Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:pro-inflammatory cytokine mediated pathway
go back to main search page
Accession:PW:0000926 term browser browse the term
Definition:An early response of the innate immunity is the secretion of cytokines critical for the acute inflammatory response. The major pro-inflammatory cytokines are tumor necrosis factor alpha and the interleukins 1 and 6.


show annotations for term's descendants           Sort by:
pro-inflammatory cytokine mediated pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmgb1 high mobility group box 1 IDA MMO:0000166, MMO:0000669, MMO:0000656 RGD PMID:29091898 RGD:15090820 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Icam1 intercellular adhesion molecule 1 IDA MMO:0000166, MMO:0000669, MMO:0000656 RGD PMID:29091898 RGD:15090820 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il1b interleukin 1 beta IDA MMO:0000166, MMO:0000669, MMO:0000656 RGD PMID:29091898 RGD:15090820 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 IDA MMO:0000166, MMO:0000669, MMO:0000656 RGD PMID:29091898 RGD:15090820 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 IDA MMO:0000166, MMO:0000669, MMO:0000656 RGD PMID:29091898 RGD:15090820 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IDA MMO:0000166, MMO:0000669, MMO:0000656 RGD PMID:29091898 RGD:15090820 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Tnf tumor necrosis factor IDA RGD PMID:29091898 RGD:15090820 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
interleukin-1 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aim2 absent in melanoma 2 ISO RGD PMID:20303873 RGD:5490211 NCBI chr13:85,865,206...85,906,996
Ensembl chr13:85,866,284...85,906,975 		JBrowse link
G Casp1 caspase 1 ISO PID
RGD		 PMID:19302047 PMID:20303873 PID:200089, RGD:5490210, RGD:5490211 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex ISO PID PID:200089 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Erc1 ELKS/RAB6-interacting/CAST family member 1 ISO PID PID:200089 NCBI chr 4:152,763,664...153,055,724
Ensembl chr 4:152,767,419...153,055,639 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta ISO PID PID:200089 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma ISO PID PID:200089 NCBI chr  X:152,216,485...152,241,476
Ensembl chr  X:152,216,596...152,239,499 		JBrowse link
G Il1a interleukin 1 alpha ISO PID
RGD		 PMID:20081871 PID:200089, RGD:5490209 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta ISO PID
RGD		 PMID:20081871 PID:200089, RGD:5490209 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1r1 interleukin 1 receptor type 1 ISO
IMP		 PID
RGD		 PMID:20081871 PMID:20967881 PID:200089, RGD:5490209, RGD:5130945 NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937 		JBrowse link
G Il1r2 interleukin 1 receptor type 2 ISO PID
RGD		 PMID:20081871 PID:200089, RGD:5490209 NCBI chr 9:42,384,280...42,424,726
Ensembl chr 9:42,384,433...42,424,725 		JBrowse link
G Il1rap interleukin 1 receptor accessory protein ISO RGD PMID:20081871 RGD:5490209 NCBI chr11:74,062,999...74,199,530
Ensembl chr11:74,070,304...74,199,530 		JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO PID
RGD		 PMID:20081871 PID:200089, RGD:5490209 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 ISO PID
RGD		 PMID:20086235 PMID:18535784 PID:200089, RGD:5490215, RGD:5490218 NCBI chr  X:151,768,621...151,778,521
Ensembl chr  X:151,768,777...151,778,521 		JBrowse link
G Irak2 interleukin-1 receptor-associated kinase 2 ISO RGD PMID:20086235 RGD:5490215 NCBI chr 4:146,786,004...146,842,615
Ensembl chr 4:146,786,100...146,842,602 		JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 ISO PID PID:200089 NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:55,653,962...55,713,121 		JBrowse link
G Irak4 interleukin-1 receptor-associated kinase 4 ISO PID
RGD		 PMID:20086235 PMID:18535784 PID:200089, RGD:5490215, RGD:5490218 NCBI chr 7:125,682,502...125,708,294
Ensembl chr 7:125,682,488...125,717,837 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit ISO PID PID:200089 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 ISO PID PID:200089 NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293 		JBrowse link
G Map3k3 mitogen activated protein kinase kinase kinase 3 ISO PID PID:200089 NCBI chr10:91,020,174...91,088,852
Ensembl chr10:91,020,174...91,088,848 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 ISO PID
RGD		 PMID:20086235 PMID:18535784 PID:200089, RGD:5490215, RGD:5490218 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ISO PID PID:200089 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor ISO PID
