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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:gastric adenocarcinoma
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Accession:DOID:3717 term browser browse the term
Definition:A stomach carcinoma that derives_from epithelial cells of glandular origin. (DO)
Synonyms:exact_synonym: adenocarcinoma of stomach;   cancer of stomach, adenocarcinoma;   stomach adenocarcinoma
 xref: NCI:C24227;   NCI:C4004
For additional species annotation, visit the Alliance of Genome Resources.



show annotations for term's descendants           Sort by:
 
gastric adenocarcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor type 1 ISO ClinVar Annotator: match by term: Adenocarcinoma of stomach ClinVar PMID:25326637 PMID:26619011 NCBI chr 3:42,978,558...43,097,892
Ensembl chr 3:42,978,561...43,098,241
JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO ClinVar Annotator: match by term: Adenocarcinoma of stomach ClinVar PMID:17611497 PMID:18256540 PMID:18392055 PMID:18504432 PMID:18611285 More... NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Amigo2 adhesion molecule with Ig like domain 2 ISO mRNA:increased expression:serosa of stomach (human) RGD PMID:15107827 RGD:13838842 NCBI chr 7:128,391,493...128,394,589
Ensembl chr 7:128,390,412...128,394,695
JBrowse link
G Arid1a AT-rich interaction domain 1A exacerbates
disease_progression
severity
ISO mRNA, protein:decreased expression:mucosa of stomach (human)
protein:decreased expression:stomach (human)
mRNA:decreased expression:mucosa of stomach (human)
RGD PMID:24293408 PMID:22808142 PMID:25717252 RGD:125097521, RGD:125097488, RGD:126848753 NCBI chr 5:145,908,181...145,981,609
Ensembl chr 5:145,908,181...145,985,564
JBrowse link
G B2m beta-2 microglobulin ISO ClinVar Annotator: match by term: Adenocarcinoma of stomach ClinVar PMID:26619011 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO ClinVar Annotator: match by term: Adenocarcinoma of stomach ClinVar PMID:12068308 PMID:12198537 PMID:12960123 PMID:14679157 PMID:15035987 More... NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
JBrowse link
G Calr calreticulin ameliorates ISO human cell line and construct in a mouse model RGD PMID:25619450 RGD:150521705 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
JBrowse link
G Cat catalase ISO protein:decreased expression:blood serum (human) RGD PMID:31396300 RGD:126908003 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cd44 CD44 molecule (Indian blood group) disease_progression ISO mRNA, protein:splice variant, increased expression:stomach RGD PMID:16425351 RGD:2289356 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
JBrowse link
G Cdh1 cadherin 1 severity ISO ClinVar Annotator: match by term: Adenocarcinoma of stomach
mRNA:decreased expression:mucosa of stomach (human)
ClinVar
RGD
PMID:10896919 PMID:11968083 PMID:12588804 PMID:12944922 PMID:14500541 More... RGD:125097521 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A ISO ClinVar Annotator: match by term: Adenocarcinoma of stomach ClinVar PMID:7780957 PMID:8521414 PMID:8595405 PMID:8723678 PMID:9324288 More... NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Cnot9 CCR4-NOT transcription complex subunit 9 ISO ClinVar Annotator: match by term: Adenocarcinoma of stomach ClinVar PMID:26619011 NCBI chr 9:76,084,269...76,109,111
Ensembl chr 9:76,084,334...76,109,100
JBrowse link
G Crebbp CREB binding protein ISO ClinVar Annotator: match by term: Adenocarcinoma of stomach ClinVar PMID:21390126 PMID:21680795 PMID:21796119 PMID:22832583 PMID:23334668 More... NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
JBrowse link
G Ctnnb1 catenin beta 1 ISO ClinVar Annotator: match by term: Adenocarcinoma of stomach ClinVar PMID:9065402 PMID:9065403 PMID:9294210 PMID:9927029 PMID:10027390 More... NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 ISO ClinVar Annotator: match by term: Adenocarcinoma of stomach ClinVar PMID:15457249 PMID:16397024 PMID:16988931 PMID:18339846 PMID:18413839 More... NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 ISO ClinVar Annotator: match by term: Adenocarcinoma of stomach ClinVar PMID:26619011 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525
JBrowse link
G Fbxw7 F-box and WD repeat domain containing 7 ISO ClinVar Annotator: match by term: Adenocarcinoma of stomach ClinVar PMID:25741868 PMID:26619011 NCBI chr 2:170,150,552...170,310,698
Ensembl chr 2:170,149,694...170,309,941
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 ISO ClinVar Annotator: match by term: Adenocarcinoma of stomach ClinVar PMID:10766980 PMID:23819449 PMID:25741868 PMID:26619011 PMID:26822237 More... NCBI chr16:66,492,445...66,546,731
