Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:prostate adenocarcinoma
go back to main search page
Accession:DOID:2526 term browser browse the term
Definition:A prostate carcinoma that derives_from epithelial cells of glandular origin. (DO)
Synonyms:exact_synonym: adenocarcinoma of prostate;   prostatic adenocarcinoma
 alt_id: MIM:601188
 xref: EFO:0000673;   NCI:C2919
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
prostate adenocarcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing susceptibility ISO DNA:SNPs, haplotypes:5' utr, introns, exon:multiple RGD PMID:21397927 RGD:8694410 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Adipor1 adiponectin receptor 1 susceptibility ISO DNA:SNPs, haplotype:intron, exon: (rs12733285, rs7539452) (human) RGD PMID:21397927 RGD:8694410 NCBI chr13:45,859,461...45,879,248
Ensembl chr13:45,859,533...45,879,241 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 treatment ISO ClinVar Annotator: match by term: Adenocarcinoma of prostate ClinVar
RGD		 PMID:17611497 PMID:18256540 PMID:18392055 PMID:18504432 PMID:18611285 More... RGD:13504677 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 treatment ISO RGD PMID:20638364 RGD:13504677 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 treatment ISO RGD PMID:20638364 RGD:13504677 NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708 		JBrowse link
G Ar androgen receptor treatment IDA RGD PMID:18439064 RGD:10043341 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Bin1 bridging integrator 1 ISO RGD PMID:12532338 RGD:1580047 NCBI chr18:24,009,731...24,067,267
Ensembl chr18:24,009,653...24,067,263 		JBrowse link
G Birc6 baculoviral IAP repeat-containing 6 ameliorates ISO mRNA:increased expression:prostate gland (human) RGD PMID:31964418 RGD:153344516 NCBI chr 6:20,722,922...20,916,396
Ensembl chr 6:20,722,922...20,916,434 		JBrowse link
G Birc7 baculoviral IAP repeat-containing 7 exacerbates ISO mRNALincreased expression:prostate gland (human) RGD PMID:31964418 RGD:153344516 NCBI chr 3:168,047,824...168,052,606
Ensembl chr 3:168,047,824...168,052,606 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO ClinVar Annotator: match by term: Adenocarcinoma of prostate | ClinVar Annotator: match by term: Prostate adenocarcinoma ClinVar
RGD		 PMID:2493360 PMID:12068308 PMID:12198537 PMID:12460918 PMID:12460919 More... RGD:2315868 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463 		JBrowse link
G Camk2n1 calcium/calmodulin-dependent protein kinase II inhibitor 1 treatment ISO RGD PMID:25003983 RGD:18337280 NCBI chr 5:150,674,819...150,676,600
Ensembl chr 5:150,673,507...150,676,600 		JBrowse link
G Ccnb1 cyclin B1 severity ISO RGD PMID:10193948 RGD:2315940 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccne2 cyclin E2 ISO RGD PMID:25315431 RGD:13504706 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632 		JBrowse link
G Cd9 CD9 molecule disease_progression ISO DNA, mRNA:deletion, point mutation, decreased expression:prostate gland RGD PMID:17406028 RGD:2326197 NCBI chr 4:158,256,328...158,289,136
Ensembl chr 4:158,256,328...158,289,222 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A ISO ClinVar Annotator: match by term: Prostate adenocarcinoma ClinVar PMID:25741868 PMID:26619011 PMID:28492532 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Chd4 chromodomain helicase DNA binding protein 4 ISO mRNA:decreased expression:prostate gland (human) RGD PMID:28486105 RGD:153323299 NCBI chr 4:157,898,503...157,931,632
Ensembl chr 4:157,899,391...157,931,541 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex treatment ISO RGD PMID:26379052 RGD:13504774 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Clu clusterin treatment IEP RGD PMID:24118288 RGD:9068419 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Cnot9 CCR4-NOT transcription complex subunit 9 ISO ClinVar Annotator: match by term: Prostate adenocarcinoma ClinVar PMID:26619011 NCBI chr 9:76,084,269...76,109,111
Ensembl chr 9:76,084,334...76,109,100 		JBrowse link
G Creb3l4 cAMP responsive element binding protein 3-like 4 ISO RGD PMID:17270658 PMID:11830526 RGD:13504714, RGD:13504715 NCBI chr 2:175,690,340...175,695,846
Ensembl chr 2:175,690,335...175,695,932 		JBrowse link
