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Term:autoimmune thrombocytopenic purpura
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Accession:DOID:8924 term browser browse the term
Definition:Thrombocytopenia occurring in the absence of toxic exposure or a disease associated with decreased platelets. It is mediated by immune mechanisms, in most cases IMMUNOGLOBULIN G autoantibodies which attach to platelets and subsequently undergo destruction by macrophages. The disease is seen in acute (affecting children) and chronic (adult) forms.
Synonyms:exact_synonym: AITP;   Autoimmune Thrombocytopenia;   ITP;   Idiopathic Thrombocytopenic Purpuras;   Immune Thrombocytopenia;   Immune Thrombocytopenias;   Immune Thrombocytopenic Purpura;   Werlhof disease;   Werlhof's disease;   Werlhofs disease;   autoimmune thrombocytopenias;   autoimmune thrombocytopenic purpuras;   idiopathic thrombocytopenic purpura;   immune thrombocytopenic purpuras;   primary thrombocytopenic purpura
 narrow_synonym: chronic idiopathic thrombocytopenic purpura
 related_synonym: Ideopath thrombocytopenic pur;   Idiopathic purpura
 primary_id: MESH:D016553
 alt_id: OMIM:188030
 xref: ICD10CM:D69.3;   ICD9CM:287.31;   NCI:C3446;   ORDO:3002
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autoimmune thrombocytopenic purpura term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adamts13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 JBrowse link 3 5,519,921 5,558,390 RGD:11554173
G Alb albumin JBrowse link 14 19,176,275 19,191,793 RGD:11036083
G Cd40 CD40 molecule JBrowse link 3 161,519,789 161,534,943 RGD:11344977
G Cd40lg CD40 ligand JBrowse link X 159,703,703 159,714,886 RGD:11344977
G Cd86 CD86 molecule JBrowse link 11 67,060,305 67,117,990 RGD:11354966
G Dnmt3a DNA methyltransferase 3 alpha JBrowse link 6 28,205,375 28,346,052 RGD:9588662
G Dnmt3b DNA methyltransferase 3 beta JBrowse link 3 149,131,541 149,170,061 RGD:9588662
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:11049162
G Fcgr2a Fc fragment of IgG receptor IIa JBrowse link 13 91,146,878 91,163,691 RGD:11040883
G Fcgr2b Fc fragment of IgG receptor IIb JBrowse link 13 89,329,298 89,343,916 RGD:11040933
G Fcgr3a Fc fragment of IgG receptor IIIa JBrowse link 13 89,385,775 89,396,047 RGD:11040776
G Gp1ba glycoprotein Ib platelet subunit alpha JBrowse link 10 57,260,680 57,263,546 RGD:10450841
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:11041894
G Il18 interleukin 18 JBrowse link 8 55,009,666 55,016,286 RGD:11073600
G Il1a interleukin 1 alpha JBrowse link 3 121,824,712 121,836,122 RGD:11051966
G Il1rn interleukin 1 receptor antagonist JBrowse link 3 1,449,778 1,468,624 RGD:11528541
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:11528541
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:11041894
G Itgb3 integrin subunit beta 3 JBrowse link 10 92,667,869 92,783,413 RGD:10755473
G Mir130a microRNA 130a JBrowse link 3 72,141,037 72,141,124 RGD:11073600
G Mir3581 microRNA 3581 JBrowse link 6 133,893,418 133,893,497 RGD:10755694
G Plat plasminogen activator, tissue type JBrowse link 16 74,098,263 74,122,897 RGD:11541072
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 JBrowse link 2 206,342,066 206,390,348 RGD:6484673
G RT1-Bb RT1 class II, locus Bb JBrowse link 20 4,043,726 4,049,367 RGD:11041758
G RT1-Db1 RT1 class II, locus Db1 JBrowse link 20 4,087,621 4,097,190 RGD:11041758
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:11073598

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15609
    disease of anatomical entity 14966
      immune system disease 2645
        Thrombocytopenic Purpura 40
          autoimmune thrombocytopenic purpura 26
Path 2
Term Annotations click to browse term
  disease 15609
    disease of anatomical entity 14966
      Hemic and Lymphatic Diseases 1900
        hematopoietic system disease 1545
          blood coagulation disease 572
            hemorrhagic disease 560
              blood platelet disease 260
                thrombocytopenia 200
                  Thrombotic Microangiopathies 67
                    Thrombocytopenic Purpura 40
                      autoimmune thrombocytopenic purpura 26
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.