RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Postoperative Cognitive Dysfunction
Accession: DOID:9006358
browse the term
Definition: A short-term decline in cognitive function (especially in memory and thinking) that may last from a few days to a few weeks after major surgery.
Synonyms: exact_synonym: Agitated Emergence; Agitations, Emergence; Anesthesia Emergence Delirium; Emergence Agitation; Emergence Delirium; Emergence Excitement; POCD; Post-Operative Delirium; Postanesthetic Excitement; post-operative delirium; postoperative confusion; postoperative delirium
primary_id: MESH:D000071257
alt_id: DOID:9000228
xref: EFO:0009954
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Ager
advanced glycosylation end product-specific receptor
IEP
mRNA, protein:increased expression:hippocampus
RGD
PMID:23078219
RGD:597805826
NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,151,965...4,155,685
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Agtr1a
angiotensin II receptor, type 1a
IEP
RGD
PMID:24814703
RGD:10047100
NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,381,467...34,435,660
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Agtr1b
angiotensin II receptor, type 1b
IEP
RGD
PMID:24814703
RGD:10047100
NCBI chr 2:104,774,005...104,849,262
Ensembl chr 2:104,773,930...104,849,310
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Akt1
AKT serine/threonine kinase 1
treatment
IEP
RGD
PMID:30221701
RGD:597931096
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
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App
amyloid beta precursor protein
treatment
IEP ISO
protein:increased expression:hippocampus protein:increased expression:plasma
RGD
PMID:35317728 PMID:35317728 PMID:33574912 PMID:30221701
RGD:597830151 , RGD:597830151 , RGD:597830178 , RGD:597931096
NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971
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Bace1
beta-secretase 1
treatment
IEP IMP
RGD
PMID:33574912 PMID:30221701
RGD:597830178 , RGD:597931096
NCBI chr 8:55,038,842...55,061,138
Ensembl chr 8:55,038,823...55,064,918
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Bax
BCL2 associated X, apoptosis regulator
treatment
IEP
RGD
PMID:33574912
RGD:597830178
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
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Bcl2
BCL2, apoptosis regulator
treatment
IEP
RGD
PMID:33574912
RGD:597830178
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
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Bdnf
brain-derived neurotrophic factor
treatment
IEP ISO
associated with brain ischemia
RGD
PMID:29571823 PMID:34964700 PMID:29599834 PMID:33324197 PMID:29065194 PMID:30232930 PMID:32564283 More...
RGD:401959211 , RGD:401965400 , RGD:401976548 , RGD:405850212 , RGD:596933096 , RGD:596936243 , RGD:596936414
NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657
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Casp3
caspase 3
treatment
IEP
RGD
PMID:33574912 PMID:30221701
RGD:597830178 , RGD:597931096
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
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Creb1
cAMP responsive element binding protein 1
treatment
IDA ISO
protein:decreased phosphorylation:hippocampus
RGD
PMID:29571823 PMID:36688960 PMID:37736695
RGD:401959211 , RGD:401959611 , RGD:401960090
NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339
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Gdnf
glial cell derived neurotrophic factor
treatment
IEP IDA ISO
protein:decreased expression:hippocampus,urine associated with rheumatic heart disease;protein:increased expression:serum protein:altered expression:hippocampus, urine
RGD
PMID:36688960 PMID:25251457 PMID:33324197 PMID:28918204 PMID:29512789 PMID:34728231 More...