G Ctnnb1 catenin beta 1 ISO ClinVar Annotator: match by term: Adenocarcinoma of prostate | ClinVar Annotator: match by term: Prostate adenocarcinoma ClinVar PMID:9065402 PMID:9065403 PMID:9294210 PMID:9500465 PMID:9927029 More... NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Dnmt1 DNA methyltransferase 1 ISO mRNA,protein:increased expression:prostate gland: RGD PMID:17178860 RGD:2289681 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659 		JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha ISO mRNA:increased expression:prostate gland: RGD PMID:17178860 RGD:2289681 NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687 		JBrowse link
G Dnmt3b DNA methyltransferase 3 beta ISO mRNA,protein:increased expression:prostate gland: RGD PMID:17178860 RGD:2289681 NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 ISO ClinVar Annotator: match by term: Prostate adenocarcinoma ClinVar PMID:23220880 PMID:26619011 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Fgf2 fibroblast growth factor 2 disease_progression ISO RGD PMID:14522896 RGD:2290290 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 ISO RGD PMID:23576558 PMID:18068632 RGD:13504748, RGD:2298702 NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350 		JBrowse link
G Grb2 growth factor receptor bound protein 2 ISO RGD PMID:26103942 RGD:11056009 NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309 		JBrowse link
G Hras HRas proto-oncogene, GTPase ISO ClinVar Annotator: match by term: Adenocarcinoma of prostate | ClinVar Annotator: match by term: Prostate adenocarcinoma ClinVar PMID:1904555 PMID:3510078 PMID:11150980 PMID:16155195 PMID:16170316 More... NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 ISO ClinVar Annotator: match by term: Prostate adenocarcinoma ClinVar PMID:18772396 PMID:19657110 PMID:19798509 PMID:19818334 PMID:20946881 More... NCBI chr 9:66,534,146...66,563,703
Ensembl chr 9:66,534,146...66,563,708 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor treatment
disease_progression		 ISO
IMP		 RGD PMID:26452103 PMID:25862373 PMID:25442907 PMID:8692980 RGD:13504753, RGD:13504767, RGD:13504768, RGD:13504771 NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta treatment ISO RGD PMID:27196761 RGD:13504772 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Ilk integrin-linked kinase disease_progression ISO protein:increased expression:tumor: high-grade tumors versus adjacent BHP (P<0.001), BHP from cancer-free patients (P<0.002), or low-grade tumors (P=0.003), also associated with proliferative index (P=0.001), but inversely related to 5-year survival (p=0.004) (human) RGD PMID:11448915 RGD:2301734 NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140 		JBrowse link
G Insr insulin receptor treatment ISO RGD PMID:26452103 RGD:13504753 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit disease_progression ISO RGD PMID:9748134 RGD:2290484 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kdr kinase insert domain receptor ISO
IEP		 protein:increased expression:prostate gland RGD PMID:17491265 PMID:20808233 RGD:2291925, RGD:5684541 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Lrrc56 leucine rich repeat containing 56 ISO ClinVar Annotator: match by term: Adenocarcinoma of prostate ClinVar PMID:1904555 PMID:3510078 PMID:11150980 PMID:16155195 PMID:16170316 More... NCBI chr 1:196,299,843...196,315,170
Ensembl chr 1:196,299,846...196,315,172 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 disease_progression IDA
ISO		 metastasis; inhibition reduced invasiveness of prostate tumor cells
ClinVar Annotator: match by term: Prostate adenocarcinoma		 ClinVar
RGD		 PMID:23444215 PMID:25157968 PMID:26619011 PMID:12688676 RGD:2292631 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 treatment ISO RGD PMID:28492138 PMID:22139534 RGD:13504818, RGD:13504820 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Med12 mediator complex subunit 12 ISO ClinVar Annotator: match by term: Prostate adenocarcinoma ClinVar PMID:26619011 NCBI chr  X:66,404,807...66,427,775
Ensembl chr  X:66,404,760...66,428,387 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor ISO human gene in mouse model RGD PMID:14522256 PMID:20195545 RGD:7207413, RGD:7207781 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 ameliorates ISO human cells in mouse model RGD PMID:25664849 RGD:153002575 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451 		JBrowse link
G Nfkbia NFKB inhibitor alpha severity ISO protein:increased serine phosphorylation RGD PMID:15712212 PMID:15073126 RGD:2298768, RGD:13506768 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Pam peptidylglycine alpha-amidating monooxygenase ISO mRNA:increased expression:prostate gland (human) RGD PMID:11221851 RGD:6483769 NCBI chr 9:97,998,581...98,271,966
Ensembl chr 9:98,122,916...98,271,965 		JBrowse link
