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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Postoperative Cognitive Dysfunction
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Accession:DOID:9006358 term browser browse the term
Definition:A short-term decline in cognitive function (especially in memory and thinking) that may last from a few days to a few weeks after major surgery.
Synonyms:exact_synonym: Agitated Emergence;   Agitations, Emergence;   Anesthesia Emergence Delirium;   Emergence Agitation;   Emergence Delirium;   Emergence Excitement;   POCD;   Post-Operative Delirium;   Postanesthetic Excitement;   post-operative delirium;   postoperative confusion;   postoperative delirium
 primary_id: MESH:D000071257
 alt_id: DOID:9000228
 xref: EFO:0009954


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Postoperative Cognitive Dysfunction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor IEP mRNA, protein:increased expression:hippocampus RGD PMID:23078219 RGD:597805826 NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,151,965...4,155,685 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a IEP RGD PMID:24814703 RGD:10047100 NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,381,467...34,435,660 		JBrowse link
G Agtr1b angiotensin II receptor, type 1b IEP RGD PMID:24814703 RGD:10047100 NCBI chr 2:104,774,005...104,849,262
Ensembl chr 2:104,773,930...104,849,310 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 treatment IEP RGD PMID:30221701 RGD:597931096 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G App amyloid beta precursor protein treatment IEP
ISO 		protein:increased expression:hippocampus
protein:increased expression:plasma 		RGD PMID:35317728 PMID:35317728 PMID:33574912 PMID:30221701 RGD:597830151, RGD:597830151, RGD:597830178, RGD:597931096 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971 		JBrowse link
G Bace1 beta-secretase 1 treatment IEP
IMP 		RGD PMID:33574912 PMID:30221701 RGD:597830178, RGD:597931096 NCBI chr 8:55,038,842...55,061,138
Ensembl chr 8:55,038,823...55,064,918 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator treatment IEP RGD PMID:33574912 RGD:597830178 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator treatment IEP RGD PMID:33574912 RGD:597830178 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bdnf brain-derived neurotrophic factor treatment IEP
ISO 		associated with brain ischemia RGD PMID:29571823 PMID:34964700 PMID:29599834 PMID:33324197 PMID:29065194 More... RGD:401959211, RGD:401965400, RGD:401976548, RGD:405850212, RGD:596933096, RGD:596936243, RGD:596936414 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657 		JBrowse link
G Casp3 caspase 3 treatment IEP RGD PMID:33574912 PMID:30221701 RGD:597830178, RGD:597931096 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 treatment IDA
ISO 		protein:decreased phosphorylation:hippocampus RGD PMID:29571823 PMID:36688960 PMID:37736695 RGD:401959211, RGD:401959611, RGD:401960090 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339 		JBrowse link
G Gdnf glial cell derived neurotrophic factor treatment IEP
IDA
ISO 		protein:decreased expression:hippocampus,urine
associated with rheumatic heart disease;protein:increased expression:serum
protein:altered expression:hippocampus, urine 		RGD PMID:36688960 PMID:25251457 PMID:33324197 PMID:28918204 PMID:29512789 More... RGD:401959611, RGD:405849389, RGD:405850212, RGD:405850250, RGD:405850251, RGD:405866364 NCBI chr 2:58,621,327...58,647,242
Ensembl chr 2:58,621,327...58,647,240 		JBrowse link
G Hmgb1 high mobility group box 1 IEP mRNA, protein:increased expression:hippocampus RGD PMID:23078219 RGD:597805826 NCBI chr12:11,009,236...11,015,941
Ensembl chr16:39,039,050...39,041,327
Ensembl chr12:39,039,050...39,041,327 		JBrowse link
G Igf1 insulin-like growth factor 1 treatment IEP
ISO
IMP 		mRNA:decreased expression:hippocampus
mRNA:decreased expression:plasma 		RGD PMID:35317728 PMID:35317728 PMID:33574912 RGD:597830151, RGD:597830151, RGD:597830178 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764 		JBrowse link
