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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Nerve Degeneration
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Accession:DOID:9002955 term browser browse the term
Definition:Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
Synonyms:exact_synonym: Nerve Degenerations;   Neuron Degeneration;   Neuron Degenerations
 related_synonym: striatal degeneration
 primary_id: MESH:D009410
 alt_id: RDO:0000427
For additional species annotation, visit the Alliance of Genome Resources.

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Nerve Degeneration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora1 adenosine A1 receptor ISO CTD Direct Evidence: therapeutic CTD PMID:23437309 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852 		JBrowse link
G Adra1b adrenoceptor alpha 1B ISO CTD Direct Evidence: marker/mechanism CTD PMID:12871582 NCBI chr10:29,392,762...29,450,644
Ensembl chr10:29,392,762...29,450,644 		JBrowse link
G Agtpbp1 ATP/GTP binding carboxypeptidase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16952463 NCBI chr17:5,510,009...5,614,416
Ensembl chr17:5,511,385...5,614,435 		JBrowse link
G Ank2 ankyrin 2 IEP RGD PMID:12949909 RGD:1599116 NCBI chr 2:231,224,643...231,522,655
Ensembl chr 2:231,226,949...231,648,122 		JBrowse link
G Aplp2 amyloid beta precursor like protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11784781 NCBI chr 8:32,298,526...32,328,821
Ensembl chr 8:32,298,532...32,328,839 		JBrowse link
G Apoe apolipoprotein E ISO CTD Direct Evidence: marker/mechanism CTD PMID:19522546 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057 		JBrowse link
G App amyloid beta precursor protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:11784781 PMID:11800653 PMID:12396081 PMID:12963085 PMID:16951259 PMID:17600377 PMID:19631677 PMID:20111991 PMID:20359466 PMID:23726866 PMID:23827522 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
G Arg2 arginase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30618589 NCBI chr 6:102,311,097...102,338,406
Ensembl chr 6:102,311,116...102,338,520 		JBrowse link
G Atp13a2 ATPase cation transporting 13A2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22847264 NCBI chr 5:159,512,208...159,531,631
Ensembl chr 5:159,512,285...159,531,637 		JBrowse link
G Atrn attractin ISO CTD Direct Evidence: marker/mechanism CTD PMID:16860906 NCBI chr 3:123,434,409...123,567,922
Ensembl chr 3:123,434,409...123,567,918 		JBrowse link
G Atxn3 ataxin 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:9635424 NCBI chr 6:125,817,420...125,853,461
Ensembl chr 6:125,819,640...125,853,461 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19740541 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator ISO CTD Direct Evidence: therapeutic CTD PMID:20385067 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:11146106 PMID:17967740 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bdnf brain-derived neurotrophic factor IEP
ISO		 CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:8921280 PMID:8978711 PMID:15372491 PMID:19457078 PMID:19686240, PMID:18313855 RGD:10059347 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210 		JBrowse link
G Becn1 beclin 1 IEP protein:increased expression:lumbar spinal cord ventral horn RGD PMID:21436843 RGD:5685686 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297 		JBrowse link
G Casp3 caspase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:14999069 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cd4 Cd4 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:9546790 NCBI chr 4:157,381,862...157,408,357
Ensembl chr 4:157,383,052...157,408,176 		JBrowse link
G Cd44 CD44 molecule (Indian blood group) ISO CTD Direct Evidence: marker/mechanism CTD PMID:15191797 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658 		JBrowse link
G Cd9 CD9 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:19522546 NCBI chr 4:157,977,163...158,010,091