G Pdgfa platelet derived growth factor subunit A ISO protein:increased expression:prostate RGD PMID:7524068 RGD:2292156 NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497 		JBrowse link
G Pdgfra platelet derived growth factor receptor alpha ISO protein:increased expression:prostate RGD PMID:7524068 RGD:2292156 NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 treatment ISO RGD PMID:17562488 RGD:13506808 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO ClinVar Annotator: match by term: Adenocarcinoma of prostate | ClinVar Annotator: match by term: Prostate adenocarcinoma ClinVar PMID:15016963 PMID:15254419 PMID:15520168 PMID:15608678 PMID:15647370 More... NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta treatment ISO RGD PMID:18755892 RGD:13217420 NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663 		JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha ISO ClinVar Annotator: match by term: Prostate adenocarcinoma ClinVar PMID:25741868 PMID:26168268 PMID:26619011 PMID:28492532 PMID:31687265 More... NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129 		JBrowse link
G Prkcq protein kinase C, theta IEP mRNA:increased expression:prostate RGD PMID:8180127 RGD:1625625 NCBI chr17:67,246,394...67,379,049
Ensembl chr17:67,246,394...67,378,704 		JBrowse link
G Pten phosphatase and tensin homolog ISO ClinVar Annotator: match by term: Prostate adenocarcinoma ClinVar PMID:1945792 PMID:9467011 PMID:9915974 PMID:10866302 PMID:11051241 More... NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase treatment ISO RGD PMID:15754006 RGD:13506897 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit disease_progression ISO protein:increased expression:prostate gland RGD PMID:15712212 PMID:15073126 RGD:2298768, RGD:13506768 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Smad4 SMAD family member 4 ISO ClinVar Annotator: match by term: Prostate adenocarcinoma ClinVar PMID:6604412 PMID:12116240 PMID:15031030 PMID:26619011 NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438 		JBrowse link
G Spop speckle type BTB/POZ protein ISO ClinVar Annotator: match by term: Adenocarcinoma of prostate | ClinVar Annotator: match by term: Prostate adenocarcinoma ClinVar PMID:23265383 PMID:26619011 NCBI chr10:80,358,121...80,438,983
Ensembl chr10:80,358,124...80,483,955 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 disease_progression ISO protein:increased activity:prostate RGD PMID:9748134 RGD:2290484 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Tert telomerase reverse transcriptase treatment ISO RGD PMID:19903903 RGD:11038656 NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561 		JBrowse link
G Tmprss2 transmembrane serine protease 2 disease_progression ISO protein:increased expression, altered localization:prostate gland RGD PMID:18338334 RGD:2324904 NCBI chr11:36,934,306...36,973,779
Ensembl chr11:36,934,306...36,973,715 		JBrowse link
G Tp53 tumor protein p53 ISO ClinVar Annotator: match by term: Adenocarcinoma of prostate | ClinVar Annotator: match by term: Prostate adenocarcinoma ClinVar PMID:1349175 PMID:1565143 PMID:1565144 PMID:1591732 PMID:1631137 More... NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Xpo1 exportin 1 ISO ClinVar Annotator: match by term: Prostate adenocarcinoma ClinVar PMID:26619011 NCBI chr14:97,233,282...97,275,536
Ensembl chr14:97,233,270...97,275,498 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19051
    disease of cellular proliferation 7791
      cancer 5635
        cell type cancer 3841
          carcinoma 3280
            adenocarcinoma 1713
              prostate adenocarcinoma 61
                lymphoepithelioma-like acinar prostate adenocarcinoma 0
                prostate colloid adenocarcinoma 0
                prostate signet ring cell adenocarcinoma 0
                prostatic acinar adenocarcinoma 0
Path 2
Term Annotations click to browse term
  disease 19051
    disease of anatomical entity 18384
      Urogenital Diseases 5271
        Urogenital Neoplasms 2207
          reproductive system neoplasm 1292
            reproductive organ cancer 1277
              male reproductive organ cancer 834
                prostate cancer 830
                  prostate carcinoma 154
                    prostate adenocarcinoma 61
                      lymphoepithelioma-like acinar prostate adenocarcinoma 0
                      prostate colloid adenocarcinoma 0
                      prostate signet ring cell adenocarcinoma 0
                      prostatic acinar adenocarcinoma 0
paths to the root