RGD		 PMID:20086235 PMID:18535784 PID:200089, RGD:5490215, RGD:5490218 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 ISO PID PID:200089 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nlrp1a NLR family, pyrin domain containing 1A ISO RGD PMID:20303873 RGD:5490211 NCBI chr10:55,778,560...55,833,639
Ensembl chr10:55,778,560...55,825,180 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 ISO RGD PMID:19302047 PMID:20303873 RGD:5490210, RGD:5490211 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Peli1 pellino E3 ubiquitin protein ligase 1 ISO RGD PMID:20086235 RGD:5490215 NCBI chr14:95,254,274...95,309,168
Ensembl chr14:95,254,589...95,308,285 		JBrowse link
G Peli2 pellino E3 ubiquitin protein ligase family member 2 ISO RGD PMID:20086235 RGD:5490215 NCBI chr15:21,393,262...21,537,737
Ensembl chr15:21,393,262...21,535,106 		JBrowse link
G Peli3 pellino E3 ubiquitin protein ligase family member 3 ISO RGD PMID:20086235 RGD:5490215 NCBI chr 1:202,230,034...202,242,900
Ensembl chr 1:202,232,228...202,242,857 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO PID PID:200089 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO PID PID:200089 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Prkci protein kinase C, iota ISO PID PID:200089 NCBI chr 2:112,321,919...112,382,305
Ensembl chr 2:112,321,929...112,382,352 		JBrowse link
G Prkcz protein kinase C, zeta ISO PID PID:200089 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367 		JBrowse link
G Pycard PYD and CARD domain containing ISO RGD PMID:19302047 PMID:20303873 RGD:5490210, RGD:5490211 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO PID PID:200089 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sigirr single Ig and TIR domain containing ISO RGD PMID:20081871 RGD:5490209 NCBI chr 1:196,195,363...196,208,692
Ensembl chr 1:196,199,462...196,202,269 		JBrowse link
G Sqstm1 sequestosome 1 ISO PID PID:200089 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 ISO PID
RGD		 PMID:20086235 PMID:18535784 PID:200089, RGD:5490215, RGD:5490218 NCBI chr 7:111,675,829...111,707,058
Ensembl chr 7:111,686,371...111,707,058 		JBrowse link
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 ISO PID
RGD		 PMID:20086235 PMID:18535784 PID:200089, RGD:5490215, RGD:5490218 NCBI chr 1:2,375,026...2,425,115
Ensembl chr 1:2,375,490...2,424,756 		JBrowse link
G Tab3 TGF-beta activated kinase 1 (MAP3K7) binding protein 3 ISO RGD PMID:18535784 RGD:5490218 NCBI chr  X:49,972,414...50,044,658
Ensembl chr  X:49,972,330...50,042,056 		JBrowse link
G Ticam2 TIR domain containing adaptor molecule 2 ISO PID PID:200089 NCBI chr18:39,289,902...39,311,462
Ensembl chr18:39,294,453...39,311,462 		JBrowse link
G Tollip toll interacting protein ISO PID
RGD		 PMID:18535784 PID:200089, RGD:5490218 NCBI chr 1:196,961,585...196,984,252
Ensembl chr 1:196,950,771...196,983,625 		JBrowse link
G Traf6 TNF receptor associated factor 6 ISO
IMP		 PID
RGD		 PMID:20086235 PMID:20967881 PMID:18535784 PID:200089, RGD:5490215, RGD:5130945, RGD:5490218 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507 		JBrowse link
G Ube2n ubiquitin-conjugating enzyme E2N ISO PID
RGD		 PMID:20086235 PMID:18535784 PID:200089, RGD:5490215, RGD:5490218 NCBI chr 7:30,154,330...30,184,373
Ensembl chr 7:30,154,616...30,184,355 		JBrowse link
G Ube2v1 ubiquitin conjugating enzyme E2 V1 ISO PID
RGD		 PMID:20086235 PMID:18535784 PID:200089, RGD:5490215, RGD:5490218 NCBI chr 3:156,317,339...156,340,198
Ensembl chr 3:156,316,781...156,340,273 		JBrowse link
interleukin-6 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin ISO PID PID:200146 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786 		JBrowse link
G Adam10 ADAM metallopeptidase domain 10 ISO RGD PMID:21145125 RGD:5686846 NCBI chr 8:71,346,008...71,477,889
Ensembl chr 8:71,345,837...71,477,889 		JBrowse link
G Adam17 ADAM metallopeptidase domain 17 ISO RGD PMID:22029668 PMID:21145125 RGD:5686834, RGD:5686846 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO PID PID:200146 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta ISO PID PID:200146 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Cebpd CCAAT/enhancer binding protein delta ISO PID PID:200146 NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829 		JBrowse link