G Igfbp7 insulin-like growth factor binding protein 7 ISO protein:increased expression:plasma (human) RGD PMID:25543030 RGD:401960875 NCBI chr14:31,091,681...31,151,623
Ensembl chr14:31,091,347...31,151,620 		JBrowse link
G Il1b interleukin 1 beta treatment IDA
IEP 		protein:increased expression:hippocampus (rat)
mRNA, protein:increased expression:hippocampus 		RGD PMID:22959208 PMID:29571823 PMID:33390808 PMID:23078219 PMID:30221701 RGD:7204702, RGD:401959211, RGD:401965467, RGD:597805826, RGD:597931096 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il1rn interleukin 1 receptor antagonist treatment ISO human protein in a rat model RGD PMID:23077050 RGD:8551854 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732 		JBrowse link
G Il6 interleukin 6 treatment IEP protein:increased expression:hippocampus (rat) RGD PMID:33390808 PMID:28684969 PMID:30221701 RGD:401965467, RGD:597538492, RGD:597931096 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Ireb2 iron responsive element binding protein 2 IEP protein:increased expression:hippocampus (rat) RGD PMID:23229539 RGD:12904023 NCBI chr 8:64,124,152...64,207,702
Ensembl chr 8:64,154,945...64,205,520 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 treatment IDA
ISO 		protein:decreased phosphorylation:hippocampus RGD PMID:36688960 PMID:37736695 RGD:401959611, RGD:401960090 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 treatment IDA
ISO 		protein:decreased phosphorylation:hippocampus RGD PMID:36688960 PMID:37736695 RGD:401959611, RGD:401960090 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mir320a microRNA 320a treatment IMP
ISO 		protein:increased expression:plasma RGD PMID:35317728 PMID:35317728 RGD:597830151, RGD:597830151 NCBI chr15:51,926,088...51,926,169
Ensembl chr15:51,926,088...51,926,169 		JBrowse link
G Ngf nerve growth factor treatment ISO
IEP 		associated with brain ischemia RGD PMID:30481505 PMID:30481505 PMID:34964700 PMID:29599834 RGD:401965395, RGD:401965395, RGD:401965400, RGD:401976548 NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 treatment IDA
IEP 		associated with Traumatic Brain Injuries;mRNA:decreased expression:hippocampus, hypothalamus RGD PMID:28086911 PMID:36637480 RGD:408345237, RGD:408364984 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 IEP
IMP 		protein:increased expression:hippocampus (rat) RGD PMID:33390808 PMID:33390808 RGD:401965467, RGD:401965467 NCBI chr19:47,619,853...47,964,089
Ensembl chr19:47,619,853...47,964,078 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 treatment IEP
ISO 		RGD PMID:29065194 PMID:30232930 PMID:32564283 RGD:596933096, RGD:596936243, RGD:596936414 NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,564,570...5,874,628 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta treatment IEP RGD PMID:30221701 RGD:597931096 NCBI chr 8:108,474,017...108,579,140
Ensembl chr 8:108,474,019...108,579,331 		JBrowse link
G Tlr2 toll-like receptor 2 treatment IEP RGD PMID:32300366 PMID:28684969 RGD:597538486, RGD:597538492 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194 		JBrowse link
G Tlr4 toll-like receptor 4 treatment IEP RGD PMID:32300366 PMID:28684969 RGD:597538486, RGD:597538492 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007 		JBrowse link
G Tnf tumor necrosis factor treatment IEP protein:increased expression:hippocampus (rat)
mRNA, protein:increased expression:hippocampus 		RGD PMID:29571823 PMID:33390808 PMID:23078219 RGD:401959211, RGD:401965467, RGD:597805826 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19167
    Pathological Conditions, Signs and Symptoms 13667
      Pathologic Processes 8430
        Postoperative Complications 861
          Postoperative Cognitive Dysfunction 30
Path 2
Term Annotations click to browse term
  disease 19167
    disease of anatomical entity 18473
      nervous system disease 14369
        central nervous system disease 12646
          brain disease 11866
            disease of mental health 8496
              cognitive disorder 2320
                psychotic disorder 1221
                  substance-induced psychosis 139
                    subacute delirium 33
                      Postoperative Cognitive Dysfunction 30
paths to the root