NCBI chr 9:66,534,146...66,563,703
Ensembl chr 9:66,534,146...66,563,708 		JBrowse link
G Ifnb1 interferon beta 1 ISO CTD Direct Evidence: therapeutic CTD PMID:2297754 NCBI chr 5:103,020,969...103,021,523
Ensembl chr 5:103,020,969...103,021,523 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 disease_progression ISO DNA:hypermethylation
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:21347663 PMID:17541304 RGD:2301466 NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083 		JBrowse link
G Kdm6a lysine demethylase 6A ISO CTD Direct Evidence: marker/mechanism CTD PMID:21822268 NCBI chr  X:4,337,466...4,477,100
Ensembl chr  X:4,337,750...4,477,062 		JBrowse link
G Kdr kinase insert domain receptor disease_progression ISO RGD PMID:16515971 PMID:18645275 RGD:2291934, RGD:2301755 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Kiss1 KiSS-1 metastasis-suppressor ISO RGD PMID:17164231 RGD:2292127 NCBI chr13:44,774,823...44,780,707
Ensembl chr13:44,774,823...44,780,612 		JBrowse link
G Kiss1r KISS1 receptor severity ISO RGD PMID:17164231 RGD:2292127 NCBI chr 7:9,785,135...9,790,283
Ensembl chr 7:9,785,135...9,788,793 		JBrowse link
G Kmt2a lysine methyltransferase 2A ISO CTD Direct Evidence: marker/mechanism CTD PMID:21822268 NCBI chr 8:45,116,771...45,193,320
Ensembl chr 8:45,118,814...45,193,181 		JBrowse link
G Kmt2c lysine methyltransferase 2C ISO CTD Direct Evidence: marker/mechanism CTD PMID:21822268 NCBI chr 4:9,620,638...9,834,787
Ensembl chr 4:9,609,627...9,833,539 		JBrowse link
G Kras KRAS proto-oncogene, GTPase ISO mRNA:increased expression:urinary bladder
ClinVar Annotator: match by term: Transitional cell carcinoma of the bladder		 ClinVar
RGD		 PMID:2278970 PMID:3122217 PMID:12460918 PMID:15696205 PMID:16361624 More... RGD:2314836 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Lrrc56 leucine rich repeat containing 56 ISO ClinVar Annotator: match by term: Transitional cell carcinoma of the bladder ClinVar PMID:1904555 PMID:3510078 PMID:11150980 PMID:12835555 PMID:16155195 More... NCBI chr 1:196,299,843...196,315,170
Ensembl chr 1:196,299,846...196,315,172 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 ISO ClinVar Annotator: match by term: Transitional cell carcinoma of the bladder ClinVar PMID:17366577 PMID:17551924 PMID:19915144 PMID:21107320 PMID:22197931 More... NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 ISO ClinVar Annotator: match by term: Transitional cell carcinoma of the bladder ClinVar PMID:26619011 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mir100 microRNA 100 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30026881 NCBI chr 8:41,901,225...41,901,304
Ensembl chr 8:41,901,225...41,901,304 		JBrowse link
G Mir145 microRNA 145 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30026881 NCBI chr18:55,099,640...55,099,727
Ensembl chr18:55,099,640...55,099,727 		JBrowse link
G Mir205 microRNA 205 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25586904 NCBI chr13:105,035,878...105,035,985
Ensembl chr13:105,035,878...105,035,985 		JBrowse link
G Mir34b microRNA 34b ISO CTD Direct Evidence: marker/mechanism CTD PMID:30026881 NCBI chr 8:51,410,244...51,410,327
Ensembl chr 8:51,410,244...51,410,327 		JBrowse link
G Mir532 microRNA 532 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30639441 NCBI chr  X:15,247,315...15,247,393
Ensembl chr  X:15,247,315...15,247,393 		JBrowse link
G Mir99a microRNA 99a ISO CTD Direct Evidence: marker/mechanism CTD PMID:30026881 NCBI chr11:16,200,443...16,200,523
Ensembl chr11:16,200,443...16,200,523 		JBrowse link
G Mmp14 matrix metallopeptidase 14 ISO RGD PMID:9751409 RGD:2314950 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864 		JBrowse link
G Mmp15 matrix metallopeptidase 15 ISO RGD PMID:9751409 RGD:2314950 NCBI chr19:9,663,449...9,684,943
Ensembl chr19:9,663,449...9,684,943 		JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO protein:increased expression:plasma RGD PMID:16901349 RGD:2290349 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Msh2 mutS homolog 2 ISO associated with Lynch syndrome RGD PMID:22883484 RGD:126790557 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase susceptibility ISO DNA:transversion:cds:g.1298A>C (human) RGD PMID:21046286 RGD:6893477 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO ClinVar Annotator: match by term: Transitional cell carcinoma of the bladder ClinVar PMID:24625776 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nat2 N-acetyltransferase 2 susceptibility ISO DNA:polymorphism RGD PMID:12402313 RGD:2303765 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Ncor1 nuclear receptor co-repressor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21822268 NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 ISO ClinVar Annotator: match by term: Transitional cell carcinoma of the bladder ClinVar PMID:26619011 PMID:29018201 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nras NRAS proto-oncogene, GTPase ISO mRNA:increased expression:urinary bladder