Ensembl chr16:66,494,042...66,547,350
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 ISO ClinVar Annotator: match by term: Adenocarcinoma of stomach ClinVar PMID:7719344 PMID:8651276 PMID:9462761 PMID:9719378 PMID:10851026 More... NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626
JBrowse link
G Gnas GNAS complex locus ISO ClinVar Annotator: match by term: Adenocarcinoma of stomach ClinVar PMID:1594625 PMID:1944469 PMID:2549426 PMID:3720010 PMID:7739708 More... NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262
JBrowse link
G Hnrnpa0 heterogeneous nuclear ribonucleoprotein A0 severity ISO mRNA:decreased expression:gastric adenocarcinoma (human) RGD PMID:23007704 RGD:9854641
G Hras HRas proto-oncogene, GTPase ISO ClinVar Annotator: match by term: Adenocarcinoma of stomach ClinVar PMID:11150980 PMID:12835555 PMID:16155195 PMID:16170316 PMID:16329078 More... NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Il1b interleukin 1 beta ISO protein:increased expression:blood serum (human) RGD PMID:31396300 RGD:126908003 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 ISO protein:increased expression:blood serum (human) RGD PMID:31396300 RGD:126908003 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Irf1 interferon regulatory factor 1 ISO RGD PMID:9679752 RGD:1600013 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase ISO ClinVar Annotator: match by term: Adenocarcinoma of stomach ClinVar PMID:7530509 PMID:9438854 PMID:11073817 PMID:11276010 PMID:11526490 More... NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652
JBrowse link
G Kmt2d lysine methyltransferase 2D ISO RGD PMID:30177394 RGD:150521710 NCBI chr 7:129,980,744...130,022,088
Ensembl chr 7:129,962,887...130,020,325
JBrowse link
G Kras KRAS proto-oncogene, GTPase ISO ClinVar Annotator: match by term: Adenocarcinoma of stomach ClinVar PMID:2278970 PMID:3122217 PMID:12460918 PMID:15696205 PMID:16361624 More... NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Lrrc56 leucine rich repeat containing 56 ISO ClinVar Annotator: match by term: Adenocarcinoma of stomach ClinVar PMID:11150980 PMID:12835555 PMID:16155195 PMID:16170316 PMID:16329078 More... NCBI chr 1:196,299,843...196,315,170
Ensembl chr 1:196,299,846...196,315,172
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 ISO ClinVar Annotator: match by term: Adenocarcinoma of stomach ClinVar PMID:23444215 PMID:25157968 PMID:26619011 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 ISO ClinVar Annotator: match by term: Adenocarcinoma of stomach ClinVar PMID:18042262 PMID:26619011 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 severity ISO protein:increased expression:stomach (human) RGD PMID:10854223 RGD:150429764 NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993
JBrowse link
G Med12 mediator complex subunit 12 ISO ClinVar Annotator: match by term: Adenocarcinoma of stomach ClinVar PMID:26619011 NCBI chr  X:66,404,622...66,427,772
Ensembl chr  X:66,404,760...66,428,387
JBrowse link
G Mir20a microRNA 20a ISO miRNA:increased expression:stomach, serum,extracellular exosome RGD PMID:27756776 RGD:25823155 NCBI chr15:92,181,084...92,181,168
Ensembl chr15:92,181,084...92,181,168
JBrowse link
G Mlh1 mutL homolog 1 ISO ClinVar Annotator: match by term: Adenocarcinoma of stomach ClinVar PMID:15340264 PMID:17510385 PMID:18307539 PMID:19419416 PMID:22136435 More... NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617
JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO ClinVar Annotator: match by term: Adenocarcinoma of stomach ClinVar PMID:26619011 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Nras NRAS proto-oncogene, GTPase ISO ClinVar Annotator: match by term: Adenocarcinoma of stomach ClinVar PMID:1654209 PMID:2278970 PMID:2407301 PMID:2674680 PMID:2989702 More... NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO ClinVar Annotator: match by term: Adenocarcinoma of stomach ClinVar PMID:15016963 PMID:15254419 PMID:15520168 PMID:15608678 PMID:15647370 More... NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
JBrowse link
G Pmepa1 prostate transmembrane protein, androgen induced 1 ISO mRNA:increased expression:stomach RGD PMID:11568975 RGD:2315108 NCBI chr 3:162,011,884...162,060,137
Ensembl chr 3:162,012,751...162,060,454
JBrowse link
G Pole DNA polymerase epsilon, catalytic subunit ISO ClinVar Annotator: match by term: Adenocarcinoma of stomach ClinVar PMID:25228659 PMID:26619011 PMID:29352080 NCBI chr12:46,345,420...46,393,984
Ensembl chr12:46,345,420...46,393,939
JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha ISO ClinVar Annotator: match by term: Adenocarcinoma of stomach ClinVar PMID:25741868 PMID:26168268 PMID:26619011 NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129