Ensembl chr 4:157,977,162...158,010,166 		JBrowse link
G Cdh1 cadherin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12387456 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395 		JBrowse link
G Cdh2 cadherin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12387456 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684 		JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17581637 NCBI chr10:67,862,054...67,863,255
Ensembl chr10:67,862,054...67,863,255 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit ISO CTD Direct Evidence: therapeutic CTD PMID:21715663 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit ISO CTD Direct Evidence: therapeutic CTD PMID:21715663 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785 		JBrowse link
G Cnr1 cannabinoid receptor 1 IEP
ISO		 CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:11517236 PMID:24211273, PMID:18313855 RGD:10059347 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056 		JBrowse link
G Cntf ciliary neurotrophic factor ISO CTD Direct Evidence: therapeutic CTD PMID:15372491 NCBI chr 1:229,599,009...229,601,032
Ensembl chr 1:229,599,009...229,601,032 		JBrowse link
G Cp ceruloplasmin ISO CTD Direct Evidence: therapeutic CTD PMID:18804145 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853 		JBrowse link
G Ctnnb1 catenin beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12387456 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372 		JBrowse link
G Dag1 dystroglycan 1 IEP RGD PMID:16228655 RGD:11537480 NCBI chr 8:116,980,501...116,993,182
Ensembl chr 8:116,980,497...116,993,193 		JBrowse link
G Ddc dopa decarboxylase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19522546 NCBI chr14:91,905,919...91,996,816
Ensembl chr14:91,905,919...91,996,774 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 ISO CTD Direct Evidence: therapeutic CTD PMID:17005863 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382 		JBrowse link
G Eef1a2 eukaryotic translation elongation factor 1 alpha 2 IEP protein:increased expression:CA1&CA3 fields of hippocampus: RGD PMID:8750861 RGD:10401216 NCBI chr 3:176,657,104...176,666,282
Ensembl chr 3:176,657,107...176,666,282 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:16492139 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041 		JBrowse link
G Epo erythropoietin ISO CTD Direct Evidence: therapeutic CTD PMID:17010629 PMID:17166730 PMID:19497871 PMID:30837834 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266 		JBrowse link
G Epor erythropoietin receptor ISO CTD Direct Evidence: therapeutic CTD PMID:19497871 NCBI chr 8:22,969,737...22,974,468
Ensembl chr 8:22,969,745...22,974,321 		JBrowse link
G Ets2 ETS proto-oncogene 2, transcription factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19522546 NCBI chr11:36,075,709...36,092,495
Ensembl chr11:36,075,709...36,092,495 		JBrowse link
G F2 coagulation factor II ISO CTD Direct Evidence: marker/mechanism CTD PMID:19969022 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031 		JBrowse link
G Fgf2 fibroblast growth factor 2 ISO CTD Direct Evidence: therapeutic CTD PMID:10203697 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681 		JBrowse link
G Ghrl ghrelin and obestatin prepropeptide ISO CTD Direct Evidence: therapeutic CTD PMID:19429016 NCBI chr 4:145,674,157...145,678,066
Ensembl chr 4:145,674,157...145,678,066 		JBrowse link
G Grin2d glutamate ionotropic receptor NMDA type subunit 2D ISO CTD Direct Evidence: marker/mechanism CTD PMID:19911010 NCBI chr 1:101,819,068...101,859,146
Ensembl chr 1:101,820,461...101,856,881 		JBrowse link
G Grm4 glutamate metabotropic receptor 4 ISO CTD Direct Evidence: therapeutic CTD PMID:17446080 NCBI chr20:6,745,682...6,791,521
Ensembl chr20:6,745,682...6,791,519 		JBrowse link
G Grn granulin precursor ISO CTD Direct Evidence: therapeutic CTD PMID:21820214 NCBI chr10:90,377,103...90,383,207
Ensembl chr10:90,376,933...90,383,205 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 IEP protein:decreased expression:spinal cord RGD PMID:21436843 RGD:5685686 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762 		JBrowse link