ClinVar Annotator: match by term: Transitional cell carcinoma of the bladder		 ClinVar
RGD		 PMID:1654209 PMID:2278970 PMID:2407301 PMID:2674680 PMID:2989702 More... RGD:2314836 NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase severity ISO DNA:missense mutation:exon:p.S326C (rs1052133) (human) RGD PMID:22110223 RGD:8657372 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766 		JBrowse link
G Pabpc1 poly(A) binding protein, cytoplasmic 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25783786 NCBI chr 7:67,777,438...67,789,731
Ensembl chr 7:67,777,381...67,789,744 		JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 severity ISO protein:increased expression:urinary bladder RGD PMID:18167251 RGD:2299157 NCBI chr 1:152,111,172...152,226,390
Ensembl chr 1:152,111,188...152,226,383 		JBrowse link
G Phb1 prohibitin 1 disease_progression ISO protein:increased expression:urinary bladder RGD PMID:17465217 RGD:2292396 NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO ClinVar Annotator: match by term: Transitional cell carcinoma of the bladder ClinVar PMID:15016963 PMID:15254419 PMID:15520168 PMID:15608678 PMID:15647370 More... NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pla2g4a phospholipase A2 group IVA IEP mRNA:increased expression:bladder RGD PMID:16621493 RGD:1642457 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266 		JBrowse link
G Plau plasminogen activator, urokinase severity ISO protein:increased expression:urinary tract, tumor (human)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:14644129 PMID:15191676 RGD:7241280 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 ISO mRNA, protein:increased expression:urinary bladder RGD PMID:17205510 RGD:2292435 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891 		JBrowse link
G Prom1 prominin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:32673656 NCBI chr14:66,989,545...67,094,534
Ensembl chr14:66,990,160...67,094,527 		JBrowse link
G Pten phosphatase and tensin homolog ISO ClinVar Annotator: match by term: Transitional cell carcinoma of the bladder ClinVar PMID:26619011 PMID:27535533 PMID:28492532 PMID:29706350 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Ptges prostaglandin E synthase ISO
IEP		 protein:increased expression:urinary bladder
mRNA:increased expression:urinary bladder		 RGD PMID:14499677 PMID:16621493 RGD:2300088, RGD:1642457 NCBI chr 3:14,177,892...14,189,236 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 disease_progression ISO protein:increased expression:urinary bladder
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:10582676 PMID:10873095 PMID:12151359 PMID:12664575 PMID:18449376 RGD:2300124 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rad50 RAD50 double strand break repair protein ISO RGD PMID:16288216 RGD:2293511 NCBI chr10:37,809,353...37,861,309
Ensembl chr10:37,808,726...37,861,396 		JBrowse link
G Rassf1 Ras association domain family member 1 ISO DNA, protein:hypermethylation, decreased expression:promoter, urinary bladder RGD PMID:18480993 RGD:2299862 NCBI chr 8:108,225,023...108,236,164
Ensembl chr 8:108,225,023...108,236,164 		JBrowse link
G Rel REL proto-oncogene, NF-kB subunit ISO RGD PMID:12452071 RGD:2300270 NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892 		JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit ISO mRNA, protein:increased expression:urinary bladder mucosa, nucleus RGD PMID:12452071 RGD:2300270 NCBI chr 1:79,257,738...79,285,490
Ensembl chr 1:79,257,725...79,285,507 		JBrowse link
G Rheb Ras homolog, mTORC1 binding ISO ClinVar Annotator: match by term: Transitional cell carcinoma of the bladder ClinVar PMID:26619011 NCBI chr 4:10,278,970...10,320,160
Ensembl chr 4:10,279,370...10,320,160 		JBrowse link
G Rxra retinoid X receptor alpha ISO ClinVar Annotator: match by term: Transitional cell carcinoma of the bladder ClinVar PMID:26619011 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712 		JBrowse link
G Sf3b1 splicing factor 3b, subunit 1 ISO ClinVar Annotator: match by term: Transitional cell carcinoma of the bladder ClinVar PMID:26619011 NCBI chr 9:56,492,403...56,532,300
Ensembl chr 9:56,492,403...56,532,300 		JBrowse link
G Sfn stratifin disease_progression ISO DNA:hypermethylation:promoter RGD PMID:16964403 RGD:2299929 Ensembl chr 5:145,826,201...145,831,314 JBrowse link
