PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html ).
Term: interleukin-1 signaling pathway
Accession: PW:0000883
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Definition: Interleukin-1 signaling, primarily via interleukin-1beta, plays important roles in innate and adaptive immune responses. Binding of the processed cytokine to its receptor allows for the recruitment of several accessory and adaptor proteins leading to the activation of NF-kappaB and MAPK signaling cascades. A natural receptor antagonist and a decoy receptor act as regulators of interleukin-1alpha and beta.
Synonyms: related_synonym: Il-1 signaling pathway; Interleukin-1 signaling; interleukin-1-mediated signaling pathway
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Aim2
absent in melanoma 2
ISO
RGD
PMID:20303873
RGD:5490211
NCBI chr13:85,865,206...85,906,996
Ensembl chr13:88,404,048...88,439,318
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Casp1
caspase 1
ISO
PID RGD
PMID:19302047 PMID:20303873
PID:200089, RGD:5490210 , RGD:5490211
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:10,746,333...10,882,275
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Chuk
component of inhibitor of nuclear factor kappa B kinase complex
ISO
PID
PID:200089
NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:252,908,749...252,944,273
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Erc1
ELKS/RAB6-interacting/CAST family member 1
ISO
PID
PID:200089
NCBI chr 4:154,435,936...154,727,987
Ensembl chr 4:154,435,944...154,727,987
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Ikbkb
inhibitor of nuclear factor kappa B kinase subunit beta
ISO
PID
PID:200089
NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911
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Ikbkg
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
ISO
PID
PID:200089
NCBI chr X:152,216,485...152,241,476
Ensembl chr X:157,367,639...157,392,757
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Il1a
interleukin 1 alpha
ISO
PID RGD
PMID:20081871
PID:200089, RGD:5490209
NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013
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Il1b
interleukin 1 beta
ISO
PID RGD
PMID:20081871
PID:200089, RGD:5490209
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
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Il1r1
interleukin 1 receptor type 1
ISO IMP
PID RGD
PMID:20081871 PMID:20967881
PID:200089, RGD:5490209 , RGD:5130945
NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:50,000,566...50,076,579
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Il1r2
interleukin 1 receptor type 2
ISO
PID RGD
PMID:20081871
PID:200089, RGD:5490209
NCBI chr 9:49,879,928...49,920,374
Ensembl chr 9:49,877,266...49,920,374
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Il1rap
interleukin 1 receptor accessory protein
ISO
RGD
PMID:20081871
RGD:5490209
NCBI chr11:87,567,813...87,704,346
Ensembl chr11:87,575,116...87,704,342
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Il1rn
interleukin 1 receptor antagonist
ISO
PID RGD
PMID:20081871
PID:200089, RGD:5490209
NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732
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Irak1
interleukin-1 receptor-associated kinase 1
ISO
PID RGD
PMID:20086235 PMID:18535784
PID:200089, RGD:5490215 , RGD:5490218
NCBI chr X:151,768,621...151,778,521
Ensembl chr X:156,920,081...156,929,825
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Irak2
interleukin-1 receptor-associated kinase 2
ISO
RGD
PMID:20086235
RGD:5490215
NCBI chr 4:146,786,004...146,842,615
Ensembl chr 4:148,341,719...148,398,210
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Irak3
interleukin-1 receptor-associated kinase 3
ISO
PID
PID:200089
NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:57,539,557...57,598,706
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Irak4
interleukin-1 receptor-associated kinase 4
ISO
PID RGD
PMID:20086235 PMID:18535784
PID:200089, RGD:5490215 , RGD:5490218
NCBI chr 7:125,682,502...125,708,294
Ensembl chr 7:127,561,717...127,597,109
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
ISO
PID
PID:200089
NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285
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Map2k6
mitogen-activated protein kinase kinase 6
ISO
PID
PID:200089
NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,872,546...95,987,721
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Map3k3
mitogen activated protein kinase kinase kinase 3
ISO
PID
PID:200089
NCBI chr10:91,020,174...91,088,852
Ensembl chr10:91,519,888...91,588,651
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Map3k7
mitogen activated protein kinase kinase kinase 7
ISO
PID RGD
PMID:20086235 PMID:18535784
PID:200089, RGD:5490215 , RGD:5490218
NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:51,154,352...51,212,012
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Mapk8
mitogen-activated protein kinase 8
ISO
PID
PID:200089
NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427
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Myd88
MYD88, innate immune signal transduction adaptor
ISO
PID RGD
PMID:20086235 PMID:18535784
PID:200089, RGD:5490215 , RGD:5490218
NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:127,952,161...127,956,230
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Nfkb1
nuclear factor kappa B subunit 1
ISO
PID
PID:200089
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:226,689,745...226,783,088
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Nlrp1a
NLR family, pyrin domain containing 1A
ISO
RGD
PMID:20303873
RGD:5490211
NCBI chr10:55,778,560...55,833,639
Ensembl chr10:56,277,134...56,323,880
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Nlrp3
NLR family, pyrin domain containing 3
ISO
RGD
PMID:19302047 PMID:20303873
RGD:5490210 , RGD:5490211
NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394
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Peli1
pellino E3 ubiquitin protein ligase 1
ISO
RGD
PMID:20086235
RGD:5490215
NCBI chr14:95,254,274...95,309,168
Ensembl chr14:99,455,811...99,510,466
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Peli2
pellino E3 ubiquitin protein ligase family member 2
ISO
RGD
PMID:20086235
RGD:5490215
NCBI chr15:21,393,262...21,537,737
Ensembl chr15:23,872,984...24,014,817
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Peli3
pellino E3 ubiquitin protein ligase family member 3
ISO
RGD
PMID:20086235
RGD:5490215
NCBI chr 1:202,230,034...202,242,900
Ensembl chr 1:211,661,610...211,672,239
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Pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
ISO
PID
PID:200089
NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:117,143,468...117,177,411
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Pik3r1
phosphoinositide-3-kinase regulatory subunit 1
ISO
PID
PID:200089
NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347
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Prkci
protein kinase C, iota
ISO
PID
PID:200089
NCBI chr 2:112,321,919...112,382,305
Ensembl chr 2:114,250,398...114,310,784
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Prkcz
protein kinase C, zeta
ISO
PID
PID:200089
NCBI chr 5:171,101,774...171,212,694
Ensembl chr 5:171,101,774...171,212,674
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Pycard
PYD and CARD domain containing
ISO
RGD
PMID:19302047 PMID:20303873
RGD:5490210 , RGD:5490211
NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:192,032,124...192,033,419
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Rela
RELA proto-oncogene, NF-kB subunit
ISO
PID
PID:200089
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
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Sigirr
single Ig and TIR domain containing
ISO
RGD
PMID:20081871
RGD:5490209
NCBI chr 1:196,195,363...196,208,692
Ensembl chr 1:205,627,708...205,637,802
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Sqstm1
sequestosome 1
ISO
PID
PID:200089
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:35,026,598...35,037,750
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Tab1
TGF-beta activated kinase 1/MAP3K7 binding protein 1
ISO
PID RGD
PMID:20086235 PMID:18535784
PID:200089, RGD:5490215 , RGD:5490218
NCBI chr 7:111,675,829...111,707,058
Ensembl chr 7:113,555,819...113,587,351
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Tab2
TGF-beta activated kinase 1/MAP3K7 binding protein 2
ISO
PID RGD
PMID:20086235 PMID:18535784
PID:200089, RGD:5490215 , RGD:5490218
NCBI chr 1:2,375,026...2,425,115
Ensembl chr 1:4,195,400...4,245,485
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Tab3
TGF-beta activated kinase 1 (MAP3K7) binding protein 3
ISO
RGD
PMID:18535784
RGD:5490218
NCBI chr X:49,972,414...50,044,658
Ensembl chr X:53,923,492...53,995,610
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Ticam2
TIR domain containing adaptor molecule 2
ISO
PID
PID:200089
NCBI chr18:39,289,902...39,311,462
Ensembl chr18:41,478,539...41,512,243
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Tollip
toll interacting protein
ISO
PID RGD
PMID:18535784
PID:200089, RGD:5490218
NCBI chr 1:196,961,585...196,984,252
Ensembl chr 1:206,380,308...206,411,988
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Traf6
TNF receptor associated factor 6
ISO IMP
PID RGD
PMID:20086235 PMID:18535784 PMID:20967881
PID:200089, RGD:5490215 , RGD:5490218 , RGD:5130945
NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:108,418,513...108,443,328
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Ube2n
ubiquitin-conjugating enzyme E2N
ISO
PID RGD
PMID:20086235 PMID:18535784
PID:200089, RGD:5490215 , RGD:5490218
NCBI chr 7:30,154,330...30,184,373
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Ube2v1
ubiquitin conjugating enzyme E2 V1
ISO
PID RGD
PMID:20086235 PMID:18535784
PID:200089, RGD:5490215 , RGD:5490218
NCBI chr 3:156,317,339...156,340,198
Ensembl chr 3:176,736,325...176,788,278
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