G Ifng interferon gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:15153526 PMID:16307444 PMID:19457078 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Igf1 insulin-like growth factor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:9452187 PMID:10203697 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609 		JBrowse link
G Igf2 insulin-like growth factor 2 ISO CTD Direct Evidence: therapeutic CTD PMID:24667322 NCBI chr 1:215,828,102...215,839,081
Ensembl chr 1:215,828,102...215,846,911 		JBrowse link
G Itgam integrin subunit alpha M ISO CTD Direct Evidence: therapeutic CTD PMID:32375810 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960 		JBrowse link
G Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 ISO CTD Direct Evidence: therapeutic CTD PMID:18619942 NCBI chr 7:120,717,378...120,744,602
Ensembl chr 7:120,717,375...120,744,602 		JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15256069 NCBI chr11:35,011,007...35,262,362
Ensembl chr11:35,024,196...35,099,383 		JBrowse link
G Lep leptin ISO CTD Direct Evidence: therapeutic CTD PMID:17993459 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818 		JBrowse link
G Lrp8 LDL receptor related protein 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18172410 NCBI chr 5:127,404,348...127,476,636
Ensembl chr 5:127,404,450...127,476,641 		JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19741132 NCBI chr 7:132,857,311...133,018,549
Ensembl chr 7:132,857,628...133,018,584 		JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha IEP protein:increased expression:lumbar spinal cord ventral horn RGD PMID:21436843 RGD:5685686 NCBI chr 3:150,801,289...150,802,935
Ensembl chr 3:150,801,289...150,802,935 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19911010 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19911010 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mpz myelin protein zero ISO CTD Direct Evidence: marker/mechanism CTD PMID:16676325 NCBI chr13:89,524,204...89,530,070
Ensembl chr13:89,524,329...89,530,068 		JBrowse link
G Mt1 metallothionein 1 ISO CTD Direct Evidence: therapeutic CTD PMID:11835189 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724 		JBrowse link
G Mt2A metallothionein 2A ISO CTD Direct Evidence: therapeutic CTD PMID:11835189 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740 		JBrowse link
G Ngf nerve growth factor ISO CTD Direct Evidence: therapeutic CTD PMID:22666365 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453 		JBrowse link
G Ngfr nerve growth factor receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:10436046 NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061 		JBrowse link
G Nos1 nitric oxide synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:9436549 PMID:10791088 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341 		JBrowse link
G Ntf3 neurotrophin 3 ISO CTD Direct Evidence: therapeutic CTD PMID:8921280 PMID:8978711 NCBI chr 4:158,636,883...158,705,886
Ensembl chr 4:158,636,884...158,705,886 		JBrowse link
G Ntf4 neurotrophin 4 ISO CTD Direct Evidence: therapeutic CTD PMID:8921280 NCBI chr 1:101,405,314...101,408,145
Ensembl chr 1:101,405,314...101,408,145 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase ISO CTD Direct Evidence: marker/mechanism CTD PMID:26629949 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326 		JBrowse link
G Otc ornithine transcarbamylase ISO CTD Direct Evidence: marker/mechanism CTD PMID:24161480 NCBI chr  X:13,524,804...13,601,074
Ensembl chr  X:13,524,607...13,601,069 		JBrowse link
G Otx2 orthodenticle homeobox 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20573704 NCBI chr15:25,500,037...25,511,619
Ensembl chr15:25,502,019...25,505,691 		JBrowse link
G Pank2 pantothenate kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20493851 NCBI chr 3:123,807,911...123,841,797