G Skp2 S-phase kinase associated protein 2 disease_progression ISO protein:increased expression:kidney RGD PMID:15351619 RGD:2315044 NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338 		JBrowse link
G Smad4 SMAD family member 4 ISO protein:decreased expression:urinary bladder RGD PMID:16859125 RGD:2299980 NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438 		JBrowse link
G Sox2 SRY-box transcription factor 2 disease_progression ISO RGD PMID:22899292 RGD:8661672 NCBI chr 2:117,536,929...117,539,338
Ensembl chr 2:117,536,929...117,539,338 		JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 disease_progression ISO protein:increased expression:urine RGD PMID:15963628 RGD:2300385 NCBI chr18:35,870,723...35,882,693
Ensembl chr18:35,824,550...35,882,642 		JBrowse link
G Stag2 stromal antigen 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24121792 NCBI chr  X:120,974,687...121,105,677
Ensembl chr  X:120,974,857...121,105,677 		JBrowse link
G Tacc3 transforming, acidic coiled-coil containing protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24121792 NCBI chr14:77,051,209...77,065,343
Ensembl chr14:77,051,215...77,065,219 		JBrowse link
G Terc telomerase RNA component disease_progression ISO RNA:increased expression:ureter urothelium RGD PMID:10570439 RGD:2291974 NCBI chr 2:112,815,654...112,816,041 JBrowse link
G Tert telomerase reverse transcriptase disease_progression ISO mRNA:increased expression:urine, urothelial cell RGD PMID:17961306 RGD:2291982 NCBI chr 1:29,637,213...29,659,509
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
G Tff1 trefoil factor 1 ISO protein:increased expression:urinary bladder urothelium RGD PMID:7965392 RGD:2298573 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Tfrc transferrin receptor disease_progression ISO RGD PMID:9373912 RGD:2292023 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 ISO protein:decreased expression:plasma RGD PMID:16901349 RGD:2290349 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 ISO protein:decreased expression:plasma RGD PMID:16901349 RGD:2290349 NCBI chr10:103,541,199...103,590,611 JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: therapeutic CTD PMID:3361654 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 ISO protein:increased expression:bladder
ClinVar Annotator: match by term: Transitional cell carcinoma of the bladder
CTD Direct Evidence: marker/mechanism		 ClinVar
CTD
RGD		 PMID:1349175 PMID:1359493 PMID:1565143 PMID:1565144 PMID:1569604 More... RGD:2290532 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp63 tumor protein p63 ISO RGD PMID:18955789 RGD:2315431 NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398 		JBrowse link
G Tp73 tumor protein p73 disease_progression ISO mRNA:increased expression:kidney RGD PMID:15492852 RGD:2290588 NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128 		JBrowse link
G Tymp thymidine phosphorylase ISO RGD PMID:15841086 RGD:2293720 NCBI chr 7:120,438,768...120,444,088
Ensembl chr 7:120,438,770...120,443,874
Ensembl chr 7:120,438,770...120,443,874 		JBrowse link
G U2af1 U2 small nuclear RNA auxiliary factor 1 ISO ClinVar Annotator: match by term: Transitional cell carcinoma of the bladder ClinVar PMID:22158538 PMID:23029227 PMID:23861105 PMID:24498085 PMID:26619011 NCBI chr20:9,742,904...9,753,840
Ensembl chr20:9,742,905...9,753,832 		JBrowse link
G Vdr vitamin D receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:16080513 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
G Xpo5 exportin 5 severity ISO mRNA:increased expression:urothelium (human) RGD PMID:22766726 RGD:11041723 NCBI chr 9:14,740,182...14,778,171
Ensembl chr 9:14,740,182...14,778,171 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 susceptibility ISO DNA:SNP: :p.R194W RGD PMID:18199464 RGD:2293824 NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701 		JBrowse link
bladder urothelial carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actl7a actin-like 7a ISO RGD PMID:29058301 RGD:13831338 NCBI chr 5:71,447,447...71,450,440
Ensembl chr 5:71,447,071...71,450,908 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO ClinVar Annotator: match by term: Transitional cell bladder carcinoma ClinVar PMID:17611497 PMID:18256540 PMID:18392055 PMID:18504432 PMID:18611285 More... NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO ClinVar Annotator: match by term: Transitional cell bladder carcinoma ClinVar PMID:12068308 PMID:12460918 PMID:12460919 PMID:12960123 PMID:14612909 More... NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A ISO ClinVar Annotator: match by term: Transitional cell bladder carcinoma ClinVar PMID:7780957 PMID:8521414 PMID:9324288 PMID:10491434 PMID:16234564 More... NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Crebbp CREB binding protein ISO ClinVar Annotator: match by term: Transitional cell bladder carcinoma ClinVar PMID:21390126 PMID:21680795 PMID:21796119 PMID:22832583 PMID:23334668 More... NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888 		JBrowse link