RGD:401959611 , RGD:405849389 , RGD:405850212 , RGD:405850250 , RGD:405850251 , RGD:405866364
NCBI chr 2:58,621,327...58,647,242
Ensembl chr 2:58,621,327...58,647,240
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Hmgb1
high mobility group box 1
IEP
mRNA, protein:increased expression:hippocampus
RGD
PMID:23078219
RGD:597805826
NCBI chr12:11,009,236...11,015,941
Ensembl chr16:39,039,050...39,041,327 Ensembl chr12:39,039,050...39,041,327
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Igf1
insulin-like growth factor 1
treatment
IEP ISO IMP
mRNA:decreased expression:hippocampus mRNA:decreased expression:plasma
RGD
PMID:35317728 PMID:35317728 PMID:33574912
RGD:597830151 , RGD:597830151 , RGD:597830178
NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764
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Igfbp7
insulin-like growth factor binding protein 7
ISO
protein:increased expression:plasma (human)
RGD
PMID:25543030
RGD:401960875
NCBI chr14:31,091,681...31,151,623
Ensembl chr14:31,091,347...31,151,620
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Il1b
interleukin 1 beta
treatment
IDA IEP
protein:increased expression:hippocampus (rat) mRNA, protein:increased expression:hippocampus
RGD
PMID:22959208 PMID:29571823 PMID:33390808 PMID:23078219 PMID:30221701
RGD:7204702 , RGD:401959211 , RGD:401965467 , RGD:597805826 , RGD:597931096
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
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Il1rn
interleukin 1 receptor antagonist
treatment
ISO
human protein in a rat model
RGD
PMID:23077050
RGD:8551854
NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732
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Il6
interleukin 6
treatment
IEP
protein:increased expression:hippocampus (rat)
RGD
PMID:33390808 PMID:28684969 PMID:30221701
RGD:401965467 , RGD:597538492 , RGD:597931096
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
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Ireb2
iron responsive element binding protein 2
IEP
protein:increased expression:hippocampus (rat)
RGD
PMID:23229539
RGD:12904023
NCBI chr 8:64,124,152...64,207,702
Ensembl chr 8:64,154,945...64,205,520
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Mapk1
mitogen activated protein kinase 1
treatment
IDA ISO
protein:decreased phosphorylation:hippocampus
RGD
PMID:36688960 PMID:37736695
RGD:401959611 , RGD:401960090
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
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Mapk3
mitogen activated protein kinase 3
treatment
IDA ISO
protein:decreased phosphorylation:hippocampus
RGD
PMID:36688960 PMID:37736695
RGD:401959611 , RGD:401960090
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
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Mir320a
microRNA 320a
treatment
IMP ISO
protein:increased expression:plasma
RGD
PMID:35317728 PMID:35317728
RGD:597830151 , RGD:597830151
NCBI chr15:51,926,088...51,926,169
Ensembl chr15:51,926,088...51,926,169
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Ngf
nerve growth factor
treatment
ISO IEP
associated with brain ischemia
RGD
PMID:30481505 PMID:30481505 PMID:34964700 PMID:29599834
RGD:401965395 , RGD:401965395 , RGD:401965400 , RGD:401976548
NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
treatment
IDA IEP
associated with Traumatic Brain Injuries;mRNA:decreased expression:hippocampus, hypothalamus
RGD
PMID:28086911 PMID:36637480
RGD:408345237 , RGD:408364984
NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843
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Nr3c2
nuclear receptor subfamily 3, group C, member 2
IEP IMP
protein:increased expression:hippocampus (rat)
RGD
PMID:33390808 PMID:33390808
RGD:401965467 , RGD:401965467
NCBI chr19:47,619,853...47,964,089
Ensembl chr19:47,619,853...47,964,078
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Ntrk2
neurotrophic receptor tyrosine kinase 2
treatment
IEP ISO
RGD
PMID:29065194 PMID:30232930 PMID:32564283
RGD:596933096 , RGD:596936243 , RGD:596936414
NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,564,570...5,874,628
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Pik3cb
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
treatment
IEP
RGD
PMID:30221701
RGD:597931096
NCBI chr 8:108,474,017...108,579,140
Ensembl chr 8:108,474,019...108,579,331
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Tlr2
toll-like receptor 2
treatment
IEP
RGD
PMID:32300366 PMID:28684969
RGD:597538486 , RGD:597538492
NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194
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Tlr4
toll-like receptor 4
treatment
IEP
RGD
PMID:32300366 PMID:28684969
RGD:597538486 , RGD:597538492
NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007
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Tnf
tumor necrosis factor
treatment
IEP
protein:increased expression:hippocampus (rat) mRNA, protein:increased expression:hippocampus
RGD
PMID:29571823 PMID:33390808 PMID:23078219
RGD:401959211 , RGD:401965467 , RGD:597805826
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
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