Ensembl chr 3:123,807,952...123,841,797 		JBrowse link
G Park7 Parkinsonism associated deglycase ISO CTD Direct Evidence: therapeutic CTD PMID:29649621 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724 		JBrowse link
G Pde8b phosphodiesterase 8B ISO ClinVar Annotator: match by term: Striatal Degeneration ClinVar NCBI chr 2:24,718,548...24,955,533
Ensembl chr 2:24,719,976...24,923,128 		JBrowse link
G Pink1 PTEN induced kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24161480 NCBI chr 5:156,677,146...156,689,258
Ensembl chr 5:156,677,146...156,689,415 		JBrowse link
G Plat plasminogen activator, tissue type ISO CTD Direct Evidence: marker/mechanism CTD PMID:19911010 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma ISO CTD Direct Evidence: therapeutic CTD PMID:18289512 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISO CTD Direct Evidence: marker/mechanism CTD PMID:17687034 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Psen1 presenilin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19522546 NCBI chr 6:107,169,514...107,221,000
Ensembl chr 6:107,169,528...107,216,798 		JBrowse link
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17360923 NCBI chr 1:103,197,918...103,258,309
Ensembl chr 1:103,197,915...103,256,823 		JBrowse link
G Selenop selenoprotein P ISO CTD Direct Evidence: marker/mechanism CTD PMID:18172410 NCBI chr 2:53,105,912...53,116,198
Ensembl chr 2:53,109,684...53,114,858 		JBrowse link
G Sirt1 sirtuin 1 ISO CTD Direct Evidence: therapeutic CTD PMID:17581637 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199 		JBrowse link
G Slc18a2 solute carrier family 18 member A2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18643795 NCBI chr 1:280,397,831...280,457,968
Ensembl chr 1:280,423,079...280,457,148 		JBrowse link
G Slc1a1 solute carrier family 1 member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28703795 NCBI chr 1:246,955,017...247,035,159
Ensembl chr 1:246,954,980...247,037,056 		JBrowse link
G Slc1a2 solute carrier family 1 member 2 ISO CTD Direct Evidence: therapeutic CTD PMID:22645130 NCBI chr 3:92,518,679...92,665,731
Ensembl chr 3:92,640,752...92,665,644 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12871582 PMID:18206288 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983 		JBrowse link
G Snca synuclein alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:21039522 PMID:23106139 PMID:27585560 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285 		JBrowse link
G Sncg synuclein, gamma ISO RGD PMID:19246516 RGD:6478696 NCBI chr16:10,722,110...10,726,648
Ensembl chr16:10,722,106...10,726,707 		JBrowse link
G Sod1 superoxide dismutase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17581637 PMID:19243126 PMID:24885036 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Sod2 superoxide dismutase 2 ISO CTD Direct Evidence: therapeutic CTD PMID:11146106 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Tf transferrin resistance IDA RGD PMID:17010319 RGD:1601536 NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333 		JBrowse link
G Tgfa transforming growth factor alpha ISO CTD Direct Evidence: therapeutic CTD PMID:9263032 NCBI chr 4:117,961,877...118,045,923
Ensembl chr 4:117,962,319...118,046,344 		JBrowse link
G Th tyrosine hydroxylase ISO CTD Direct Evidence: marker/mechanism CTD PMID:12871582 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287 		JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:9710261 PMID:15153526 PMID:22921461 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tsc2 TSC complex subunit 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21419848 NCBI chr10:13,962,006...13,996,684
Ensembl chr10:13,961,947...13,996,584 		JBrowse link
G Uchl3 ubiquitin C-terminal hydrolase L3 ISO RGD PMID:11555633 RGD:1302546 NCBI chr15:86,153,624...86,198,127
Ensembl chr15:86,153,628...86,198,127 		JBrowse link
G Vegfa vascular endothelial growth factor A treatment ISO associated with Diabetes Mellitus, Experimental; RGD PMID:26201024 RGD:11079183 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