G Ctnnb1 catenin beta 1 ISO ClinVar Annotator: match by term: Transitional cell bladder carcinoma ClinVar PMID:9065402 PMID:9065403 PMID:9294210 PMID:10027390 PMID:10192393 More... NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 ISO ClinVar Annotator: match by term: Transitional cell bladder carcinoma ClinVar PMID:18413839 PMID:22046346 PMID:22908275 PMID:23220880 PMID:25157968 More... NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 ISO ClinVar Annotator: match by term: Transitional cell bladder carcinoma ClinVar PMID:26619011 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525 		JBrowse link
G Fbxw7 F-box and WD repeat domain containing 7 ISO ClinVar Annotator: match by term: Transitional cell bladder carcinoma ClinVar PMID:25741868 PMID:26619011 NCBI chr 2:170,150,552...170,310,698
Ensembl chr 2:170,149,694...170,309,941 		JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 severity ISO ClinVar Annotator: match by term: Transitional cell bladder carcinoma
protein:increased expression:urothelial cells (human)		 ClinVar
RGD		 PMID:1908846 PMID:7773297 PMID:8589699 PMID:8845844 PMID:8858131 More... RGD:38500205 NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341 		JBrowse link
G Hras HRas proto-oncogene, GTPase ISO ClinVar Annotator: match by term: Transitional cell bladder carcinoma ClinVar PMID:1904555 PMID:3510078 PMID:11150980 PMID:12835555 PMID:16155195 More... NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 ISO ClinVar Annotator: match by term: Transitional cell bladder carcinoma ClinVar PMID:18772396 PMID:19657110 PMID:19798509 PMID:19818334 PMID:20946881 More... NCBI chr 9:66,534,146...66,563,703
Ensembl chr 9:66,534,146...66,563,708 		JBrowse link
G Kdm6a lysine demethylase 6A susceptibility ISO associated with upper tract urothelial carcinoma; DNA:mutations:multiple: (human) RGD PMID:30352907 RGD:150429735 NCBI chr  X:4,337,466...4,477,100
Ensembl chr  X:4,337,750...4,477,062 		JBrowse link
G Kras KRAS proto-oncogene, GTPase ISO ClinVar Annotator: match by term: Transitional cell bladder carcinoma ClinVar PMID:2278970 PMID:3122217 PMID:12460918 PMID:15696205 PMID:16361624 More... NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Lrrc56 leucine rich repeat containing 56 ISO ClinVar Annotator: match by term: Transitional cell bladder carcinoma ClinVar PMID:1904555 PMID:3510078 PMID:11150980 PMID:12835555 PMID:16155195 More... NCBI chr 1:196,299,843...196,315,170
Ensembl chr 1:196,299,846...196,315,172 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 ISO ClinVar Annotator: match by term: Transitional cell bladder carcinoma ClinVar PMID:17366577 PMID:17551924 PMID:19915144 PMID:21107320 PMID:22197931 More... NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Nras NRAS proto-oncogene, GTPase ISO ClinVar Annotator: match by term: Transitional cell bladder carcinoma ClinVar PMID:1654209 PMID:2278970 PMID:2407301 PMID:2674680 PMID:2989702 More... NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO ClinVar Annotator: match by term: Transitional cell bladder carcinoma ClinVar PMID:15016963 PMID:15254419 PMID:15520168 PMID:15608678 PMID:15647370 More... NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pten phosphatase and tensin homolog ISO ClinVar Annotator: match by term: Transitional cell bladder carcinoma ClinVar PMID:26619011 PMID:27535533 PMID:28492532 PMID:29706350 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Tp53 tumor protein p53 ISO ClinVar Annotator: match by term: Transitional cell bladder carcinoma ClinVar PMID:1349175 PMID:1359493 PMID:1565143 PMID:1565144 PMID:1569604 More... NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17289
    disease of cellular proliferation 7054
      cancer 5018
        cell type cancer 3413
          carcinoma 2931
            transitional cell carcinoma 136
              Bartholin's gland transitional cell carcinoma 0
              bladder urothelial carcinoma + 20
              endometrial transitional cell carcinoma 0
              fallopian tube transitional cell carcinoma 0
              ovary transitional cell carcinoma 0
              papillary transitional carcinoma 0
              prostate transitional cell carcinoma 0
              renal pelvis transitional cell carcinoma + 0
              sarcomatoid transitional cell carcinoma + 0
              upper tract urothelial carcinoma + 0
              ureter transitional cell carcinoma + 0
              urethra transitional cell carcinoma 0
paths to the root