G Crp C-reactive protein ISO PID PID:200146 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Fgg fibrinogen gamma chain ISO PID PID:200146 NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit ISO PID PID:200146 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Foxo1 forkhead box O1 ISO PID PID:200146 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G Gab1 GRB2-associated binding protein 1 ISO PID PID:200146 NCBI chr19:27,131,262...27,239,236
Ensembl chr19:27,131,262...27,239,236 		JBrowse link
G Gab2 GRB2-associated binding protein 2 ISO PID PID:200146 NCBI chr 1:151,429,844...151,625,708
Ensembl chr 1:151,429,695...151,625,031 		JBrowse link
G Grb2 growth factor receptor bound protein 2 ISO PID
RGD		 PMID:22029668 PID:200146, RGD:5686834 NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309 		JBrowse link
G Hck HCK proto-oncogene, Src family tyrosine kinase ISO PID PID:200146 NCBI chr 3:141,571,587...141,614,696
Ensembl chr 3:141,571,587...141,614,693 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 ISO PID PID:200146 NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788 		JBrowse link
G Il6 interleukin 6 ISO
IDA		 PID
RGD		 PMID:12773095 PMID:28186964 PMID:23825534 PMID:21881215 PMID:22029668 PID:200146, RGD:1580493, RGD:127229952, RGD:11062097, RGD:5686839, RGD:5686834 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Il6r interleukin 6 receptor ISO PID
RGD		 PMID:22029668 PMID:21881215 PID:200146, RGD:5686834, RGD:5686839 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536 		JBrowse link
G Il6st interleukin 6 cytokine family signal transducer ISO
IMP		 PID
RGD		 PMID:22029668 PMID:18280048 PMID:21881215 PID:200146, RGD:5686834, RGD:5686900, RGD:5686839 NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936 		JBrowse link
G Irf1 interferon regulatory factor 1 ISO PID PID:200146 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166 		JBrowse link
G Jak1 Janus kinase 1 ISO PID
RGD		 PMID:21881215 PID:200146, RGD:5686839 NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926 		JBrowse link
G Jak2 Janus kinase 2 ISO PID
RGD		 PMID:21881215 PID:200146, RGD:5686839 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit ISO PID PID:200146 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit ISO PID PID:200146 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035 		JBrowse link
G Lbp lipopolysaccharide binding protein ISO PID PID:200146 NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586 		JBrowse link
G Lmo4 LIM domain only 4 ISO PID PID:200146 NCBI chr 2:233,264,180...233,280,881
Ensembl chr 2:233,264,182...233,280,880 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 ISO PID PID:200146 NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993 		JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 ISO PID PID:200146 NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293 		JBrowse link
G Mapk11 mitogen-activated protein kinase 11 ISO PID PID:200146 NCBI chr 7:120,218,471...120,225,488
Ensembl chr 7:120,218,478...120,225,395 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 ISO PID PID:200146 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member ISO PID PID:200146 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mitf melanocyte inducing transcription factor ISO PID PID:200146 NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor ISO PID PID:200146 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Pias1 protein inhibitor of activated STAT, 1 ISO PID PID:200146 NCBI chr 8:63,338,150...63,451,670
Ensembl chr 8:63,338,150...63,438,905 		JBrowse link
G Pias3 protein inhibitor of activated STAT, 3 ISO PID PID:200146 NCBI chr 2:184,232,546...184,241,455
Ensembl chr 2:184,232,571...184,241,480 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO PID PID:200146 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO PID PID:200146 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Prkcd protein kinase C, delta ISO PID PID:200146 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 ISO PID
RGD		 PMID:22029668 PID:200146, RGD:5686834 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925 		JBrowse link
G Rac1 Rac family small GTPase 1 ISO PID PID:200146 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 ISO PID PID:200146 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 ISO PID
RGD		 PMID:22029668 PMID:9815779 PID:200146, RGD:5686834, RGD:155631264 NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107 		JBrowse link
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 ISO RGD PMID:22029668 RGD:5686834 NCBI chr 6:88,042,966...88,156,140
Ensembl chr 6:88,042,966...88,156,692 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 ISO PID
