Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:interleukin-1 signaling pathway
go back to main search page
Accession:PW:0000883 term browser browse the term
Definition:Interleukin-1 signaling, primarily via interleukin-1beta, plays important roles in innate and adaptive immune responses. Binding of the processed cytokine to its receptor allows for the recruitment of several accessory and adaptor proteins leading to the activation of NF-kappaB and MAPK signaling cascades. A natural receptor antagonist and a decoy receptor act as regulators of interleukin-1alpha and beta.
Synonyms:related_synonym: Il-1 signaling pathway;   Interleukin-1 signaling;   interleukin-1-mediated signaling pathway
View Interactive Diagram


show annotations for term's descendants           Sort by:
interleukin-1 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aim2 absent in melanoma 2 ISO RGD PMID:20303873 RGD:5490211 NCBI chr13:85,865,206...85,906,996
Ensembl chr13:88,404,048...88,439,318 		JBrowse link
G Casp1 caspase 1 ISO PID
RGD		 PMID:19302047 PMID:20303873 PID:200089, RGD:5490210, RGD:5490211 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:10,746,333...10,882,275 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex ISO PID PID:200089 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:252,908,749...252,944,273 		JBrowse link
G Erc1 ELKS/RAB6-interacting/CAST family member 1 ISO PID PID:200089 NCBI chr 4:154,435,936...154,727,987
Ensembl chr 4:154,435,944...154,727,987 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta ISO PID PID:200089 NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma ISO PID PID:200089 NCBI chr  X:152,216,485...152,241,476
Ensembl chr  X:157,367,639...157,392,757 		JBrowse link
G Il1a interleukin 1 alpha ISO PID
RGD		 PMID:20081871 PID:200089, RGD:5490209 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013 		JBrowse link
G Il1b interleukin 1 beta ISO PID
RGD		 PMID:20081871 PID:200089, RGD:5490209 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il1r1 interleukin 1 receptor type 1 ISO
IMP 		PID
RGD		 PMID:20081871 PMID:20967881 PID:200089, RGD:5490209, RGD:5130945 NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:50,000,566...50,076,579 		JBrowse link
G Il1r2 interleukin 1 receptor type 2 ISO PID
RGD		 PMID:20081871 PID:200089, RGD:5490209 NCBI chr 9:49,879,928...49,920,374
Ensembl chr 9:49,877,266...49,920,374 		JBrowse link
G Il1rap interleukin 1 receptor accessory protein ISO RGD PMID:20081871 RGD:5490209 NCBI chr11:87,567,813...87,704,346
Ensembl chr11:87,575,116...87,704,342 		JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO PID
RGD		 PMID:20081871 PID:200089, RGD:5490209 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 ISO PID
RGD		 PMID:20086235 PMID:18535784 PID:200089, RGD:5490215, RGD:5490218 NCBI chr  X:151,768,621...151,778,521
Ensembl chr  X:156,920,081...156,929,825 		JBrowse link
G Irak2 interleukin-1 receptor-associated kinase 2 ISO RGD PMID:20086235 RGD:5490215 NCBI chr 4:146,786,004...146,842,615
Ensembl chr 4:148,341,719...148,398,210 		JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 ISO PID PID:200089 NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:57,539,557...57,598,706 		JBrowse link
G Irak4 interleukin-1 receptor-associated kinase 4 ISO PID
RGD		 PMID:20086235 PMID:18535784 PID:200089, RGD:5490215, RGD:5490218 NCBI chr 7:125,682,502...125,708,294
Ensembl chr 7:127,561,717...127,597,109 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit ISO PID PID:200089 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 ISO PID PID:200089 NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,872,546...95,987,721 		JBrowse link
G Map3k3 mitogen activated protein kinase kinase kinase 3 ISO PID PID:200089 NCBI chr10:91,020,174...91,088,852
Ensembl chr10:91,519,888...91,588,651 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 ISO PID
RGD		 PMID:20086235 PMID:18535784 PID:200089, RGD:5490215, RGD:5490218 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:51,154,352...51,212,012 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ISO PID PID:200089 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor ISO PID