G Vps54 VPS54 subunit of GARP complex ISO CTD Direct Evidence: marker/mechanism CTD PMID:19693665 NCBI chr14:106,153,407...106,207,715
Ensembl chr14:106,153,575...106,207,658 		JBrowse link
G Wdr41 WD repeat domain 41 ISO ClinVar Annotator: match by term: Striatal Degeneration ClinVar NCBI chr 2:24,668,108...24,717,280
Ensembl chr 2:24,668,116...24,717,267 		JBrowse link
G Xdh xanthine dehydrogenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:9147382 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494 		JBrowse link
G Zfp110 zinc finger protein 110 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18815271 NCBI chr 1:65,741,769...65,757,709
Ensembl chr 1:65,742,089...65,756,528 		JBrowse link
G Zmat3 zinc finger, matrin type 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17234339 NCBI chr 2:118,715,229...118,746,109
Ensembl chr 2:118,721,334...118,745,766 		JBrowse link
Retrograde Degeneration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qb complement C1q B chain IEP mRNA:increased expression RGD PMID:16934480 RGD:1599508 NCBI chr 5:155,246,444...155,251,995
Ensembl chr 5:155,246,447...155,252,003 		JBrowse link
Striatal Degeneration, Autosomal Dominant term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde8b phosphodiesterase 8B ISO CTD Direct Evidence: marker/mechanism CTD NCBI chr 2:24,718,548...24,955,533
Ensembl chr 2:24,719,976...24,923,128 		JBrowse link
Striatal Degeneration, Autosomal Dominant 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 ISO ClinVar Annotator: match by term: Striatal degeneration, autosomal dominant 1 ClinVar PMID:25741868 NCBI chr 1:216,293,087...216,630,339
Ensembl chr 1:216,293,087...216,630,339 		JBrowse link
G Pde8b phosphodiesterase 8B ISO ClinVar Annotator: match by term: Striatal degeneration, autosomal dominant 1
ClinVar Annotator: match by OMIM:609161		 OMIM
ClinVar		 PMID:20085714 PMID:24033266 PMID:25741868 PMID:26475694 PMID:26769607 PMID:28492532 NCBI chr 2:24,718,548...24,955,533
Ensembl chr 2:24,719,976...24,923,128 		JBrowse link
G Wdr41 WD repeat domain 41 ISO ClinVar Annotator: match by term: Striatal degeneration, autosomal dominant 1 ClinVar NCBI chr 2:24,668,108...24,717,280
Ensembl chr 2:24,668,116...24,717,267 		JBrowse link
Striatal Degeneration, Autosomal Dominant 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde10a phosphodiesterase 10A ISO ClinVar Annotator: match by term: Striatal degeneration, autosomal dominant 2 ClinVar
OMIM		 PMID:25741868 PMID:27058447 PMID:29159890 NCBI chr 1:52,360,296...52,544,448
Ensembl chr 1:52,360,296...52,544,450 		JBrowse link
Subacute Combined Degeneration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd40 CD40 molecule treatment IMP
IDA		 RGD PMID:16716410, PMID:16716410 RGD:2313422, RGD:2313422 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704 		JBrowse link
G Cd40lg CD40 ligand treatment IEP
IDA		 protein:increased expression:cerebrospinal fluid RGD PMID:16716410, PMID:16716410 RGD:2313422, RGD:2313422 NCBI chr  X:159,703,703...159,714,886
Ensembl chr  X:159,703,578...159,716,562 		JBrowse link
Thiamine Metabolism Dysfunction Syndrome 4 (Bilateral Striatal Degeneration and Progressive Polyneuropathy Type) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc25a19 solute carrier family 25 member 19 ISO ClinVar Annotator: match by OMIM:613710
ClinVar Annotator: match by term: Striatal necrosis, bilateral, and progressive polyneuropathy		 ClinVar
OMIM		 PMID:19798730 NCBI chr10:104,166,594...104,179,523
Ensembl chr10:104,166,598...104,179,523 		JBrowse link
Wallerian Degeneration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccar2 cell cycle and apoptosis regulator 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24252177 NCBI chr15:51,818,887...51,834,443
Ensembl chr15:51,818,897...51,834,030 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 IEP RGD PMID:9030624 RGD:68774 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 IEP RGD PMID:9030624 RGD:68774 NCBI chr 7:2,989,202...3,010,610