JBrowse link
G Pten phosphatase and tensin homolog ISO ClinVar Annotator: match by term: Adenocarcinoma of stomach ClinVar PMID:9467011 PMID:9915974 PMID:10866302 PMID:11504908 PMID:11875759 More... NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 ISO ClinVar Annotator: match by term: Adenocarcinoma of stomach ClinVar PMID:26619011 PMID:26822237 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase ISO ClinVar Annotator: match by term: Adenocarcinoma of stomach ClinVar PMID:1760348 PMID:8601312 PMID:10064593 PMID:12077328 PMID:17603482 More... NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Rhoa ras homolog family member A ISO ClinVar Annotator: match by term: Adenocarcinoma of stomach ClinVar PMID:26619011 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G RT1-Ba RT1 class II, locus Ba susceptibility ISO associated with Helicobacter Infections;DNA:polymorphism: :HLA-DQA1*0102 (human) RGD PMID:9506344 RGD:127285393 NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744
JBrowse link
G Smad4 SMAD family member 4 ISO ClinVar Annotator: match by term: Adenocarcinoma of stomach ClinVar PMID:6604412 PMID:8898652 PMID:9214508 PMID:9285566 PMID:9582123 More... NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438
JBrowse link
G Tp53 tumor protein p53 ISO ClinVar Annotator: match by term: Adenocarcinoma of stomach
DNA:missense mutations, loss of heterozygosity:multiple
ClinVar
RGD
PMID:1349175 PMID:1359493 PMID:1565143 PMID:1565144 PMID:1569604 More... RGD:14995496 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
Gastric Adenocarcinoma and Proximal Polyposis of the Stomach term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway ISO ClinVar Annotator: match by term: Gastric adenocarcinoma and proximal polyposis of the stomach OMIM
ClinVar
PMID:21813476 PMID:22027476 PMID:27087319 PMID:27343414 PMID:28492532 More... NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696
JBrowse link
gastric cardia adenocarcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin disease_progression ISO RGD PMID:15585392 RGD:11035298 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
gastric papillary adenocarcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gli1 GLI family zinc finger 1 ISO protein:increased expression:stomach RGD PMID:17259107 RGD:150340552 NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251
JBrowse link
G Smo smoothened, frizzled class receptor ISO protein:increased expression:stomach RGD PMID:17259107 RGD:150340552 NCBI chr 4:58,344,101...58,372,828
Ensembl chr 4:58,343,529...58,373,829
JBrowse link
gastric tubular adenocarcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gli1 GLI family zinc finger 1 ISO protein:increased expression:stomach RGD PMID:17259107 RGD:150340552 NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251
JBrowse link
G Smo smoothened, frizzled class receptor ISO protein:increased expression:stomach RGD PMID:17259107 RGD:150340552 NCBI chr 4:58,344,101...58,372,828
Ensembl chr 4:58,343,529...58,373,829
JBrowse link
linitis plastica term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Psca prostate stem cell antigen ISO CTD Direct Evidence: marker/mechanism CTD PMID:18488030 NCBI chr 7:106,598,203...106,603,114
Ensembl chr 7:106,595,284...106,609,746
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17289
    disease of cellular proliferation 7054
      cancer 5018
        cell type cancer 3413
          carcinoma 2931
            adenocarcinoma 1485
              gastric adenocarcinoma 53
                Gastric Adenocarcinoma and Proximal Polyposis of the Stomach 1
                gastric cardia adenocarcinoma 1
                gastric diffuse adenocarcinoma + 1
                gastric papillary adenocarcinoma 2
                gastric tubular adenocarcinoma 2
                microinvasive gastric cancer 0
Path 2
Term Annotations click to browse term
  disease 17289
    disease of anatomical entity 16625
      gastrointestinal system disease 6078
        Digestive System Neoplasms 3440
          Gastrointestinal Neoplasms 3319
            Stomach Neoplasms 422
              stomach cancer 159
                stomach carcinoma 76
                  gastric adenocarcinoma 53
                    Gastric Adenocarcinoma and Proximal Polyposis of the Stomach 1
                    gastric cardia adenocarcinoma 1
                    gastric diffuse adenocarcinoma + 1
                    gastric papillary adenocarcinoma 2
                    gastric tubular adenocarcinoma 2
                    microinvasive gastric cancer 0
paths to the root