RGD		 PMID:22029668 PMID:21881215 PID:200146, RGD:5686834, RGD:5686839 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO PID
RGD		 PMID:22029668 PMID:21881215 PID:200146, RGD:5686834, RGD:5686839 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 ISO PID PID:200146 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tnfsf11 TNF superfamily member 11 ISO PID PID:200146 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
G Tyk2 tyrosine kinase 2 ISO PID
RGD		 PMID:21881215 PID:200146, RGD:5686839 NCBI chr 8:19,641,881...19,667,157
Ensembl chr 8:19,641,884...19,667,044 		JBrowse link
G Vav1 vav guanine nucleotide exchange factor 1 ISO PID PID:200146 NCBI chr 9:2,161,985...2,209,951
Ensembl chr 9:2,157,900...2,208,937 		JBrowse link
tumor necrosis factor mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 ADAM metallopeptidase domain 17 ISO PID
RGD		 PMID:12655295 PID:200102, RGD:2292150 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639 		JBrowse link
G Bag4 BAG cochaperone 4 ISO PID
RGD		 PMID:12655295 PID:200102, RGD:2292150 NCBI chr16:66,288,678...66,305,893
Ensembl chr16:66,288,678...66,308,663 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 ISO PID
RGD		 PMID:23085193 PID:200102, RGD:7800730 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 ISO PID
RGD		 PMID:23085193 PID:200102, RGD:7800730 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Casp8 caspase 8 ISO PID PID:200102 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Cav1 caveolin 1 ISO PID PID:200102 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex ISO PID
RGD		 PMID:12655295 PID:200102, RGD:2292150 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Cyld CYLD lysine 63 deubiquitinase ISO PID
RGD		 PMID:21119682 PMID:23312890 PID:200102, RGD:7800735, RGD:7800734 NCBI chr19:18,310,632...18,373,696
Ensembl chr19:18,314,019...18,373,658 		JBrowse link
G Fadd Fas associated via death domain ISO PID
RGD		 PMID:12655295 PID:200102, RGD:2292150 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta ISO PID
RGD		 PMID:12655295 PID:200102, RGD:2292150 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma ISO PID
RGD		 PMID:12655295 PID:200102, RGD:2292150 NCBI chr  X:152,216,485...152,241,476
Ensembl chr  X:152,216,596...152,239,499 		JBrowse link
G Itch itchy E3 ubiquitin protein ligase ISO RGD PMID:23312890 PMID:21119682 RGD:7800734, RGD:7800735 NCBI chr 3:143,642,348...143,733,745
Ensembl chr 3:143,645,637...143,733,543 		JBrowse link
G Madd MAP-kinase activating death domain ISO PID PID:200102 NCBI chr 3:77,114,330...77,157,865
Ensembl chr 3:77,114,314...77,157,701 		JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 ISO PID PID:200102 NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492 		JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 ISO PID PID:200102 NCBI chr12:2,591,312...2,600,534
Ensembl chr12:2,591,219...2,604,222 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 ISO PID PID:200102 NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463 		JBrowse link
G Map3k3 mitogen activated protein kinase kinase kinase 3 ISO PID PID:200102 NCBI chr10:91,020,174...91,088,852
Ensembl chr10:91,020,174...91,088,848 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 ISO PID PID:200102 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 ISO PID
RGD		 PMID:21135871 PID:200102, RGD:5490225 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Map4k2 mitogen activated protein kinase kinase kinase kinase 2 ISO PID PID:200102 NCBI chr 1:203,645,098...203,660,782
Ensembl chr 1:203,645,153...203,660,331 		JBrowse link
G Map4k3 mitogen-activated protein kinase kinase kinase kinase 3 ISO PID PID:200102 NCBI chr 6:14,276,623...14,446,321
Ensembl chr 6:14,277,121...14,446,334 		JBrowse link
G Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 ISO PID PID:200102 NCBI chr 9:42,200,708...42,326,708
Ensembl chr 9:42,200,278...42,326,698 		JBrowse link
G Map4k5 mitogen-activated protein kinase kinase kinase kinase 5 ISO PID PID:200102 NCBI chr 6:88,284,087...88,377,118
Ensembl chr 6:88,284,094...88,376,799 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 ISO PID PID:200102 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nrk Nik related kinase ISO PID PID:200102 NCBI chr  X:102,365,765...102,462,957
Ensembl chr  X:102,365,765...102,459,657 		JBrowse link
G Nsmaf neutral sphingomyelinase activation associated factor ISO PID PID:200102 NCBI chr 5:19,517,795...19,578,773
Ensembl chr 5:19,518,348...19,577,627 		JBrowse link
