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Term:interleukin-1 signaling pathway
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Accession:PW:0000883 term browser browse the term
Definition:Interleukin-1 signaling, primarily via interleukin-1beta, plays important roles in innate and adaptive immune responses. Binding of the processed cytokine to its receptor, allows for the recruitment of several accessory and adaptor proteins leading to the activation of NF-kappaB and MAPK signaling cascades. A natural receptor antagonist and a decoy receptor act as regulators of interleukin 1alpha and beta.
Synonyms:related_synonym: Il-1 signaling pathway;   PID:200089

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interleukin-1 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aim2 absent in melanoma 2 JBrowse link 13 91,919,834 91,963,080 RGD:5490211
G Casp1 caspase 1 JBrowse link 8 2,605,743 2,614,637 RGD:5490210
RGD:6484113
RGD:5490211
G Chuk component of inhibitor of nuclear factor kappa B kinase complex JBrowse link 1 263,848,829 263,884,354 RGD:6484113
G Erc1 ELKS/RAB6-interacting/CAST family member 1 JBrowse link 4 152,087,393 152,380,023 RGD:6484113
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:6484113
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma JBrowse link X 156,254,187 156,280,046 RGD:6484113
G Il1a interleukin 1 alpha JBrowse link 3 121,824,712 121,836,122 RGD:5490209
RGD:6484113
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:5490209
RGD:6484113
G Il1r1 interleukin 1 receptor type 1 JBrowse link 9 46,962,291 47,038,139 RGD:5490209
RGD:6484113
RGD:5130945
G Il1r2 interleukin 1 receptor type 2 JBrowse link 9 46,840,646 46,881,241 RGD:5490209
RGD:6484113
G Il1rap interleukin 1 receptor accessory protein JBrowse link 11 77,456,648 77,593,208 RGD:5490209
G Il1rn interleukin 1 receptor antagonist JBrowse link 3 1,449,778 1,468,624 RGD:5490209
RGD:6484113
G Irak1 interleukin-1 receptor-associated kinase 1 JBrowse link X 156,716,469 156,726,367 RGD:5490215
RGD:6484113
RGD:5490218
G Irak2 interleukin-1 receptor-associated kinase 2 JBrowse link 4 145,594,575 145,651,066 RGD:5490215
G Irak3 interleukin-1 receptor-associated kinase 3 JBrowse link 7 64,922,830 64,982,224 RGD:6484113
G Irak4 interleukin-1 receptor-associated kinase 4 JBrowse link 7 135,803,723 135,831,006 RGD:5490215
RGD:6484113
RGD:5490218
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6484113
G Map2k6 mitogen-activated protein kinase kinase 6 JBrowse link 10 98,707,160 98,823,054 RGD:6484113
G Map3k3 mitogen activated protein kinase kinase kinase 3 JBrowse link 10 94,280,703 94,349,372 RGD:6484113
G Map3k7 mitogen activated protein kinase kinase kinase 7 JBrowse link 5 47,183,142 47,244,424 RGD:5490215
RGD:6484113
RGD:5490218
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6484113
G Myd88 MYD88, innate immune signal transduction adaptor JBrowse link 8 128,022,512 128,027,462 RGD:5490215
RGD:6484113
RGD:5490218
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:6484113
G Nlrp1a NLR family, pyrin domain containing 1A JBrowse link 10 57,692,474 57,747,608 RGD:5490211
G Nlrp3 NLR family, pyrin domain containing 3 JBrowse link 10 45,884,324 45,918,290 RGD:5490210
RGD:5490211
G Peli1 pellino E3 ubiquitin protein ligase 1 JBrowse link 14 106,008,086 106,062,566 RGD:5490215
G Peli2 pellino E3 ubiquitin protein ligase family member 2 JBrowse link 15 24,942,218 25,086,350 RGD:5490215
G Peli3 pellino E3 ubiquitin protein ligase family member 3 JBrowse link 1 220,191,209 220,204,032 RGD:5490215
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6484113
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6484113
G Prkci protein kinase C, iota JBrowse link 2 115,941,998 116,002,550 RGD:6484113
G Prkcz protein kinase C, zeta JBrowse link 5 172,658,071 172,769,492 RGD:6484113
G Pycard PYD and CARD domain containing JBrowse link 1 199,438,029 199,439,062 RGD:5490210
RGD:5490211
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6484113
G Sigirr single Ig and TIR domain containing JBrowse link 1 213,898,395 213,907,697 RGD:5490209
G Sqstm1 sequestosome 1 JBrowse link 10 35,704,728 35,716,316 RGD:6484113
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 JBrowse link 7 121,350,953 121,382,100 RGD:5490215
RGD:6484113
RGD:5490218
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 JBrowse link 1 1,999,574 2,017,574 RGD:5490215
RGD:6484113
RGD:5490218
G Tab3 TGF-beta activated kinase 1 (MAP3K7) binding protein 3 JBrowse link X 54,035,958 54,090,282 RGD:5490218
G Ticam2 toll-like receptor adaptor molecule 2 JBrowse link 18 40,555,106 40,572,569 RGD:6484113
G Tollip toll interacting protein JBrowse link 1 214,823,993 214,844,861 RGD:5490218
RGD:6484113
G Traf6 TNF receptor associated factor 6 JBrowse link 3 91,252,829 91,271,607 RGD:5490215
RGD:6484113
RGD:5130945
RGD:5490218
G Ube2n ubiquitin-conjugating enzyme E2N JBrowse link 7 36,610,147 36,640,190 RGD:5490215
RGD:6484113
RGD:5490218
G Ube2v1 ubiquitin conjugating enzyme E2 V1 JBrowse link 3 164,343,833 164,366,684 RGD:5490215
RGD:6484113
RGD:5490218

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Term Annotations click to browse term
  pathway 6016
    signaling pathway 2585
      cytokine and chemokine mediated signaling pathway 558
        cytokine mediated signaling pathway 473
          Interleukin mediated signaling pathway 245
            interleukin-1 family mediated signaling pathway 44
              interleukin-1 signaling pathway 44
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.