RGD		 PMID:20086235 PMID:18535784 PID:200089, RGD:5490215, RGD:5490218 NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:127,952,161...127,956,230 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 ISO PID PID:200089 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Nlrp1a NLR family, pyrin domain containing 1A ISO RGD PMID:20303873 RGD:5490211 NCBI chr10:55,778,560...55,833,639
Ensembl chr10:56,277,134...56,323,880 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 ISO RGD PMID:19302047 PMID:20303873 RGD:5490210, RGD:5490211 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394 		JBrowse link
G Peli1 pellino E3 ubiquitin protein ligase 1 ISO RGD PMID:20086235 RGD:5490215 NCBI chr14:95,254,274...95,309,168
Ensembl chr14:99,455,811...99,510,466 		JBrowse link
G Peli2 pellino E3 ubiquitin protein ligase family member 2 ISO RGD PMID:20086235 RGD:5490215 NCBI chr15:21,393,262...21,537,737
Ensembl chr15:23,872,984...24,014,817 		JBrowse link
G Peli3 pellino E3 ubiquitin protein ligase family member 3 ISO RGD PMID:20086235 RGD:5490215 NCBI chr 1:202,230,034...202,242,900
Ensembl chr 1:211,661,610...211,672,239 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO PID PID:200089 NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:117,143,468...117,177,411 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO PID PID:200089 NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347 		JBrowse link
G Prkci protein kinase C, iota ISO PID PID:200089 NCBI chr 2:112,321,919...112,382,305
Ensembl chr 2:114,250,398...114,310,784 		JBrowse link
G Prkcz protein kinase C, zeta ISO PID PID:200089 NCBI chr 5:171,101,774...171,212,694
Ensembl chr 5:171,101,774...171,212,674 		JBrowse link
G Pycard PYD and CARD domain containing ISO RGD PMID:19302047 PMID:20303873 RGD:5490210, RGD:5490211 NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:192,032,124...192,033,419 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO PID PID:200089 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Sigirr single Ig and TIR domain containing ISO RGD PMID:20081871 RGD:5490209 NCBI chr 1:196,195,363...196,208,692
Ensembl chr 1:205,627,708...205,637,802 		JBrowse link
G Sqstm1 sequestosome 1 ISO PID PID:200089 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:35,026,598...35,037,750 		JBrowse link
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 ISO PID
RGD		 PMID:20086235 PMID:18535784 PID:200089, RGD:5490215, RGD:5490218 NCBI chr 7:111,675,829...111,707,058
Ensembl chr 7:113,555,819...113,587,351 		JBrowse link
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 ISO PID
RGD		 PMID:20086235 PMID:18535784 PID:200089, RGD:5490215, RGD:5490218 NCBI chr 1:2,375,026...2,425,115
Ensembl chr 1:4,195,400...4,245,485 		JBrowse link
G Tab3 TGF-beta activated kinase 1 (MAP3K7) binding protein 3 ISO RGD PMID:18535784 RGD:5490218 NCBI chr  X:49,972,414...50,044,658
Ensembl chr  X:53,923,492...53,995,610 		JBrowse link
G Ticam2 TIR domain containing adaptor molecule 2 ISO PID PID:200089 NCBI chr18:39,289,902...39,311,462
Ensembl chr18:41,478,539...41,512,243 		JBrowse link
G Tollip toll interacting protein ISO PID
RGD		 PMID:18535784 PID:200089, RGD:5490218 NCBI chr 1:196,961,585...196,984,252
Ensembl chr 1:206,380,308...206,411,988 		JBrowse link
G Traf6 TNF receptor associated factor 6 ISO
IMP 		PID
RGD		 PMID:20086235 PMID:18535784 PMID:20967881 PID:200089, RGD:5490215, RGD:5490218, RGD:5130945 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:108,418,513...108,443,328 		JBrowse link
G Ube2n ubiquitin-conjugating enzyme E2N ISO PID
RGD		 PMID:20086235 PMID:18535784 PID:200089, RGD:5490215, RGD:5490218 NCBI chr 7:30,154,330...30,184,373 JBrowse link
G Ube2v1 ubiquitin conjugating enzyme E2 V1 ISO PID
RGD		 PMID:20086235 PMID:18535784 PID:200089, RGD:5490215, RGD:5490218 NCBI chr 3:156,317,339...156,340,198
Ensembl chr 3:176,736,325...176,788,278 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2635
      cytokine and chemokine mediated signaling pathway 570
        cytokine mediated signaling pathway 485
          Interleukin mediated signaling pathway 256
            interleukin-1 family mediated signaling pathway 44
              interleukin-1 signaling pathway 44
paths to the root