G Prkci protein kinase C, iota ISO PID PID:200102 NCBI chr 2:112,321,919...112,382,305
Ensembl chr 2:112,321,929...112,382,352 		JBrowse link
G Prkcz protein kinase C, zeta ISO PID PID:200102 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367 		JBrowse link
G Rack1 receptor for activated C kinase 1 ISO PID PID:200102 NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975 		JBrowse link
G Rbck1 RANBP2-type and C3HC4-type zinc finger containing 1 ISO RGD PMID:23085193 RGD:7800730 NCBI chr 3:140,789,079...140,806,017
Ensembl chr 3:140,789,080...140,806,005 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO PID PID:200102 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rffl ring finger and FYVE-like domain containing E3 ubiquitin protein ligase ISO PID PID:200102 NCBI chr10:67,740,711...67,803,669
Ensembl chr10:67,740,712...67,824,434 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 ISO PID
RGD		 PMID:12655295 PMID:23085193 PID:200102, RGD:2292150, RGD:7800730 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824 		JBrowse link
G Rnf11 ring finger protein 11 ISO RGD PMID:21119682 PMID:23312890 RGD:7800734 RGD:7800735 NCBI chr 5:124,212,433...124,243,125
Ensembl chr 5:124,212,445...124,234,750 		JBrowse link
G Rnf31 ring finger protein 31 ISO RGD PMID:23085193 RGD:7800730 NCBI chr15:29,083,047...29,095,328
Ensembl chr15:29,083,631...29,101,915 		JBrowse link
G Sharpin SHANK-associated RH domain interactor ISO RGD PMID:23085193 RGD:7800730 NCBI chr 7:108,070,681...108,075,012
Ensembl chr 7:108,070,687...108,074,955 		JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 ISO PID PID:200102 NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794 		JBrowse link
G Smpd2 sphingomyelin phosphodiesterase 2 ISO PID PID:200102 NCBI chr20:44,986,229...44,989,343
Ensembl chr20:44,986,231...44,989,441 		JBrowse link
G Sqstm1 sequestosome 1 ISO PID PID:200102 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 ISO PID PID:200102 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 ISO PID
RGD		 PMID:21135871 PID:200102, RGD:5490225 NCBI chr 7:111,675,829...111,707,058
Ensembl chr 7:111,686,371...111,707,058 		JBrowse link
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 ISO PID
RGD		 PMID:21135871 PID:200102, RGD:5490225 NCBI chr 1:2,375,026...2,425,115
Ensembl chr 1:2,375,490...2,424,756 		JBrowse link
G Tab3 TGF-beta activated kinase 1 (MAP3K7) binding protein 3 ISO RGD PMID:21135871 RGD:5490225 NCBI chr  X:49,972,414...50,044,658
Ensembl chr  X:49,972,330...50,042,056 		JBrowse link
G Tax1bp1 Tax1 binding protein 1 ISO RGD PMID:23312890 PMID:21119682 RGD:7800734, RGD:7800735 NCBI chr 4:81,821,991...81,877,906
Ensembl chr 4:81,821,989...81,879,100 		JBrowse link
G Tnf tumor necrosis factor ISO PID
RGD		 PMID:12655295 PID:200102, RGD:2292150 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 ISO RGD PMID:23312890 PMID:21119682 RGD:7800734, RGD:7800735 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A ISO
IMP		 PID
RGD		 PMID:12655295 PMID:20967881 PID:200102, RGD:2292150, RGD:5130945 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B ISO PID
RGD		 PMID:12655295 PID:200102, RGD:2292150 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206 		JBrowse link
G Tnik TRAF2 and NCK interacting kinase ISO PID PID:200102 NCBI chr 2:111,184,352...111,587,993
Ensembl chr 2:111,184,387...111,580,750 		JBrowse link
G Tradd TNFRSF1A-associated via death domain ISO PID
RGD		 PMID:12655295 PID:200102, RGD:2292150 NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638 		JBrowse link
G Traf1 TNF receptor-associated factor 1 ISO PID PID:200102 NCBI chr 3:18,222,024...18,242,163
Ensembl chr 3:18,222,054...18,241,807 		JBrowse link
G Traf2 Tnf receptor-associated factor 2 ISO
IMP		 PID
RGD		 PMID:12655295 PMID:23085193 PMID:20967881 PID:200102, RGD:2292150, RGD:7800730, RGD:5130945 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538 		JBrowse link
G Traf5 TNF receptor-associated factor 5 ISO RGD PMID:23085193 RGD:7800730 NCBI chr13:103,569,944...103,618,747
Ensembl chr13:103,572,314...103,618,709 		JBrowse link
G Txn1 thioredoxin 1 ISO PID PID:200102 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    regulatory pathway 3867
      immune response pathway 539
        innate immune response pathway 296
          inflammatory response pathway 228
            pro-inflammatory cytokine mediated pathway 130
              interleukin-1 signaling pathway 44
              interleukin-6 signaling pathway 48
              tumor necrosis factor mediated signaling pathway + 54
paths to the root