Ensembl chr 7:2,989,340...3,010,350 		JBrowse link
G Fcgr2a Fc fragment of IgG receptor IIa IEP mRNA:increased expression:sciatic nerve, macrophage RGD PMID:1533683 RGD:2316290 NCBI chr13:91,146,878...91,163,691
Ensembl chr13:91,168,973...91,198,036
Ensembl chr13:91,168,973...91,198,036 		JBrowse link
G Il18 interleukin 18 IEP mRNA, protein:increased expression:macrophage, microglia: RGD PMID:11494369 RGD:4889526 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299 		JBrowse link
G Mag myelin-associated glycoprotein IEP RGD PMID:12730963 RGD:9685301 NCBI chr 1:89,345,325...89,360,905
Ensembl chr 1:89,345,429...89,360,733 		JBrowse link
G Nefh neurofilament heavy IEP protein:decreased expression:neuron RGD PMID:10646539 RGD:9698439 NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557 		JBrowse link
G Nefl neurofilament light IEP protein:decreased expression:neuron RGD PMID:10646539 RGD:9698439 NCBI chr15:44,799,378...44,803,251
Ensembl chr15:44,799,334...44,804,574 		JBrowse link
G Nefm neurofilament medium IEP protein:decreased expression:neuron RGD PMID:10646539 RGD:9698439 NCBI chr15:44,855,307...44,860,604
Ensembl chr15:44,855,310...44,860,604 		JBrowse link
G Nf1 neurofibromin 1 IEP protein:increased expression:sciatic nerve: RGD PMID:8847098 RGD:12790590 NCBI chr10:66,732,460...66,928,706
Ensembl chr10:66,690,133...66,928,903 		JBrowse link
G Nmnat1 nicotinamide nucleotide adenylyltransferase 1 ISO CTD Direct Evidence: therapeutic CTD PMID:27822499 NCBI chr 5:166,409,460...166,430,291
Ensembl chr 5:166,409,461...166,430,254 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 IEP RGD PMID:10320723 RGD:1642322 NCBI chr16:24,779,480...24,789,131
Ensembl chr16:24,779,477...24,788,740 		JBrowse link
G Pgf placental growth factor ISO RGD PMID:21264946 RGD:6483582 NCBI chr 6:108,994,016...109,004,598
Ensembl chr 6:108,994,018...109,004,598 		JBrowse link
G Pla2g4a phospholipase A2 group IVA IEP
ISO		 RGD PMID:14664823, PMID:18718965 RGD:1642469, RGD:6482738 NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693 		JBrowse link
G Pla2g6 phospholipase A2 group VI ISO RGD PMID:18718965 RGD:6482738 NCBI chr 7:120,519,479...120,559,716
Ensembl chr 7:120,519,467...120,559,347 		JBrowse link
G Rxra retinoid X receptor alpha IEP mRNA:increased expression:sciatic nerve RGD PMID:16782282 RGD:1643108 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908 		JBrowse link
G Sirt1 sirtuin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24252177 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199 		JBrowse link
G Srsf3 serine and arginine rich splicing factor 3 IEP associated with Sciatic Neuropathy RGD PMID:8568916 RGD:10059662 NCBI chr20:6,288,285...6,298,218
Ensembl chr20:6,288,267...6,298,213 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 IEP mRNA:increased expression:optic (II) nerve, sciatic nerve RGD PMID:14997937 RGD:2302105 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 IEP protein:decreased expression:sciatic nerve RGD PMID:14997937 RGD:2302105 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 IEP mRNA, protein:increased expression:dorsal root ganglion RGD PMID:16683235 RGD:1600154 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072 		JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 IEP mRNA, protein:increased expression:dorsal root ganglion RGD PMID:16683235 RGD:1600154 NCBI chr 7:23,543,125...23,594,170
Ensembl chr 7:23,544,215...23,594,133 		JBrowse link
G Tlr2 toll-like receptor 2 ISO RGD PMID:18003835 RGD:2312723 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061 		JBrowse link
G Tlr4 toll-like receptor 4 ISO RGD PMID:18003835 RGD:2312723 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052 		JBrowse link
G Ube4b ubiquitination factor E4B ISO CTD Direct Evidence: therapeutic CTD PMID:27822499 NCBI chr 5:166,156,033...166,259,069
Ensembl chr 5:166,156,033...166,259,069 		JBrowse link
Term paths to the root